Transanal Irrigation for Neurogenic Bowel Dysfunction in Multiple Sclerosis: A Retrospective Study

Maëlys Teng,Gabriel Miget,Mirella Moutounaïck,Florian Kervinio,Audrey Charlanes,Camille Chesnel,Frédérique Le Breton,Gérard Amarenco 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.2

Background/AimsSixty-eight percent of multiple sclerosis (MS) patients suffer from neurogenic bowel dysfunction (NBD). Transanal irrigation (TAI) is part of the therapeutic strategy. This retrospective study aims to assess the efficacy of TAI in MS population. MethodsTwenty-eight MS patients who underwent TAI after a learning period were included. We collected several demographic data: MS disease characteristics, treatments, urinary and bowel dysfunction characteristics, urodynamic parameters, results of the NBD score, the Urinary Symptom Profile (USP) score, and the Patient Global Impression of Severity score, completed by patients before the learning and during the follow-up consultation. We defined 4 specific groups depending on the NBD score severity: very minor, minor, moderate, and severe. ResultsMean follow-up was 124 days, 85.0% were initially constipated and 36% had fecal incontinence. After TAI, improvement of NBD score was higher in initial Moderate NBD score group with 75.0% of patients decreasing their NBD score into lower severity categories. Few modifications were observed for baseline Very minor and Severe NBD score groups with 60.0% and 87.5% of patients staying in the same category. Statistical improvement of USP voiding dysfunction score was observed (95% CI, –6.13-–1.19; P = 0.005) without improvement of overactive bladder USP sub-score. ConclusionsTAI is effective in NBD, especially in MS patients with initial Moderate NBD score. Improvement of voiding dysfunction following TAI confirms the pelvic organ cross-talk and the need to systematically consider and treat bowel dysfunction in MS to also improve urinary symptoms.

Effect of internal structures on the accuracy of 3D printed full-arch dentition preparation models in different printing systems

Teng Ma,Tiwu Peng,Yang Lin,Mindi Zhang,Guanghui Ren 대한치과보철학회 2023 The Journal of Advanced Prosthodontics Vol.15 No.3

PURPOSE. The objective of this study was to investigate how internal structures influence the overall and marginal accuracy of full arch preparations fabricated through additive manufacturing in different printing systems. MATERIALS AND METHODS. A full-arch preparation digital model was set up with three internal designs, including solid, hollow, and grid. These were printed using three different resin printers with nine models in each group. After scanning, each data was imported into the 3D data processing software together with the master cast, aligned and trimmed, and then put into the 3D data analysis software again to compare the overall and marginal deviation whose results are expressed using root mean square values and color maps. To evaluate the trueness of the resin model, the test data and reference data were compared, and the precision was evaluated by comparing the test data sets. Color maps were observed for qualitative analysis. Data were statistically analyzed by one-way analysis of variance and Bonferroni method was used for post hoc comparison (α = .05). RESULTS. The influence of different internal structures on the accuracy of 3D printed resin models varied significantly (P < .05). Solid and grid models showed better accuracy, while the hollow model exhibited poor accuracy. The color maps show that the resin models have a tendency to shrink inwards. CONCLUSION. The internal structure design influences the accuracy of the 3D printing model, and the effect varies in different printing systems. Irrespective of the kind of printing system, the printing accuracy of hollow model was observed to be worse than those of solid and grid models.

CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cells

Teng-jiao Ma,Zhi-wei Zhang,Yilu Lu,Ying-ying Zhang,Da-chang Tao,Yun-qiang Liu,Yong-xin Ma 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Circadian genes control most of the physiological functions in cancer cells, including cell proliferation, migration, and invasion. The CLOCK and BMAL1 complex plays a central role in circadian rhythms. Previous studies have shown that circadian genes may act as oncogenes or tumor-suppressor genes. In addition, F-actin, regulated by RHOA, has been shown to participate in tumor progression. However, the roles of the CLOCK and BMAL1 genes in the regulation of tumor progression via the RHOA-ROCK-CFL pathway remain largely unclear. Here we first indicate that the rearrangement of F-actin is regulated by CLOCK and BMAL1. We found that CLOCK and BMAL1 can upregulate RHOA expression by inhibiting CUL3-mediated ubiquitination and activate RHOA by reducing the interaction between RHOA and RhoGDI. Consequently, CLOCK and BMAL1 control the expression of the components of the RHOA-ROCK-CFL pathway, which alters the dynamics of F-actin/G-actin turnover and promotes cancer cell proliferation, migration,

Neoadjuvant Chemotherapy Is Effective in Those Infected With SARS-CoV-2: The Real-World Experience of a Large Chinese Breast Cancer Center

Teng Ma,Tianyi Ma,Lulu Wang,Haibo Wang 한국유방암학회 2024 Journal of breast cancer Vol.27 No.3

