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Wang Sha,Yuan Anjie,Zeng Liping,Hou Sikai,Wang Meng,Li Lei,Cai Zhendong,Zhong Guowei 한국미생물학회 2021 The journal of microbiology Vol.59 No.1
Aspergillus fumigatus is a well-known opportunistic pathogen that causes invasive aspergillosis (IA) infections with high mortality in immunosuppressed individuals. Morphogenesis, including hyphal growth, conidiation, and cell wall biosynthesis is crucial in A. fumigatus pathogenesis. Based on a previous random insertional mutagenesis library, we identified the putative polysaccharide synthase gene Afcps1 and its paralog Afcps2. Homologs of the cps gene are commonly found in the genomes of most fungal and some bacterial pathogens. Afcps1/cpsA is important in sporulation, cell wall composition, and virulence. However, the precise regulation patterns of cell wall integrity by Afcps1/cpsA and further effects on the immune response are poorly understood. Specifically, our in-depth study revealed that Afcps1 affects cell-wall stability, showing an increased resistance of ΔAfcps1 to the chitinmicrofibril destabilizing compound calcofluor white (CFW) and susceptibility of ΔAfcps1 to the β-(1,3)-glucan synthase inhibitor echinocandin caspofungin (CS). Additionally, deletion of Afcps2 had a normal sporulation phenotype but caused hypersensitivity to Na+ stress, CFW, and Congo red (CR). Specifically, quantitative analysis of cell wall composition using high-performance anion exchange chromatography- pulsed amperometric detector (HPAEC-PAD) analysis revealed that depletion of Afcps1 reduced cell wall glucan and chitin contents, which was consistent with the downregulation of expression of the corresponding biosynthesis genes. Moreover, an elevated immune response stimulated by conidia of the ΔAfcps1 mutant in marrow-derived macrophages (BMMs) during phagocytosis was observed. Thus, our study provided new insights into the function of polysaccharide synthase Cps1, which is necessary for the maintenance of cell wall stability and the adaptation of conidia to the immune response of macrophages in A. fumigatus.
Cai, Yong-Lin,Li, Jun,Lu, Ai-Ying,Zheng, Yu-Ming,Zhong, Wei-Ming,Wang, Wei,Gao, Jian-Quan,Zeng, Hong,Cheng, Ji-Ru,Tang, Min-Zhong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
The objective of this study was to investigate the diagnostic significance of EBV antibody combined detection for nasopharyngeal carcinoma (NPC) in a high incidence region of southern China. Two hundred and eleven untreated NPC patients, 203 non-NPC ENT patients, and 210 healthy controls were recruited for the study. The titers of VCA/IgA and EA/IgA were assessed by immunoenzyme assay, and the levels of Rta/IgG and EBNA1/IgA were determined by enzyme-linked immunosorbent assay. The levels of VCA/IgA, EA/IgA, Rta/IgG and EBNA1/IgA demonstrated no association with gender or age (p>0.05). The receiver operating characteristic curve and the area under the curve were used to evaluate the diagnostic value. The sensitivity of VCA/IgA (98.1%) and the specificity of EA/IgA (98.5%) were the highest. When a logistic regression model was used to combine the results from multiple antibodies to increase the accuracy, the combination of VCA/IgA+Rta/IgG, whose area under the curve was 0.99, had the highest diagnostic efficiency, and its sensitivity, specificity and Youden index were 94.8%, 98.0% and 0.93 respectively. The data suggest that the combination of VCA/IgA+Rta/IgG may be most suitable for NPC serodiagnosis.
Risk Factors of Postoperative Nosocomial Pneumonia in Stage I-IIIa Lung Cancer Patients
Wang, Zeng,Cai, Xin-Jun,Shi, Liang,Li, Fei-Yan,Lin, Neng-Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Background: To investigate the related risk factors of postoperative nosocomial pneumonia (POP) in patients withI-IIIa lung cancer. Methods: Medical records of 511 patients who underwent resection for lung cancer between January 2012 to December 2012 were retrospectively reviewed. Risk factors of postoperative pneumonia were identified and evaluated by univariate and multivariate analyses. Results: The incidence of postoperative pneumonia in these lung cancer patients was 2.9% (15 cases). Compared with 496 patients who had no pneumonia infection after operation, older age (>60), histopathological type of squamous cell carcinoma and longer surgery time (>3h) were significant risk factors by univariate analysis. Other potential risk factors such as alcohol consumption, history of smoking, hypersensitivity, hypertension, diabetes mellitus and so on were not showed such significance in this study. Further, the multivariate analysis revealed that old age (>60 years) (OR 5.813, p=0.018) and histopathological type of squamous cell carcinoma (OR 5.831, p<0.001) were also statistically significant independent risk factors for postoperative pneumonia. Conclusions: This study demonstrated that being old aged (>60 years) and having squamous cell carcinoma histopathological type might be important factors in determining the risk of postoperative pneumonia in lung cancer patients after surgery.
