Asparagus Polysaccharide and Gum with Hepatic Artery Embolization Induces Tumor Growth and Inhibits Angiogenesis in an Orthotopic Hepatocellular Carcinoma Model

Weng, Ling-Ling,Xiang, Jian-Feng,Lin, Jin-Bo,Yi, Shang-Hui,Yang, Li-Tao,Li, Yi-Sheng,Zeng, Hao-Tao,Lin, Sheng-Ming,Xin, Dong-Wei,Zhao, Hai-Liang,Qiu, Shu-Qi,Chen, Tao,Zhang, Min-Guang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.

Influence of the Donor Side of Photosystem II on the Photogeneration of Superoxide Radicals and Chlorophyll a Fluorescence

Weng, Jun,Zhang, Suping,Pan, Jingxi,Jinxing, Chen,Xu, Chunhe Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2

Direct EPR evidence of the photo-generation of superoxide radicals ( $O_2$$^{-.}$) was obtained by using spin trapping techniques in spinach photosystem II (PSII) membranes. $O_2$$^{-.}$ was detected by following the formation of 5-diethoxyphosphoryl-5-methyl-1 -pyrroline-N-oxide (DEPMPO) superoxide adducts, DEPMPO-OOH. The significant increase of the EPR signal amplitude of DEPMPO-OOH in N$H_2O$H-, CaC $l_2$- and NaCl-treated PSII membranes showed that the oxygen-evolving system has a close relation to the $O_2$$^{-.}$ production. PSII membranes with inactivated donor side could not prevent the $O_2$$^{-.}$ production efficiently. Treatments on PSII donor side also influence the maximum level and the kinetics of Chlorophyll (Chi) a fluorescence. Results suggested that manganese cluster and extrinsic proteins might affect Chi a fluorescence in ways different from that happens at the acceptor side of PSII.SII.SII.

Dietary supplementation with different types of fiber in gestation and lactation: effects on sow serum biochemical values and performance

Weng Ruey-Chee 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.8

Objective: Three types of dietary fiber were fed to sows during gestation and lactation stages to monitor their physiological and metabolic adaptations during the pre-partum period and to determine how these effects may influence the lactation period and sow performance. Methods: Soon after breeding, 54 sows were selected and were fed with 20% supplementation as fed of wheat bran (WB), soya hulls (SH), or rice hulls (RH) in diets during gestation and lactation. Sows were weighed, backfat thickness was measured ultrasonically and jugular blood samples were collected from all sows. The litter size was equalized to 10, by fostering piglets from sows on the same treatment. Results: Sows gained 22.0, 21.8, and 25.5 kg of net maternal body weight during gestation (for WB, SH, and RH sows, respectively; p = 0.007). There was no treatment effect on the body weight change during lactation (p = 0.158), however RH sows consumed an average of 133.66 kg of feed, WB sows took 121.29 kg and SH sows took 126.77 kg during lactation (p<0.001). The SH litters gained an average of 59.34 kg of weight during lactation, while other litters gained 51.58 and 49.98 kg (for WB and RH litters, respectively; p<0.001). Exception for aspartate aminotransferase and alanine aminotransferase, measured serum biochemical values were broadly in agreement with earlier reports. Despite the use of additional vegetable oil to balance the energy level, RH sows still had lower concentrations of serum triglycerides in late gestation. Conclusion: Different types of fibrous ingredients in the gestation diet influenced most of the investigated reference values for sows. The values of serum biochemical parameters were generally not affected by fiber type during the lactation stage. The SH supplementation for sows is an effective approach to give heavier litters at birth and weaning and to increase voluntary feed intake in early lactation.

Solubility of N-ethylcarbazole in ethanol+petroleum ether mixtures at various temperatures

Wenge Yang,Keyi Wu,Yong-Hong Hu,Tuan Zhang,Qirun Guo,Shouhai Yang,Ying Shi 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.6

The solubility of N-ethylcarbazole in (ethanol+petroleum ether) binary solvent mixtures was measured with the temperature changing from 280.15 K to 316.15 K. The experimental data matched the solvent/Redlich-Kister (CNIBS/R-K) equation and the Jouyban-Acree equation. Computational results showed the CNIBS/R-K equation was more suitable than the Jouyban-Acree equation. The solution process in the thermodynamic properties, including the Gibbs energy, enthalpy, and entropy, was calculated by the van’t Hoff analysis.

Path Following Control of Automated Guided Vehicle Based on Model Predictive Control with State Classification Model and Smooth Transition Strategy

Weng Xun,Zhang Jingtian,Ma Ying 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.3

Path following control of the automatic guided vehicle (AGV) for material handling in the plant requires a smooth and high-precision continuous attitude adjustment. However, there are many difficulties in designing the controller, such as actuator saturation, parameter selection, and the influence of deviations relations. In this paper, an improved model predictive control SCMPC-ST with a state classification model (SCM) and a smooth transition (ST) strategy is proposed to address these problems. First, based on the deviations relations and the actuator saturation, the SCM is designed to divide the pose states of AGV into three stages. With clearly objective functions and boundary constraints, SCM allows the pose states can be transferred sequentially, which avoids the problem of parameter selection. Second, use the analytical method to resolve SCM to directly obtain the desired control law, which provides excellent performance in real-time. Finally, the smooth transition strategy is built to adjust the control law at the transition step and overshoot step to ensure the stability of the control process. Simulation results show that by focusing on adjusting the deviations relations, SCMPC-ST can make AGV eliminate all deviations continuously and smoothly while maintaining high accuracy.

