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RISS 인기검색어
- 검색키워드
- 저자 : Wen-Yuh Lin (검색결과 4 건)
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Streptomyces Telomeres Contain a Promoter
Lin, Yuh-ru,Hahn, Mi-Young,Roe, Jung-Hye,Huang, Tzu-Wen,Tsai, Hsiu-Hui,Lin, Yung-Feng,Su, Tsung-Sheng,Chan, Yu-Jiun,Chen, Carton W. American Society for Microbiology 2009 Journal of Bacteriology Vol.191 No.3
<B>ABSTRACT</B><P>Bidirectional replication of the linear chromosomes and plasmids of <I>Streptomyces</I> spp. results in single-strand overhangs at their 3′ ends, which contain extensive complex palindromic sequences. The overhangs are believed to be patched by DNA synthesis primed by a terminal protein that remains covalently bound to the 5′ ends of the telomeres. We discovered that in vitro a conserved 167-bp telomere DNA binds strongly to RNA polymerase holoenzyme and exhibits promoter activities stronger than those of an rRNA operon. In vivo, the telomere DNA exhibited promoter activity in both orientations on a circular plasmid in <I>Streptomyces</I>. The telomere promoter is also active on a linear plasmid during exponential growth. Such promoter activity in a telomere has not hitherto been observed in eukaryotic or prokaryotic replicons. <I>Streptomyces</I> telomere promoters may be involved in priming the terminal Okazaki fragment (during replication) replicative transfer (during conjugation), or expression of downstream genes (including a conserved <I>ttrA</I> helicase-like gene involved in conjugal transfer). Interestingly, the <I>Streptomyces</I> telomeres also function as a promoter in <I>Escherichia coli</I> and as a transcription enhancer in yeast.</P>
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Design and Performance Evaluation of Hexagonal Topology Networks with Novel Routing Algorithms
Yuh-Jiuh Cheng,Bor-Tauo Chen,Wen-Lin Cheng 한국통신학회 2020 한국통신학회 APNOMS Vol.2020 No.09
The heuristic shortest path routing algorithms and performance evaluation are proposed to find the most suitable optical path between the two nodes of the optical switch in hexagonal topology network. The advantages of hexagonal optical switching network are easy to expand and have flexible fault tolerant. If we want to expand hexagonal topology network, we can increase the number of levels. A 7-level hexagonal topology network with 294 nodes has been designed and its routing algorithm has also been designed. Finally, we evaluated the performance of 4-level hexagonal topology network with different algorithms such as SPRA-AI (Shortest Path Routing Algorithm with Artificial Intelligence using decision tree), SPRA-SPT (Shortest Path Routing Algorithm with Spanning Tree), and SPRA-PDP (Shortest Path Routing Algorithm with Pure Distance Prediction). The simulated traffic mode is also captured from the actual core network to obtain the authenticity of the simulation results.
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Antioxidative Activities of Kefir
Liu, Je-Ruei,Lin, Yuh-Yih,Chen, Ming-Ju,Chen, Li-Ju,Lin, Chin-Wen Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.4
This study aims to evaluate the antioxidative activities of cow-milk kefir and goat-milk kefir. Antioxidative mechanisms, including radical-scavenging effects, ferrous-ion chelating ability, reducing power and antioxidant activity, were investigated herein. Kefirs demonstrated significantly greater scavenging effects upon 1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide radicals, an inhibition effect upon linoleic-acid peroxidation, and more substantial reducing power, but reduced glutathione peroxidase (GSH-Px) activity than was the case for milks. There was no significant difference between milks and kefirs as regards ferrous-ion chelating ability and superoxide dismutase (SOD) activity. These findings have demonstrated that kefirs possess antioxidant activity, thereby suggesting that kefirs are potential candidates for the role of useful natural antioxidant supplements for the human diet.
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Enhancing antimicrobial activity of mastoparan-B by amino acid substitutions
Mars J. Yang,Wen-Yuh Lin,Chun-Hsien Lin,Ching-Lin Shyu,Roger F. Hou,Wu-Chun Tu 한국응용곤충학회 2013 Journal of Asia-Pacific Entomology Vol.16 No.4
This study evaluated antimicrobial and hemolytic activities of mastoparan-B (MP-B) isolated fromthe venomof the hornet, Vespa basalis, and its analogs after substituting certain amino acid (aa) residues.MP-B exhibited significantly different antimicrobial activities against bacteria species/strains tested, especially two Escherichia coli strains, Staphylococcus xylosus and Citrobacter koseri at low dosages, and was non-specific against certain Gram-positive and -negative bacteria. Our results indicated that hydrophobicitymodification by single aa substitution may enhance their antimicrobial activities. An aa substituted MP-B, viz., MP-B-1, inwhich Trp substituted for Leu3, became more effective than the original peptide at inhibiting or killing the bacterial species tested, especially Klebsiella pneumonia, Salmonella typhimurium, and Salmonella Cholerasuis, and even up to 8 timesmore effective in some cases. However, MP-B-2 was virtually similar to MP-B against each bacterial species assayed,while MP-B-3 reduced its effectiveness greatly compared to others. On the other hand, MP-B and its analogs were not effective against the beneficial probiotics and they were not hemolytic to erythrocytes at the dosages tested. Our results suggested that MP-B becomes more potent against specific pathogenic bacteria and safe to the probiotics after undergoing appropriate amino acid substitutions.
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