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LED 파장이 Saccharomyces cerevisiae의 생장에 미치는 영향
쉬시아오통(Xiaotong Xu),이지은(Ji-Eun Lee),정소미(So-Mi Jeong),강우신(Woo-Sin Kang),류시형(Si-Hyeong Ryu),김한호(Han-Ho Kim),김수룡(Su-Ryong Kim),이가혜(Ga-Hye Lee),안동현(Dong-Hyun Ahn) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.3
본 연구에서는 다양한 LED 파장이 S. cerevisiae의 생육에 미치는 영향을 확인하였다. 270 nm UV-LED를 S. cerevisiae에 10분 동안 조사한 경우 100% 생장억제로 가장 뛰어난 억제 효과를 보였고, 360 ㎚ UV-LED를 S. cerevisiae에 180분 동안 조사한 경우 유의적인 생장억제 효과를 보였다. 465~675 ㎚ Vis-LED 조사의 경우 UV-LED보다 낮은 생장억제 효과를 보였고, 60분 조사 시 대조구에 비해 약 0.94 log CFU/mL의 감소를 확인하였다. 반면, 620~ 630 ㎚ Vis-LED를 S. cerevisiae에 180분 동안 조사한 경우, S. cerevisiae의 생장이 유의적으로 촉진됨을 확인할 수 있었다. 850 ㎚ IR-LED의 경우 S. cerevisiae의 생육이 미미하게 촉진되는 것으로 나타났고, 5,000~7,000 ㎚ IRLED를 조사한 경우에는 S. cerevisiae 생장에 특별한 작용이 없음을 확인할 수 있었다. 따라서 S. cerevisiae의 생장 특성에 따른 다양한 LED 파장을 이용한다면 식품산업에서 S. cerevisiae의 효율적인 활용이 가능할 것으로 판단되며, 더불어 다양한 LED 파장의 활용이 식품산업에 있어 잠재적 이용가치가 있는 것으로 사료된다. Light-emitting diodes (LEDs) are divided into ultraviolet LEDs (UV-LEDs), visible LEDs (Vis-LEDs), and infrared LEDs (IR-LEDs). LEDs of different wavelengths have different functions. This study examined the effects of different wavelengths on the growth of Saccharomyces cerevisiae. S. cerevisiae cells were incubated for 48 h at 30℃. Subsequently, S. cerevisiae suspensions were diluted to 1×10³∼1×10⁴ CFU/mL and 1×10<SUP>7</SUP> CFU/mL. The S. cerevisiae suspensions were then exposed to UV-LED (270 ㎚ and 365 ㎚), Vis-LED (465∼475 ㎚ and 620∼630 ㎚), and IR-LED (850 ㎚ and 5,000∼7,000 ㎚), with a lamp-to-suspension distance of 4.5 ㎝. The microorganisms were irradiated by 270 ㎚ UV-LED for 10 and 30 min and 365 ㎚ UV-LED, Vis-LED, and IR-LED for 60 and 180 min, respectively. Among the LEDs used, the 465∼475 ㎚ Vis-LED had the strongest inhibitory ability on S. cerevisiae. In contrast, the 620∼630 ㎚ Vis-LED and infrared LED showed either low antibacterial activity or even no bacteriostatic ability.
The ameliorating effects of stigmasterol on scopolamine-induced memory impairments in mice
Park, Se Jin,Kim, Dong Hyun,Jung, Jun Man,Kim, Jong Min,Cai, Mudan,Liu, Xiaotong,Hong, Jin Gyu,Lee, Chang Hwan,Lee, Kang Ro,Ryu, Jong Hoon Elsevier 2012 european journal of pharmacology Vol.676 No.1
<P><B>Abstract</B></P><P>Stigmasterol, a kind of phytosterol, is present in small amounts in various foods. In the present study, we investigated the effects of stigmasterol on scopolamine-induced memory impairments using the passive avoidance and the Morris water maze tasks in mice. In addition, changes in memory-related molecules, including extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB), were examined following the administration of stigmasterol. Scopolamine-induced memory impairments were significantly attenuated by the administration of stigmasterol (10mg/kg) in the passive avoidance task. In the Morris water maze task, the escape latencies were significantly decreased in the stigmasterol-treated group compared to the scopolamine-treated group during the training phase. The swimming times within the target zone during the probe trial were significantly increased as compared to scopolamine-treated mice. Furthermore, the ameliorating effect of stigmasterol on scopolamine-induced memory dysfunction was blocked by a sub-effective dose of dizocilpine (MK-801), an NMDA receptor antagonist, and tamoxifen, an estrogen receptor antagonist, in the passive avoidance task. In addition, the expression levels of phosphorylated ERK and CREB in the hippocampus were significantly increased by stigmasterol, which was blocked by tamoxifen or MK-801 with scopolamine. These results suggest that stigmasterol-induced cognitive ameliorative effects are mediated by the enhancement of cholinergic neurotransmission system via the activation of estrogen or NMDA receptors.</P>