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RISS 인기검색어
- 검색키워드
- 저자 : Vicente Pérez (검색결과 4 건)
- 무료
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Vicente Pla-Martí,Jose Martín-Arévalo,Rosa Martí-Fernández,David Moro-Valdezate,Stephanie García-Botello,Alejandro Espí-Macías,Miguel Mínguez-Pérez,Maria Dolores Ruiz-Carmona,Jose Vicente Roig-Vila 대한대장항문학회 2022 Annals of Coloproctolgy Vol.38 No.1
Purpose: This study was performed to evaluate the long-term evolution of continence and patient’s quality of life after surgical treatment for obstetric fecal incontinence. Methods: A prospective longitudinal study was conducted including consecutive patients who underwent sphincteroplasty for severe obstetric fecal incontinence. The first phase analyzed changes in continence and impact on quality of life. The second phase studied the long-term evolution reevaluating the same group of patients 6 years later. Degree of fecal incontinence was calculated using the Cleveland Clinic Score (CCS). Quality of life assessment was carried out with the Fecal Incontinence Quality of Life scale. Results: Thirty-five patients with median age of 55 years (range, 28 to 73 years) completed the study. Phase 1 results: after a postoperative follow-up of 30 months (4 to 132 months), CCS had improved significantly from a preoperative of 15.7±3.1 to 6.1±5.0 (P<0.001). Phase 2 results: median follow-up in phase 2 was 110 months (76 to 204 months). The CCS lowered to 8.4±4.9 (P=0.04). There were no significant differences between phases 1 and 2 in terms of quality of life; lifestyle (3.47± 0.75 vs. 3.16±1.04), coping/behavior (3.13±0.83 vs. 2.80±1.09), depression/self-perception (3.65±0.80 vs. 3.32± 0.98), and embarrassment (3.32±0.90 vs. 3.12±1.00). Conclusion: Sphincteroplasty offers good short-medium term outcomes in continence and quality of life for obstetric fecal incontinence treatment. Functional clinical results deteriorate over time but did not impact on patients’ quality of life.
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Anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human uterus
Victor Manuel Muñoz-Pérez,Mario I. Ortiz,Héctor A. Ponce-Monter,Vicente Monter-Pérez,Guillermo Barragán-Ramírez 대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.4
The aim of this study was to evaluate the in vitro anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human myometrium. Samples from the pregnant human myometrium were used in functional tests to evaluate the inhibitory effect of α-bisabolol (560, 860, 1,200 and 1,860 µM) on spontaneous myometrial contractions. The intracellular cyclic adenosine monophosphate (cAMP) levels generated in response to α-bisabolol in human myometrial homogenates were measured by ELISA. The anti-inflammatory effect of α-bisabolol was determined through the measurement of two pro-inflammatory cytokines, tumor necrosis factor-α (TNFα) and interleukin (IL)-1β, and the anti-inflammatory cytokine IL-10, in pregnant human myometrial explants stimulated with lipopolysaccharide (LPS). Forskolin was used as a positive control to evaluate the cAMP and cytokine levels. α-Bisabolol was found to induce a significant inhibition of spontaneous myometrial contractions at the highest concentration level (p<0.05). α-Bisabolol caused a concentration-dependent decrease in myometrial cAMP levels (p<0.05) and a concentration-dependent decrease in LPS-induced TNFα and IL-1β production, while IL-10 production did not increase significantly (p>0.05). The anti-inflammatory and utero-relaxant effects induced by α-bisabolol were not associated with an increase in cAMP levels in pregnant human myometrial samples. These properties place α-bisabolol as a potentially safe and effective adjuvant agent in cases of preterm birth, an area of pharmacological treatment that requires urgent improvement.
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Potential strategies for prevention of tumor spillage in minimally invasive radical hysterectomy
Vicente Bebia,Sonia Monreal-Clua,Assumpció Pérez-Benavente,Silvia Franco-Camps,Berta Díaz-Feijoo,Antonio Gil-Moreno 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.5
Objective: The publication of a prospective [1] and several retrospective [2,3] studiesdescribing a worse prognosis in patients affected with early-stage cervical cancer whounderwent a minimally invasive radical hysterectomy has raised a high concern in whatmeasures should be undertaken in order to revert these results. Potential strategies [4] toprevent tumor spillage have been previously proposed. Methods: In this video, we describe nine strategies that should be addressed in future trialsregarding this procedure. Results: These strategies are:1. Fallopian tubes should be coagulated prior to start the surgery. 2. All sentinel lymph nodes and lymphadenectomy specimens should be obtained withoutlymph nodes fragmentation. 3. All surgical specimens should be extracted within a containment bag. 4. Uterine manipulators must never be used. 5. Prior to vaginal section, a closed knotted ligature should be placed around the vagina,proximal to the section line, and the remaining vaginal cavity profusely washed. 6. Once the vagina is opened, the surgical specimen should be extracted vaginally within aspecimen retrieval bag. 7. After surgery, the pelvic cavity is profusely washed with physiological serum, and the vaginashould be washed with iodopovidone diluted to 10% [5]. 8. Port-site metastasis prevention measures should be performed. 9. Every action made to prevent tumor spillage should be recorded in the surgical report. Conclusion: As there is a biological rationale in these measures that would prevent tumorspillage and seeding, there is a need of prospectively exploring them within appropriatestudies in order to determine their own oncological outcome.
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Gonzalo Gurrea,Vicente Blanca-Giménez,Vicente Pérez,María-Antonia Serrano,Juan-Carlos Moreno,Solar Radiation Group of the Universitat Politècnica de València 한국기상학회 2018 Asia-Pacific Journal of Atmospheric Sciences Vol.54 No.4
The goal of this study was to statistically analyse the variability of global irradiance and ultraviolet erythemal (UVER) irradiance and their interrelationships with global and UVER irradiance, global clearness indices and ozone. A prediction of short-term UVER solar irradiance values was also obtained. Extreme values of UVER irradiance were included in the data set, as well as a time series of ultraviolet irradiance variability (UIV). The study period was from 2005 to 2014 and approximately 250,000 readings were taken at 5-min intervals. The effect of the clearness indices on global irradiance variability (GIV) and UIV was also recorded and bi-dimensional distributions were used to gather information on the two measured variables. With regard to daily GIVand UIV, it is also shown that for global clearness index (kt) values lower than 0.6 both global and UVER irradiance had greater variability and that UIVon cloud-free days (kt higher than 0.65) exceeds GIV. To study the dependence between UIVand GIV the χ2 statistical method was used. It can be concluded that there is a 95% probability of a clear dependency between the variabilities.A connection between high kt (corresponding to cloudless days) and low variabilities was found in the analysis of bidimensional distributions. Extreme values of UVER irradiance were also analyzed and it was possible to calculate the probable future values of UVER irradiance by extrapolating the values of the adjustment curve obtained from the Gumbel distribution.
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