Purpose During the major shift in China's policies on coronavirus disease 2019 (COVID-19), many residents will be infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) over a short period, including a few patients with breast cancer undergoing neoadjuvant chemotherapy (NAC). Moreover, it is unknown whether this comorbidity affects the efficacy of NAC for breast cancer and the patient's psychological state and quality of life (QOL). This study aims to answer these questions. Methods The clinical data of 2,793 patients with breast cancer who received NAC at The Affiliated Hospital of Qingdao University were retrospectively collected. The infected and non-infected groups were divided according to whether they were infected with COVID-19 during NAC. Propensity score matching was used to reduce patient selection bias. The effectiveness, psychological well-being, and QOL of the two groups were compared. Results No discernible differences were observed in the pathological complete response rates (p = 0.307) and major histological responses rate (p = 0.398) between the infected and non-infected groups. Following the full course of NAC, the Functional Assessment of Cancer Treatment General (p < 0.001) and Functional Assessment of Cancer Therapy for Breast Cancer (p < 0.001) were lower in the infected group than the non-infected group, the Hospital Anxiety and Depression Scale (HADS) anxiety scale (p < 0.001) and HADS depression scale (p < 0.001) were considerably higher in the infected group than the non-infected group. Conclusion With timely treatment and effective medical management, SARS-CoV-2 does not appear to affect the efficacy of NAC; however, it can significantly affect the QOL of patients and increase their psychological distress. Therefore, in addition to a timely assessment of the efficacy of NAC, it is necessary to dynamically understand the patient's psychological state and QOL. Purpose During the major shift in China's policies on coronavirus disease 2019 (COVID-19), many residents will be infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) over a short period, including a few patients with breast cancer undergoing neoadjuvant chemotherapy (NAC). Moreover, it is unknown whether this comorbidity affects the efficacy of NAC for breast cancer and the patient's psychological state and quality of life (QOL). This study aims to answer these questions. Methods The clinical data of 2,793 patients with breast cancer who received NAC at The Affiliated Hospital of Qingdao University were retrospectively collected. The infected and non-infected groups were divided according to whether they were infected with COVID-19 during NAC. Propensity score matching was used to reduce patient selection bias. The effectiveness, psychological well-being, and QOL of the two groups were compared. Results No discernible differences were observed in the pathological complete response rates (p = 0.307) and major histological responses rate (p = 0.398) between the infected and non-infected groups. Following the full course of NAC, the Functional Assessment of Cancer Treatment General (p < 0.001) and Functional Assessment of Cancer Therapy for Breast Cancer (p < 0.001) were lower in the infected group than the non-infected group, the Hospital Anxiety and Depression Scale (HADS) anxiety scale (p < 0.001) and HADS depression scale (p < 0.001) were considerably higher in the infected group than the non-infected group. Conclusion With timely treatment and effective medical management, SARS-CoV-2 does not appear to affect the efficacy of NAC; however, it can significantly affect the QOL of patients and increase their psychological distress. Therefore, in addition to a timely assessment of the efficacy of NAC, it is necessary to dynamically understand the patient's psychological state and QOL.

Forest Fire Monitoring Based on Mixed Wireless Sensor Networks

Teng Ma,Yun Liu,Junsong Fu,Ya Jing 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.3

Forest fires can be fatal threats. Motivated by the need to detect fire early and locate forest fires clearly, in this paper, we propose a paradigm called the forest fire monitoring paradigm (FFMP). The purpose of the FFMP is for forest fire early detection and locating based on mixed wireless sensor networks (WSNs). Different from pure static and mobile WSNs, mixed WSNs are composed of both mobile sensor nodes and static sensor nodes. Mixed WSNs are a tradeoff between cost and coverage. In the FFMP, the mobile sensor nodes perform as cluster heads and they will construct a backbone network in which the mobile sensor nodes can connect with their neighbors and be capable of transmitting data to the base station. Each static sensor node chooses one neighboring mobile sensor node as its cluster head and uploads the generated messages to the cluster head. The mobile sensor nodes then fuses the information and transfers the fusion results to the base station, where the data were further processed to obtain the temperature distribution graph and locate the fires. The simulation illustrates that our approach performs well in early forest fire detection and locating. In addition, our approach can significantly prolong the lifetime of WSNs.

