Genome-wide association study of gastric adenocarcinoma in Asia: a comparison of associations between cardia and non-cardia tumours

Hu, Nan,Wang, Zhaoming,Song, Xin,Wei, Lixuan,Kim, Byung Sik,Freedman, Neal D,Baek, Jiwon,Burdette, Laurie,Chang, Jiang,Chung, Charles,Dawsey, Sanford M,Ding, Ti,Gao, Yu-Tang,Giffen, Carol,Han, Yaling British Medical Association 2016 Gut Vol.65 No.10

<P>Objective Genome-wide association studies (GWAS) of gastric cancer have reported differences in single-nucleotide polymorphism (SNP) associations for tumour subtypes, particularly when divided by location into the gastric cardia versus the non-cardia. Design Here we present results for a GWAS using 2350 East Asian gastric cancer cases divided as 1189 gastric cardia and 1027 gastric non-cardia cases and 2708 controls. We also included up to 3042 cardia cases, 4359 non-cardia cases and 7548 controls for replication from two Chinese studies and one Korean study. From the GWAS, we selected 12 top SNPs for each gastric cancer subtype, 4 top SNPs for total gastric cancer and 1 SNP in MUC1 for replication testing. Results We observed genome-wide significant associations for rs10074991 in PRKAA1 at 5p13.1 for cardia (p=7.36x10(-12)) and non-cardia cancers (p=2.42x10(-23)) with per allele OR (95% CI) for the combined endpoint of 0.80 (0.77 to 0.83). At 6p21.1, rs2294693 near UNC5CL was significantly associated with gastric non-cardia cancer risk (p=2.50x10(-8)), with OR (95% CI) of 1.18 (1.12 to 1.26), but there was only a nominal association for cardia cancer (p=1.47x10(-2)). We also confirmed a previously reported association for rs4072037 in MUC1 with p=6.59x10(-8) for total gastric cancer and similar estimates for cardia and non-cardia cancers. Three SNPs in PSCA previously reported to be associated with gastric non-cardia cancer showed no apparent association for cardia cancer. Conclusions Our results suggest that associations for SNPs with gastric cancer show some different results by tumour location in the stomach.</P>

Research on the Multi-Focus Image Fusion Method Based on the Lifting Stationary Wavelet Transform

Hu, Kaiqun,Feng, Xin Korea Information Processing Society 2018 Journal of information processing systems Vol.14 No.5

For the disadvantages of multi-scale geometric analysis methods such as loss of definition and complex selection of rules in image fusion, an improved multi-focus image fusion method is proposed. First, the initial fused image is quickly obtained based on the lifting stationary wavelet transform, and a simple normalized cut is performed on the initial fused image to obtain different segmented regions. Then, the original image is subjected to NSCT transformation and the absolute value of the high frequency component coefficient in each segmented region is calculated. At last, the region with the largest absolute value is selected as the postfusion region, and the fused multi-focus image is obtained by traversing each segment region. Numerical experiments show that the proposed algorithm can not only simplify the selection of fusion rules, but also overcome loss of definition and has validity.

Plasma Targeted Metabolomics Analysis for Amino Acids and Acylcarnitines in Patients with Prediabetes, Type 2 Diabetes Mellitus, and Diabetic Vascular Complications

Xin Li,Yancheng Li,Yuanhao Liang,Ruixue Hu,Wenli Xu,Yufeng Liu 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.2

