http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Nguyen, Van Du,Zheng, Shaohui,Han, Jiwon,Le, Viet Ha,Park, Jong-Oh,Park, Sukho Elsevier 2017 Colloids and Surfaces B Vol.154 No.-
<P><B>Abstract</B></P> <P>The aim of this work is to prepare and evaluate a novel lipid-polymer hybrid liposomal nanoplatform (hyaluronic acid-magnetic nanoparticle-liposomes, HA-MNP-LPs) as a vehicle for targeted delivery and triggered release of an anticancer drug (docetaxel, DTX) in human breast cancer cells. We first synthesize an amphiphilic hyaluronic acid hexadecylamine polymer (HA-C<SUB>16</SUB>) to enhance the targeting ability of the hybrid liposome. Next, HA-MNP-LPs are constructed to achieve an average size of 189.93±2.74nm in diameter. In addition, citric acid-coated magnetic nanoparticles (MNPs) are prepared and embedded in the aqueous cores while DTX is encapsulated in the hydrophobic bilayers of the liposomes. Experiments with coumarin 6 loaded hybrid liposomes (C6/HA-MNP-LPs) show that the hybrid liposomes have superior cellular uptake in comparison with the conventional non-targeting liposomes (C6/MNP-LPs), and the result is further confirmed by Prussian blue staining. Under near-infrared laser irradiation (NIR, 808nm), the HA-MNP-LPs aqueous solution can reach 46.7°C in 10min, and the hybrid liposomes released over 20% more drug than the non-irradiated liposomes. Using a combination of photothermal irradiation and chemotherapy, the DTX-loaded hybrid liposomes (DTX/HA-MNP-LPs) significantly enhance therapeutic efficacy, with the IC<SUB>50</SUB> value of 0.69±0.10μg/mL, which is much lower than the values for DTX monotherapy. Consequently, the prepared hybrid nanoplatform may offer a promising drug delivery vehicle with selective targeting and enhanced drug release in treating CD44-overexpressing cancers.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel polymer-lipid nanohybrid liposomes for active tumor targeting are synthesized. </LI> <LI> Magnetic nanoparticles and drug are encapsulated for photothermal-chemotherapy. </LI> <LI> Nanohybrid liposomes significantly enhance cellular uptake to breast cancer cells. </LI> <LI> Near-infrared light can trigger drug release from the nanohybrid liposomes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Determinants Influencing Housing-Option Decision of Gen Y: The Case of Vietnam
Ha Thu LUONG(Ha Thu LUONG ),Dung Manh TRAN(Dung Manh TRAN ),Dan Linh Ngoc NGUYEN(Dan Linh Ngoc NGUYEN ),Van Bao NGUYEN(Van Bao NGUYEN ),Anh Thuc LE(Anh Thuc LE ),Hieu Van PHAM(Hieu Van PHAM ) 한국유통과학회 2023 유통과학연구 Vol.21 No.7
The Impact of Capital on Growth of Small and Medium Enterprises: Evidence from Vietnam
Van Dung HA,Van Tung NGUYEN,Truong Thanh Nhan DANG 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.1
Small and medium businesses (SMEs) play a critical role in the economy, yet they are plagued by a shortage of finance. Determining the influence of cash sources both inside and outside the firm is critical to the company’s survival and growth. As a result, the purpose of this research is to determine the impact of capital on the growth of SMEs in Vietnam. The key factors of this research are equity and liabilities, which are two proxies for a firm’s capital. The data is based on the results of a survey conducted every two years from 2005 to 2015, which included over 2,600 SMEs in 20 processing and manufacturing industries in ten provinces and cities, including Hanoi, Hai Phong, Ho Chi Minh City, Ha Tay, Phu Tho, Nghe An, Quang Nam, Khanh Hoa, Lam Dong, and Long An. The findings show that characteristics such as equity capital, total workforce growth rate, and male entrepreneurs have a positive impact on enterprise growth, whereas liabilities, firm age, and export have a negative impact on enterprise growth. The study has demonstrated that equity has a positive impact while liabilities have a negative impact on the growth of Vietnamese SMEs.