Three Treatment Methods via the Hepatic Artery for Hepatocellular Carcinoma - A Retrospective Study

Ma, Teng-Chuang,Shao, Hai-Bo,Xu, Yang,Xu, Ke Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

Background: To evaluate the relative effectiveness of different treatments of hepatocellular carcinoma (HCC) via the hepatic artery. Materials and Methods: The study sample group consisted of 418 patients who were randomly selected from 2008 to 2012 with a first diagnosis of HCC and treated with transcatheter arterial chemoembolization (TACE) or without (TAE) chemotherapy or transcatheter arterial infusion (TAI). We collected data including tumor size preoperative and one month thereafter to compare change in areas across the three groups, along with various laboratory indexes for comparison. Results: The overall average change of areas was $240.8{\pm}72.1mm^2$. In the three groups it was $265.0{\pm}58.0mm^2$ vs. $250.5{\pm}51.9mm^2$ vs. $123.7{\pm}26.2mm^2$. In groups TACE and TAE values were larger than in group TAI (p<0.01), but the difference between the two was not statistically significant (p= 0.191). Additionally, U/L change of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in groups TACE and TAE was greater than in the TAI cases ($24.0{\pm}13.5$ vs. $20.9{\pm}12.1$ vs. $5.47{\pm}8.20$ and $25.6{\pm}13.5$ vs.$23.2{\pm}12.28$ vs.$5.48{\pm}14.3$) on the preoperative day and two days thereafter (p<0.01). Between the two groups there was no significant cariation (p= 0.320 and p= 0.609). However, the AST and ALT recovered to normal levels one month later on therapy with liver protecting drugs. Conclusion: The groups TACE and TAE demonstrated more effective reduction of tumor size than group TAI. While lipiodol caused acute liver function damage, this proved reversible.

A Reliable Information Fusion Algorithm for Reputation Based Wireless Sensor Networks

Teng Ma,Yun Liu,Junsong Fu,Ya Jing 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.1

In wireless sensor networks (WSNs), cryptographic primitives alone cannot provide a sufficient solution to the secure information fusion problem, therefore reputation systems have been introduced into WSNs. In a cluster, each sensor node has a single reputation value that is evaluated by the other sensor nodes in the same cluster. In this paper, we propose a novel, reliable information fusion algorithm, called reputation-driven information fusion (RDIF). In this work, a clustering algorithm is employed to divide all of the sensor nodes into many clusters. Then, a reputation system is established for each cluster, and an information fusion algorithm driven by reputation values is performed by the cluster head. In addition to the sensor nodes’ reputation values, we also consider the values of the readings collected by the sensor nodes and eliminate the outliers before fusing information. The simulation results show that RDIF can improve the reliability and accuracy of fusion results significantly when some compromised nodes appear in the WSNs.

