YouTube: A good source for retrograde intrarenal surgery?

Senol Tonyali 대한비뇨의학회 2021 Investigative and Clinical Urology Vol.62 No.2

Purpose: To evaluate the quality of videos for retrograde intrarenal surgery (RIRS) on YouTube (Google, LLC) from the perspective of both patients and physicians. Materials and Methods: All videos longer than 2 minutes returned by the YouTube search engine in response to the keyword search “retrograde intrarenal surgery” were included in this study. The quality of content was analyzed by using the validated Journal of the American Medical Association Benchmark Score (JAMAS) and the Global Quality Score (GQS). Two surgeons developed the RIRS Scoring System (RIRSSS) to evaluate the technical quality of the videos. A video power index (VPI) was used to score the popularity of the videos. Results: A total of 63 videos with a median of 389 views were included in the present study. Forty-three videos (68.3%) were provided by health care professionals and 53 videos (84.1%) included technical aspects about RIRS. The median (interquartile range) GQS, JAMAS, RIRSSS, and VPI scores were 2 (1–3), 1 (1–2), 2 (1–5), and 0.41 (0.08–1.29), respectively. Videos with audio had significantly higher GQS and RIRSSS scores than did with videos with no audio (p<0.001, p=0.039, respectively). The GQS of videos providing general information about RIRS was higher, whereas RIRSSS scores were higher for videos detailing technical aspects (p=0.027, p=0.038, respectively). Conclusions: The quality of YouTube videos containing information about RIRS evaluated in this study was very low. It is necessary for health care organizations to prepare online materials and upload these materials to popular social media platforms to convey accurate information to patients.

Spatially variable effects on seismic response of the cable-stayed ‎bridges considering local soil site conditions

Zeliha Tonyali,Sevket Ates,Suleyman Adanur 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.70 No.2

In this study, stochastic responses of a cable-stayed bridge subjected to the spatially varying earthquake ground motion are investigated for variable local soil cases and wave velocities. Quincy Bay-view cable-stayed bridge built on the Mississippi River in Illinois, USA selected as a numerical example. The bridge is composed of two H-shaped concrete towers, double plane fan type cables and a composite concrete-steel girder deck. The spatial variability of the ground motion is considered with the coherency function, which is represented by the components of incoherence, wave-passage and site-response effects. The incoherence effect is investigated by considering Harichandran and Vanmarcke model, the site-response effect is outlined by using hard, medium and soft soil types, and the wave-passage effect is taken into account by using 1000, 600 and 200 m/s wave velocities for the hard, medium and soft soils, respectively. Mean of maximum response values obtained from the analyses are compared with those of the specific cases of the ground motion model. It is concluded that the obtained results from the bridge model increase as the differences between local soil conditions cases of the bridge supports change from firm to soft. Moreover, the variation of the wave velocity has important effects on the responses of the deck and towers as compared with those of the travelling constant wave velocity case. In addition, the variability of the ground motions should be considered in the analysis of long span cable-stayed bridges to obtain more accurate results in calculating the bridge responses.

Eff ectiveness of Soil–Structure Interaction and Dynamic Characteristics on Cable-Stayed Bridges Subjected to Multiple Support Excitation

Şevket Ateş,Zeliha Tonyali,Kurtuluş Soyluk,Adamou Marou Seyni Samberou 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.2

The purpose of the study is to determine the eff ects of multiple support excitations (MSE) and soil–structure interaction (SSI) on the dynamic characteristics of cable-stayed bridges founded on pile foundation groups. In the design of these structures, it is important to consider the eff ects of spatial variability of earthquake ground motions. To do this, the time histories of the ground motions are generated based on the spatially varying ground motion components of incoherence, wave-passage, and site-response. The eff ects of SSI on the response of a bridge subjected to the MSE are numerically illustrated using a three-dimensional model of Quincy Bayview cable-stayed bridge in the USA. The soil around the pile is linearly elastic, homogeneous isotropic half space represented by dynamic impedance functions based on the Winkler model of soil reaction. Structural responses obtained from the dynamic analysis of the bridge system show the importance of the SSI and the MSE eff ects on the dynamic responses of cable-stayed bridges.

Efficiency and Side Effects of Sorafenib Therapy for Advanced Hepatocellular Carcinoma: A Retrospective Study by the Anatolian Society of Medical Oncology

