Risk of hypertension in cancer patients treated with abiraterone: a meta-analysis

Xiaolei Zhu,Shenhong Wu 대한고혈압학회 2019 Clinical Hypertension Vol.25 No.3

Background: Hypertension is one of the major side effects associated with abiraterone in the treatment of advanced prostate cancer. The specific contribution of abiraterone to hypertension has not been defined. We performed a systematic review and meta-analysis of randomized clinical trials to determine its overall risk. Methods: Databases including Pubmed (up to July 2018) and Google scholar (up to July 2018) were searched to identify relevant studies. Eligible studies were prospective randomized clinical trials with prostate cancer treated with abiraterone and prednisone. The incidence and relative risk (RR) of hypertension was calculated using random-effects or fixed-effects model depending on the heterogeneity of included studies. Results: A total of five studies including 5445 patients were selected for analysis. Among patients receiving abiraterone, the overall incidences of all grade and high grade (grade 3 and 4) were 21.9% (95% CI: 13.6–33.2%) and 10.2% % (95% CI: 6.9–11.6%). Abiraterone was associated with a significantly increased risk of hypertension of all grade with a relative risk of 1.80 (95% CI: 1.47–2.19%, p < 0.001) and high grade with a relative risk of 2.11 (95%CI: 1.66–2.68%, p < 0.001) in comparison with controls. The risk of hypertension may be affected by concurrent use of prednisone with 5 mg daily is associated with higher incidence than that of prednisone 5 mg twice daily (32.4% vs 16.5%). Conclusion: There is a significant increase of developing hypertension in prostate cancer patients treated with abiraterone. Appropriate monitoring and management is strongly recommended to reduce the risk of cardiovascular events and treatment interruptions.

Risks and management of hypertension in cancer patients undergoing targeted therapy: a review

Xiaolei Zhu,Shenhong Wu 대한고혈압학회 2022 Clinical Hypertension Vol.28 No.-

Rapid progress over the last decade has added numerous agents targeting specific cellular signaling pathways to the treatment armamentarium for advanced cancer. However, many of these agents can cause hypertension resulting in major adverse cardiovascular event.A systematic literature search was performed on the databases PubMed and Google Scholar for papers published in English until December 2020. This review summarizes the risk, mechanism, diagnosis, and management of hypertension in cancer patients undergoing targeted therapy. The risk and pathogenesis of hypertension vary widely with different classes of targeted agents. Currently there is a paucity of data investigating optimal management of hypertension with targeted therapy. A practical approach is discussed with a focus on the goal of blood pressure control as well as drug selection based on the mechanism of hypertension in the context of advanced cancer, treatment toxicity, comorbidity, and drug-drug interactions. This review also discusses many studies that have explored hypertension as a biomarker for cancer treatment efficacy and as a pharmacodynamic biomarker to titrate drug dose.The diversity of targeted agents has provided important insights into the pathogenesis of hypertension in cancer patients. The underlying mechanism may provide a guidance to the management of hypertension. Further studies are needed to investigate optimal treatment and hypertension as a biomarker for cancer treatment.

Glucosinolates in Chinese Brassica Vegetables and Its Regulatory Mechanisms

Zhujun Zhu,Huasen Wang,Xinjuan Chen,Jing Yang,Xiaolei Ni 한국원예학회 2008 한국원예학회 기타간행물 Vol.- No.-

Photoactive Organic/Inorganic Hybrid Materials with Nanosegregated Donor–Acceptor Arrays

Fabrice Mathevet,Xiaolei Zhu,Cheriehan Hessin,Aude Salam,Lydia Sosa-Vargas,David Kreher,Chihaya Adachi,Anna Proust,Pierre Mialane,Jerome Marrot,Aude Bouchet,Michel Sliwa,Stephane Mery,Benoit Heinrich 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2

We designed and synthesized a first example of mesogenic donor-acceptor polyoxometalate (POM)-based hybrid. The structural and electronic properties of the hybrid compound were evaluated through combination of small- and wide-angle X-ray scattering, optical microscopy, electrochemistry and photoluminescence. In the solid state, the compound behaves as a birefringent solid, displaying a lamellar organization in which double-layers of POMs and bis(thiophene)thienothiophene organic donors alternate regularly. Noticeably, the subunit organizations in the composite are similar to that observed for the individual POM and organic donor precursors. Photophysical studies showed that in the hybrid, the fluorescence of the organic donor unit is considerably quenched both in solution and in the solid state, which is attributed to occurrence of intramolecular charge-separated state.

