Solar-powered electrocoagulation treatment of wet flue gas desulfurization wastewater using dimensionally stable anode and induced electrode

Xin Lin,Junda Gong,Hang Li,Haiyun Zhang,Yang Yu,Wenyi Tan 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.1

Solar-powered electrocoagulation (EC) process is proven to be an alternative option for wet flue gas desulfurization (WFGD) wastewater treatment, due to simultaneous removal of multiple pollutants efficiently and reduce the operation costs significantly. Rapid and stable photoelectricity response is necessary for the removal efficiency of pollutants (eg. COD and turbudity), especially in low solar irradiation intensity. In this paper, dimensionally stable anode (DSA) and operation voltages in EC process driven by solar cells were investigated, for the purpose of the optimized removal of pollutants, including COD, turbidity, (free residual chlorine and chlorine dioxide). The results show that the removal efficiency of COD and turbidity can respectively reach 59.12% and 39.11% within 30 min of illumination time (the enhanced solar radiation = 915.8 W m<SUP>-2</SUP>), when Ti-based plates were adopted. The concentration of free residual chlorine and chlorine dioxide can reach 2.70 and 5.31 mg L<SUP>-1</SUP>, indicating that chlorine ions present in WFGD wastewater have been converted into active chlorine partly. Solar-powered EC equipped with Ti-based plates have a potential prospect in EC process for WFGD wastewater treatment.

Realgar transforming solution-induced differentiation of NB4 cell by the degradation of PML/RARa partially through the ubiquitin–proteasome pathway

Yang Hai,Xin Wang,Peng Song,Jian-yin Li,Longhe Zhao,Fei Xie,Xiang-min Tan,Qin-Jian Xie,Lan Yu,Yang Li,Zhengrong Wu,Hong Yu Li 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.8

PML/retinoic acid receptor alpha (RARa), as ahallmark of acute promyeloid leukemia (APL), is directlyrelated to the outcome of clinical APL remedy. It isreported that arsenicals can effectively degrade PML/RARa, such as arsenic trioxide and realgar. However, thehigh toxicity or insolubility have hampered their clinicalapplications. Realgar transforming solution (RTS) wasproduced from realgar by bioleaching process in our lab. Previous studies demonstrated that RTS had a significantanti-cancer ability on chronic myeloid leukemia throughoncoprotein degradation. The capacity of RTS on treatingAPL is what is focused on in this study. The results showedthat RTS had a noticeable sensitivity in NB4 cell, and RTSremarkably down-regulated PML/RARa expression andinduced cell differentiation. Further, RTS could accumulatePML/RARa into the nuclear bodies and then executedegradation, which could be reversed by proteasomeinhibitor MG132. The results also exhibited that thereduction of RTS-induced PML/RARa expression accompaniedby the elevation of ubiquitin and SUMO-1 proteinexpression. Finally, PML and SUMO-1 had been demonstratedto be co-localized after RTS treatment byimmunofluorescence co-localization assay and immunoprecipitationassay. In conclusion, these results suggestedthat RTS-induced cell differentiation may attribute to thePML/RARa degradation partially through the ubiquitin–proteasome pathway.

Efficiency calculation of the ⁿMCP with ¹⁰B doping based on mathematical models

Yang, Jianqing,Zhou, Jianrong,Zhang, Lianjun,Tan, Jinhao,Jiang, Xingfen,Zhou, Jianjin,Zhou, Xiaojuan,Hou, Linjun,Song, Yushou,Sun, XinLi,Zhang, Quanhu,Sun, Zhijia,Chen, Yuanbo Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.7

The ⁿMCP (Neutron sensitive microchannel plate) combined with advanced readout electronics is widely used in energy selective neutron imaging because of its good spatial and timing resolution. Neutron detection efficiency is a crucial parameter for the ⁿMCP. In this paper, a mathematical model based on the oblique cylindrical channel and elliptical pore was established to calculate the neutron absorption probability, the escape probability of charged particles and overall detection efficiency of ⁿMCP and analyze the effects of neutron incident position, pore diameter, wall thickness and bias angle. It was shown that when the doping concentration of the ⁿMCP was 10 mol%, the thickness of ⁿMCP was 0.6 mm, the detection efficiency could reach maximum value, about 24% for thermal neutrons if the pore diameter was 6 ㎛, the wall thickness was 2 ㎛ and the bias angle was 3 or 6°. The calculated results are of great significance for evaluating the detection efficiency of the ⁿMCP. In a subsequent companion paper, the mathematical model would be extended to the case of the spatial resolution and detection efficiency optimization of the coating ⁿMCP.

