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Yoo Seung Soo,Lee Sunwoong,Choi Jin Eun,Hong Mi Jeong,Do Sook Kyung,Lee Jang Hyuck,Lee Won Kee,Park Ji Eun,Lee Yong Hoon,Choi Sun Ha,Seo Hyewon,Lee Jaehee,Lee Shin Yup,Cha Seung Ick,Kim Chang Ho,Kang 대한의학회 2023 Journal of Korean medical science Vol.38 No.45
Background: Neurogenic differentiation 1 (NeuroD1) is a representative small cell lung cancer (SCLC) transcription regulator involved in the carcinogenesis and behavior of SCLC. Histone modifications play an important role in transcription, and H3 lysine 4 trimethylation (H3K4me3) is primarily associated with promoter regions. Methods: We investigated the association between single nucleotide polymorphisms (SNPs) in NeuroD1 and H3K4me3 coincident regions, selected using ChIP sequencing (ChIP-seq), and the clinical outcomes of 261 patients with SCLC. Results: Among 230 SNPs, two were significantly associated with both the chemotherapy response and overall survival (OS) of patients with SCLC. RNF145 rs2043268A>G was associated with worse chemotherapy response and OS (under a recessive model, adjusted odds ratio [aOR], 0.50, 95% confidence interval [CI], 0.26–0.94, P = 0.031, and adjusted hazard ratio [aHR], 1.88, 95% CI, 1.38–2.57, P < 0.001). CINP rs762105A>G was also associated with worse chemotherapy response and OS (under a dominant model, aOR, 0.47, 95% CI, 0.23–0.99, P = 0.046, and aHR, 2.03, 95% CI, 1.47–2.82, P < 0.001). ChIP–quantitative polymerase chain reaction and luciferase assay confirmed that the two SNPs were located in the active promoter regions and influenced the promoter activity of each gene. Conclusion: To summarize, among SNPs selected using ChIP-seq in promoter regions with high peaks in both NeuroD1 and H3K4me3, RNF145 rs2043268A>G and CINP rs762105A>G were associated with clinical outcomes in patients with SCLC and also affected the promoter activity of each gene.
Yoo, Seung Soo,Hong, Mi Jeong,Choi, Jin Eun,Lee, Jang Hyuck,Baek, Sun Ah,Lee, Won Kee,Lee, So Yeon,Lee, Shin Yup,Lee, Jaehee,Cha, Seung Ick,Kim, Chang Ho,Cho, Sukki,Park, Jae Yong The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.3
<P>Recently, genetic variants in the WNT signaling pathway have been reported to affect the survival outcome of Caucasian patients with early stage non-small cell lung cancer (NSCLC). We therefore attempted to determine whether these same WNT signaling pathway gene variants had similar impacts on the survival outcome of NSCLC patients in a Korean population. A total of 761 patients with stages I–IIIA NSCLC were enrolled in this study. Eight variants of WNT pathway genes were genotyped and their association with overall survival and disease-free survival were analyzed. None of the eight variants were significantly associated with overall survival or disease-free survival. There were no differences in survival outcome after stratifying the subjects according to age, gender, smoking status, and histological type. These results suggest that genetic variants in the WNT signaling pathway may not affect the survival outcome of NSCLC in a Korean population.</P>
Interactive terrestrial digital multimedia broadcasting (T-DMB) player
Won-Sik Cheong,Jihun Cha,Sangwoo Ahn,Won-Hyuck Yoo,Kyung Ae Moon IEEE 2007 IEEE transactions on consumer electronics Vol.53 No.1
<P>This paper presents an interactive terrestrial digital multimedia broadcasting (T-DMB) player. Interactive T-DMB contents consist of the main AV streams and additional data streams such as BIFS (binary format for scene) streams, OD streams, and image streams. In order to properly play interactive T-DMB contents, presented player includes BIFS decoder, BIFS manager and JPEG decoder modules. The implementation of the interactive player and its capabilities are presented along with usage examples.</P>