Ha, Van Thai,Beak, Heung Soo,Kim, Eunji,Baek, Kwang-Soo,Hossen, Muhammad Jahangir,Yang, Woo Seok,Kim, Yong,Kim, Jun Ho,Yang, Sungjae,Kim, Jeong-Hwan,Joo, Yung Hyup,Lee, Chang Seok,Choi, Joonho,Shin, H Hindawi Publishing Corporation 2014 MEDIATORS OF INFLAMMATION Vol.2014 No.-
<P>AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting as a suppressor of melanin synthesis and tyrosinase expression. Since macrophage-mediated inflammatory responses are critical for skin health, here we investigated the potential anti-inflammatory activity of AP736. The effects of AP736 on various inflammatory events such as nitric oxide (NO)/prostaglandin (PG) E<SUB>2</SUB> production, inflammatory gene expression, phagocytic uptake, and morphological changes were examined in RAW264.7 cells. AP736 was found to strongly inhibit the production of both NO and PGE<SUB>2</SUB> in lipopolysaccharide- (LPS-) treated RAW264.7 cells. In addition, AP736 strongly inhibited both LPS-induced morphological changes and FITC-dextran-induced phagocytic uptake. Furthermore, AP736 also downregulated the expression of multiple inflammatory genes, such as inducible NO synthase (iNOS), cyclooxygenase- (COX-) 2, and interleukin- (IL-) 1<I>β</I> in LPS-treated RAW264.7 cells. Transcription factor analysis, including upstream signalling events, revealed that both NF-<I>κ</I>B and AP-1 were targeted by AP736 via inhibition of the IKK/I<I>κ</I>B<I>α</I> and IRAK1/TAK1 pathways. Therefore, our results strongly suggest that AP736 is a potential anti-inflammatory drug due to its suppression of NF-<I>κ</I>B-IKK/I<I>κ</I>B<I>α</I> and AP-1-IRAK1/TAK1 signalling, which may make AP736 useful for the treatment of macrophage-mediated skin inflammation.</P>
Molecular Characterization of Hypernodulation in Soybean
Van, Kyu-Jung,Ha, Bo-Keun,Hwang, Eun-Young,Kim, Moon-Young,Heu, Sung-Gi,Lee, Suk-Ha The Korean Society of Plant Pathology 2003 Plant Pathology Journal Vol.19 No.1
SS2-2, a hypernodulating soybean mutant was isolated by EMS mutagenesis from Sinpaldalkong 2. This auto-regulation mutant showed greater number of nodules and smaller plant size than its wild type Sinpaldalkong 2. SSR markers were used to identify DNA variation at SSR loci from different soybean LG. The only SSR marker that detected a length polymorphism between SS2-2 and its wild type ancestor was Satt294 on LG C1 instead of LG H, locating a hypernodulating gene. Sequencing data of flanking Satt294 indicated that the size variation was due to extra stretch of TTA repeats of the SSR motif in SS2-2, along with $A\longrightarrow$G transversion. In spite of phenotypic differences between the wild type and its hypernodulating mutants, genomic DNA poly-morphisms at microsatellite loci could not control regulation of nodule formation. The cDNA-AFLP method was applied to compare differential display of cDNA between Sinpaldalkong 2 and SS2-2. After isolation and sequence comparison with many AELP fragments, several interesting genes were identified. Northern blot analysis, immunolocalization and/or the yeast two-hybrid system with these genes might provide information on regulation of nodule development in SS2-2.