Background: We hypothesized that specific amino acids or acylcarnitines would have benefits for the differential diagnosis of diabetes. Thus, a targeted metabolomics for amino acids and acylcarnitines in patients with diabetes and its complications was carried out. Methods: A cohort of 54 normal individuals and 156 patients with type 2 diabetes mellitus and/or diabetic complications enrolled from the First Affiliated Hospital of Jinzhou Medical University was studied. The subjects were divided into five main groups: normal individuals, impaired fasting glucose, overt diabetes, diabetic microvascular complications, and diabetic peripheral vascular disease. The technique of tandem mass spectrometry was applied to obtain the plasma metabolite profiles. Metabolomics multivariate statistics were applied for the metabolic data analysis and the differential metabolites determination. Results: A total of 10 cross-comparisons within diabetes and its complications were designed to explore the differential metabolites. The results demonstrated that eight comparisons existed and yielded significant metabolic differences. A total number of 24 differential metabolites were determined from six selected comparisons, including up-regulated amino acids, down-regulated medium-chain and long-chain acylcarnitines. Altered differential metabolites provided six panels of biomarkers, which were helpful in distinguishing diabetic patients. Conclusion: Our results demonstrated that the biomarker panels consisted of specific amino acids and acylcarnitines which could reflect the metabolic variations among the different stages of diabetes and might be useful for the differential diagnosis of prediabetes, overt diabetes and diabetic complications.

Spectrum Sensing for Cognitive Networks Based on Dimensionality Reduction and Random Forest

Xin Wang,Jin-Kuan Wang,Zhi-Gang Liu,Bin Wang,Xi Hu 보안공학연구지원센터(IJSIP) 2014 International Journal of Signal Processing, Image Vol.7 No.3

Colorimetric and Fluorescent Detecting Phosgene by a Second-Generation Chemosensor

Hu, Ying,Zhou, Xin,Jung, Hyeseung,Nam, Sang-Jip,Kim, Myung Hwa,Yoon, Juyoung American Chemical Society 2018 ANALYTICAL CHEMISTRY - Vol.90 No.5

<P>Because of the current shortage of first-generation phosgene sensors, increased attention has been given to the development of fluorescent and colorimetric based methods for detecting this toxic substance. In an effort focusing on this issue, we designed the new, second-generation phosgene chemosensor <B>1</B> and demonstrated that it undergoes a ring-opening reaction with phosgene in association with color and fluorescent changes with a detection limit of 3.2 ppb. Notably, in comparison with the first-generation sensor RB-OPD, <B>1</B> not only undergoes a much faster response toward phosgene with an overall response time within 2 min, but it also generates no byproducts during the sensing process. Finally, sensor <B>1</B> embedded nanofibers were successfully fabricated and used for accurate and sensitive detection of phosgene.</P> [FIG OMISSION]</BR>

Limiting the wind-induced deflection amplitude of an overhead conductor: establishment of multi-rigid-body model and optimization of structural parameters

Xin Hu,Zhangqi Wang,Rui Tian 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.7

To limit the wind-induced deflection amplitude of an overhead conductor, this study proposes a calculation model and an optimization model for overhead lines. According to the geometric deformation relationship and the principle of energy conservation, a multi-rigidbody model (MRBM) is proposed for the wind-induced deflection of the overhead lines. An aeroelastic model wind tunnel test was designed to verify the accuracy of the MRBM; the efficiency of the MRBM was verified through comparison with the finite element model (FEM). The optimization model is presented, and the structural parameters of the transmission lines in the actual project are optimized and analyzed. The results show that the accuracy of the MRBM can meet engineering requirements; the solution time is shorter than FEM, and the MRBM is easily called by the optimization algorithm. The structural parameter optimization effectively limits the deflection amplitude of the overhead conductor according to the engineering requirements.

Clinical Prognostic Factors in 86 Chinese Patients with Primary Myelodysplastic Syndromes and Trisomy 8: A Single Institution Experience

Xin-Yue Liu,Qing-Fang Yue,Lei Chen,Xiao-Mei She,Bin Hu,Yu Hu,Ping Zou 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.2

