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- 저자 : Xiangyu Meng (검색결과 4 건)
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Jiangtao Su,Na Lin,Xiangyu You,Heshuang Dai,Meng Rao,Lu Ye,Fan Ye,Le Cai,Yuxin Chen,Gao Zhou,Xiaoxia Guo 한국고분자학회 2023 Macromolecular Research Vol.31 No.11
Systemic toxicity, poor aqueous solubility, and poorly cell permeable ability hindered the clinical application of Celastrol. In this study, we aimed to design and synthesize an amphiphilic conjugate to encapsulate Celastrol into micelles to improve its water solubility, cellular membrane penetration, improving the clinic translation potential of Celastrol for the treatment of psoriasis. For this purpose, we first synthesized gelatin and oleic acid conjugate (GOC-1), and then covalently bonded 4-(3-boronophenylamino)-4-oxobutanoic acid (BPOA) with GOC-1 to form a stable GOC-2 conjugate which can self-assemble into micelles in aqueous solution. Celastrol (Cel) was physically encapsulated into the core of GOCs micelles. The dynamic stability, particle size, drug release, zeta potential, drug-loading efficiency, and surface morphology of Cel/loaded GOCs nano-micelles were determined. In addition, cell viability, cellular uptake of Cel/loaded GOC-2, and skin permeation and in vivo anti-psoriasis effect of Cel-loaded GOC-2 were investigated. Our results have shown that Cel/loaded GOC-1 and Cel/loaded GOC-2 have spherical shapes with diameters of around 200–300 nm. Compared to GOC-1, GOC-2 micelles showed higher drug-loading efficiency and excellent permeation ability in vitro. Moreover, Cel/GOC-2 micelles reduced erythema and white scales on the dorsal skin of psoriatic mice. In conclusion, BPOA attached GOC nanoparticles as a Celastrol carrier not only increase its water solubility but also improve drug-loading efficiency and cell permeation ability, exhibiting superior anti-psoriatic effect than the commercially available tacrolimus. Our work is expected to provide a facile approach to prepare nanocarrier for Celastrol to improve the clinic translation potential of Celastrol.
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The role of WRKY47 gene in regulating selenium tolerance in Arabidopsis thaliana
Xi Wu,Manzhi Tao,Yun Meng,Xiangyu Zhu,Liangwen Qian,Alia Shah,Wei Wang,Shuqing Cao 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.1
Selenium stress has a serious impact on the growth of plants. However, the available understanding on the mechanism of Se stress response is still insufficient. In this study, we found that the WRKY47 gene plays an important role in maintaining Se homeostasis and tolerance in Arabidopsis thaliana. Expression of WRKY47 is induced by Se stress. The wrky47 mutants are sensitive to Se stress, and this sensitivity is associated with a decrease in the transcription levels of Se-detoxify genes HMT1 and HMT3. Surprisingly, the WRKY47-overexpression lines also showed increased sensitivity to Se stress and had increased Se content; this correlates to an increase in the transcription level of Se-uptake gene PHT1;4 but not Se-detoxify genes HMT1 and HMT3. Our results suggest that gain- and loss-of-function mutations in WRKY47 enhance the sensitivity of A. thaliana plants to Se stress through different mechanisms.
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LDA 기반의 토픽모델링을 이용한 철도차량용 무선급전시스템 연구 동향 분석
음수민(Soomin Eum),이수길(Sugil Lee),Xiangyu Meng,조성원(Sung Won Cho),이철웅(Chulung Lee) 대한산업공학회 2019 대한산업공학회지 Vol.45 No.4
Research on WPT (Wireless Power Transfer) technologies for locomotives based on large-capacity wireless power transmission systems is underway, and interest pertaining to this technology is also increasing in related industries. Although there is a growing trend for analysis in both domestic and overseas markets, research that supports strategies through detailed technology classification and analysis of the trends for WPT technology for locomotives are insufficient. Therefore, this study is intended to produce detailed research topics, which analyze WPT technology for locomotives, by topic modeling based on the LDA (Latent Dirichlet Allocation) algorithm and to extract topics by time series analysis. It is expected that the WPT technology for locomotives derived from this study and its results will be used to effectively establish the research direction in the future.
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The Focused Electrode Ring for Electrohydrodynamic Jet and Printing on Insulated Substrate
Zeshan Abbas,Dazhi Wang,Liangkun Lu,Zhaoliang Du,Xiangyu Zhao,Kuipeng Zhao,Meng Si,Penghe Yin,Xi Zhang,Yan Cui,Junsheng Liang 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.23 No.5
Drop-on-demand electrohydrodynamic jet (DoD E-Jet) printing is considered a well-known type of fabrication method contemporary since it can be used to print high-resolution microstructures (< 1 μm) on various insulating substrates. This paper presents a numerical study of DoD E-Jet printing using a novel combination of needle and focused electrode ring to print stable and consistent microdroplets on a Polyethylene terephthalate substrate. Primarily, a phase field method was used to generate a stable cone-jet morphology that can allow the production of high-resolution micron/nano structures on PET substrates. The numerical simulation of cone-jet morphology was performed by COMSOL multiphysics software. Further, the impact of key parameters such as flow rate and dc positive pulse voltage was studied on cone-jet morphology through numerical simulation. Subsequently, optimized operating parameters i.e., f = 5.3 . 10 –15 m 3 s −1 , V n = 1.9 kV and V r = 0.7 kV were achieved by performing a series of numerical experiments. Then, optimized parameters by simulation were directly used to print arrays of stable droplets on PET substrate using the focused electrode ring in different locations by regulating distance 0.2 mm to 1.3 mm between needles to focused electrode ring. The minimum size of stable microdrop was measured 3 μm on PET substrate (thickness = 0.2 mm) using a 50 μm size quartz capillary maintaining a distance of 0.2 mm between combined needle and focused electrode ring. The experimental results proved that the simulation model is useful for printing different microstructures on insulating substrates and creating a promising production path for micro-electro mechanical system and nano-electro mechanical system (MEMS and NEMS).
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