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The Effect of the Major Components of Fructus Cnidii on Osteoblasts In Vitro
Wenping Zhang,Dongming Ma,Qiduo Zhao,Torao Ishida 사단법인약침학회 2010 Journal of Acupuncture & Meridian Studies Vol.3 No.1
In traditional Chinese medicine, the cause of weak bones or bone loss is generally regarded as a result of kidney deficiency. Fructus Cnidii (FC), which is also known as She-Chuang-Zi, is a traditional herb that has been claimed to have kidney warming effects that invigorate Yang. In this study, we tried to determine the bone production-inducing effect of FC on osteoblastic cells in vitro using osthole, the main component of FC. Osteoblasts were isolated from neonatal Sprague-Dawley rat calvaria using the tissue piece culture method and treated with various concentrations of osthole ranging from 2.5 to 640 μg/mL, together with a blank control. Cell proliferation,alkaline phosphatase (ALP) activity, and bone nodules were measured. The cells were examined by hematoxylin-eosin staining, the Gomori Calcium-Cobalt method and immunofluorescent staining. The 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl tetrazolium bromide (or MTT) assay, ALP assay, and bone nodule results indicated significantly enhanced osteoblastic proliferation and differentiation at concentrations of osthole ranging from 40 to 320 μg/mL. Concentrations lower than 40 μg/mL seemed less effective, and cytotoxicity to osteoblasts was observed at concentrations higher than 320 μg/mL. These results indicate that osthole is effective at inducing osteoblastic bone formation through the up-regulation of ALP activity. FC is a Chinese herb used to treat lumbar pain in clinical practice. Further studies concerning the effects and mechanism of osthole on osteoporotic patients and animals should be performed, as these studies may lead to the development of a drug treatment for osteoporosis in the future.
Effects of Manual Acupuncture at GB34 on Carbon tetrachloride-induced Acute Liver Injury in Rats
Nobuyuki Tanahashi,Juri Shikami,Misao Yoneda,Torao Ishida 사단법인약침학회 2011 Journal of Acupuncture & Meridian Studies Vol.4 No.4
Manual acupuncture at Yanglingquan (GB34) is reported to have a beneficial effect on chronic liver damage. We, therefore, studied the effect of manual acupuncture at GB34 on acute liver damage. Rats were administered carbon tetrachloride (CCl₄) or olive oil, and direct manual acupuncture was subsequently performed at GB34 or at a sham point (a nonacupoint). In rats administered with CCl₄, the serum levels of aspartate aminotransferase and alanine aminotransferase, the total cholesterol concentration, and the levels of hepatic thiobarbituric-acid-reactive substances were suppressed by acupuncture at GB34 when compared with acupuncture at the sham point. By contrast, there was little histological difference in the liver between acupuncture at GB34 and that at the sham point in rats administered with CCl₄. These results suggest that manual acupuncture at GB34 tends to improve acute liver damage but is not sufficient by itself to completely resolve the hepatic injury.
Ken Takagi,Nobuyuki Tanahashi,Nozomi Amagasu,Kaito Mizuno,Jun Kawanokuchi,Guo Yi,Torao Ishida 사단법인약침학회 2017 Journal of Acupuncture & Meridian Studies Vol.10 No.1
A previous study on rats showed that simultaneous acupuncture stimulation at the “Bai-Hui” (GV 20) and the “Yintáng” (Ex-HN3) acupoints alleviated the state of depression to an extent similar to that achieved by pharmacotherapy. This study investigated whether the alleviation of the depressed state required simultaneous acupuncture at these two acupuncture points. For the purposes of testing the effect of acupuncture on depressive symptoms, we treated a depression model rat, where depression had been induced by using a mild water-immersion stress technique, with either acupuncture stimulation at only one acupuncture point (GV 20 or Ex-HN3) or an antidepressant, and we measured the immobile time for evaluating the state of depression. Anxiety, as a symptom commonly associated with depression, was also evaluated by measuring the number of head dips. Neither the immobile time nor the number of head dips decreased upon acupuncture stimulation. From this study, single acupuncture stimulation at either “GV 20” or “Ex-HN3” alleviated neither the state of depression nor the anxiety. The water-immersion stress used to make the depression model rats was shown not to induce anxiety; however, the stress induced by immobilizing the rats for acupuncture stimulation did lead to anxiety.
A Pilot Study Exploring the Effects of Reflexology on Cold Intolerance
Wenping Zhang,Shougo Takahashi,Takashi Miki,Hisayo Fujieda,Torao Ishida 사단법인약침학회 2010 Journal of Acupuncture & Meridian Studies Vol.3 No.1
Cold intolerance is an inability to tolerate cold temperatures and is accompanied by symptoms including headache, shoulder discomfort, dizziness and palpitations. The current study was performed to examine whether reflexology therapy affected cold intolerance in human subjects and whether the treatment was systemically effective. Ten female volunteer examinees with subjective feelings of cold were examined. After a 5-minute foot bath, 10 minutes of reflexology therapy was performed on their left foot. Skin temperature and blood flow were estimated before and after treatment, together with an interview concerning their feelings of cold and daily habits. In addition, how the recovery rate was affected by the application of a chilled-water load was also estimated. Along with significant increases in skin temperature and blood flow compared with pre-treatment at the bilateral points of KI-1, LR-3, and BL-60, a faster recovery after the application of the chilled-water load was also seen in the lower limbs on both sides. From these results, we conclude that reflexology has systemic effects and is an alternative method for treating cold intolerance.