PL-PatchSurfer: A Novel Molecular Local Surface-Based Method for Exploring Protein-Ligand Interactions

Hu, Bingjie,Zhu, Xiaolei,Monroe, Lyman,Bures, Mark G.,Kihara, Daisuke MDPI 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.9

<P>Structure-based computational methods have been widely used in exploring protein-ligand interactions, including predicting the binding ligands of a given protein based on their structural complementarity. Compared to other protein and ligand representations, the advantages of a surface representation include reduced sensitivity to subtle changes in the pocket and ligand conformation and fast search speed. Here we developed a novel method named PL-PatchSurfer (Protein-Ligand PatchSurfer). PL-PatchSurfer represents the protein binding pocket and the ligand molecular surface as a combination of segmented surface patches. Each patch is characterized by its geometrical shape and the electrostatic potential, which are represented using the 3D Zernike descriptor (3DZD). We first tested PL-PatchSurfer on binding ligand prediction and found it outperformed the pocket-similarity based ligand prediction program. We then optimized the search algorithm of PL-PatchSurfer using the PDBbind dataset. Finally, we explored the utility of applying PL-PatchSurfer to a larger and more diverse dataset and showed that PL-PatchSurfer was able to provide a high early enrichment for most of the targets. To the best of our knowledge, PL-PatchSurfer is the first surface patch-based method that treats ligand complementarity at protein binding sites. We believe that using a surface patch approach to better understand protein-ligand interactions has the potential to significantly enhance the design of new ligands for a wide array of drug-targets.</P>

Controlled synthesis of Co₂C nanochains using cobalt laurate as precursor: Structure, growth mechanism and magnetic properties

Zhang, Yajing,Zhu, Yuan,Wang, Kangjun,Li, Da,Wang, Dongping,Ding, Fu,Meng, Dan,Wang, Xiaolei,Choi, Chuljin,Zhang, Zhidong Elsevier 2018 Journal of magnetism and magnetic materials Vol.456 No.-

<P><B>Abstract</B></P> <P>Cobalt carbides (Co<SUB>2</SUB>C and Co<SUB>3</SUB>C) nanocomposites exhibit interesting hard magnetic property, controlled synthesis of individual phase facilitates to clarify the magnetism of each, but it is difficult to obtain the single phase. We present a new approach to address this issue via a polyol refluxing process, using cobalt laurate as the precursor. The single phase Co<SUB>2</SUB>C magnetic nanochains self-assembled by nanoparticles are synthesized. The precursor is the key factor for controlling the growth kinetics of the Co<SUB>2</SUB>C nanochains. Cobalt, instead of cobalt carbides, is produced if cobalt chloride, acetate and acetylacetonate replace cobalt laurate as the precursor, respectively. The evolution of the growth process has been studied. In the formation of Co<SUB>2</SUB>C, first fcc-Co produces, then it transforms into Co<SUB>2</SUB>C by carbon diffusion process, and the produced carbon first exists in disordered state and then a small amount of them transforms into graphite. Saturation magnetization (<I>Ms</I>) of Co<SUB>2</SUB>C nanochains obtained at 300 °C for 20, 60, and 180 min are 27.1, 18.9, and 10.9 emu g<SUP>−1</SUP>, respectively. The decrease of <I>Ms</I> caused by increasing carbon content, and the carbon content are much larger than the stoichiometric ratio value of Co<SUB>2</SUB>C (9.2 wt%). The Co<SUB>2</SUB>C nanochains have mesoporous pore of 3.8 nm and the specific surface area of 48.6 m<SUP>2</SUP> g<SUP>−1</SUP>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The Co<SUB>2</SUB>C magnetic nanochains are synthesized using cobalt laurate as the precursor in TEG. </LI> <LI> The precursor of cobalt laurate is the key factor for controlling the growth kinetics of Co<SUB>2</SUB>C nanochains. </LI> <LI> Ms of Co<SUB>2</SUB>C nanochains obtained at 300 °C for 20, 60, and 180 min are 27.1, 18.9, and 10.9 emu g<SUP>−1</SUP>, respectively. </LI> <LI> The decrease of Ms is caused by increasing carbon content with increasing reaction time. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>We present a new approach to obtain single phase Co<SUB>2</SUB>C nanochains by using cobalt laurate as the precursor.</P> <P>[DISPLAY OMISSION]</P>

