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이지현(Lee, Jihyun),강홍구(Kang, Hong-Goo),임우택(Lim, Wootaek) 한국방송·미디어공학회 2023 한국방송공학회 학술발표대회 논문집 Vol.2023 No.6
본 논문에서는 음성 압축 시스템에 사용될 수 있는 심층 신경망 기반 장구간 예측을 제안한다. 최근 신호 처리 기술을 기반으로 한 기존 음성 코덱의 성능을 뛰어넘는 심층 신경망 기반 음성 압축 모델에 관한 연구가 이루어지고 있다. 그러나 음성 샘플 간에는 장구간의 상관성이 존재함에도 불구하고, 현재 대부분의 심층 신경망 기반 음성 압축 모델에서는 과거 샘플의 정보를 거의 활용하지 않고 있다. 본 논문에서는 현재 프레임에서 과거 샘플과의 장구간 상관성을 제거함으로써 여기 신호의 압축 효율을 높이기 위해 심층 신경망을 사용하여 과거 프레임으로부터 현재 프레임을 예측하는 방법을 제안한다. 여기 신호에 스칼라 양자화를 적용할 때 장구간 예측을 사용하지 않은 경우에 비해 전송률-왜곡 성능이 향상되는 것을 실험을 통해 확인하였으며, 여기 신호의 분포를 비교함으로써 제안된 방법의 효과를 검증한다.
Effect of norgalanthamine on renal injury induced by carbon tetrachloride in mice
Nayeon Yang,Myungsoon Ko,Minhwa Jang,Eunjun Jang,Dowook Yu,Wootaek Hong,Seongbeom Bae,Jieun Ryoo,Taekyun Shin,Meejung Ahn 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Norgalanthamine is a major component of Crinum asiaticum var. japonicum that exhibits several biological activities. This study evaluated the anti-inflammatory and anti-oxidative properties of norgalanthamine in mice with carbon tetrachloride (CCl4)-induced renal injury. Norgalanthamine (1 and 10 mg/kg) was orally administered to mice for 7 or 14 days, after which renal injury was induced by CCl4 (1.5 ml/kg, i.p.). The vehicle and positive controls consisted of phosphate-buffered saline and silymarin (100 mg/kg), respectively. In CCl4-injured mice, norgalanthamine pretreatment significantly reversed the increases in serum alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels, and the decrease in the serum glucose level. The histopathological evaluation and Iba-1 immunoreactivity also supported the protective effects of norgalanthamine against CCl4-induced kidney injury. These results suggest that norgalanthamine ameliorates oxidative renal injury, possibly through reducing enhancing antioxidant enzymes, and suppressing infiltrated macrophages.
소아의 호흡기세포융합바이러스 하기도 감염에서 총 혈청 IgE의 의의
장윤영 ( Yoon Young Jang ),이현석 ( Hyun Seok Lee ),정지은 ( Ji Eun Jeong ),홍석진 ( Suk Jin Hong ),박혜진 ( Hye Jin Park ),이계향 ( Kye Hyang Lee ),김우택 ( Wootaek Kim ),정혜리 ( Hai Lee Chung ) 대한천식알레르기학회 2016 Allergy Asthma & Respiratory Disease Vol.4 No.2
Purpose: Respiratory syncytial virus (RSV) is known to induce Th2 immune response with increased IgE production. We investigated serum IgE levels in RSV bronchiolitis/pneumonia (RSV-LRI) in relation to disease severity. Methods: One hundred seven children admitted with RSV-LRI were enrolled. The patients were divided into 2 groups according to serum IgE levels: the high IgE (n=39, more than 2 standard deviations from the mean levels for age-matched controls) and low IgE groups (n=68). We investigated if there were any differences in clinical and laboratory findings, and recurrence of wheezing between the 2 groups. The difference in IgE levels between severe (severity score≥3) and nonsevere groups was also studied. Results: More frequent and prolonged fever was observed in the high IgE group than in the low IgE group (P<0.05). Patients showing severe symptoms or respiratory difficulties were more frequently seen in the high IgE group (P=0.01). There was no difference in parental allergy and atopic sensitization. The nearly same findings were observed in reanalysis of data from patients with the first RSV-LRI, but recurrence of wheezing was significantly higher in the high IgE group than in the low IgE group (P=0.04). Patients with high IgE levels were more frequently seen in severe patients than in nonsevere patients (P=0.01). Conclusion: Our study showed that children who presented with high serum IgE levels during RSV infections had more severe symptoms compared to those with low IgE levels. It suggests that measurement of total serum IgE levels might be helpful in evaluating disease severity and recurrent wheezing in children admitted with RSV-LRI. (Allergy Asthma Respir Dis 2016;4:126-132)
천식 소아에서 혈청 vascular endothelial growth factor, transforming growth factor-beta1과 YKL-40 증가의 임상적 의의
장윤영 ( Yoon Young Jang ),이현석 ( Hyun Seok Lee ),정지은 ( Ji Eun Jeong ),이은주 ( Eun Joo Lee ),홍석진 ( Suk Jin Hong ),박혜진 ( Hye Jin Park ),이계향 ( Kye Hyang Lee ),김우택 ( Wootaek Kim ),정혜리 ( Hai Lee Chung ) 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.6
Purpose: Vascular endothelial growth factor (VEGF), transforming growth factor beta1 (TGF-β1), and platelet derived growth factor (PDGF) are known to be involved in the pathogenesis of inflammation and remodeling in asthmatic airways. YKL-40, a chitinase-like protein, and clusterin have been reported to be biomarkers for severe asthma. We examined the serum levels of growth factors, YKL-40, and clusterin in children with acute asthma or stable asthma, and investigated their correlation with clinical findings and lung function parameters. Methods: Forty-one children (≥6 years of age) with asthma were enrolled, and 2 groups were defined: 23 patients admitted with acute asthma (acute asthma group) and 18 patients with stable asthma (stable asthma group). The serum levels of VEGF, TGF-β1, PDGF-BB, YKL-40, and clusterin were measured using enzyme-linked immunosorbent assay and assessed in relation to clinical manifestations and spirometric parameters. Fifteen age-matched controls were also studied. Results: The serum levels of VEGF, TGF-β1, and YKL-40 were significantly elevated in children with acute asthma compared to controls. The serum levels of VEGF and YKL-40 were higher in the stable asthma group than in controls. The serum levels of VEGF, TGF-β1, and YKL-40 were not different between the acute asthma and stable asthma groups. The serum VEGF levels in the acute asthma group correlated significantly with asthma severity. The serum TGF-β1 levels in stable asthma group showed a significant inverse correlation with (FEV1) forced expiratory volume in one second and FEF25% 75% (forced expiratory flow between 25 and 75 percent of expired vital capacity). Serum YKL-40 had no significant relationship with clinical manifestations and spirometric parameters. Conclusion: Our study suggests that increased serum levels of VEGF and YKL-40 might affect asthmatic airways not only during acute exacerbation but also in stable state and that serum TGF-β1 might be a biomarker for airway obstruction in children with asthma. (Allergy Asthma Respir Dis 2015;3:417-424)