Yijiang Zeng,Yu Pan,Ning Wang,Jian Chen,Xianhui Cai 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.5
The creep fracture behavior between selective laser melted (SLMed) and forged alloy 230 after testing at 1200 °C under differentapplied stresses was compared. The results showed that both the creep behavior of SLMed and forged alloy 230 followedthe power law and obeyed the Monkman–Grant relation. The SLMed samples parallel to the building direction exhibitedsuperior creep resistance than those perpendicular to the building direction, and the forged samples were in between, whilethey all exhibited poor creep ductility compared with that of the forged samples. Furthermore, the relations of applied stressand maximum allowable creep lifetime could be built to evaluate the creep resistance of the alloys. The SLMed samplesparallel to the building direction showed discrete trans/intergranular cracks, while those perpendicular to the building directionand forged materials depicted continuous and discrete intergranular cracks, respectively. Furthermore, the creep fracturemodes at different loadings were revealed by correlating the creep damage tolerance factor with the fractured microstructure. In addition, the effects of the initial microstructure characteristics, such as grain morphology, grain boundaries, grain size,internal defects and precipitates, on the creep strength and life at high temperatures were presented and analyzed.
Gui Wang,Ben Lin,Ding‑ding Lu,San‑xi Deng,Guang‑jun Zeng,Xu‑feng Cai,Jin‑feng Li,Dan‑yang Liu 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.8
The mechanical properties and low-cycle fatigue behavior of the hot-rolled AA2195 Al-Li alloy taken along the longitudinaldirection and transverse direction were investigated. The anisotropy ductility of the alloy with the short-term naturalaging (T4-SN), long-term natural aging (T4-LN), and T6 artificial aging alloy is mainly related to the grain structure andgrain boundaries, whereas the weakened anisotropy of ductility is attributed to the appearance of PFZs. The T4-SN andT4-LN specimens present the cyclic hardening phenomenon due to the interaction of dislocations with dislocations or theGuinier–Preston zone. The cyclic softening phenomenon in T6 specimens is attributed to that the dislocations cut throughthe T1precipitates, and some dislocations bypass the non-shearable precipitates, which activates more potential slip systemsto shear the T1precipitates.
Meng Fu,Fa-zeng Lian,Ji-jie Wang,Wen-li Pei,Yu-lan Chen,Hong-cai Yang 한국자기학회 2004 Journal of Magnetics Vol.9 No.4
The HDDR (Hydrogenation-Disproportionation-Desorption-Recombination) process is a special method to produce anisotropic NdFeB powders for bonded magnet. The effect of the modified HDDR process on magnetic properties of Nd₂Fe₁₄B-based magnet with several composition Nd_(11.2)Fe_(66.5-x)Co_(15.4)B_(6.8)Zr_(0.1)Ga_x (x = 0~1.0) and that of microelement Ga, disproportional temperature and annealing temperature on jHc, grain size were investigated in order to produce anisotropic powder with high magnetic properties. It was found that modified HDDR process is very effective to enhance magnetic properties and to fine grain size. The addition of Ga could change disproportionation character remarkably of the alloy and could improve magnetic properties of magnet powder. Increasing annealing temperature induces significant grain growth. And grain size produced by modified HDDR process is significantly smaller than those produced by conventional HDDR process.
Xiaoyu Xu,Qiongyu Lu,Zheng Wang,Ping Cai,Zhao Zeng,Ling Zhang,Man Wang,Liang Ma,Changgeng Ruan,Suning Chen 대한암학회 2021 Cancer Research and Treatment Vol.53 No.3
Platelet-derived growth factor receptor beta (PDGFRB) rearrangements play an important role in the pathogenesis of eosinophilia-associated myeloid/lymphoid neoplasms. Up to now, more than 70 PDGFRB fusions have been identified. Here, a novel PDGFRB fusion gene CSNK2A1-PDGFRB has been identified in myeloproliferative neoplasm (MPN) with eosinophilia by RNA-sequencing, which has been verified by reverse transcription polymerase chain reaction and Sanger sequencing. The new PDGFRB fusion partner gene CSNK2A1 encoded one of the two catalytic subunit of casein kinase II (CK2). To our knowledge, this is the first report on the involvement of CSNK2A1 in fusion genes, especially fusion with another kinase PDGFRB in MPN. In addition, the CSNK2A1-PDGFRB fusion retained the entire kinase domain of PDGFRB and response to imatinib at low concentration. The patient with CSNK2A1-PDGFRB was sensitive to imatinib treatment and acquired sustained complete remission.