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High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias
Peng Du,Gregory O’Grady,Niranchan Paskaranandavadivel,Shou-jiang Tang,Thomas Abell,Leo K Cheng 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.2
Background/Aims It is now recognised that gastric dysrhythmias are best characterised by their spatial propagation pattern. Hyperglycemia is an important cause of gastric slow wave dysrhythmia, however, the spatiotemporal patterns of dysrhythmias in this context have not been investigated. This study aims to investigate the relationship between hyperglycemia and the patterns of dysrhythmias by employing high-resolution (multi-electrode) mapping simultaneously at the anterior and posterior gastric serosa. Methods High-resolution mapping (8 × 16 electrodes per serosal) was performed in 4 anesthetized hounds. Baseline recordings (21 ± 8 minutes) were followed by intravenous injection of glucagon (0.5 mg per dose) and further recordings (59 ± 15 minutes). Blood glucose levels were monitored manually using a glucose sensing kit at regular 5-minute intervals. Slow wave activation maps, amplitudes, velocity, anisotropic ratio, and frequency were calculated. Differences were compared between baseline and post glucagon injection. Results Baseline slow waves propagated symmetrically and antegrade. The blood glucose levels were increased by an average of 112% compared to the baseline by the end of the recordings. All subjects demonstrated elevated incidence of slow wave dysrhythmias following injection compared to the baseline (48 ± 23% vs 6 ± 4%, P < 0.05). Dysrhythmias arose simultaneously or independently on anterior and posterior serosa. Spatial dysrhythmias occurred before and persisted after the onset and disappearance of temporal dysrhythmias. Conclusions Infusion of glucagon induced gastric slow wave dysrhythmias, which occurred across a heterogeneous range of patterns and frequencies. The spatial dysrhythmias of gastric slow waves were shown to be more prevalent and persisted over a longer period of time compared to the temporal dysrhythmias.
( Cheng Wu ),( Lijie Liu ),( Peng Zhao ),( Dan Tang ),( Dingkang Yao ),( Liang Zhu ),( Zhiqiang Wang ) 대한소화기학회 2015 Gut and Liver Vol.9 No.5
Background/Aims: To screen for serum protein/peptide biomarkers of hepatitis B virus (HBV)-associated chronic hepatic lesions in an attempt to profile the progression of HBV-associated chronic hepatic lesions using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) techniques. Methods: Using SELDI-TOF MS, serum protein/peptide profiles on the CM10 ProteinChip arrays were obtained from a training group including 26 HBV-associated hepatocellular carcinoma patients with liver cirrhosis (LC), 30 HBV-associated LC patients, 85 patients at different stages of liver fibrosis, and 30 asymptomatic HBV carriers. The most valuable SELDI peak for predicting the progression to LC in HBV-infected patients was identified. Results: A SELDI peak of M/Z 5805 with value for predicting LC in HBV-infected patients was found and was identified as a peptide of the C-terminal fraction of the fibrinogen a-chain precursor, isoform 1. Conclusions: The peptide of the C-terminal fraction of the fibrinogen α-chain precursor, isoform 1 with M/Z 5805, may be a serological biomarker for progression to LC in HBV-infected patients. (Gut Liver 2015;9:665-671)
Ma, Peng-Cheng,Liu, Ming-Yang,Zhang, Hao,Wang, Sheng-Qi,Wang, Rui,Wang, Kai,Wong, Yiu-Kei,Tang, Ben-Zhong,Hong, Soon-Hyung,Paik, Kyung-Wook,Kim, Jang-Kyo American Chemical Society 2009 ACS APPLIED MATERIALS & INTERFACES Vol.1 No.5
<P>Nanocomposites reinforced with hybrid fillers of carbon nanotubes (CNTs) and carbon black (CB) are developed, aiming at enhancing the electrical conductivity of composites with balanced mechanical properties while lowering the cost of the final product. Epoxy-based nanocomposites were prepared with varying combinations of CNTs and CB as conducting fillers, and their electrical and mechanical properties were evaluated. It was shown that the addition of CNTs in CB composites enhanced the electrical conductivity of composites: a low percolation threshold was achieved with 0.2 wt % CNTs and 0.2 wt % CB particles. The CB particles also enhanced the ductility and fracture toughness of nanocomposites, confirming the synergistic effect of CB as a multifunctional filler. The novelty of this work lies in the synergy arising from the combination of two conducting fillers with unique geometric shapes and aspect ratios as well as different dispersion characteristics, which have not been specifically considered previously.</P>
Two new tirucallane triterpenoids from the leaves of Aquilaria sinensis
Jin Tang Cheng,Ya Qiong Han,Juan He,Xing De Wu,Liao Bin Dong,Li Yan Peng,Yan Li,Qin Shi Zhao 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.9
Two new tirucallane triterpenoids, aquilacallanesA–B (1–2), together with 15 known compounds(3–17) were isolated from the leaves of Aquilaria sinensis. The structures of these new compounds were elucidated onthe basis of extensive spectroscopic analyses. All compoundswere evaluated for their cytotoxic activity againstfive human cancer cell lines. The known compounds,ursolic acid (7) and 5,7,40-trimethoxyflavone (14), exhibitedweak cytotoxic activity against some cells.