Distribution of Arsenic Fraction in Soil Around Abandoned Mining Area and Uptake by Rice
Hyuck-Soo Kim,Woo-Ri Go,Dae-Won Kang,Ji-Hyock Yoo,Kye-Hoon Kim,Won-Il Kim 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5
Arsenic (As) contamination of agricultural soils resulting from mining activity has caused major concern due to the potential health risk. Therefore the current study was carried out to investigate the relationship between fractionation of As in soil and rice uptake and to provide a basic information for adequate management of As contaminated agricultural soil. Twenty agricultural soils and rice affected by the abandoned mining sites were collected. Soil chemical properties and As concentrations (total and sequential extracted) in soils were determined and As concentrations in polished rice were analyzed. The average concentration of As in non-specifically adsorbed (F1), specifically adsorbed (F2), amorphous hydrous oxides of Fe and Al (F3), crystalline hydrous oxides of Fe and Al (F4) and residual phase (F5) were 0.08, 1.38, 10.34, 3.26 and 10.98 mg kg<SUP>-1</SUP>, respectively. Both soil pH and available phosphorus were positively correlated with the concentrations of As in F1 and F2. These results indicate that increasing the soil pH and available phosphorus can significantly increase the easily mobile fractions of As (F1 and F2). The average concentration of As in polished rice was 0.09 mg kg<SUP>-1</SUP>. The concentrations of As in F1 and F2 showed a positive correlation with the concentrations of As in polished rice. Therefore soil pH and available phosphorus affect the distribution of As fractionation in soils and thus affect As bioavailability.
Hyuck-Soo Kim,Dae-Won Kang,Da-In Kim,Seul Lee,Sang-Won Park,Ji-Hyock Yoo,Won-Il Kim 한국토양비료학회 2016 한국토양비료학회지 Vol.49 No.5
The current study was carried out to investigate total and inorganic arsenic (As) concentrations in 112 rice samples (husked rice and polished rice) grown around the abandoned mining areas and to estimate the potential health risk through dietary intake of rice in Korea. Mean concentrations of total As in husked rice and polished rice were 0.23 and 0.13 mg kg<SUP>-1</SUP>, respectively. Also, average inorganic As concentrations in husked rice and polished rice were 0.09 and 0.05 mg kg<SUP>-1</SUP>, respectively. These levels are lower than the standard guideline value (0.2 mg kg<SUP>-1</SUP>) for inorganic As in polished rice recommended by Korea Ministry of Food and Drug Safety and Codex. For health risk assessment, the average values of cancer risk probability was 5.7×10<SUP>-5</SUP> which was less than the acceptable cancer risk of 10<SUP>-6</SUP>~10<SUP>-4</SUP> for regulatory purpose. Also, hazard quotient values were lower than 1.0. Therefore, these results demonstrated that human exposure to inorganic As through dietary intake of rice collected from abandoned mining areas might not cause adverse health effects.
DTV-to-DMB 비디오 변환을 위한 Center Average 축소 방식
유원혁(Yoo Won-Hyuck),정원식(Jeong Won-Sik),김규헌(Kim Kyu-heon) 한국방송·미디어공학회 2005 한국방송공학회 학술발표대회 논문집 Vol.2005 No.-
DTV-to-DMB 비디오 변환을 위해서는 기본적으로 MPEG-2 MP@HL의 HDTV/SDTV급 영상을 MPEG-4 AVC BP@1.3의 QCIF/QVGA/WDF/CIF급 영상으로 변환하는 과정이 필요하다. 본 논문에서는 DTV-to-DMB 비디오 변환을 위해 DTV의 고해상도 영상을 DMB의 저해상도 영상으로 축소하는 방식을 제안하고 있다. DTV-to-DMB 비디오 변환은 실시간 변환이 고려되어야 하며, 실시간 변환을 위해서는 축소 방식의 시간 복잡도가 고려 되어야 한다. 일반적으로 낮은 시간 복잡도를 갖는 영상 축소 방식으로는 대상 영상의 하나의 픽셀을 참조 영상 내 대응하는 픽셀들 중 한 픽셀을 선택하여 결정하는 방식(just Get A Pixel)이 있으며, 참조 영상의 대응하는 픽셀들의 평균값을 선택하는 방식 (Average Shrink)과 중간값을 선택하는 방식 (Median Shrink)이 있다. 한편, DTV 영상은 인터레이스 방식을 사용하며 DMB의 프로그레시브 방식 영상으로 변환 처리 과정에서, 움직임이 큰 영상에 대해 사물의 윤곽선이 계단 모양으로 보이는 재그 에지 (Jagged Edge) 현상이 나타난다. 본 논문에서는 대상 영상의 한 픽셀을 참조 영상의 대응하는 픽셀들 중 중간 위치의 몇 개 픽셀들과 주변 인접 픽셀들을 선출하여 그것들의 평균값 (Average)을 구하여 결정하는 Center Average 축소 방식을 제안한다. 제안된 방식은 기본적인 축소 방식을 기반으로 하여 낮은 시간 복잡도를 갖으며, 재그 에지 (Jagged Edge) 현상을 줄여 준다.
