http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Amelioration of mercury-induced autoimmunity by 4-1BB.
Vinay, Dass S,Kim, Jung D,Kwon, Byoung S American Association of Immunologists 2006 Journal of Immunology Vol.177 No.8
<P>In certain strains of mice, subtoxic doses of HgCl2 (mercuric chloride; mercury) induce a complex autoimmune condition characterized by the production of antinucleolar IgG Abs, lymphoproliferation, increased serum levels of IgG1/IgE Abs, and deposition of renal immune complexes. 4-1BB is an important T cell costimulatory molecule that has been implicated in T cell proliferation and cytokine production, especially production of IFN-gamma. To elucidate T cell control mediated by the 4-1BB signaling pathway in this syndrome, we assessed the effect of administering agonistic anti-4-1BB mAb on mercury-induced autoimmunity. Groups of A.SW mice (H-2s) received mercury/control Ig or mercury/anti-4-1BB or PBS alone. Anti-4-1BB mAb treatment resulted in a dramatic reduction of mercury-induced antinucleolar Ab titers, serum IgG1/IgE induction, and renal Ig deposition. These effects may be related to the present finding that anti-4-1BB mAb decreases B cell numbers and function. The anti-4-1BB mAb-treated mercury group also showed a marked reduction in Th2-type cytokines but an increase in Th1-type cytokines and chemokines. Increased IFN-gamma production due to anti-4-1BB mAb treatment appears to be responsible for the observed B cell defects because neutralization of IFN-gamma in vivo substantially restored B cell numbers and partly restored IgG1/IgE. Collectively, our results indicate that 4-1BB mAb can down-regulate mercury-induced autoimmunity by affecting B cell function in an IFN-gamma-dependent manner and thus, preventing the development of autoantibody production and tissue Ig deposition.</P>
Durability of fluoropolymer and antibacterial finishes on woven surgical gown fabrics
Vinay Kumar Midha,Ravikant Vashisht,Varsha Midha 한국의류학회 2014 Fashion and Textiles Vol.1 No.1
Commercially available polyester, polyester-cotton and cotton plain woven fabrics of 150 g/m2 weight and cotton woven fabric samples of 200 g/m2 weight with plain, twill and satin weave were studied for their suitability as surgical gowns. Water repellent and anti bacterial finishes were applied in single bath using pad-dry-cure method with four concentration levels of these finishes. Liquid barrier properties of samples were analyzed by water impact penetration and hydrostatic pressure test. Parallel streak method was used to measure the antibacterial activity on the fabric samples with Staphylococcus aureus. The fabric samples were also analyzed for air permeability and stiffness. Optimum concentration level of fluoropolymer and antibacterial finishes for achieving desired liquid barrier and antibacterial properties were determined for each fabric samples. Fabric samples were subjected to repeated laundering cycles to evaluate the durability of finishes. It was observed that polyester fabric samples and 200 g/m2 cotton twill woven fabrics show highest level of liquid barrier protection of Level 2 according to Association for the Advancement of Medical Instrumentation (AAMI) standards, with 4% and 7% fluoropolymers. The fabrics maintain their barrier protection upto 20 laundering cycles, whereas 100% cotton fabric samples show minimal liquid barrier protection and do not provide Level 2 protection even at 4% and 7% fluoropolymer.
The tumour necrosis factor/TNF receptor superfamily: therapeutic targets in autoimmune diseases
Vinay, D. S.,Kwon, B. S. Blackwell Publishing Ltd 2011 Clinical and experimental immunology Vol.164 No.2
<P><B>Summary</B></P><P>Autoimmune diseases are characterized by the body's ability to mount immune attacks on self. This results from recognition of self‐proteins and leads to organ damage due to increased production of pathogenic inflammatory molecules and autoantibodies. Over the years, several new potential therapeutic targets have been identified in autoimmune diseases, notable among which are members of the tumour necrosis factor (TNF) superfamily. Here, we review the evidence that certain key members of this superfamily can augment/suppress autoimmune diseases.</P>
Vinay Kumar Jadoun,Nikhil Gupta,Khaleequr Rehman Niazi,Anil Swarnkar 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.5
This paper presents an Enhanced Particle Swarm Optimization (EPSO) to solve short-term hydrothermal scheduling (STHS) problem with non-convex fuel cost function and a variety of operational constraints related to hydro and thermal units. The operators of the conventional PSO are dynamically controlled using exponential functions for better exploration and exploitation of the search space. The overall methodology efficiently regulates the velocity of particles during their flight and results in substantial improvement in the conventional PSO. The effectiveness of the proposed method has been tested for STHS of two standard test generating systems while considering several operational constraints like system power balance constraints, power generation limit constraints, reservoir storage volume limit constraints, water discharge rate limit constraints, water dynamic balance constraints, initial and end reservoir storage volume limit constraints, valve-point loading effect, etc. The application results show that the proposed EPSO method is capable to solve the hard combinatorial constraint optimization problems very efficiently.
Vinay Mahishale,Bhagyashri Patil,Mitchelle Lolly,Ajith Eti,Sujeer Khan 전남대학교 의과학연구소 2015 전남의대학술지 Vol.51 No.2
There is growing evidence that tobacco smoking is an important risk factor for tuberculosis(TB). India, with a population of 1.26 billion, has the highest number of bothTB patients and smokers. The convergence of these two important health hazards islikely severely affecting India’s TB control programs. This study was carried out to determinethe prevalence of smoking in newly diagnosed pulmonary TB patients and theimpact of smoking on disease outcomes in a tertiary care hospital. All patients newlydiagnosed with pulmonary TB as per the Revised National Tuberculosis Program ofIndia (RNTCP) 2013 criteria were enrolled in the study. On the basis of their self-reportedsmoking status, the participants were classified as never smokers, currentsmokers, and ex-smokers. Patients were started on anti-TB treatment and were followedfor 2 years. Among the 2350 subjects (1,758 males and 592 females), 1,593 patients(67.78%) were never smokers. Current and ex-smokers numbered 757 (32.21%),of which 751 (31.95%) were males and 6 (0.26%) were females. Smoking was associatedwith more extensive lung disease, lung cavitation, and positive sputum smear and cultureresults at baseline. In both current smokers and ex-smokers, sputum smears andcultures were significantly more likely to remain positive after 2 months of treatment. Ex-smokers and current smokers had significantly high rates of defaults, treatmentfailures, and relapses. The prevalence of smoking is very high in TB patients. Tobaccosmoking is associated with a considerably increased risk of advanced and more severedisease in the form of lung cavitations, positive sputum smear and culture results, andslower smear and culture conversion after initiation of treatment. Smoking has a greatnegative effect on treatment completion, cure rates, and relapse rates in patients withpulmonary TB.