Calculation and analysis of switching losses in IGBT devices based on switching transient processes
Hao, Bin,Peng, Cheng,Tang, Xinling,Zhao, Zhibin The Korean Institute of Power Electronics 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.10
Accurately revealing the generation mechanism and the mathematical relationship with system parameters of the power loss in the switching transients of high-voltage large power IGBT devices is very important for the device selection and circuit design of converter equipment. To reveal the mechanism of generating switching losses, this paper analyzes the switching transient processes of the IGBT devices in the basic commutation circuit in detail. Then this paper proposes an accurate calculation method based on a finite state machine (FSM) for the switching losses of IGBT devices, and verifies the correctness of this method. To further reveal the mathematical relationships among switching losses, device parameters, and loop parameters, approximate analytical formulas for the switching loss of different switching transient processes are mathematically derived, which can provide a theoretical basis for reducing the switching losses in converters.
Photonic Microcavity-Enhanced Magnetic Plasmon Resonance of Metamaterials for Sensing Applications
Chen, Jing,Peng, Cheng,Qi, Shibin,Zhang, Qian,Tang, Chaojun,Shen, Xueyang,Da, Haixia,Wang, Lianhui,Park, Gun-Sik IEEE 2019 IEEE photonics technology letters Vol.31 No.2
<P>We first investigate numerically photonic microcavity-enhanced magnetic plasmon (MP) resonance in metamaterials for high-quality refractive index sensing. The metamaterials consist of a top periodic array of U-shaped metallic split-ring resonators (SRRs), a middle dielectric layer, and a bottom metallic backed plate. The top metallic SRRs that are placed at about Bragg distance above the bottom metallic plate constitute a photonic microcavity. Because the MP resonance excited in metallic SRRs is coupled to the photonic microcavity mode supported by the photonic microcavity, the radiative damping of the MP resonance is strongly reduced, and consequently, its linewidth is decreased dramatically. Benefiting from the narrow linewidth, large modulation depth, and giant magnetic field enhancement at the MP resonance, the cavity-coupled metamaterial sensor has very high sensitivity ( <TEX>$\text {S}= 400$</TEX> nm/RIU and <TEX>$\text {S}^{\ast } = 26$</TEX>/RIU) and figure of merit ( <TEX>$\text {FOM}= 33$</TEX> and FOM* = 4215), which suggests that the proposed metamaterials have potential in applications of plasmonic biosensors.</P>
MSFM: Multi-view Semantic Feature Fusion Model for Chinese Named Entity Recognition
Jingxin Liu,Jieren Cheng,Xin Peng,Zeli Zhao,Xiangyan Tang,Victor S. Sheng 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.6
Named entity recognition (NER) is an important basic task in the field of Natural Language Processing (NLP). Recently deep learning approaches by extracting word segmentation or character features have been proved to be effective for Chinese Named Entity Recognition (CNER). However, since this method of extracting features only focuses on extracting some of the features, it lacks textual information mining from multiple perspectives and dimensions, resulting in the model not being able to fully capture semantic features. To tackle this problem, we propose a novel Multi-view Semantic Feature Fusion Model (MSFM). The proposed model mainly consists of two core components, that is, Multi-view Semantic Feature Fusion Embedding Module (MFEM) and Multi-head Self-Attention Mechanism Module (MSAM). Specifically, the MFEM extracts character features, word boundary features, radical features, and pinyin features of Chinese characters. The acquired font shape, font sound, and font meaning features are fused to enhance the semantic information of Chinese characters with different granularities. Moreover, the MSAM is used to capture the dependencies between characters in a multi-dimensional subspace to better understand the semantic features of the context. Extensive experimental results on four benchmark datasets show that our method improves the overall performance of the CNER model.
Chen, Jing,Nie, Hai,Peng, Cheng,Qi, Shibin,Tang, Chaojun,Zhang, Ying,Wang, Lianhui,Park, Gun-Sik IEEE 2018 Journal of Lightwave Technology Vol.36 No.16
<P>We report an effective method to enhance and modify the magnetic plasmon (MP) resonance in three-dimensional (3D) optical metamaterials consisting of periodic arrays of silver vertical split-ring resonators (VSRRs) for high-sensitivity sensing. By positioning the 3D metamaterials above a thick silver film separated by a silica dielectric spacer layer, the strong coupling between the MP resonance in the VSRRs and the surface plasmons polaritons (SPPs) propagating on the silver film can be realized and gives rise to an ultra-narrowband hybrid MP mode with a huge enhancement of magnetic fields. For the coupling to happen, the magnetic field direction of the SPPs should be parallel to the magnetic moment induced in the VSRRs. More importantly, because the ultra-narrowband hybrid MP mode is extremely sensitive to the surrounding media, the sensitivity and the figure of merit (FOM) of the 3D metamaterials can reach as high as 700 nm/RIU and 170, respectively, suggesting that the proposed 3D metamaterials hold potential applications in label-free biomedical sensing.</P>