Frequency and clinical features of deficient mismatch repair in ovarian clear cell and endometrioid carcinoma

Tamaki Tanaka,Kazuhiro Takehara,Natsumi Yamashita,Mika Okazawa-Sakai,Kazuya Kuraoka,Norihiro Teramoto,Kenichi Taguchi,Katsushige Yamashiro,Hidenori Kato,Tomoya Mizunoe,Rie Suzuki,Dan Yamamoto,Arisa Ue 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.5

Objective: To clarify the frequency of deficient mismatch repair (dMMR) in Japanese ovarian cancer patients, we examined microsatellite instability (MSI) status and immunohistochemistry (IHC) subtypes, including endometrioid carcinoma (EMC), clear cell carcinoma (CCC), or a mixture of both (Mix). Methods: We registered 390 patients who were diagnosed with EMC/CCC/Mix between 2006 and 2015 and treated at seven participating facilities. For 339 patients confirmed eligible by the Central Pathological Review Board, MSI, IHC, and MutL homolog 1 methylation analyses were conducted. The tissues of patients with Lynch syndrome (LS)-related cancer histories, such as colorectal and endometrial cancer, were also investigated. Results: MSI-high (MSI-H) status was observed in 2/217 CCC (0.9%), 10/115 EMC (8.7%), and 1/4 Mix (25%). Additionally, loss of MMR protein expression (LoE-MMR) was observed in 5/219 (2.3%), 16/115 (14.0%), and 1/4 (25%) patients with CCC, EMC, and Mix, respectively. Both MSI-H and LoE-MMR were found significantly more often in EMC (p<0.001). The median (range) ages of patients with MMR expression and LoE-MMR were 54 (30–90) and 46 (22–76) (p=0.002), respectively. In the multivariate analysis, advanced stage and histological type were identified as prognostic factors. Conclusion: The dMMR rate for EMC/CCC was similar to that reported in Western countries. In Japan, it is assumed that the dMMR frequency is higher because of the increased proportion of CCC.

Disinfection by Ozone Microbubbles Can Cause Morphological Change of Fusarium oxysporum f. sp. melonis Spores

Tamaki, Masahiko,Kobayashi, Fumiyuki,Ikeura, Hiromi,Sato, Michio The Korean Society of Plant Pathology 2018 Plant Pathology Journal Vol.34 No.4

To investigate the difference in the disinfectant efficiency of ozone microbubbles ($O_3MB$) and ozone millibubbles ($O_3MMB$), the morphological change of the treated Fusarium oxysporum f. sp. melonis spores was observed with scanning and transmission electron microscopies (SEM and TEM). The disinfectant efficiency of $O_3MB$ on F. oxysporum f. sp. melonis spores was greater than that of $O_3MMB$. On observation with SEM, it was revealed that morphological change of F. oxysporum f. sp. melonis spores was caused by $O_3MB$ and $O_3MMB$, and damage to the spore surfaces by $O_3MB$ occurred sooner than that by $O_3MMB$. On observation with TEM, it was furthermore confirmed that F. oxysporum f. sp. melonis spores treated with $O_3MB$ induced wavy deformation of cell membrane and the intracellular change different from that with $O_3MMB$. Therefore, the greater disinfection efficiency of $O_3MB$ was suggested to be caused due to the function of the MB in addition to the oxidative power of $O_3$.

Clinical Utility of Mac-2 Binding Protein Glycosylation Isomer in Chronic Liver Diseases

Tamaki Nobuharu,Kurosaki Masayuki,Loomba Rohit,Izumi Namiki 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.1

An accurate evaluation of liver fibrosis is clinically important in chronic liver diseases. Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel serum marker for liver fibrosis. In this review, we discuss the role of M2BPGi in diagnosing liver fibrosis in chronic hepatitis B and C, chronic hepatitis C after sustained virologic response (SVR), and nonalcoholic fatty liver disease (NAFLD). M2BPGi predicts not only liver fibrosis but also the hepatocellular carcinoma (HCC) development and prognosis in patients with chronic hepatitis B and C, chronic hepatitis C after SVR, NAFLD, and other chronic liver diseases. M2BPGi can also be used to evaluate liver function and prognosis in patients with cirrhosis. M2BPGi levels vary depending on the etiology and the presence or absence of treatment. Therefore, the threshold of M2BPGi for diagnosing liver fibrosis and predicting HCC development has to be adjusted according to the background and treatment status.

Study on Flow Fields in Variable Area Nozzles for Radial Turbines

Tamaki, Hideaki,Unno, Masaru Korean Society for Fluid machinery 2008 International journal of fluid machinery and syste Vol.1 No.1

The flow behind the variable area nozzle which corresponds to the flow at the leading edge of the impeller was measured with a 3-hole yaw probe and calculated with CFD. Two nozzle throat-areas were investigated. One is the smallest and the other is the largest opening for the variable nozzle. Test results agreed with the calculated results qualitatively. The leakage flow through the tip clearance of the nozzle vane significantly affected the flow field downstream of the nozzle vane with the smallest opening. However, the effect on leakage flow on the flow field downstream of the nozzle vane with the largest opening was very weak and the effect of wake is dominant.

Experimental Study on Surge Inception in a Centrifugal Compressor

Tamaki, Hideaki Korean Society for Fluid machinery 2009 International journal of fluid machinery and syste Vol.2 No.4

An investigation of surge inception in a centrifugal compressor was done with measurements of steady and unsteady static pressure. Vaneless diffuser and vaned diffuser were tested. Analyses of the static pressure and the pressure fluctuation showed that stall at the impeller leading edge occurred at first, and then it extended to downstream. In case of the vaneless diffuser, deterioration of the pressure rise in the impeller triggered instability. For the vande diffuser, instability that was generated in the impeller propagated into the vaned diffuser, however the pressure recovery by the vaned diffuser made the operation of the compressor stable at low flow rate.

