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Nobuhisa Kanahara(Nobuhisa Kanahara ),Hiroshi Kimura(Hiroshi Kimura ),Toshihiko Kinoshita(Toshihiko Kinoshita ),Masaomi Iyo(Masaomi Iyo ),Yoshiteru Takekita(Yoshiteru Takekita ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Dopamine supersensitivity psychosis (DSP) is an unstable clinical condition observed in individuals with schizophrenia who have been treated with an antipsychotic medication at a high dosage and/or for a long period. An up-regulation of dopamine D2 receptors (DRD2) is thought to be involved in the essential pathology of DSP. An antipsychotic agent with both tight binding to DRD2 and a long half-life is generally effective for treating DSP, but a patient who meets the criteria of treatment-resistant schizophrenia sometimes needs treatment with clozapine. We report the case details of two patients whose DSP was not controlled with several antipsychotics but was successfully controlled with asenapine. Asenapine binds to a broad range of dopamine receptors and serotonin receptors, and it is thus distinct from other atypical antipsychotics. The unique profile of asenapine may contribute to the control of severe DSP symptoms in individuals with schizophrenia.
( In-hee Hwang ),( Ryo Kinoshita ),( Takayuki Matsuo ),( Ryoji Sameshima ),( Toshihiko Matsuto ) 한국폐기물자원순환학회(구 한국폐기물학회) 2015 한국폐기물자원순환학회 3RINCs초록집 Vol.2015 No.-
The effects of temperature, water vapor content, and Ca(OH)<sub>2</sub> addition amount on HCl removal rate as well as form of final product were investigated by lab-scale experiments. Moreover, the composition of calcium compound in fly ashes obtained from operating municipal solid waste incinerators (MSWIs) was examined. As the results, CaOHCl was found as a main product of the reaction between Ca(OH)<sub>2</sub> and HCl. Water vapor improved the removal rate of HCl at low temperature less than 150℃, which did not lead to CaCl<sub>2</sub> generation. From the analysis of fly ashes obtained from MSWIs, it suggested that excessive Ca(OH)<sub>2</sub> may result in CaOHCl formation rather than CaCl<sub>2</sub>.
Evaluation methodology on flowability of on-site produced slaked lime
( Kyohei Gonda ),( In-hee Hwang ),( Toshihiko Matsuto ),( Takayuki Matsuo ),( Yasumasa Tojo ),( Ryo Kinoshita ) 한국폐기물자원순환학회(구 한국폐기물학회) 2019 한국폐기물자원순환학회 심포지움 Vol.2019 No.1
Slaked lime is commonly used as alkali agent for dry scrubbing of hydrogen chloride and sulfur oxides in flue gas discharged from municipal solid waste incinerators (MSWIs). As the utilization amount of slake lime is the most among chemicals used in MSWI, its impact on the operating cost is significant. For this reason, the on-site production of slaked lime was attempted by using cheap quicklime and a simplified hydrator in MSWI. However, the discharge problem of fly ash occurred at the hopper of bag filter (BF) owing to the poor flow property of on-site produced slaked lime when it was tested in the demonstration facility. In this study, we developed lab-scale of flowability tests to evaluate the flow property of produced slaked lime as well as to find the optimum condition of on-site production. First, three kinds of flowability tests were examined to understand the behavior of slaked lime in hopper. Procedure and details of each test method were determined using reference samples: one is commercial slaked lime (MS) which did not occur bridging problems in the demonstration test. The other is on-site produced slaked lime (TR) which occurred bridging problem in the same test. Details of each test were determined as follows: 1) slide test at slope: a specimen with a fixed volume (9 ㎠×6mm) was placed on SUS plate and the inclination of SUS plate was increased. The angle of slide, θ [°] that the specimen was falling from SUS plate was determined; 2) Stirring torque test: 2.5 kg of sample was filled in a stainless container. While the blades attached to the motor were stirred at 1 rpm, the resistance generated was measured as torque, T [Nㆍm]; 3) orifice outflow test: a 400 g of sample in a SUS hopper was discharged through an orifice with diameter 24 to 60 mm. From the relationship between orifice diameter and outflow rate, OD<sub>50</sub> [mm] that 50% mass of slake lime was discharged (OD<sub>50</sub>) was determined. Various kinds of on-site produced slaked limes were prepared to understand the relationship between flowability and production conditions. Molar ratio of distilled water to quicklime (WR), residence time in hydrator, stirring rate, addition of chemical, pulverization strength, etc. were tested as production conditions. Fig. 1 shows that the angle of slide increases as the moisture content of on-site slaked lime increases. As the fraction of particle size less than 5μm increases, both torque and OD<sub>50</sub> increase (Figs. 2 and 3). It was found that the flow property of slaked lime could be improved by reducing the moisture content and the fraction of particle size less than 5μm.
Atsushi Tsutsumi,Tetsufumi Kanazawa,Hiroki Kikuyama,Gaku Okugawa,Hiroyuki Uenishi,Toshio Miyamoto,Naoki Matsumoto,Jun Koh,Kazuhiro Shinosaki,Toshifumi Kishimoto,Hiroshi Yoneda,Toshihiko Kinoshita 대한신경정신의학회 2009 PSYCHIATRY INVESTIGATION Vol.6 No.3
We investigated the possible association between genetic polymorphisms in the dopamine receptor and serotonin transporter genes and the responses of schizophrenic patients treated with either risperidone or perospirone. The subjects comprised 27 patients with schizophrenia who were clinically evaluated both before and after treatment. The genotyping of the polymorphisms of the dopamine D2 receptor gene (DRD2) (rs1801028 and rs6277), the dopamine D4 receptor gene (DRD4) (120-bp tandem repeats and rs1800955), and serotonin transporter gene (5HTT)(variable number of tandem repeats; VNTR) were performed using the real-time polymerase chain reaction and sequencing. In DRD2 and 5HTT-VNTR, there were no significant correlations between clinical response and polymorphism in the case of risperidone, and for perospirone treatment it was impossible to analyze the clinical evaluation due to the absence of genotype information. On the other hand, in DRD4 there were significant correlations in the two-factor interaction effect on the Positive and Negative Syndrome Scale (PANSS) between the two drugs [120-bp tandem repeat, p=0.003; rs1800955, p=0.043]. Although the small sample represents a serious limitation, these results suggest that variants in DRD4 are a predictor of whether treatment will be more effective with risperidone or with perospirone in individual patients. We investigated the possible association between genetic polymorphisms in the dopamine receptor and serotonin transporter genes and the responses of schizophrenic patients treated with either risperidone or perospirone. The subjects comprised 27 patients with schizophrenia who were clinically evaluated both before and after treatment. The genotyping of the polymorphisms of the dopamine D2 receptor gene (DRD2) (rs1801028 and rs6277), the dopamine D4 receptor gene (DRD4) (120-bp tandem repeats and rs1800955), and serotonin transporter gene (5HTT)(variable number of tandem repeats; VNTR) were performed using the real-time polymerase chain reaction and sequencing. In DRD2 and 5HTT-VNTR, there were no significant correlations between clinical response and polymorphism in the case of risperidone, and for perospirone treatment it was impossible to analyze the clinical evaluation due to the absence of genotype information. On the other hand, in DRD4 there were significant correlations in the two-factor interaction effect on the Positive and Negative Syndrome Scale (PANSS) between the two drugs [120-bp tandem repeat, p=0.003; rs1800955, p=0.043]. Although the small sample represents a serious limitation, these results suggest that variants in DRD4 are a predictor of whether treatment will be more effective with risperidone or with perospirone in individual patients.