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Ryu, Ji-Won,Yoon, A-Hyang,Ahn, Jong-Mo Korean Academy of Orofacial Pain and Oral Medicine 2019 Journal of Oral Medicine and Pain Vol.44 No.2
Purpose: The aim of this study is to evaluate the correlation between tongue pain and tenderness of tongue by digital palpation (DP) in Burning Mouth Syndrome (BMS) patients. Methods: One hundred thirty-four consecutive patients (60 BMS with tongue pain and 74 non-BMS) who attended the Department of Oral Medicine (Chosun University Dental Hospital, Gwangju, Korea) from January 2018 to December 2018 were included in this study. The examined sites were anterior, lateral (right and left) and central part of the tongue. The pain sites were reported by the patients and the tender points on DP test were recorded by the clinicians. DP test was performed by well-trained clinicians with palpation of the tongue with 0.5 kg pressure using the thumb and index finger. Obtained results for BMS and non-BMS group were compared using t-test (p<0.05). Results: 1. The BMS group had higher tender score on DP test of the tongue and there was a significant difference between the BMS and non-BMS groups. 2. The accuracy of the pain site and the tender point was shown to be 0.68 total (anterior 0.68; right lateral 0.69; left lateral 0.70; central 0.61). Conclusions: This study suggests that the tenderness to DP of the tongue could be related to the painsites in the BMS patients. Further study is needed to confirm the usefulness of DP test of the tongue to examine the BMS patients.
Anti-complement Effects of Anion-Substituted Poly(vinyl alcohol) Membranes
Ryu, Kyu-Eun,Rhim, Hyang-Shuk,Park, Chong-Won,Chun, Heung-Jae,Hong, Seung-Hwa,Kim, Young-Chai,Lee, Young-Moo The Polymer Society of Korea 2004 Macromolecular Research Vol.12 No.1
In a continuation of our previous studies on blood compatibility profiles of anion-substituted poly(vinyl alcohol) (PVA) membranes, in which hydroxyl groups have been replaced with carboxymethyl (C-PVA) and sulfonyl groups (S-PVA), we have studied the activation of complement components and the changes in white cell and platelet count in vitro and compared them with those of unmodified PVA, Cuprophane, and low-density polyethylene. Complement activation of fluid phase components, C3a, Bb, iC3b, and SC5b-9, and of bound phases, C3c, C3d, and SC5b-9, were assessed by enzyme-linked immunosorbent assay (ELISA) and immunoblot, respectively. The changes in the number of white cells and platelets following complement activation were counted using a Coulter counter. C-PVA and S-PVA activated C3 to a lesser extent than did PVA, which we attribute to the diminished level of surface nucleophiles of the samples. In addition, C- and S-PVA exhibit increased inhibition of Bb production, resulting in a decrease in the extent of C5 activation. Consequently, because of the reduced activation of C3 and C5, C- and S-PVA samples cause marked decreases in the SC5b-9 levels in plasma. We also found that the negatively charged sulfonate and carboxylate groups of the samples cause a greater extent of adsorbtion of the positively charged anaphylatoxins, C3a and C5a, because of strong electrostatic attraction, which in turn provides an inhibition of chemotaxis and activation of leukocytes. The ability to inhibit complement production, together with the binding ability of anaphylatoxins of the C- and S-PVA samples, leads to a prominent decrease in lysis of leukocytes as well as activation of platelets.
( Won Kon Kim ),( Hyun Ju Cho ),( Su In Ryu ),( Hyang Ran Hwang ),( Do Hyung Kim ),( Hye Young Ryu ),( Jin Woong Chung ),( Tae Yoon Kim ),( Byoung Chul Park ),( Kwang Hee Bae ),( Yong Ko ),( Sang Chul 생화학분자생물학회 2008 BMB Reports Vol.41 No.8
Atopic dermatitis (AD) is a chronic inflammatory skin disease that induces changes in various inflammatory skin cells. The prevalence of AD is as high as 18% in some regions of the world, and is steadily rising. However, the pathophysiology of AD is poorly understood. To identify the proteins involved in AD pathogenesis, a comparative proteomic analysis of protein expression in peripheral blood mononuclear cells isolated from AD patients and healthy donors was conducted. Significant changes were observed in the expressions of fourteen proteins, including the vinculin, PITPNB, and Filamin A proteins. Among the proteins, α-SNAP and FLNA decreased significantly, and PITPNB increased significantly in AD patients compared with control subjects; these findings were further confirmed by real-time PCR and Western blot analysis. The comparative proteome data may provide a valuable clue to further understand AD pathogenesis, and several differentially regulated proteins may be used as biomarkers for diagnosis and as target proteins for the development of novel drugs.