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Son Tae Hyun,Kim Shin-Hye,Shin Hye-Lim,Kim Dongsoo,Huh Jin-Sung,Ryoo Rhim,Choi Yongseok,Choi Sik-Won 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.9
Osteoporosis, Greek for “porous bone,” is a bone disease characterized by a decrease in bone strength, microarchitectural changes in the bone tissues, and an increased risk of fracture. An imbalance of bone resorption and bone formation may lead to chronic metabolic diseases such as osteoporosis. Wolfiporia extensa, known as “Bokryung” in Korea, is a fungus belonging to the family Polyporaceae and has been used as a therapeutic food against various diseases. Medicinal mushrooms, mycelium and fungi, possess approximately 130 medicinal functions, including antitumor, immunomodulating, antibacterial, hepatoprotective, and antidiabetic effects, and are therefore used to improve human health. In this study, we used osteoclast and osteoblast cell cultures treated with Wolfiporia extensa mycelium water extract (WEMWE) and investigated the effect of the fungus on bone homeostasis. Subsequently, we assessed its capacity to modulate both osteoblast and osteoclast differentiation by performing osteogenic and anti-osteoclastogenic activity assays. We observed that WEMWE increased BMP-2-stimulated osteogenesis by inducing Smad-Runx2 signal pathway axis. In addition, we found that WEMWE decreased RANKL-induced osteoclastogenesis by blocking c-Fos/NFATc1 via the inhibition of ERK and JNK phosphorylation. Our results show that WEMWE can prevent and treat bone metabolic diseases, including osteoporosis, by a biphasic activity that sustains bone homeostasis. Therefore, we suggest that WEMWE can be used as a preventive and therapeutic drug.
Son, Han Am,Choi, Sang Koo,Jeong, Eun Sook,Kim, Bohyun,Kim, Hyun Tae,Sung, Won Mo,Kim, Jin Woong American Chemical Society 2016 Langmuir Vol.32 No.35
<P>Microbially enhanced oil recovery involves the use of microorganisms to extract oil remaining in reservoirs. Here, we report fabrication of microgel particles with immobilized Bacillus subtilis for application to microbially enhanced oil recovery. Using B. subtilis isolated from oil-contaminated soils in Myanmar, we evaluated the ability of this microbe to reduce the interfacial tension at the oil water interface via production of biosurfactant molecules, eventually yielding excellent emulsification across a broad range of the medium pH and ionic strength. To safely deliver B. subtilis into a permeable porous medium, in this study, these bacteria were physically immobilized in a hydrogel mesh of microgel particles. In a core flooding experiment, in which the microgel particles were injected into a column packed with silica beads, we found that these particles significantly increased oil recovery in a concentration-dependent manner. This result shows that a mesh of microgel particles encapsulating biosurfactant-producing microorganisms holds promise for recovery of oil from porous media.</P>
Son, Seung-Myoung,Ha, Sang-Yun,Yoo, Hae-Yong,Oh, Dongryul,Kim, Seok-Jin,Kim, Won-Seog,Ko, Young-Hyeh Springer Science and Business Media LLC 2017 Modern pathology Vol.30 No.1
<P>The prognostic role of MYC has been well documented in non-central nervous system diffuse large B-cell lymphoma; however, it remains controversial in central nervous system diffuse large B-cell lymphoma. To investigate the prognostic value of MYC, we analyzed the MYC protein expression by immunohistochemistry, mRNA expression by RNA in situ hybridization, and gene status by fluorescence in situ hybridization in 74 cases of central nervous system diffuse large B-cell lymphoma. Moreover, we examined the correlation between MYC translocation, mRNA expression, and protein expression. The mean percentage of MYC immunopositive cells was 49%. Using a 44% cutoff value, 49 (66%) cases showed MYC protein overexpression. The result of mRNA in situ hybridization using the RNA scope technology was obtained using the H-scoring system; the median value was 34.2. Using the cutoff value of 