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Wu, Xiang-Mei,Liu, Xing,Jiao, Qing-Fang,Fu, Shao-Yue,Bu, You-Quan,Song, Fang-Zhou,Yi, Fa-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Human papillomavirus (HPV) is the primary etiologic agent of cervical cancer. Consideration of safety and non human leukocyte antigen restriction, protein vaccine has become the most likely form of HPV therapeutic vaccine, although none have so far been reported as effective. Since tumor cells consistently express the two proteins E6 and E7, most therapeutic vaccines target one or both of them. In this study, we fabricated DC vaccines by transducing replication-defective recombinant adenoviruses expressing E6/E7 fusion gene of HPV-16, to investigate the lethal effects of specific cytotoxic T lymphocytes (CTL) against CaSki cells in vitro. Mouse immature dendritic cells (DC) were generated from bone marrow, and transfected with pAd-E6/E7 to prepare a DC vaccine and to induce specific CTL. The surface expression of CD40, CD68, MHC II and CD11c was assessed by flow cytometry (FCM), and the lethal effects of CTL against CaSki cells were determined by DAPI, FCM and CCK-8 methods. Immature mouse DC was successfully transfected by pAd-E6/E7 in vitro, and the transfecting efficiency was 40%-50%. A DC vaccine was successfully prepared and was used to induce specific CTL. Experimental results showed that the percentage of apoptosis and killing rate of CaSki cells were significantly increased by coculturing with the specific CTL (p <0.05). These results illustrated that a DC vaccine modified by HPV-16 E6/E7 gene can induce apoptosis of CaSki cells by inducing CTL, which may be used as a new strategy for biological treatment of cervical cancer.
SiC particulate reinforced aluminum matrix composite coatings prepared by laser powder deposition
Xu Xiang-yang,Han Jian-min,Li Wei-jing,Liu Yuan-fu,Liu Long-mei 한양대학교 세라믹연구소 2006 Journal of Ceramic Processing Research Vol.7 No.2
A SiC particulate reinforced aluminum matrix composite coatings for wear resistance improvement were investigated. Laser powder deposition processing was optimized, the microstructure of the coatings was analyzed, and the wear resistance of the coatings was evaluated. Under optimized processing, a laser powder deposited coating is free of cracks and porosity. SiC particles were uniformly distributed in the coating and well bonded with the matrix. A laser powder deposited coating consists of α-Al, SiC, Al4C3, Si and Al2O3 phases. Due to formation of Al4C3 and Si phases and crystal grain refinement, the wear resistance of laser powder deposited coatings was increased 2.06-3.76 times that of the aluminum alloy substrate based on the high hardness and deformation resistance of the SiC particles.
( Jing Liu ),( Xiang Gao ),( Ye Chen ),( Qiao Mei ),( Liangru Zhu ),( Jiaming Qian ),( Pinjin Hu ),( Qian Cao ) 대한장연구학회 2021 Intestinal Research Vol.19 No.3
Background/Aims: Risk of venous thrombosis is increased in patients with inflammatory bowel disease (IBD); data on Asian IBD patients is limited and status quo of thrombosis screening and prophylaxis are unknown. Therefore, we aimed to investigate the incidence, screening, prophylaxis, and risk factors for venous thrombosis among Asian IBD patients. Methods: Medical files of patients with Crohn’s disease (CD) and ulcerative colitis (UC) from 17 hospitals across China between 2011 and 2016 were reviewed for venous thrombosis, use of screening and prophylaxis. A case-control study was performed among hospitalized patients with venous thrombosis and their age-, sex-matched IBD controls hospitalized around the same period; disease characteristics and known provoking factors of venous thrombosis were recorded. Risk factors were analyzed in both univariate and logistic regression analyses. Results: A total of 8,459 IBD patients were followed for 12,373 person-year. Forty-six patients (0.54%) had venous thrombosis, yielding an incidence of 37.18 per 10,000 person-year. Incidence increased with age, especially among CD. Less than 20% of patients received screening tests and 35 patients (0.41%) received prophylaxis. Severe disease flare was an independent risk factor for venous thrombosis (odds ratio [95% confidence interval]: CD, 9.342 [1.813-48.137]; UC, 5.198 [1.268-21.305]); past use of steroids and extensive involvement were 2 additional risk factors in CD and UC, respectively. Conclusions: Incidence of venous thrombosis in China was 37.18 per 10,000 person-year (0.54%). Use of screening and prophylaxis were rare. Severe disease flare was an independent risk factor for thrombosis among hospitalized patients. (Intest Res 2021;19:313-322)
Single-Atom Switches and Single-Atom Gaps Using Stretched Metal Nanowires
Wang, Qingling,Liu, Ran,Xiang, Dong,Sun, Mingyu,Zhao, Zhikai,Sun, Lu,Mei, Tingting,Wu, Pengfei,Liu, Haitao,Guo, Xuefeng,Li, Zong-Liang,Lee, Takhee American Chemical Society 2016 ACS NANO Vol.10 No.10