Berk, Veli,Kaplan, Mehmet Ali,Tonyali, Onder,Buyukberber, Suleyman,Balakan, Ozan,Ozkan, Metin,Demirci, Umut,Ozturk, Turkan,Bilici, Ahmet,Tastekin, Didem,Ozdemir, Nuriye,Unal, Olcun Umit,Oflazoglu, Utk Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Background: Inoperable and metastatic hepatocellular carcinoma (HCC) is associated with a poor prognosis and low chemotherapeutic efficiency. Sorafenib is an oral multi-kinase inhibitor exerting its effects via the RAF/MEK/ERK pathway, vascular endothelial growth factor receptor (VEGFR) and platelet derived growth factor receptor beta (PDGFR-${\beta}$) tyrosine kinases. Randomized studies have shown a significant contribution of sorafenib to life expectancy and quality of life of cancer patients. The aim of the present study is to evaluate the efficacy and side effects of sorafenib therapy in Turkey. Materials and Methods: Data for 103 patients (82 males, 21 females) receiving sorafenib therapy in 13 centers from February 2008 to December 2012 were evaluated. Median age was 61 years and median ECOG performance status was 1 (range: 0-2). 60 patients (58%) had hepatitis B, 15 patients (15%) had hepatitis C infection and 12 patients (12%) had a history of alcohol consumption. All of the patients had Child scores meeting the utilization permit of the drug in our country (Child A). Results: A total of 571 cycles of sorafenib therapy were administered with a median of four per patient. Among the evaluable cases, there was partial response in 15 (15%), stable disease in 52 (50%), and progressive disease in 36 (35%). Median progression-free survival was 18 weeks and median overall survival was 48 weeks. The dose was reduced only in 6 patients and discontinued in 2 patients due to grade 3-4 toxicity, 18 patients (17%) suffering hand-foot syndrome, 7 (7%) diarrhea, and 2 (2%) vomiting. Conclusions: This retrospective study demonstrated better efficacy of sorafenib therapy in patients with advanced HCC compared to the literature while progression-free survival and overall survival findings were comparable. The side effect rates indicate that the drug was tolerated well. In conclusion, among the available treatment options, sorafenib is an efficient and tolerable agent in patients with inoperable or metastatic HCC.

Comparative analysis of the same technique-the same surgeon approach in the surgical treatment of pilonidal sinus disease

Emin Kose,Mustafa Hasbahceci,Hasan Tonyali,Muslum Karagulle 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.93 No.2

Purpose: Although there are several surgical methods for treatment of sacrococcygeal pilonidal sinus, there is no widespread consensus. In this study, we aimed to compare primary closure, Limberg, and modified Limberg flap techniques, with each performed by each of 3 surgeons. Methods: A total of 802 patients who were operated on for pilonidal sinus disease were included in this retrospective cohort study. Patients were evaluated in 3 groups: group 1 (limited excision + primary closure), group 2 (large excision + Limberg flap technique), and group 3 (large excision + modified Limberg technique). Development of early or late period complications was accepted as primary outcome. Results: Mean patient age was 28.1 ± 6.7 years. Operation time in group 1 was 44.0 ± 14.5 minutes, and was shorter in comparison to other 2 groups (P < 0.001). One or more complications developed in 171 patients (21.3%) within study group. Highest complication rate was in group 1, with a rate of 30.7% (P < 0.001). Rate of wound dehiscence and recurrence in group 1 were differed significantly from other groups (P < 0.001 and P = 0.001, respectively). Conclusion: Based on the same technique-the same surgeon approach, comparison of surgical methods for treatment of pilonidal sinus showed that modified Limberg and Limberg techniques are superior to primary closure technique in terms of general complication, wound dehiscence, and recurrence rates.

Prognostic Factors and Adjuvant Treatments for Surgically Treated Cancers of the Biliary Tract: A Multicentre Study of the Anatolian Society of Medical Oncology (ASMO)

Unal, Olcun Umit,Oztop, Ilhan,Assoc, Tugba Kos,Turan, Nedim,Kucukoner, Mehmet,Helvaci, Kaan,Berk, Veli,Sevinc, Alper,Yildiz, Ramazan,Cinkir, Havva yesil,Tonyali, Onder,Demirci, Umut,Aktas, Bilge,Balak Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22

Background: Biliary tract cancers are rare, and surgical resection is the standard treatment at early stages. However, reports on the benefits of adjuvant treatment following surgical resection are conflicting. This study aimed to evaluate the factors affecting survival and adjuvant treatments in patients with surgically treated biliary tract cancers. Materials and Methods: Patient clinical features, adjuvant treatments, and efficacy and prognostic factor data were evaluated. Survival analyses were performed using SPSS 15.0. Results: The median overall survival was 30.7 months (95% confidence interval [CI], 18.4-42.9 months). Median survival was 19 months (95% CI, 6-33) for patients treated with fluorouracil based chemotherapy and 53 months (95% CI, 33.2-78.8) with gemcitabine based chemotherapy(p=0.033). On univariate analysis, poor prognostic factors for survival were galbladder localization, perineural invasion, hepatic invasion, a lack of adjuvant chemoradiotherapy treatment, and a lack of lymph node dissection. On multivariate analysis, perineural invasion was a poor prognostic factor (p=0.008). Conclusions: Biliary tract cancers generally have poor prognoses. The main factors affecting survival are tumour localization, perineural invasion, hepatic invasion, adjuvant chemoradiotherapy, and lymph node dissection. Gemcitabine-based adjuvant chemotherapy is more effective than 5-fluorouracil-based chemotherapy.