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RISS 인기검색어
- 검색키워드
- 저자 : Wenqing Yu (검색결과 5 건)
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New Hanger Design Approach of Tied-Arch Bridge to Enhance Its Robustness
Wenqing Wu,Hao Wang,Yan-Jie Zhu,Jiangyu Yu,Hao Zhao,Hui Zhang 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.11
As the crucial components among the tied-arch bridge, the local failure of hangers may trigger a progressive collapse through the entire tied-arch bridge. However, the current design guidance as regards hangers still lacks consideration of structure robustness under an extreme hazard. To improve the structural robustness of tied-arch bridge under extreme conditions, a new hanger design method is proposed, which is termed as asymmetric parallel double-hanger system. Based on Miner’s linear cumulative damage law, an analysis on the fatigue life of the double-hanger system was conducted to verify the feasibility of the proposal, and then a dynamic time-history analysis was employed to simulate the transitory fracture impact due to one or more hangers fracturing. According to the simulation results, the structural robustness is greatly enhanced with asymmetric parallel-double hanger system design, when compared with single hanger system design. When one or more hangers reveal local damage, it will not trigger a progress failure to the whole structure in particular. Several practical suggestions of bridge system’s load-carrying capacity are also put forward for the future arch bridge design at the end of this paper.
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Artificial neural network reconstructs core power distribution
Wenhuai Li,Peng Ding,Wenqing Xia,Shu Chen,Fengwan Yu,Chengjie Duan,Dawei Cui,Chen Chen 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.2
To effectively monitor the variety of distributions of neutron flux, fuel power or temperatures in thereactor core, usually the ex-core and in-core neutron detectors are employed. The thermocouples fortemperature measurement are installed in the coolant inlet or outlet of the respective fuel assemblies. Itis necessary to reconstruct the measurement information of the whole reactor position. However, thereading of different types of detector in the core reflects different aspects of the 3D power distribution. The feasibility of reconstruction the core three-dimension power distribution by using different combinations of in-core, ex-core and thermocouples detectors is analyzed in this paper to synthesize theuseful information of various detectors. A comparison of multilayer perceptron (MLP) network and radialbasis function (RBF) network is performed. RBF results are more extreme precision but also moresensitivity to detector failure and uncertainty, compare to MLP networks. This is because that localizedneural network could offer conservative regression in RBF. Adding random disturbance in trainingdataset is helpful to reduce the influence of detector failure and uncertainty. Some convolution neuralnetworks seem to be helpful to get more accurate results by use more spatial layout information, thoughrelative researches are still under way
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Zhengxia Wang,Ningfei Ji,Zhongqi Chen,Zhixiao Sun,Chaojie Wu,Wenqing Yu,Fan Hu,Mao Huang,Mingshun Zhang 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.5
Purpose: CD4+T cells are essential in the pathogenesis of allergic asthma. We have previously demonstrated that microRNA-1165-3p (miR-1165-3p) was significantly reduced in T-helper type (Th) 2 cells and that miR-1165-3p was a surrogate marker for atopic asthma. Little is known about the mechanisms of miR-1165-3p in the regulation of Th2-dominated allergic inflammation. We aimed to investigate the associations between Th2 differentiation and miR-1165b-3p in asthma as well as the possible mechanisms. Methods: CD4+ naïve T cells were differentiated into Th1 or Th2 cells in vitro. MiR-1165-3p was up-regulated or down-regulated using lentiviral systems during Th1/Th2 differentiation. In vivo, the lentiviral particles with the miR-1165-3p enhancer were administered by tail vein injection on the first day of a house dust mite -induced allergic airway inflammation model. Allergic inflammation and Th1/Th2 differentiation were routinely monitored. To investigate the potential targets of miR-1165-3p, biotin-microRNA pull-down products were sequenced, and the candidates were further verified with a dual-luciferase reporter assay. The roles of a target protein phosphatase, Mg2+/Mn2+-dependent 1A (PPM1A), in Th2 cell differentiation and allergic asthma were further explored. Plasma PPM1A was determined by ELISA in 18 subjects with asthma and 20 controls. Results: The lentivirus encoding miR-1165-3p suppressed Th2-cell differentiation in vitro. In contrast, miR-1165-3p silencing promoted Th2-cell development. In the HDM-induced model of allergic airway inflammation, miR-1165-3p up-regulation was accompanied by reduced airway hyper-responsiveness, serum immunoglobulin E, airway inflammation and Th2-cell polarization. IL-13 and PPM1A were the direct targets of miR-1165-3p. The expression of IL-13 or PPM1A was inversely correlated with that of miR-1165-3p. PPM1A regulated the signal transducer and activator of transcription and AKT signaling pathways during Th2 differentiation. Moreover, plasma PPM1A was significantly increased in asthmatic patients. Conclusions: MiR-1165-3p negatively may regulate Th2-cell differentiation by targeting IL-13 and PPM1A in allergic airway inflammation.
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Gao Shan,Guo Tingting,Luo Shuyu,Zhang Yan,Ren Zehao,Lang Xiaona,Hu Gaoyong,Zuo Duo,Jia Wenqing,Kong Dexin,Yu Haiyang,Qiu Yuling 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.6
Chronic myeloid leukemia (CML) is a slowly progressing hematopoietic cell disorder. Sphingosine kinase 1 (SPHK1) plays established roles in tumor initiation, progression, and chemotherapy resistance in a wide range of cancers, including leukemia. However, small-molecule inhibitors targeting SPHK1 in CML still need to be developed. This study revealed the role of SPHK1 in CML and investigated the potential anti-leukemic activity of hirsuteine (HST), an indole alkaloid obtained from the oriental plant Uncaria rhynchophylla, in CML cells. These results suggest that SPHK1 is highly expressed in CML cells and that overexpression of SPHK1 represents poor clinical outcomes in CML patients. HST exposure led to G2/M phase arrest, cellular apoptosis, and downregulation of Cyclin B1 and CDC2 and cleavage of Caspase 3 and PARP in CML cells. HST shifted sphingolipid rheostat from sphingosine 1-phosphate (S1P) towards the ceramide coupled with a marked inhibition of SPHK1. Mechanistically, HST significantly blocked SPHK1/S1P/S1PR1 and BCR-ABL/PI3K/Akt pathways. In addition, HST can be docked with residues of SPHK1 and shifts the SPHK1 melting curve, indicating the potential protein-ligand interactions between SPHK1 and HST in both CML cells. SPHK1 overexpression impaired apoptosis and proliferation of CML cells induced by HST alone. These results suggest that HST, which may serve as a novel and specific SPHK1 inhibitor, exerts anti-leukemic activity by inhibiting the SPHK1/S1P/ S1PR1 and BCR-ABL/PI3K/Akt pathways in CML cells, thus conferring HST as a promising anti-leukemic drug for CML therapy in the future.
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