63.5, 16 (22%) cases showed MYC mRNA overexpression. MYC gene rearrangement was detected in five out of 68 (7%) cases. MYC translocation showed no statistically significant correlation with mRNA expression; however, all MYC translocation-positive cases showed MYC protein overexpression, with a higher mean percentage of MYC protein expression than that of translocation-negative cases (78 vs 48%, P=0.001). The level of MYC mRNA expression was moderately correlated with the level of MYC protein expression (P < 0.001). The mean percentage of MYC protein expression in the high MYC mRNA group was higher than that in the low MYC mRNA group (70 vs 47%, P<0.001). A univariate analysis showed that age over 60 years, Eastern Cooperative Oncology Group (ECOG) performance status >= 2 and MYC protein overexpression were significantly associated with an increased risk of death. MYC translocation and MYC mRNA expression had no prognostic significance. On multivariate analysis, MYC protein overexpression and ECOG score retained prognostic significance.</P>
Son, Sung Yun,Kim, Jae Won,Lee, JooHyeon,Kim, Guan-Woo,Hong, Jisu,Kim, Jin Young,Park, Taiho The Royal Society of Chemistry 2018 Journal of materials chemistry. A, Materials for e Vol.6 No.47
<P>Morphologies and optoelectronic/mechanical properties of semiconducting polymers are significantly affected by their configurations. In this study, thiophene units are introduced into the backbone of a semiconducting polymer in either a regular (PffBT-T4) or a random (PffBT-RT4) manner to determine whether the resulting semiconducting polymers are suitable for developing efficient polymer solar cells. The energy levels of both polymers are highly similar because they share the same ratio of subunits in their backbones; however, PffBT-RT4 has lower crystallinity than PffBT-T4 due to its random configuration. Microstructural analyses indicate that PffBT-RT4 exhibits a shorter π-π stacking distance than PffBT-T4. Since short π-π stacking distance benefits interchain charge transport, PffBT-RT4 shows higher space-charge-limited current mobility, and PffBT-RT4 solar cells exhibit higher power conversion efficiency (PCE; 8.84%) than their PffBT-T4 counterparts (7.25%). In addition, PffBT-RT4 solar cells with active layers, prepared using a green solvent without any additive, show an encouraging PCE of 7.23%. Moreover, flexible solar cells based on PffBT-RT4 are much more stable during bending cycles than PffBT-T4 flexible solar cells. Therefore, this study demonstrates that the random configuration approach is a promising design strategy to realize semiconducting polymers for efficient, green-solvent-processable flexible polymer solar cells.</P>
Graphene oxide-gold nanozyme for highly sensitive electrochemical detection of hydrogen peroxide
Jin, Ga Hyun,Ko, Euna,Kim, Min Ki,Tran, Van-Khue,Son, Seong Eun,Geng, Yanfang,Hur, Won,Seong, Gi Hun Elsevier 2018 Sensors and actuators. B, Chemical Vol.274 No.-
<P><B>Abstract</B></P> <P>We fabricated a nafion/graphene oxide-gold nanoparticle (GO-AuNP) hybrid modified indium tin oxide (ITO) electrode and proposed an electrochemical method to detect hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>) using 3,3,5,5,-tetramethylbenzidine (TMB) as a redox mediator. The GO-AuNP hybrids were employed as nanozymes, which function as peroxidase mimics and show highly effective catalytic activity. Based on the high catalytic activity, enzyme mimics were entrapped on the ITO electrode to construct an electrochemical H<SUB>2</SUB>O<SUB>2</SUB> sensor by coating nafion polymer. During the catalytic reaction, the peroxidase substrate TMB was oxidized to form the TMB oxidation product, which not only produces a blue color detected by absorbance change, but also generates an electrochemical current. As a result, both spectrophotometric and electrochemical methods were used to determine H<SUB>2</SUB>O<SUB>2</SUB> concentration. The spectrophotometric detection displayed a linearity for H<SUB>2</SUB>O<SUB>2</SUB> concentration from 10 μM to 5 mM (r<SUP>2</SUP> = 0.989), with an estimated detection limit of 2 μM. In the electrochemical detection, the TMB peak current had a good linear relationship with H<SUB>2</SUB>O<SUB>2</SUB> concentration from 10 nM to 10 mM, with an estimated detection limit of 1.9 nM, which was much lower than that of the spectrophotometric method result.