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Tang Ri,Tang Ri,Xu Qiaoyi,Feng Jinhua,Zhou Yang,Xing Shunpeng,He Zhengyu,Gao Yuan 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Recent clinical research has revealed that mechanical ventilation (MV) can initiate pulmonary fibrosis and induce mechanical ventilation-induced pulmonary fibrosis (MVPF). However, the underlying mechanism remains largely uncharacterized. Based on a mouse model of MVPF and an alveolar epithelial cell cyclic strain model, the present study explores the possible mechanism of MVPF. Single-cell RNA-sequencing and EV RNA-sequencing analysis revealed that MV promoted apoptosis signal-regulating kinase 1 (ASK1)-mediated endoplasmic reticulum (ER) stress pathway activation and extracellular vesicle (EV) release from alveolar epithelial cells. Furthermore, the ASK1-ER stress pathway was shown to mediate mechanical stretch (MS)- or MV-induced EV release and lung fibroblast activation in vivo and in vitro. These processes were suppressed by ER stress inhibitors or by silencing ASK1 with ASK1- short hairpin RNA (shRNA). In addition, MVPF was suppressed by inhibiting ASK1 and ER stress in vivo. Therefore, the present study demonstrates that ASK1-ER stress pathway-mediated fibrotic-EV release from alveolar epithelial cells contributes to fibroblast activation and the initiation of pulmonary fibrosis during MV. The inhibited release of EVs targeting the ASK1-ER stress pathway might be a promising treatment strategy for MVPF.
Preparation of decorative slag glass-ceramics and research on the solidification of heavy metals
Yang Tang,Xiaodong Hao,Zhenxiang Fang,Xinyu Bai,Guangyu Wang,Hongxia Zhang,Leibo Deng,Hua Chen,Ming Zhao,Yongsheng Du 한양대학교 청정에너지연구소 2023 Journal of Ceramic Processing Research Vol.24 No.1
Glass-ceramics with different CuO additions were prepared with Fe2O3 and Cr2O3 as composite nucleating agents, rare earthcontainingblast furnace slag (REBFS) as the main raw material. The existence state and stability of heavy metals Cu, Mn andCr in glass-ceramics were investigated. The results showed that Cr ions contributed to the generation of spinel phase, whileCu ions and Mn ions can enter the spinel crystal and exist stably, which indicated that there was a synergistic solidificationof Cu, Mn and Cr. The depolymerization effect of the copper ions contributed to the transformation of the crystal morphologyfrom dendrites to spherulites. Moreover, the increase in CuO contents promoted glass-ceramics from green to copper red. Based on the leaching experimental data analysis of heavy metals in glass-ceramics, the leaching concentration of heavy metalsCu, Cr and Mn were much lower than the standard leaching toxicity limit of hazardous waste (GB5085.3–2007, China). Theresults showed that the conversion of REBFS into environmentally friendly glass-ceramics can realize solid waste resourceutilization.
Simulation of a neutron imaging detector prototype based on SiPM array readout
Tang Mengjiao,Zhang Lianjun,Tang Bin,He Gaokui,Huang Chang,Zhao Jiangbin,Liu Yang 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.9
Neutron imaging technology as a means of non-destructive detection of materials is complementary to X-ray imaging. Silicon photomultiplier (SiPM), a new type of optical readout device, has overcome some shortcomings of traditional photomultiplier tube (PMT), such as high-power consumption, large volume, high price, uneven gain response, and inability to work in strong magnetic fields. Its application in the field of neutron detection will be an irresistible general trend. In this paper, a thermal neutron imaging detector based on 6 LiF/ZnS scintillation screen and SiPM array readout was developed. The design of the detector geometry was optimized by geant4 Monte Carlo simulation software. The optimized detector was evaluated with a step wedge sample. The results show that the detector prototype with a 48 mm 48 mm sensitive area can achieve about 38% detection efficiency and 0.26 mm position resolution when using a 300 mm thick 6 LiF/ZnS scintillation screen and a 2 mm thick Bk7 optical guide coupled with SiPM array, and has good neutron imaging capability. It provides effective data support for developing high-performance imaging detectors applied to the China Spallation Neutron Source (CSNS).
Preparation of W–V functionally gradient material by spark plasma sintering
Tang Yi,Qiu Wenbin,Chen Longqing,Yang Xiaoliang,Song Yangyipeng,Tang Jun 한국원자력학회 2020 Nuclear Engineering and Technology Vol.52 No.8
Functionally gradient material (FGM) is promisingly effective in mitigating the thermal stress between plasma facing materials (PFM) and structural materials. However, the corresponding research with respect to W/V FGM has not been reported yet. In this work, we firstly report the successful fabrication of W/V FGM by a combined technology of mechanical alloying (MA) and spark plasma sintering (SPS). The microhardness and microstructure of the consolidated sample were both investigated. W/V stacks show significantly enhanced microhardness (>100%) compared with pure W plate, which is beneficial to the integral strength of the hybrid structure. Furthermore, we clarify that the different ductility of W and V should be carefully considered, otherwise W/V powder might aggregate and lead to the formation of compositional segregation, and simultaneously unmask the impact of V proportion on the distribution of second phase in WeV binary alloy system. This w
REAL SOLUTIONS OF THE EQUATION (equation omitted)
Yang, Zhong-Peng,Cao, Chong-Gu,Tang, Xiao-Min 한국전산응용수학회 2003 Journal of applied mathematics & informatics Vol.13 No.1
For an n ${\times}$ n real matrix X, let ${\Phi}$(X) = X o (X$\^$-1/)$\^$T/, where o stands for the Hadamard (entrywise) product. Suppose A, B, G and D are n ${\times}$ n real nonsingular matrices, and among them there are at least one solutions to the equation (equation omitted). An equivalent condition which enable (equation omitted) become a real solution ot the equation (equation omitted), is given. As application, we get new real solutions to the matrix equation (equation omitted) by applying the results of Zhang. Yang and Cao [SIAM.J.Matrix Anal.Appl, 21(1999), pp: 642-645] and Chen [SIAM.J.Matrix Anal.Appl, 22(2001), pp:965-970]. At the same time, all solutions of the matrix equation (equation omitted) are also given.
