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Printed photonic elements: nanoimprinting and beyond
Zhang, Cheng,Subbaraman, Harish,Li, Qiaochu,Pan, Zeyu,Ok, Jong G.,Ling, Tao,Chung, Chi-Jui,Zhang, Xingyu,Lin, Xiaohui,Chen, Ray T.,Guo, L. Jay Royal Society of Chemistry 2016 Journal of Materials Chemistry C Vol.4 No.23
<P>In order to manufacture large-scale photonic devices of various dimensions at a low cost, a number of patterning techniques have been developed. Nanoimprint lithography is among the most promising given its unique advantages, such as high resolution, fast processing speed, high throughput, compatibility with diverse materials, and low cost. This review covers various aspects of nanoimprint lithography, including its operational principles, material requirements, and different ways of implementation. Nanoimprint lithography facilitates numerous high-performance and low-cost photonic elements, including optical interconnects, sensors, solar cells, and metamaterials. In addition, other related patterning techniques, together with their utilization for photonic device fabrication and their integration with nanoimprint lithography, are briefly discussed.</P>
Zhang, Yuangeng,Petrov, Valentin,Griebner, Uwe,Zhang, Xingyu,Choi, Sun Young,Gwak, Ji Yoon,Rotermund, Fabian,Mateos, Xavier,Yu, Haohai,Zhang, Huaijin,Liu, Junhai Optical Society of America 2014 Optics express Vol.22 No.5
<P>A diode-pumped Yb:CLNGG laser is mode-locked with a single-walled carbon nanotube saturable absorber (SWCNT-SA) for the first time. Pulse durations as short as 90 fs are obtained at ~1049 nm with 0.4% output coupler, the shortest pulses to our knowledge for a diode-pumped 1-?m laser applying SWCNTs as saturable absorber. Using 3% output coupler, the maximum average output power reached 90 mW at a repetition frequency of 83 MHz.</P>
Zhang, Lu,Feng, Qiang,Wang, Jiuling,Zhang, Shuai,Ding, Baoquan,Wei, Yujie,Dong, Mingdong,Ryu, Ji-Young,Yoon, Tae-Young,Shi, Xinghua,Sun, Jiashu,Jiang, Xingyu American Chemical Society 2015 ACS NANO Vol.9 No.10
<P>The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and <I>in vivo</I> stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell–particle interaction. Here we develop a microfluidic chip allowing for the synthesis of structurally well-defined lipid-polymer nanoparticles of the same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force microscope and atomistic simulations reveal that MPs have a lower flexibility than BPs, resulting in a more efficient cellular uptake and thus anticancer effect than BPs do. This flexibility-regulated cell–particle interaction may have important implications for designing drug nanocarriers.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-10/acsnano.5b05792/production/images/medium/nn-2015-05792e_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b05792'>ACS Electronic Supporting Info</A></P>
Zhang Ning,Liu Huan,Zhang Tianwen,Kan Hongmin,Wang Xiaoyang,Cui Xingyu 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.3
The paper was prepared spherical hexagonal boron nitride with different microstructures under flowing ammoniaatmosphere. The effect of boron source component ratios (molar ratio of borax and boric acid) on the phase composition ofthe sample were studied: the work also explored the effect of boron source component ratio on the microstructure andadsorption performance of h-BN. Spherical hexagonal boron nitride had corresponding to shell structure, mesoporousstructure, and solid structure when the ratio of boron source components respectively was 1 : 0.5, 1 : 1, and 1 : 2. Between 1 : 1and 1:0.5, the former had an lower adsorptions at low relative pressures. On the contrary, the adsorption of former wouldincreased at higher relative pressures and reached up 276.02 cm3 g−1, and the maximum adsorption of the latter reached only228.20 cm3 g−1. Under any relative pressure, the adsorption capacity was the lowest when the boron source composition ratiowas 1 : 2.
Hydroxychloroquine and chloroquine: a potential and controversial treatment for COVID-19
Li Zou,Lijun Dai,Xingyu Zhang,Zhaohui Zhang,Zhentao Zhang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.8
A novel coronavirus, later named SARS-CoV-2,was fi rst reported in China in December 2019 and subsequentlywidely identifi ed in the United States, Japan, SouthKorea, France, India, and other countries. The diseasecaused by SARS-CoV-2 infection was called COVID-19. The high fatality and morbidity rates of COVID-19 makeit the third largest global epidemic in this century. However,there are currently no approved antiviral drugs for theCOVID-19 treatment. Recently, two old antimalarial drugs,hydroxychloroquine and chloroquine, have been found toexert anti-SARS-CoV-2 eff ects both in vitro and in vivo. Preliminaryclinical evidence suggests these drugs may havean eff ect on the treatment of COVID-19. Herein, we reviewthe pharmacokinetics characteristics and antiviral eff ects ofthese drugs, in addition to their side eff ects and clinical evidenceof their use for the COVID-19 treatment.
Achalasia: The Current Clinical Dilemma and Possible Pathogenesis
Xingyu Jia,Songfeng Chen,Qianjun Zhuang,Niandi Tan,Mengyu Zhang,Yi Cui,Jinhui Wang,Xiangbin Xing,Yinglian Xiao 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.2
Achalasia is a primary esophageal motility disorder manifested by dysphagia and chest pain that impair patients’ quality of life, and it also leads to chronic esophageal inflammation by food retention and increases the risk of esophageal cancer. Although achalasia has long been reported, the epidemiology, diagnosis and treatment of achalasia are not fully understood. The current clinical dilemma of achalasia is mainly due to its unclear pathogenesis. In this paper, epidemiology, diagnosis treatment, as well as possible pathogenesis of achalasia will be reviewed and summarized. The proposed hypothesis on the pathogenesis of achalasia is that genetically susceptible populations potentially have a higher risk of infection with viruses, triggering autoimmune and inflammation responses to inhibitory neurons in lower esophageal sphincter.
Xiu Zhang,Xingyu Wang,Takenao Sugi,Akio Ikeda,Takashi Nagamine,Hiroshi Shibasaki,Masatoshi Nakamura 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
Quantitative analysis and detection of abnormalities for electroencephalogram (EEG) recordings during evoked activities are essential for clinical diagnosis on neurological disorders. However, the process of interpreting EEG is time consuming and requires experienced electroencephalographers (EEGers). In this study, a method of automatic EEG interpretation during hyperventilation was proposed. The purpose is to provide a quantitative interpretation of EEG which is able to conform to EEGers’visual inspection. The final integrated results of automatic interpretation were compared with EEGers’evaluation, and showed high consistence.
Xiu Zhang,Xingyu Wang,Bei Wang,Takenao Sugi,Masatoshi Nakamura 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.2
The objective of this study is to design a meal assistance system operated by electromyogram (EMG) signals. The system consists of four parts, EMG data acquisition, onset analysis, control circuit and operation of meal assistance robot. An algorithm based on EMG power with adaptive threshold is proposed for onset analysis, and applied to the operation of robot via control circuit. The performance of EMG-control system is tested in rate of success and comfort by both subjective and objective indices. The results show EMG signals acquired from active muscles in a human body can be used as control signals for the apparatus, by the proposed onset detection algorithm with adaptive threshold. The high rate of success and comfort of meal assistance system operated by EMG signals guarantee its use for patients with disabled upper limbs.