Nano-porous Silicon Microcavity Sensors for Determination of Organic Fuel Mixtures
Van Hoi Pham,Huy Bui,Le Ha Hoang,Thuy Van Nguyen,The Anh Nguyen,Thanh Son Pham,Quang Minh Ngo 한국광학회 2013 Current Optics and Photonics Vol.17 No.5
We present the preparation and characteristics of liquid-phase sensors based on nano-porous silicon multilayer structures for determination of organic content in gasoline. The principle of the sensor is a determination of the cavity-resonant wavelength shift caused by refractive index change of the nano-porous silicon multilayer cavity due to the interaction with liquids. We use the transfer matrix method (TMM)for the design and prediction of characteristics of microcavity sensors based on nano-porous silicon multilayer structures. The preparation process of the nano-porous silicon microcavity is based on electrochemical etching of single-crystal silicon substrates, which can exactly control the porosity and thickness of the porous silicon layers. The basic characteristics of sensors obtained by experimental measurements of the different liquids with known refractive indices are in good agreement with simulation calculations. The reversibility of liquid-phase sensors is confirmed by fast complete evaporation of organic solvents using a low vacuum pump. The nano-porous silicon microcavity sensors can be used to determine different kinds of organic fuel mixtures such as bio-fuel (E5), A92 added ethanol and methanol of different concentrations up to 15%.
Ha Huu Do,Ha Huu Do,Wenwu Guo,Mahider Tekalne,Quyet Van Le,Thang Phan Nguyen,Jin Hyuk Cho,Sang Hyun Ahn,Soo Young Kim 대한금속·재료학회 2022 ELECTRONIC MATERIALS LETTERS Vol.18 No.1
Reversible metal electrodeposition (RME) windows are a promising material for electrochromic windows and electronic display applications. However, the lifetime of RME devices is a major drawback in the preparation of commercial and practical devices. In this study, we propose a new strategy to prolong the stability and improve the efficiency of RME devices. By using tungsten oxide, a well-known electrochromic material, to modify the surface of a transparent conductive electrode, superior, stable, and highly effective devices were prepared successfully. By applying a low potential of − 0.8 V to 0.5 V, the RME device can quickly switch between a bleached state and colored state with different colors changing from transparent to black and deep blue. The performance improvement of the RME device can be explained by the simultaneous reduction of tungsten oxide and metal ion deposition in the conductive substrate under an applied potential. Furthermore, the lifetime of the device increased significantly (over 1500 cycles) owing to the shielding role of tungsten oxide film in the acid medium, which is an indispensable component of reversible electrochromic devices.
HA, Van Dung Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.2
This study focuses on determining the impacts of organizational culture on the accounting information system and the operational performance of small and medium-sized enterprises in Ho Chi Minh City. The paper is organized in five parts: introduction, literature review, research methodology, research results, and conclusion and policy implications. Based on the samples of 353 respondents working in small and mediumsized enterprises in Ho Chi Minh City, the research employs both qualitative and quantitative methods to find the answers for research questions. Group discussion, which yields final observed variables of the factors of organizational culture is used for qualitative method. Statistics, assessment of the reliability of Cronbach's Alpha scale, exploratory factor analysis (EFA), confirmatory factor analysis (CFA) and structural equation modeling (SEM) are used for quantitative procedure. The results show that mission, involvement and inconsistency in organizational culture positively affect the accounting information system of small and medium-sized firms in Vietnam. In addition, mission, involvement, adaptability and consistency in organizational culture are found to have positive impacts on the firm operational performance. Another finding of the study is that the accounting information system has a positive effect on operational performance of small and medium-sized firms in Vietnam.
An Alternative Strategy for Catch-Up Economy in Vietnam, A Lesson for Developing Countries
Van Ha NGUYEN 인하대학교 산업경제연구소 2010 경상논집 Vol.24 No.1
This paper describes catching-up models of earlier late-comers such as Japan, Korea, and China. From that, it discusses the role of FDI (foreign direct investment) and other supporting industries in the growth of the current economy in Vietnam. These elements can help Vietnam to access the latest technology, and innovation as well as to improve the highly skilled labor, which are the central factors to the catching-up process. Finally, the paper proposes an alternative model of the catching-up process for Vietnam, which will take into account the key features of the current environment.