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Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis
( Hiromichi Shimizu ),( Toshimitsu Fujii ),( Shuji Hibiya ),( Maiko Motobayashi ),( Kohei Suzuki ),( Kento Takenaka ),( Eiko Saito ),( Masakazu Nagahori ),( Kazuo Ohtsuka ),( Mamoru Watanabe ) 대한장연구학회 2021 Intestinal Research Vol.19 No.1
Jay Kant Raut,Akira Suzuki,Toshimitsu Fukiharu,Kiminori Shimizu,Chihiro Tanaka,Shogo Takeshige 한국버섯학회 2010 한국버섯학회지 Vol.8 No.4
Addition of ammonia or any nitrogenous materials to the soil that release ammonia causing alkaline condition during decomposition stimulates the fruiting of a particular chemoecological group of fungi, called ammonia fungi (Sagara 1975). The study of ammonia fungi by artificial application of urea in forest soil has been done in diverse geographical regions such as in Japan, Taiwan, New Zealand, Western Australia, and UK. Up to date about 70 species of ammonia fungi have been recorded in those regions. However, ammonia fungi in the boreal forest of American continent have not yet been investigated. Thus, we collected the soils of A0 and the upper layer of HA horizons in plant pots from aspen forest near Edmonton, Canada. Thereafter, we applied urea (granular fertilizer; 46% nitrogen, 10 mg/g dry soil) in plant pots and incubated at 25˚C under 12 hours dark and light regime. After 40 days of incubation, several basidiomata of Coprinopsis species appeared. Among them one specimen was identified as C. rugosobispora based on macro- and microscopic features. Morphologically this species was very similar to C. phlyctidospora which was characterized by warty, ovoid basidiospores, and diverticulate veil elements. C. phlyctidospora has 4-spored basidia while C. rugosobispora had only 2-spored. In the beginning, it was thought probably it was only a 2-spored form of C. phlyctidospora. The basidiospore of C. rugosobispora (9.8-11.7×8.3-9.6㎛) was distinctly larger than that of C. phlyctidospora (8.4-10.6×6.0-7.6 ㎛). It was therefore separated from the C. phlyctidospora. Furthermore in this study we investigated its phylogenetic relationship based on the nuclear rDNA sequence in ITS regions and mating reactions among its close allies and further confirmed it as a distinct species. This is the first record of C. rugosobispora from American continent since it has been collected only from Europe (Belgium and Netherlands). Although urea effectively stimulated its occurrence but it has not yet been reported any other urea application studies so far. This indicates it is a new record in ammonia fungi as well.
Cao Vu Dung,Eiichi Sasaki,Keiji Tajima,Toshimitsu Suzuki 한국강구조학회 2015 International Journal of Steel Structures Vol.15 No.2
A common practice for the manufacture of orthotropic steel decks in Japan is to use 75% partial joint penetration welds between closed ribs and deck plates. To evaluate the effectiveness of the proposed 100% penetration on improving the fatigue strength of rib-to-deck welded joints in orthotropic steel bridge decks, four full-scale orthotropic deck specimens were subjected to laboratory testing. Specimens, consisting of a 12-mm-thick deck plate and 6-mm-thick rib, with one closed rib, were fabricated with 75% and 100% penetration. Fatigue test results showed that fatigue cracks initiated from the weld toe inside the rib in the 100% penetration specimens, but from weld root inside the rib in the 75% penetration specimens. To investigate this fatigue behavior, strain measurements were taken at 5 mm from the rib-to-deck weld line. Results of finite element analysis using the effective notch stress method indicate that a deeper partial penetration results in a slightly higher effective notch stress at the weld root of the partial penetration weld. The effective notch stress at the crack initiation location with 100% penetration is lower than that obtained with partial penetration. The open angle appears to have a significant effect on the effective notch stress at the upper weld toe when using 100% penetration. Therefore, the proposed 100% penetration appeared to have a positive effect on enhancing the fatigue resistance of rib-to-deck welded joints.
Effect of post weld treatment on cracking behaviors of beam-column connections in steel bridge piers
Liang-Jiu Jia,Hanbin Ge,Toshimitsu Suzuki 국제구조공학회 2014 Steel and Composite Structures, An International J Vol.17 No.5
A great number of moment-resisting steel structures collapsed due to ductile crack initiation at welded beam-column connections, followed by explosive brittle fracture in the Kobe (Hyogoken-Nanbu) earthquake in 1995. A series of experimental and numerical studies on cracking behaviors of beam-column connections in steel bridge piers were carried out by the authors’ team. This paper aims to study the effect of post weld treatment on cracking behaviors of the connections during a strong earthquake event. Experiments of three specimens with different weld finishes, i.e., as-welded, R-finish, and burr grinding, were conducted. The experimental results indicate that the instants of ductile crack initiation are greatly delayed for the specimens with R-finish and burr grinding finishes compared with the as-welded one. The strain concentration effect in the connection is also greatly reduced in the specimens with post weld treatment compared with the as-welded one, which was also verified in the tests.
Hanbin Ge,Liang-Jiu Jia,Lan Kang,Toshimitsu Suzuki 국제구조공학회 2014 Steel and Composite Structures, An International J Vol.17 No.6
Full penetration welded steel moment-resisting frame (SMRF) structures with welded box sections are widely employed in steel bridges, where a large number of steel bridges have been in operation for over fifty years in Japan. Welding defects such as incomplete penetration at the beam-column connections of these existing SMRF steel bridge piers were observed during inspection. Previous experiments conducted by the authors' team indicate that gusset stiffeners (termed fillets in this study) at the beam-web-to-column-web joint of the beam-column connections may play an important role on the seismic performance of the connections. This paper aims to experimentally study the effect of the fillet radius on seismic performance of the connections with large welding defects. Four specimens with different sizes of fillet radii were loaded under quasi-static incremental cyclic loading, where different load-displacement relations and cracking behaviors were observed. The experimental results show that, as the size of the fillet radius increases, the seismic performance of the connections can be greatly improved.
( Taku Kobayashi ),( Tadakazu Hisamatsu ),( Yasuo Suzuki ),( Haruhiko Ogata ),( Akira Andoh ),( Toshimitsu Araki ),( Ryota Hokari ),( Hideki Iijima ),( Hiroki Ikeuchi ),( Yoh Ishiguro ),( Shingo Kato 대한장연구학회 2018 Intestinal Research Vol.16 No.2
Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disease of the gastrointestinal tract, with increasing prevalence worldwide. IBD Ahead is an international educational program that aims to explore questions commonly raised by clinicians about various areas of IBD care and to consolidate available published evidence and expert opinion into a consensus for the optimization of IBD management. Given differences in the epidemiology, clinical and genetic characteristics, management, and prognosis of IBD between patients in Japan and the rest of the world, this statement was formulated as the result of literature reviews and discussions among Japanese experts as part of the IBD Ahead program to consolidate statements of factors for disease prognosis in IBD. Evidence levels were assigned to summary statements in the following categories: disease progression in CD and UC; surgery, hospitalization, intestinal failure, and permanent stoma in CD; acute severe UC; colectomy in UC; and colorectal carcinoma and dysplasia in IBD. The goal is that this statement can aid in the optimization of the treatment strategy for Japanese patients with IBD and help identify high-risk patients that require early intervention, to provide a better long-term prognosis in these patients. (Intest Res 2018;16:168-177)