經義決獄與中國古代司法傳統

馬騰(Ma Teng) 경북대학교 아시아연구소 2011 아시아연구 Vol.- No.13

經義決獄은 儒家 經典의 故事로서, 법률안건을 처리하는 지도 원칙은 안건을 분석하고 책임을 인정하고 형벌을 적용하는 司法活動이었다. 經義決獄은 형식적으로는 董仲舒에서 시작되어 唐·宋시대에 끝났지만 역사적인 연원은 漢初까지 거슬러 올라갈 수 있으며, 內在되어 있는 정신은 중국고대 사법전통에 뿌리를 두고 계속해서 淸末까지 이어져 왔다. 經義決獄은 尊儒之風, 儒法合流, 禮法融合 등의 원동력에서 기인하였고, 外儒內法의 鏡像이기도 하였다. 통치자들은 한편으로 春秋之義로서 안건을 처리하는 충분한 근거로서 皇權의 大통일 질서를 유지하였고, 다른 한편으로는 儒家經典을 신성한 법전으로 여겼다. 그리하여 經義에 대한 神聖化는 讖緯化하여 객관적으로 君權에 도전할 수 있는 가능성이 존재하였다. 그러나 經學의 解釋權은 통치자가 가지고 있었기 때문에 春秋의 經義는 황제와 신하들이 자기 口味에 맞게 임의적으로 해석하여 사욕을 채웠다. 儒家의 經義는 본질적으로 일종의 慣習法으로서, 經義決獄은 일종의 법률 효력을 갖는 司法活動으로서 中國 法制史중의 특정 단계의 고유한 현상이 아니라 법률의 유가화의 진행과 中華法系에 始終하는 사법전통으로서 중국의 전통적인 情理司法의 내재적인 정신인 것이었다. 情理司法의 핵심 내용은 바로 儒家倫理의 慣習法化 및 儒家 德敎心態의 윤리사법이었던 것이다. 經義決獄은 비록 많은 폐단을 갖고 있었지만 전통 법률의 儒家化, 倫理化, 自然法化하는 司法의 環節이었다. 한편으로 經義決獄을 立法과 詔令의 형식으로 교정하여 양자의 장점을 합한 것으로서, 經義決獄은 文景刑制 개혁의 경량화 이념을 계승하여 司法環節 중에서 法家式의 酷律에 대해 2차 교정한 것이었다. 다른 한편으로 經義決獄는 原心定罪로서 刻薄하고 寡恩한 사법의 객관적인 판정보다 인간성이 있었다. Jing Yi Jue Yu means to resort to classic Confucian stories or famous quotations as guiding principles to analyze and judge cases, decide penalty and sentencing. Formally speaking, Jing Yi Jue Yu dates back to Dong Zhongshu and ended up in Tang and Song Dynasties. However, the source of the tradition can be traced back to early Han Dynasty, and the spirit of it had been deeply rooted in Chinese ancient judicial tradition and lasted until the end of Qing Dynasty. It started at the time when Confucianism was highly regarded and it is also the original impetus of the merger of Confucianism and Fajia (Legalism), as well as Li (Confucian ethical code) and Fa (law). The rulers on one hand judged according to the principles prevalent during the Chun Qiu (Spring and Autumn) Period to uphold their imperial power and order, on the other hand, Confucian classics are made as sacred legal classics, hence the sanctification and mystification of the classics - objectively providing possibilities for challenging the power of the ruler. Nevertheless, the discourse power is at the hand of the rulers, the principles can be adjusted by the emperor and courtiers to the needs of them. Due to the tradition of carefully studying the Confucian classics, rulers were flexibly able to quote classics in their judging. Therefore, when disputes emerged, the final say was up to the one with higher ranking. In essence, Confucian Jing Yi is a form of common law, and as a judicial method to acquire legal validity, Jing Yi Jue Yu is not a special phenomenon happening in a particular period in China's legal history; it is, however, a judicial tradition along with the Confucianization of law and the development of Chinese legal system. It is a cradle of traditional Chinese "common sense" justice. The core of the Chinese "common sense" justice includes the common law of Confucian ethics and the ethical justice featuring Confucian teaching trough morality. Though Jing Yi Jue Yu had brought about some linking negative influence, it is a process of Confucianization, ethicalization and natural-lawing of traditional law. On one hand, together with the rectifying effect of legislation and decree, Jing Yi Jue Yu had carried on Wen-Jing Criminal Punishment Reform with the idea of reducing punishment on quilt, and re-adjust cruel punishment proposed by Fajia on judicial level. On the other hand, it is humanistic in that it had introduced the principle of judging from attempt to the objective attribution of guilt which was harsh and cruel.

墨子“尚同”内涵新探

馬騰(Ma Teng) 경북대학교 인문학술원 2010 동서사상 Vol.9 No.-

Demanding changing the chaotic situation of the era of Dongzhou and moving forward to unity, the small producers, which were represented by Mohist, posed the idea of “Shangtong”, which requested to make an absolute monarch as the symbol of a new unite order. Two famous scholars, Liang Qichao and Guo Moruo had different opinions about the question that "Is “Shangtong” a “social contract theory”, then lots of scholars afterwards also kept debating about it. From the perspective of law, the essence of “Shangtong” is autocratic monarchy, which is hugely different from the neoteric and modern politic thoughts such as equity, freedom and human rights, which were adored by the social contract theory.

[번역] 묵자 ‘상동’의 내포에 대한 새로운 탐구(墨子“尚同”内涵新探)

馬騰(Ma Teng),김용수(번역자) 경북대학교 인문학술원 2010 동서사상 Vol.9 No.-

묵가가 대표하는 농민, 공인, 상인은 춘추전국시기 분란의 국면을 전환하여 통일을 향해 달려 나갈 것을 요구하였다. 이에 묵가는 상동(相同)을 제출하여, 정치와 법률이라는 측면에서 하나의 절대적 권위를 지닌 전제군주에 호소함으로써, 새로운 통일질서의 상징으로 삼고자 하였다. 상동론이 민약론(民約論)인지에 대해서는 지난 세월의 선배인 양계초와 곽말약이 각기 견해를 펼치고 있으며, 그 이후의 학자들도 이에 대해 끊임없는 논의를 펼쳐 나가고 있다. 법률사상의 각도에서 볼 때 묵자 ‘상동’의 본질은 군주전제이며, 그것은 민약론이 숭상하는 평등, 자유, 인권 등의 근현대 정치사상의 정수와는 하늘과 땅 같은 현격한 차이가 있다. Demanding changing the chaotic situation of the era of Dongzhou and moving forward to unity, the small producers, which were represented by Mohist, posed the idea of “Shangtong”, which requested to make an absolute monarch as the symbol of a new unite order. Two famous scholars, Liang Qichao and Guo Moruo had different opinions about the question that "Is “Shangtong” a “social contract theory”, then lots of scholars afterwards also kept debating about it. From the perspective of law, the essence of “Shangtong” is autocratic monarchy, which is hugely different from the neoteric and modern politic thoughts such as equity, freedom and human rights, which were adored by the social contract theory.