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Adrianto, Indra,Wang, Shaofeng,Wiley, Graham B.,Lessard, Christopher J.,Kelly, Jennifer A.,Adler, Adam J.,Glenn, Stuart B.,Williams, Adrienne H.,Ziegler, Julie T.,Comeau, Mary E.,Marion, Miranda C.,Wa Wiley Subscription Services, Inc., A Wiley Company 2012 Vol.64 No.11
<P><B>Abstract</B></P><P><B>Objective</B></P><P>Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production and altered type I interferon expression. Genetic surveys and genome‐wide association studies have identified >30 SLE susceptibility genes. One of these genes, <I>TNIP1</I>, encodes the ABIN1 protein. ABIN1 functions in the immune system by restricting NF‐κB signaling. The present study was undertaken to investigate the genetic factors that influence association with SLE in genes that regulate the NF‐κB pathway.</P><P><B>Methods</B></P><P>We analyzed a dense set of genetic markers spanning <I>TNIP1</I> and <I>TAX1BP1</I>, as well as the <I>TNIP1</I> homolog <I>TNIP2</I>, in case–control populations of diverse ethnic origins. <I>TNIP1</I>, <I>TNIP2</I>, and <I>TAX1BP1</I> were fine‐mapped in a total of 8,372 SLE cases and 7,492 healthy controls from European‐ancestry, African American, Hispanic, East Asian, and African American Gullah populations. Levels of <I>TNIP1</I> messenger RNA (mRNA) and ABIN1 protein in Epstein‐Barr virus–transformed human B cell lines were analyzed by quantitative reverse transcription–polymerase chain reaction and Western blotting, respectively.</P><P><B>Results</B></P><P>We found significant associations between SLE and genetic variants within <I>TNIP1</I>, but not in <I>TNIP2</I> or <I>TAX1BP1</I>. After resequencing and imputation, we identified 2 independent risk haplotypes within <I>TNIP1</I> in individuals of European ancestry that were also present in African American and Hispanic populations. Levels of <I>TNIP1</I> mRNA and ABIN1 protein were reduced among subjects with these haplotypes, suggesting that they harbor hypomorphic functional variants that influence susceptibility to SLE by restricting ABIN1 expression.</P><P><B>Conclusion</B></P><P>Our results confirm the association signals between SLE and <I>TNIP1</I> variants in multiple populations and provide new insight into the mechanism by which <I>TNIP1</I> variants may contribute to SLE pathogenesis.</P>
Nanofabrication at High Throughput and Low Cost
Wiley, Benjamin J.,Qin, Dong,Xia, Younan American Chemical Society 2010 ACS NANO Vol.4 No.7
<P>The task of nanofabrication can, in principle, be divided into two separate tracks: generation and replication of the patterned features. These two tracks are different in terms of characteristics, requirements, and aspects of emphasis. In general, generation of patterns is commonly achieved in a serial fashion using techniques that are typically slow, making this process only practical for making a small number of copies. Only when combined with a rapid duplication technique will fabrication at high-throughput and low-cost become feasible. Nanoskiving is unique in that it can be used for both generation and duplication of patterned nanostructures.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2010/ancac3.2010.4.issue-7/nn101472p/production/images/medium/nn-2010-01472p_0005.gif'></P>
Carboxymethoximes(I) Carboxymethoximes and Their Methyl Esters of Ketosteroids
리챠드 H. 와일리,장세희,Wiley, Richard H.,Chang, Sae-Hee Korean Chemical Society 1968 대한화학회지 Vol.12 No.2
몇 가지의 ketosteroid의 carboxymethoxime 및 이들의 methyl ester를 합성하였고 carboxymethoxime의 중화 당량으로부터 ketosteroid의 분자량을 결정할 수 있음을 지적하였다. 또한 이들의 methyl ester는 ketosteroid의 확인인에 이용할 수 있음도 아울러 지적하였다. The carboxymethoximes and their methyl esters of several ketosteroids were synthesized. It is suggested that the molecular weights of the ketosteroids could be determined through measuring the neutralization equivalents of their carboxymethoximes. The methyl ester of these carboxymethoximes could be utilized as useful derivatives for the identification of the ketosteriods.
A Single-Center Randomized Controlled Trial Evaluating Timing of Preparation for Capsule Enteroscopy
Katherine R. Black,Wiley Truss,Cynthia I. Joiner,Shajan Peter,Frederick H. Weber Jr 대한소화기내시경학회 2015 Clinical Endoscopy Vol.48 No.3
Background/Aims: Intestinal lavage (IL) administration immediately before capsule enteroscopy (CE) is superior to lavage the day before the procedure. We aimed to determine the effect of IL timing on CE diagnostic yield. Methods: Patients referred for CE were randomized prospectively into two equal groups according to the timing of IL with 2 L of polyethylene glycol solution. Group A and B underwent IL over 2 hours beginning 14 and 4 hours, respectively, before the scheduled CE. The primary outcome measure was preparation quality, measured with a predetermined validated grading scale. Results: A total of 34 patients were randomized. The frequency of mucosal abnormalities (77% vs. 82%, p=not significant [NS]) and diagnostic yield (47% vs. 53%, p=NS) were similar between the two groups. Moreover, no significant association between the quality of small bowel preparation and the timing at which the purgative for IL was administered was observed (overall fluid transparency, p=0.936; overall mucosal invisibility, p=0.091). Conclusions: Day-before IL is equivalent to same-day IL in terms of overall preparation quality, proportion of complete studies to cecum, small bowel transit time, frequency of identified mucosal abnormalities, and overall diagnostic yield.