<P>Utilizing individual atoms or molecules as functional units in electronic circuits meets the increasing technical demands for the miniaturization of traditional semiconductor devices. To be of technological interest, these functional devices should be high-yield, consume low amounts of energy, and operate at room temperature. In this study, we developed nanodevices called quantized conductance atomic switches (QCAS) that satisfy these requirements. The QCAS operates by applying a feedback-controlled voltage to a nanoconstriction within a stretched nanowire. We demonstrated that individual metal atoms could be removed from the nanoconstriction and that the removed metal atoms could be refilled into the nanoconstriction, thus yielding a reversible quantized conductance switch. We determined the key parameters for the QCAS between the 'on' and 'off' states at room temperature under a small operating voltage. By controlling the applied bias voltage, the atoms can be further completely removed from the constriction to break the nanowire, generating single-atom nanogaps. These atomic nanogaps are quite stable under a sweeping voltage and can be readjusted with subangstrom accuracy, thus fulfilling the requirement of both reliability and flexibility for the high-yield fabrication of molecular devices.</P>
Zhao, Lian-Mei,Han, Li-Na,Ren, Feng-Zhi,Chen, Shu-Hong,Liu, Li-Hua,Wang, Ming-Xia,Sang, Mei-Xiang,Shan, Bao-En Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Cochinchina momordica seeds (CMS) have been widely used due to antitumor activity by Mongolian tribes of China. However, the details of the underlying mechanisms remain unknown. In the present study, we found that an EtOAc (ethyl ester) extract of CMS (CMSEE) induced differentiation and caused growth inhibition of melanoma B16 F1 cells. CMSEE at the concentration of $5-200{\mu}g/ml$ exhibited strongest anti-proliferative effects on B16 F1 cells among other CMS fractions (water or petroleum ether). Moreover, CMSEE induced melanoma B16 F1 cell differentiation, characterized by dendrite-like outgrowth, increasing melanogenesis production, as well as enhancing tyrosinase activity. Western blot analysis showed that sustained phosphorylation of p38 MAP accompanied by decrease in ERK1/2 and JNK dephosphorylation were involved in CMSEE-induced B16 F1 cell differentiation. Notably, 6 compounds that were isolated and identified may be responsible for inducing differentiation of CMSEE. These results indicated that CMSEE contributes to the differentiation of B16 F1 cells through modulating MAPKs activity, which may throw some light on the development of potentially therapeutic strategies for melanoma treatment.
Interaction between Barium Oxide and Carbon Film in BaO/C/Mo System under High Temperature
Yue Hui Lu,Xue Mei Wu,Lan Jian Zhuge,Xiang Huai Liu 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.1
Carbon ¯lm, used as the coating of the Mo grid in pulsed-controlled grid traveling wave tubes, can eectively suppress electron emission from the Mo grid contaminated by the emission material of the hot cathode, i.e. BaO or Ba, so that the lifetime of the tubes can be prolonged signi¯cantly but the reasons for it have not been well understood. To study the eect of it on the BaO/Mo system under high temperature, carbon ¯lms were prepared on Mo substrate at room temperature by a dual-ion-beam sputtering deposition system, and post-annealing was conducted to know their microstructure under high temperature. In our experiments, BaO layers were coated on Mo and carbon-coated Mo substrates by the chemical method to compare with each other, and the prepared BaO/Mo and BaO/C/Mo samples were annealed at two dierent temperatures of 973 K and 1223 K in order to investigate the interaction between barium oxide and carbon ¯lm under high temperature. The results show that the BaO/C/Mo changes into C/Mo after the exhaustion of BaO at 1223 K, nevertheless, This does not happen at 973 K. In this paper, the mechanism whereby the addition of carbon ¯lm can suppress the grid emission under its operating condi-tion is discussed according to the experimental results and the calculation of the reaction free energy.
( Hui Ju Ga ),( Xiang Chu ),( Yan Wen Wang ),( Fei Zhou ),( Kai Zhao ),( Zhi Mei Mu ),( Qing Xin Liu ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.12
Trichoderma harzianum ZF-2 producing laccase was isolated from decaying samples from Shandong, China, and showed dye decolorization activities. The objective of this study was to optimize its culture conditions using a statistical analysis of its laccase production. The interactions between different fermentation parameters for laccase production were characterized using a Plackett-Burman design and the response surface methodology. The different media components were initially optimized using the conventional one-factor-at-atime method and an orthogonal test design, and a Plackett-Burman experiment was then performed to evaluate the effects on laccase production. Wheat straw powder, soybean meal, and CuSO4 were all found to have a significant influence on laccase production, and the optimal concentrations of these three factors were then sequentially investigated using the response surface methodology with a central composite design. The resulting optimal medium components for laccase production were determined as follows: wheat straw powder 7.63 g/l, soybean meal 23.07 g/l, (NH4)2SO4 1 g/l, CuSO4 0.51 g/l, Tween-20 1 g/l, MgSO4 1 g/l, and KH2PO4 0.6 g/l. Using this optimized fermentation method, the yield of laccase was increased 59.68 times to 67.258 U/ml compared with the laccase production with an unoptimized medium. This is the first report on the statistical optimization of laccase production by Trichoderma harzianum ZF-2.