Research of numerical simulation method on vertical stiffness of polycal wire rope isolator

Bo Cen,Xiaofeng Lu,Xiaolei Zhu 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.6

Wire rope isolator (WRI) is widely used in the power machinery and chemical equipment, and has a better dry friction damping and stiffness softening characteristics compared with other vibration isolators. The aim of this article is to create a simplified finite element model of polycal WRI and to avoid the use of overall model on the stiffness characteristic caused by the waste of time. The numerical simulation method used in this paper is to simplify the 1 + 6 +12 single strand into a single wire. The simplified WRI model subjects to the compression load by finite element analysis and obtained the vertical static stiffness characteristics which are consistent with the experimental results.

Effect of rake angle on cutting performance during machining of stone-plastic composite material with polycrystalline diamond cutters

Pingxiang Cao,Zhaolong Zhu,Dietrich Buck,Xiaolei Guo,Mats Ekevad,Xiaodong (Alice) Wang 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.1

This study investigates the effect of rake angle on cutting performance during machining of stone-plastic composite material with diamond cutters. To that end, an orthogonal cutting experiment was designed, in which stone-plastic composite material was planed by a polycrystalline diamond (PCD) cutter to produce chips. The features studied include cutting forces, cutting heat, chip formation and cutting quality. The conclusions are as follows: Firstly, increased rake angle causes frictional force and resulting force to decrease, promoting an increase in normal force. Secondly, during planing, cutting heat is primarily distributed in the chips, with less retained in the cutting edge, and the least retained in the machined surface. The temperatures of both cutting edge and chip decline with an increase in rake angle. Thirdly, as rake angle increases, chip morphology changes from segmental to curved and then to particle chips, with chip-breaking lengths first increasing and then decreasing. Finally, an increased rake angle leads a more stable cutting process and improved cutting quality. Therefore, with the precondition of blade strength, a diamond cutter with a larger rake angle can be used to machine stone-plastic composite to improve production quality by forming a smoother machined surface.

Dynamic Power Optimization of Pilot and Data for Downlink OFDMA Systems

Yong Liu,Fei Liu,Guang Zhu,Xiaolei Wang,Yuechao Jiao 한국통신학회 2021 Journal of communications and networks Vol.23 No.4

In this paper, we investigate the power allocation prob lem in downlink orthogonal frequency-division multiple access(OFDMA) networks. Different from previous researches on powerallocation, we take into account various practical factors, such asthe stochastic traffic arrival, the time-varying channel, the queuestability requirements of all users, the channel estimation cost andthe corresponding effect of imperfect channel state information(CSI) on data transmission rate. The power allocation problemis formulated as maximizing the time-averaged data transmissionrate by optimizing pilot and data power allocation subject to thequeue stability and the maximum transmit power constraints. Thedata transmission rate is defined in terms of the pilot transmitpower, the data transmit power and the channel estimation er ror, which is non-concave. To solve the non-concave and stochas tic optimization problem, a dynamic pilot and data power alloca tion (DPDPA) algorithm is proposed with the aids of approximatetransformation, Lyapunov optimization and Lagrange dual formu lation. Moreover, we derive the bounds of performances, in termsof the time-averaged data transmission rate and queue length.

Identification and Quantification of Glucosinolates in Selected Chinese Brassica Vegetables

Xinjuan Chen,Qiongqiu Qian,Jing Yang,Xiaolei Ni,Zhujun Zhu 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-