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Graphene oxide (GO)-gold nanozymes were prepared as peroxidase mimics. </LI> <LI> The nanozymes exhibited more enhanced activity than GO and AuNP alone. </LI> <LI> The nanozymes were used for an electrochemical H<SUB>2</SUB>O<SUB>2</SUB> sensor. </LI> <LI> The detection limit was much lower than that by colorimetric method. </LI> </UL> </P>
( Jin Won Son ),( Seon Young Jee ),( Chung A Park ) 대구한의대학교 제한동의학술원 2017 東西醫學 Vol.42 No.2
Phyllostachys folium is leaves of Phyllostachys nigra (Lodd.) Munro var. henonis (Bean) Stapf. The effects of Phyllostachys folium water extract (PFE) on the carrageenan (CA) -induced acute edematous inflammation were observed by histopathological methods. The changes on the histopathology and histomorphometry of hind paw skins were observed in CA-treated rats as changes on the total skin thicknesses, infiltrated inflammatory and mast cell numbers. Marked increases of the dorsum and ventrum pedis skin thicknesses were detected as results of CA induced acute edematous inflammation on CA-treated rats as compared with intact control rat paw skins, and marked degranulation-related decreases of mast cell numbers, increases of infiltrated inflammatory cell numbers were also noticed on the both dorsum and ventrum pedis cutaneous regions in CA-treated rats, respectively. However, these CA-induced acute edematous inflammatory changes and degranulation-related decreases of mast cells were significantly inhibited by treatment with DEXA and PFE 1.0 g/㎏, respectively. Although PFE 0.3 g/㎏ treated rat paw did not show significant changes on the skin thicknesses, it significantly inhibited the inflammatory cell infiltration and mast cell degranulation on the both dorsum and ventrum pedis skin as compared with CA control rats. In conclusion, it is considered that PFE 1.0 g/㎏ inhibits the acute edematous inflammation via suppression of mast cell degranulation and inflammatory cell infiltration, because PFE 1.0 g/㎏ favorably inhibited the CA-induced increases of skin thicknesses, mast cell degranulation, and infiltrated inflammatory cells, respectively. PFE 0.3 g/㎏ did not show any significant changes on the edematous increases of skin thicknesses, but it significantly inhibited inflammatory cell infiltration and mast cell degranulation as compared with CA control rats.
An Area-Efficient, Low-VDD, Highly Reliable Multi-Cell Antifuse System Fully Operative in DRAMs
SON, Jong-Pil,KIM, Jin Ho,AHN, Woo Song,HAN, Seung Uk,YAMADA, Satoru,MOON, Byung-Sick,PARK, Churoo,HWANG, Hong-Sun,JANG, Seong-Jin,CHOI, Joo Sun,JUN, Young-Hyun,KIM, Soo-Won The Institute of Electronics, Information and Comm 2011 IEICE transactions on electronics Vol. No.
<P>A reliable antifuse scheme has been very hard to build, which has precluded its implementation in DRAM products. We devised a very reliable multi-cell structure to cope with the large process variation in the DRAM-cell-capacitor type antifuse system. The programming current did not rise above 564µA even in the nine-cell case. The cumulative distribution of the successful rupture in the multi-cell structure could be curtailed dramatically to less than 15% of the single-cell's case and the recovery problem of programmed cells after the thermal stress (300°C) had disappeared. In addition, we also presented a Post-Package Repair (PPR) scheme that could be directly coupled to the external high-voltage power rail via an additional pin with small protection circuits, saving the chip area otherwise consumed by the internal pump circuitry. A 1Gbit DDR SDRAM was fabricated using Samsung's advanced 50nm DRAM technology, successfully proving the feasibility of the proposed antifuse system implemented in it.</P>