Purpose: The objective was to determine the characteristics and prognostic factors of 86 Chinese patients with trisomy 8 aberrationsand compare the prognostic value of International Prognostic System (IPSS) and Revised IPSS (IPSS-R) in this cohort. Materials and Methods: A total of 86 cases diagnosed with primary myelodysplastic syndromes (MDS) with isolated tr8 or with tr8 and other additional cytogenetic aberrations diagnosed and treated at the Union Hospital, Tongji Medical College of Huazhong University of Science and Technology between July 2002 and March 2013 were reviewed. Results: The median survival of the entire group was 23.0 months, and acute myeloid leukemia (AML) developed in 43% (37/86) patients within the follow up time. The univariate analysis revealed that overall survival (OS) was correlated with age, thrombocytopenia,absolute neutrophil count, marrow blasts, cytogenetic status and red blood cell transfusion at diagnosis, and the multivariateanalysis revealed that age, marrow blasts, cytogenetic status and transfusion dependence were independent parameters for the OS. The cytogenetic complexity and marrow blasts had the strongest impact on the AML transformation by multivariate analysis. Comparing the two prognostic systems, both two systems could successfully discriminate risk groups for survival. IPSS-R was more refined than IPSS for predicting OS, but had no advantage in predicting the risk of AML development. Conclusion: This study confirmed the influence of clinical factors on the prognosis of 86 Chinese MDS patients with trisomy 8. In addition, IPSS-R can further refine prognostic discrimination in the IPSS risk categories.

An Experimental Study of Shear Resistance for Multisize Polypropylene Fiber Concrete Beams

Xin Yang,Ninghui Liang,Yang Hu,Rui Feng 한국콘크리트학회 2022 International Journal of Concrete Structures and M Vol.16 No.1

Study on fracture characteristics of reinforced concrete wedge splitting tests

Hu Shaowei,XU Aiqing,HU Xin,YIN Yangyang 사단법인 한국계산역학회 2016 Computers and Concrete, An International Journal Vol.18 No.3

To study the influence on fracture properties of reinforced concrete wedge splitting test specimens by the addition of reinforcement, and the restriction of steel bars on crack propagation, 7 groups reinforced concrete specimens of different reinforcement position and 1 group plain concrete specimens with the same size factors were designed and constructed for the tests. Based on the double-K fracture criterion and tests, fracture toughness calculation model which was suitable for reinforced concrete wedge splitting tensile specimens has been obtained. The results show that: the value of initial craking load Pini and unstable fracture load Pun decreases gradually with the distance of reinforcement away from specimens’s top. Compared with plain concrete specimens, addition of steel bar can reduce the value of initial fracture toughness KIini, but significantly increase the value of the critical effective crack length ac and unstable fracture toughness KIun. For tensional concrete member, the effect of anti-cracking by reinforcement was mainly acted after cracking, the best function of preventing fracture initiation was when the steel bar was placed in the middle of the crack, and when the reinforcement was across the crack and located away from crack tip, it plays the best role in inhibiting the extension of crack.

Extraction of Cellulose Nanofibrils with Ultraviolet Blocking from Agro-industrial Wastes: A Comparative Study

Xin Zhao,Fangchao Cheng,Yingcheng Hu 한국섬유공학회 2021 Fibers and polymers Vol.22 No.1

Cellulose nanofibrils (CNFs) were successfully isolated from agro-industrial waste (cornstalk, corn flesh, andcorncob) by subjecting the raw materials to organosolv and peroxide treatment, followed by ultrasonication. A detailedcomparative study was performed. Characterization results showed that the CNFs from cornstalk (CS) exhibited higher yieldand lignin content (20.81 %), compared with CNFs from corn flesh (CF) and corncob (CC). The CNFs from CF and CCexhibited similar morphology, particle size, crystallinity, and thermal stability but showed improved ultraviolet blockingability and optical transparency relative to those of CS. The CNFs from CF showed higher dispersion stability andmechanical properties than those from CS and CC. Peroxide treatment negatively influenced crystallinity and thermalstability, but exerted no apparent effect on optical transparency and mechanical strength. Thus, this study demonstrates thatagro-industrial wastes are sustainable resources for CNF production, which can potentially have a wide range of value-addedapplications. Ionic liquid-aided solvothermal treatment followed by ultrasonication is a facile and ideal method to produceCNFs with ultraviolet blocking ability.