Damage of radioprotection and antitumor effects of water-soluble propolis
Terai, Kaoru,Ryu, Myung-Sun,Itokawa, Yuka,Maenaka, Toshihiro,Nakamura, Takashi,Hasegawa, Takeo,Choi, In-Suk,Ishida, Torao,Gu, Yeun-Hwa Kyung Hee Oriental Medicine Research Center 2006 Oriental pharmacy and experimental medicine Vol.6 No.1
Some natural products are able to inhibit radiation effects and exert an antitumor effect with fewer adverse reactions; however, their antitumor effects are less than those of widely-used synthetic drugs. Propolis is a natural material that has been attracting attention, and we extracted this material with water and investigated the effect of continuous propolis administration on radioactivity-induced reduction of hemocytes, in addition to the antioxidant and antitumor effects of propolis. Following a 1-week adjustment period, water-soluble propolis was administered intraperitoneally to male ICR mice at a dose of 100 mg/kg every other day for 2 weeks. Following administration, 2 Gy whole-body irradiation was performed and the counts of leukocytes, lymphocytes, and granulocytes and monocytes in the peripheral blood were determined 1, 3, 7, 15 and 30 days after irradiation. These cells were considered since they are closely associated with immunity to radioactivity. In a second experiment, water-soluble propolis was similarly administered to the mice for 2 weeks after a 1-week adjustment period, and 2 Gy whole-body irradiation was performed. The antioxidant effects in hemocytes were then investigated using 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH), a radical generator. In a third experiment, $1\;{\times}\;10^6$ Sarcoma-180 cells were inoculated into the right thigh of mice, which were divided into four groups: control, water-soluble propolis-treated, 6 Gy irradiated and water-soluble propolis-treated + 6 Gy irradiated groups, and changes in tumor size were measured for 20 days. Statistical analysis was conducted using ANOVA for multiple groups. In the three experiments, administration of water-soluble propolis inhibited the reduction of hemocytes caused by whole-body irradiation, showed antioxidant effects against radioactivity, and inhibited tumor growth, respectively. In conclusion, our data suggest that the antioxidant effect of watersoluble propolis inhibits hemocyte reduction caused by whole-body irradiation and enhances immunological inhibition of tumor growth.
Rheumatoidal effects of Uncaria Tomentosa and Maytenus by a prolonged application
Yeunhwa Gu,Yuka Itokawa,Toshihiro Maenaka,Takenori Yamashita,Masayuki Tajima,Kaoru Tano,Hiroyo Kondo,Insuk Choi,Torao Ishida,Takashi Nakamura,Yuichi Ukawa,Kaoru Terai,Hajime Monzen,Masami Oshima,Tetsu 한의병리학회 2005 대한동의병리학회 학술대회논문집 Vol.2005 No.8
Anti-tumor Immunity and Radioprotection Effect by Fuscoporia oblique
Yeunhwa Gu,Yuka Itokawa,Toshihiro Maenaka,Takenori Yamashita,Kenichiro Tanaka,Koru Tano,Hiroyo Kondo,Insuk Choi,Torao Ishida,Takashi Nakamura,Kiyoto Saito,Kaoru Terai,Hajime Monzen,Masami Oshima,Tetsu 한의병리학회 2005 대한동의병리학회 학술대회논문집 Vol.2005 No.8
Anti-rheumatoidal effects of Uncaria Tomentosa and Maytenus by a prolonged application
Choi, In-Sook,Yamashita, Takenori,Nakamura, Takashi,Maenaka, Toshihiro,Hasegawa, Takeo,Itokawa, Yuka,Ishida, Torao,Rhee, Juong-Gile,Gu, Yeun-Hwa Kyung Hee Oriental Medicine Research Center 2005 Oriental pharmacy and experimental medicine Vol.5 No.4
Uncaria Tomentosa and Maytenus are known to have anti-inflammatory and anti-rheumatoidal effects after either a single application or application over a short-term period. We applied these natural products to Wister rats every day for two weeks and investigated the effects of this long-term application on inflammation. This was done by measuring footpad edema, which was induced by a locally injected carrageenan. There was a dramatic reduction in edema in both U. Tomentosa- and Maytenus-treated rats; furthermore, the reduction lasted as long as three days for rats treated with U. Tomentosa. When the Balb/C mice underwent similar treatment for one month, the level of IgM in the blood of U. Tomentosa-treated mice decreased while the level of IgG in Maytenus-treated mice increased. This suggests that the long lasting effects of U. Tomentosa may be related to a low level of IgM and the subclass switch from IgM to IgG. Since the anti-inflammatory effects of U. Tomentosa lasts for three days, it may prove useful in treating rheumatoid arthritis when applied for an extended period of time, especially since this product is known to have minimal side effects.
Antioxidant Activity and Anti-tumor Immunity by Propolis in Mice
Yeunhwa Gu,Yuka Itokawa,Toshihiro Maenaka,Takenori Yamashita,Norihide Mitsumoto,Kaoru Tano,Hiroyo Kondo,Insuk Choi,Torao Ishida,Takashi Nakamura,Kiyoto Saito,Kaoru Terai,Hajime Monzen,Masami Oshima,Te 한의병리학회 2005 대한동의병리학회 학술대회논문집 Vol.2005 No.8