Yang Tang,Jie Wu,Xiang Liu,Xin Yang,Yuan Wang,Haoyu Xiong 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.9
In order to realize the precise positioning of the tools in the pipeline repair operation, solve the problems of the traditional throttle speed control, such as slow response, long deceleration distance and so on, this paper explores a deceleration process of a pipeline intelligent plugging robot (PIPR) that relies on the friction between slips and the pipe, and establishes its dynamic model based on fuzzy PID force servo control. The influence of PIPR initial velocity, expected deceleration distance, accumulator setting on the response time, positioning accuracy, overshoot and stability during deceleration is analyzed, and the results show that: as the initial velocity increases, the time for slips to contact the pipe decreases, the overshoot of the centroid acceleration gradually increases, the maximum overshoot is -3.4 m/s 2 , the control time of the deceleration process is within 30 s, the positioning accuracy is within 5 %; the expected deceleration distance has a greater impact on the positioning accuracy of the system than the initial velocity; and the accumulator setting has little effect on the positioning accuracy and stability of the system. These studies provide guidance for the design of pipeline robot speed control and positioning system.
Yang Jiashu,Zhang Ming,Yang Dawei,Ma Yunfei,Tang Yuting,Xing Mengying,Li Lingyun,Chen Li,Jin Yucui,Ma Changyan 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Long noncoding RNAs (lncRNAs) have emerged as important regulators of osteoarthritis (OA), but the biological roles and clinical significance of most lncRNAs in OA are not fully understood. Microarray analysis was performed to identify differentially expressed lncRNAs, mRNAs, and miRNAs between normal and osteoarthritic cartilage. We found that AC008440.5 (abbreviated AC008), as well as AQP1 and ANKH, were highly expressed in osteoarthritic cartilage, whereas miR-328-3p was expressed at a low level in osteoarthritic cartilage. Functional assays showed that ectopic expression of AC008, AQP1, and ANKH significantly decreased chondrocyte viability and promoted chondrocyte apoptosis and extracellular matrix (ECM) degradation, whereas knockdown of AC008, AQP1, and ANKH resulted in the opposite effects. Moreover, miR-328-3p overexpression increased chondrocyte viability and attenuated chondrocyte apoptosis and ECM degradation, whereas inhibition of miR-328-3p resulted in the opposite effects. Bioinformatics analysis, RNA immunoprecipitation (RIP), and luciferase assays revealed that AC008 functioned as a competing endogenous RNA (ceRNA) to regulate miR-328-3p, which specifically targeted the AQP1 and ANKH genes. In addition, miR-328-3p significantly ameliorated MIA-induced OA, whereas AC008 accelerated OA progression in vivo. Furthermore, fat mass and obesity-associated (FTO)-mediated N6-methyladenosine demethylation downregulated AC008 transcription, while lower FTO expression led to upregulation of AC008 transcription in OA. In conclusion, our data reveal that AC008 plays a critical role in OA pathogenesis via the miR-328-3p‒AQP1/ANKH pathway, suggesting that AC008 may be a potential therapeutic target for OA.
Yang Li,Lin-Quan Tang,Li-Ting Liu,Shan-Shan Guo,Yu-Jing Liang,Xue-Song Sun,Qing-Nan Tang,Jin-Xin Bei,Jing Tan,Shuai Chen,Jun Ma,Chong Zhao,Qiu-Yan Chen,Hai-Qiang Mai 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4
Purpose The purpose of this study was to evaluate the long-term clinical outcome and toxicity of induction chemotherapy (IC) followed by concomitant chemoradiotherapy (CCRT) compared with CCRT alone for the treatment of children and adolescent locoregionally advanced nasopharyngeal carcinoma (LACANPC). Materials and Methods A total of 194 locoregionally advanced nasopharyngeal carcinoma patients younger than 21 years who received CCRT with or without IC before were included in the study population. Overall survival (OS) rate, progression-free survival (PFS) rate, locoregional recurrence-free survival (LRFS) rate, and distant metastasis-free survival (DMFS) rate were assessed by the Kaplan-Meier method and a log-rank test. Treatment toxicities were clarified and compared between two groups. Results One hundred and thiry of 194 patients received IC+CCRT. Patients who were younger and with more advanced TNM stage were more likely to receive IC+CCRT and intensive modulated radiotherapy. The addition of IC before CCRT failed to improve survival significantly. The matched analysis identified 43 well-balanced patients in both two groups. With a median follow-up of 51.5 months, no differences were found between the IC+CCRT group and the CCRT group in 5-year OS (83.7% vs. 74.6%, p=0.153), PFS (79.2% vs. 73.4%, p=0.355), LRFS (97.7% vs. 88.2%, p=0.083), and DMFS (81.6% vs. 81.6%, p=0.860). N3 was an independent prognostic factor predicting poorer OS, PFS, and DMFS. The addition of IC was associated with increased rates of grade 3 to 4 neutropenia. Conclusion This study failed to demonstrate that adding IC before CCRT could provide a significant additional survival benefit for LACANPC patients. Further investigations are warranted.