BMB Reports : Nutlin-3 downregulates p53 phosphorylation on serine and induces apoptosis in hepatocellular carcinoma cells

( Xin Li Shi ),( Jing Li Liu ),( Lai Feng Ren ),( Nan Mao ),( Fang Tan ),( Nana Ding ),( Jing Yang ),( Ming Yuan Li ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.4

Drug-resistance and imbalance of apoptotic regulation limit chemotherapy clinical application for the human hepatocellular carcinoma (HCC) treatment. The reactivation of p53 is an attractive therapeutic strategy in cancer with disrupted-p53 function. Nutlin-3, a MDM2 antagonist, has antitumor activity in various cancers. The post-translational modifications of p53 are a hot topic, but there are some controversy ideas about the function of phospho-Ser392-p53 protein in cancer cell lines in response to Nutlin-3. Therefore, we investigated the relationship between Nutlin-3 and phospho-Ser392-p53 protein expression levels in SMMC-7721 (wild-type TP53) and HuH-7 cells (mutant TP53). We demonstrated that Nutlin-3 induced apoptosis through down-regulation phospho-Ser392-p53 in two HCC cells. The result suggests that inhibition of p53 phosphorylation on Ser392 presents an alternative for HCC chemotherapy. [BMB Reports 2014; 47(4): 221-226]

Induction Chemotherapy Plus Concurrent Chemoradiotherapy versus Concurrent Chemoradiotherapy Alone in Locoregionally Advanced Nasopharyngeal Carcinoma in Children and Adolescents: A Matched Cohort Analysis

Yang Li,Lin-Quan Tang,Li-Ting Liu,Shan-Shan Guo,Yu-Jing Liang,Xue-Song Sun,Qing-Nan Tang,Jin-Xin Bei,Jing Tan,Shuai Chen,Jun Ma,Chong Zhao,Qiu-Yan Chen,Hai-Qiang Mai 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4

Purpose The purpose of this study was to evaluate the long-term clinical outcome and toxicity of induction chemotherapy (IC) followed by concomitant chemoradiotherapy (CCRT) compared with CCRT alone for the treatment of children and adolescent locoregionally advanced nasopharyngeal carcinoma (LACANPC). Materials and Methods A total of 194 locoregionally advanced nasopharyngeal carcinoma patients younger than 21 years who received CCRT with or without IC before were included in the study population. Overall survival (OS) rate, progression-free survival (PFS) rate, locoregional recurrence-free survival (LRFS) rate, and distant metastasis-free survival (DMFS) rate were assessed by the Kaplan-Meier method and a log-rank test. Treatment toxicities were clarified and compared between two groups. Results One hundred and thiry of 194 patients received IC+CCRT. Patients who were younger and with more advanced TNM stage were more likely to receive IC+CCRT and intensive modulated radiotherapy. The addition of IC before CCRT failed to improve survival significantly. The matched analysis identified 43 well-balanced patients in both two groups. With a median follow-up of 51.5 months, no differences were found between the IC+CCRT group and the CCRT group in 5-year OS (83.7% vs. 74.6%, p=0.153), PFS (79.2% vs. 73.4%, p=0.355), LRFS (97.7% vs. 88.2%, p=0.083), and DMFS (81.6% vs. 81.6%, p=0.860). N3 was an independent prognostic factor predicting poorer OS, PFS, and DMFS. The addition of IC was associated with increased rates of grade 3 to 4 neutropenia. Conclusion This study failed to demonstrate that adding IC before CCRT could provide a significant additional survival benefit for LACANPC patients. Further investigations are warranted.

Adaptive Trajectory Compensation of Large Inertia Robot

Kuo Yang,Xin-hui Liu,Bing-wei Cao,Wei Chen,Peng Tan 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.3

The electro-hydraulic controlled bionic robots suffer from path contour deviation, which is affected byinertia, system lag, and control system accuracy. The focus of this paper is on the study of a data-driven systemfor the compensation of errors in the robot’s internal arithmetic model and its own motion. A deviation predictionmodel of the robot motion process is constructed using a machine learning approach, while the spatial error, generated in the transfer process between the input trajectory and the actual output, is de-parameterized and regardedas an attribute value of the robot’s motion process. Furthermore, a data-based adaptive compensation method isproposed. The simulation model and a hardware-in-the-loop simulation platform of the proposed control strategyare constructed, in order to verify the proposed control approach. Simulation and experimental results show that theproposed compensation strategy can significantly reduce system deviation.

Simultaneous separation of three isoflavones on oligo-β-cyclodextrin substituted polystyrene-based medium and evaluation adsorption characteristics using AutoDock

Li Yang,Tianwei Tan,Jinyi Luan,Xin Wei,Yongqiang Yang,Wenqing Huang,Zhi Guo,Yujie Wang 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.2

The adsorption characteristics between three isoflavones in crude soybean sample and styrene-β-cyclodextrin (S-CD) were studied by molecular mechanics calculations with AutoDock. The discriminatory ability exhibited by S-CD against glycitin, daidzin, and genistin through the differences in the interaction energies and complex geometries could potentially serve for the chromatographic separation. The chromatographic elution order of the three analytes on oligo-β-cyclodextrin substituted polystyrene-based medium (PS-CDP) was predicted depending on the binding free energy values obtained from molecular docking simulations. The experimental results of chromatographic evaluation on PS-CDP were consistent with the simulation prediction. The three isoflavones in sample can be simultaneously separated in one-step under the optimized mobile phase, which consisted of methanol/0.1mM NH4AC=65.0/35.0 (v/v) by PS-CDP column chromatography. A glycitin purity of 95.1% with a recovery of approximate 86.3% was achieved by proper peak cutting, and that of daidzin and genistin was 95.8%, 95.4% and 96.2%, 95.7%, respectively.