박원우(Won-woo Park),마성혁(Sung Hyuck Mah),배수현(Su hyun Bae),지선영(Seon Young Ji),이유우(Yoo Woo Lee),김자영(Ja Young Kim) 한국경영학회 2020 經營學硏究 Vol.49 No.2
This study investigates the phenomenon of ‘careless responding’ that prevails in surveys. Specifically, we focus on methods of detection and the effects of screening careless responding. First, this study discusses the diverse definitions and types of careless responding. Methods of detection are introduced in the following triangular categorization: direct, unobtrusive, and statistical. The theoretical review portion provides a comparative summary of detection methods and their advantages and disadvantages to help future researchers apply a suitable one to their own study designs. Furthermore, this study conducts an empirical study to identify the impact of screening careless responding on statistical results, analyzing survey data from 3,030 employees working in a major conglomerate in Korea. The major findings are as follows: (1) According to the applied method, the target and the proportion of screened responses varied, ranging from 0.5% to 14% at maximum. Only a small proportion was detected coincidentally by two or more methods. (2) The screening of careless responding only had a slight impact on statistical figures of factor analysis, correlations, and regression. Such less than moderate impacts were in line with earlier findings and less threatening to the validation of research models. (3) Lastly, we demonstrated a multi-hurdling method that adopted two methods sequentially. To conclude, the study discusses possible applications of detection methods and avenues for future research.
Distribution of Arsenic Fraction in Soil Around Abandoned Mining Area and Uptake by Rice
Kim, Hyuck-Soo,Go, Woo-Ri,Kang, Dae-Won,Yoo, Ji-Hyock,Kim, Kye-Hoon,Kim, Won-Il 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5
Arsenic (As) contamination of agricultural soils resulting from mining activity has caused major concern due to the potential health risk. Therefore the current study was carried out to investigate the relationship between fractionation of As in soil and rice uptake and to provide a basic information for adequate management of As contaminated agricultural soil. Twenty agricultural soils and rice affected by the abandoned mining sites were collected. Soil chemical properties and As concentrations (total and sequential extracted) in soils were determined and As concentrations in polished rice were analyzed. The average concentration of As in non-specifically adsorbed (F1), specifically adsorbed (F2), amorphous hydrous oxides of Fe and Al (F3), crystalline hydrous oxides of Fe and Al (F4) and residual phase (F5) were 0.08, 1.38, 10.34, 3.26 and $10.98mgkg^{-1}$, respectively. Both soil pH and available phosphorus were positively correlated with the concentrations of As in F1 and F2. These results indicate that increasing the soil pH and available phosphorus can significantly increase the easily mobile fractions of As (F1 and F2). The average concentration of As in polished rice was $0.09mgkg^{-1}$. The concentrations of As in F1 and F2 showed a positive correlation with the concentrations of As in polished rice. Therefore soil pH and available phosphorus affect the distribution of As fractionation in soils and thus affect As bioavailability.