Inconspicuous Nasoethmoidal Encephalocele Might Be Wrongly Diagnosed

Weng Jun Tang,Wan Azman Wan Sulaiman 대한성형외과학회 2016 Archives of Plastic Surgery Vol.43 No.3

Evaluation of cadmium ratio for conceptual design of a cyclotronbased thermal neutron radiography system

Weng-Sheng Kuo 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.7

An approximate method for calculating the cadmium ratio of a cyclotron-based thermal neutron radiography system was developed. In this method, the Monte-Carlo code, MCNP6.2, was employed to calculate the neutron capture rates of Au-197, and the cadmium ratio was obtained by computing the ratio of neutron capture rates. From the simulation results, the computed cadmium ratio is reasonably acceptable, and the assumption of ignoring the fast neutron contribution to the cadmium ratio is valid.

Mobile taxi booking application service’s continuance usage intention by users

Weng, Gooi Sai,Zailani, Suhaiza,Iranmanesh, Mohammad,Hyun, Sunghyup Sean Pergamon 2017 Transportation Research Part D. Transport & Enviro Vol.57 No.-

<P><B>Abstract</B></P> <P>The long-term development of a mobile booking taxi application service depends on the continued use of its passengers. The aim of this study is to investigate the determinants of the mobile taxi booking application service’s continuance intention, using the technology continuance theory by including the perceived risk and subjective norms. The data were collected by surveying 387 users of the mobile taxi application service. The data were analysed by applying the partial least squares technique. The analysis showed that the technology continuance theory has extensive power to explain the continuance intention to use the mobile booking taxi application. Subjective norms also have a significant effect on the attitude of mobile booking taxi application users which represents an important contribution to technology continuance theory extension. The theoretical and practical significances of the study have been discussed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The early acceptance of an MTB Apps does not guarantee continuation. </LI> <LI> Studies on continuance intention of users toward MTB App use are still lacking. </LI> <LI> Results will help App developers to grasp the factors that result in continued MTB App use. </LI> </UL> </P>

Effect of Nursing Frequency and Creep Feed Provision on the Milk and Feed Intake and Performance of Zero Day Weaned Piglets Reared on a Dummy Sow

Weng, R.C.,Edwards, S.A.,Hsia, L.C. Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.11

One hundred and forty-four piglets with an average birth weight of 1,672${\pm}$13.4 g were used to evaluate different feeding strategies for piglets reared from birth on a dummy sow. A 3${\times}$2 factorial experiment compared three nursing frequencies (1, 3 or 6 h intervals) and two feeding regimes (milk only, or milk combined with access to creep feed and water). The piglets which were nursed at one hour intervals had the lightest body weights at all days, and the poorest combined milk and creep feed dry matter conversion efficiency to piglet body weight gain in the second week. Piglets which were nursed at 3 h intervals had the heaviest body weight at day 15 and 22, but those nursed at 6 h intervals achieved similar body weight by days 29 (milk withdrawal) and 36. Piglets offered creep feed were observed to wean themselves before cessation of milk availability, and the timing of this self-weaning depended on the nursing frequency. The piglets nursed at one hour intervals weaned themselves between day 22 and day 29, those nursed at 3 h intervals weaned themselves between day 15 and day 22, whilst those nursed at 6 h intervals weaned themselves between day 8 and day 15. The piglets which were nursed at 6 h intervals had the highest total dry matter intake in weeks 3 and 4 when fed with milk, creep feed and water but not when fed milk only. They consequently had the poorest dry matter conversion efficiency in the fourth week and overall when fed with milk, creep feed and water, but not when fed milk only. It is concluded that the optimal management routine under these conditions is a 3 h nursing cycle with provision of supplementary creep feed and water.

Glutathione-S-Transferase T1 Polymorphism is Associated with Esophageal Cancer Risk in Chinese Han Population

Weng, Yuan,Fei, Bojian,He, Ping,Cai, Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Background: Glutathione-S-Transferase T1 (GSTT1) gene has been shown to be involved in the development of esophageal cancer. However, the results have been inconsistent. In this study, the authors performed a meta-analysis to clarify the association between GSTT1 polymorphism and esophageal cancer risk among Chinese Han population. Methods: Published literature from PubMed, the China National Knowledge Infrastructure and Wanfang Data were searched. Pooled odds ratio (OR) and 95% confidence interval (95%CI) was calculated using a fixed- or random-effects model. Results: Eleven studies with a total of 2779 individuals were included in the meta-analysis. The results showed that GSTT1 null genotype was significantly associated with esophageal cancer risk in Chinese (OR = 1.31, 95%CI 1.12 to 1.53, p = 0.001). Further sensitivity analyses confirmed the significant association. The cumulative meta-analysis showed a trend of an obvious association between GSTT1 null genotype and esophageal cancer risk as information accumulated by year. Conclusions: This meta-analysis suggests a significant association of GSTT1 null genotype with esophageal cancer risk in the Chinese Han population.