Fault diagnosis method for rolling bearing based on VMD and improved SVM optimized by METLBO

Chao Tan,Long Yang,Haoran Chen,Liang Xin 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.10

Vibration signal processing and classification are critical for bearing fault diagnosis. In this study, a hybrid framework based on multi-envelopment teaching-learning-based optimization (METLBO) was proposed by combining parameters optimized variational mode decomposition (VMD) and improved support vector machines (ISVM). First, the average value of minimum enveloping entropy was considered the objective function of the optimizer, and the optimal parameters of VMD were obtained through METLBO optimization. Next, these optimal parameters were adopted to decompose the fault signal into intrinsic modal functions (IMFs). For ensuring fault feature robustness, the eigenvectors were formed by the energy and envelope entropy of IMFs. Finally, the ISVM model was established for training and testing by adding an input layer to the SVM to perform soft thresholding on input data. METLBO was adopted to determine the optimal soft threshold values of features and hyper-parameters of ISVM. The experimental comparison analysis revealed the effectiveness of the proposed method for bearing fault diagnosis.

DEM numerical study on mechanical behaviour of coal with different water distribution models

Lihai Tan,Xin Cai,Ting Ren,Xiaohan Yang,Yichao Rui 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.80 No.5

The mechanical behaviour and stability of coal mining engineering underground is significantly affected by ground water. In this study, nuclear magnetic resonance imaging (NMRI) technique was employed to determine the water distribution characteristics in coal specimens during saturation process, based on which the functional rule for water distribution was proposed. Then, using discrete element method (DEM), an innovative numerical modelling method was developed to simulate water-weakening effect on coal behaviour considering moisture content and water distribution. Three water distribution numerical models, namely surface-wetting model, core-wetting model and uniform-wetting model, were established to explore the water distribution influences. The feasibility and validity of the surface-wetting model were further demonstrated by comparing the simulation results with laboratory results. The investigation reveals that coal mechanical properties are affected by both water saturation coefficient and water distribution condition. For all water distribution models, micro-cracks always initiate and nucleate in the water-rich area and thus lead to distinct macro fracture characteristics. With the increase of water saturation coefficient, the failure of coal tends to be less violent with less cracks and ejected fragments. In addition, the corewetting specimen is more sensitive to water than specimens with other water distribution models.

Therapeutic Effects and Adverse Drug Reactions are Affected by Icotinib Exposure and CYP2C19 and EGFR Genotypes in Chinese Non-Small Cell Lung Cancer Patients

Chen, Jia,Zheng, Xin,Liu, Dong-Yang,Zhao, Qian,Wu, Yi-Wen,Tan, Fen-Lai,Wang, Yin-Xiang,Jiang, Ji,Hu, Pei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

Background: The aim of this study was to evaluate how CYP2C19 affects icotinib and metabolite' exposure, and to determine whether the exposure and EGFR genotype influences survival time, tumor metastasis and adverse drug reactions. Materials and Methods: 274 NSCLC patients who accepted 125mg icotinib/t.i.d. were chosen from a phase III study. Blood samples were obtained in $672^{nd}$ ($4^{th}$ week) and $1,680^{th}$ hours ($10^{th}$ week), and plasma was used to quantify the concentration of icotinib and blood cells were sampled to check the genotypes. Clinical data were also collected at the same time, including EGFR genotypes. Plasma concentrations were assessed by HPLC-MS/MS and genotype by sequencing. All data were analyzed through SPSS 17.0 and SAS 9.2. Results: CYP 2C19 genotypes affected bio-transformation from icotinib to M24 and M26, especially in poor-metabolisers. Higher icotinib concentrations (>1000 ng/mL) not only increased patient PFS and OS but also reduced tumor metastasis. Patients with mutant EGFR experienced a higher median PFS and OS (234 and 627 days), especially those with the 19del genotype demonstrating higher PR ratio. Patients who suffered grade II skin toxicity had a higher icotinib exposure than those with grade I skin toxicity or no adverse effects. Liver toxic reactions might occur in patients with greater M20 and M23 plasma concentrations. Conclusions: CYP2C19 polymorphisms significantly affect icotinib, M24 and M26 exposure. Patients with mutant EGFR genotype and higher icotinib concentration might have increased PFS and OS and lower tumor metastasis. Liver ADR events and serious skin effects might be respectively induced by greater M20, M23 and icotinib concentrations.