Emotional Intelligence as a Predictor of Writing and Public Speaking Anxieties
Stephanie Kelly,Tiffany Smith,Wiley Brown 한국경영커뮤니케이션학회 2020 Business Communication Research and Practice Vol.3 No.2
Objectives:Students and professionals who suffer from communication anxiety may have all of the skills necessary to be excellent communicators, but unable to communicate effectively as they struggle with that anxiety. Guided by the Instructional Beliefs Model, the purpose of this study is to evaluate emotional intelligence (EQ), a developable skill, as an indirect influence of writing and presentation anxieties. Methods:An online survey was disseminated to 224 business majors. Each were assessed on the dimensions of EQ, self-efficacy, writing apprehension, and public speaking anxiety. Results:The data supported a model in which the EQ dimensions of well-being and self-control, which are the dimensions of EQ that are oriented toward one’s own emotions, indirectly influence students’ public speaking anxiety through the mediation of self-efficacy. However, while all EQ dimensions were negatively correlated with writing apprehension, none appear to be an indirect influence of it. Conclusions:The findings of this study indicate that elevating an individual’s well-being and self-control can ultimately give them the tools they need to manage their anxiety when giving presentations. Through instructional strategies known to enhance these characteristics, business educators and organizational trainers should be able to assist individuals in giving better presentations.
Real-Time Visualization of Diffusion-Controlled Nanowire Growth in Solution
Ye, Shengrong,Chen, Zuofeng,Ha, Yoon-Cheol,Wiley, Benjamin J. American Chemical Society 2014 NANO LETTERS Vol.14 No.8
<P>This Letter shows that copper nanowires grow through the diffusion-controlled reduction of dihydroxycopper(I), Cu(OH)<SUB>2</SUB><SUP>–</SUP>. A combination of potentiostatic coulometry, UV–visible spectroscopy, and thermodynamic calculations was used to determine the species adding to growing Cu nanowires is Cu(OH)<SUB>2</SUB><SUP>–</SUP>. Cyclic voltammetry was then used to measure the diffusion coefficient of Cu(OH)<SUB>2</SUB><SUP>–</SUP> in the reaction solution. Given the diameter of a Cu nanowire and the diffusion coefficient of Cu(OH)<SUB>2</SUB><SUP>–</SUP>, we calculated the dependence of the diffusion-limited growth rate on the concentration of copper ions to be 26 nm s<SUP>–1</SUP> mM<SUP>–1</SUP>. Independent measurements of the nanowire growth rate with dark-field optical microscopy yielded 24 nm s<SUP>–1</SUP> mM<SUP>–1</SUP> for the growth rate dependence on the concentration of copper. Dependence of the nanowire growth rate on temperature yielded a low activation energy of 11.5 kJ mol<SUP>–1</SUP>, consistent with diffusion-limited growth.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2014/nalefd.2014.14.issue-8/nl501762v/production/images/medium/nl-2014-01762v_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl501762v'>ACS Electronic Supporting Info</A></P>
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
Adrianto, Indra,Wen, Feng,Templeton, Amanda,Wiley, Graham,King, Jarrod B,Lessard, Christopher J,Bates, Jared S,Hu, Yanqing,Kelly, Jennifer A,Kaufman, Kenneth M,Guthridge, Joel M,Alarc처n-Riquelme, Mart Nature Publishing Group, a division of Macmillan P 2011 Nature genetics Vol.43 No.3
Systemic lupus erythematosus (SLE, MIM152700) is an autoimmune disease characterized by self-reactive antibodies resulting in systemic inflammation and organ failure. TNFAIP3, encoding the ubiquitin-modifying enzyme A20, is an established susceptibility locus for SLE. By fine mapping and genomic re-sequencing in ethnically diverse populations, we fully characterized the TNFAIP3 risk haplotype and identified a TT>A polymorphic dinucleotide (deletion T followed by a T to A transversion) associated with SLE in subjects of European (P = 1.58 ? 10<SUP>??8</SUP>, odds ratio = 1.70) and Korean (P = 8.33 ? 10<SUP>??10</SUP>, odds ratio = 2.54) ancestry. This variant, located in a region of high conservation and regulatory potential, bound a nuclear protein complex composed of NF-觀B subunits with reduced avidity. Further, compared with the non-risk haplotype, the haplotype carrying this variant resulted in reduced TNFAIP3 mRNA and A20 protein expression. These results establish this TT>A variant as the most likely functional polymorphism responsible for the association between TNFAIP3 and SLE.
Excler, Jean-Louis,Delvecchio, Christopher J.,Wiley, Ryan E.,Williams, Marni,Yoon, In-Kyu,Modjarrad, Kayvon,Boujelal, Mohamed,Moorthy, Vasee S.,Hersi, Ahmad Salah,Kim, Jerome H. U.S. Department of Health and Human Services * Cen 2016 Emerging Infectious Diseases Vol.22 No.8
<P>Middle East respiratory syndrome (MERS) remains a serious international public health threat. With the goal of accelerating the development of countermeasures against MERS coronavirus (MERS-CoV), funding agencies, nongovernmental organizations, and researchers across the world assembled in Riyadh, Saudi Arabia, on November 14–15, 2015, to discuss vaccine development challenges. The meeting was spearheaded by the Saudi Ministry of Health and co-organized by the International Vaccine Institute, South Korea. Accelerating the development of a preventive vaccine requires a better understanding of MERS epidemiology, transmission, and pathogenesis in humans and animals. A combination of rodent and nonhuman primate models should be considered in evaluating and developing preventive and therapeutic vaccine candidates. Dromedary camels should be considered for the development of veterinary vaccines. Several vaccine technology platforms targeting the MERS-CoV spike protein were discussed. Mechanisms to maximize investment, provide robust data, and affect public health are urgently needed.</P>