Effect of piping systems on surge in centrifugal compressors

Hideaki Tamaki 대한기계학회 2008 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.22 No.10

There is a possibility that the exchange of the piping system may change the surge characteristic of a compressor. The piping system of a plant is not always the same as that of a test site. Then it is important to evaluate the effect of piping systems on surge characteristics in centrifugal compressors. Several turbochargers combined with different piping systems were tested. The lumped parameter model which was simplified to be solved easily was applied for the prediction of surge point. Surge lines were calculated with the linearlized lumped parameter model. The difference between the test and calculated results was within 10 %. Trajectory of surge cycle was also examined by solving the lumped parameter model. Mild surge and deep surge were successfully predicted. This study confirmed that the lumped parameter model was a very useful tool to predict the effect of piping systems on surge characteristics in centrifugal compressors, even though that was a simple model.

Study on flow fields in high specific speed centrifugal compressor with unpinched vaneless diffuser

Hideaki Tamaki 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.6

Performance of centrifugal compressors strongly depends on their internal flow fields. CFD has become indispensable tool for getting the information about flow fields in centrifugal compressors. CFD codes are usually validated by some representative data or compared with calculated results by other CFD codes, in order to ensure their accuracies. However, learning their accuracies for all types of centrifugal compressor’s specifications requires continuous works that compare experimental data obtained in developmental processes of various types of centrifugal compressors with CFD results. A prediction of a performance and a flow field of a centrifugal compressor by CFD is relatively accurate when the impact of separation and secondary flow on that flow field is weak, i.e. near design condition. Centrifugal compressors are deemed to have a wide operating range alongside high efficiencies at design points. Hence the prediction accuracy of CFD at off design conditions, where the impacts of separation and secondary flow on the flow field are strong, is critical for the design of the centrifugal compressors. This study therefore investigated the prediction accuracy of CFD using a centrifugal compressor whose geometry was intentionally changed to have a distorted flow field over a whole operating range, i.e. from choke to surge.

New Topics of dental casting investment

Yukimichi TAMAKI 대한치과재료학회 2005 대한치과기재학회 학술대회 Vol.2005 No.11

DEVELOPMENTOF HIGH-EFFICIENCY DIRECT INJECTION DIESEL ENGINE BY CAVITATION INSIDE NOZZLE HOLE AND DISTURBANCE OF LIQUID FLOW

( N Tamaki ) 한국액체미립화학회 2014 한국액체미립화학회 학술강연회 논문집 Vol.2014 No.-

Diesel engine in internal combustion engine has the highest thermal efficiency and it leads to reduce carbon dioxide caused by global warming. However, it is demanded to reduce mainly nitrogen oxide NOx and soot emission in order to improve combustion efficiency and to progress thermal efficiency. Final objects of this study are to improve combustion efficiency and to reduce exhaust gas emission concentration by improvement of spray characteristics of injection nozzle for a direct injection Diesel engine. The author`s laboratory group has investigated that at first, it is to clarify dominant factor on atomization of liquid jet and spray, the second, it is to develop high-efficiency atomization enhancement nozzle, that is, development of the nozzle, which almost same spray characteristics at low-injection pressure is obtained ones of high-injection pressure in combustion of fuel spray. On previous researches including author`s studies, it was clarified that cavitation in the nozzle hole is dominant factor of atomization of liquid jet and spray. The author`s group has investigated about improvement of spray and flow characteristics of a direct injection Diesel nozzle by using cavitation phenomena and by changing only part of the nozzle hole. In usual, magnified-nozzle, for instance, 10 times magnified-acrylic nozzle is used to observe and to investigate mutual relationships between internal flow inside the nozzle hole and disintegration behavior of spray, because it is difficult to visualize clear cavitating flow inside the actual size nozzle hole. Therefore, it is necessary to observe and investigate about mutual relationships of internal flow in the nozzle hole and atomization of spray between magnified-nozzle and scaled-up nozzle for design high-efficiency atomization enhancement nozzle. Moreover, in case it thought about the matter in terms of energy saving and effective utilization of petroleum resources, effects of kinematic viscosity of liquid on internal flow in the nozzle hole and atomization of spray was studied. In general, although twin-fluid atomizer is used for atomization of high-viscosity liquid, possibility of atomization by using pressure atomized type nozzle like that a Diesel nozzle was studied from a point of view of energy saving. Moreover, direct injection Diesel nozzles are used a single hole nozzle and multi-hole nozzle with four or six hole numbers. In case Diesel nozzle, which is on the market, was used for engine, it has reported from some automobile makers that different spray characteristics, that is, mainly spread of sprays, spray tip penetration and droplet size distributions are different at each nozzle holes. This results lead to become worse spray characteristics and combustion characteristics, and then, it leads to affect exhaust gas characteristics. At that, the author`s group has designed that gathered multi-hole spray, which the same spray like that Diesel injection nozzle as sprays injected from actual multi-hole nozzle, has been obtained by dividing one nozzle hole into four nozzle holes. Furthermore, nozzles, which was dressed with round inlet cutting at inlet or outlet of the nozzle holes, and the nozzle, which inclined nozzle holes of multi-hole nozzle from vicinity of center of nozzle to outside of one, were used, authors have tried to improve dramatically spray characteristics and flow characteristics. Finally, when spread of intermittent spray of the nozzle with round inlet cutting at inlet of the nozzle hole becomes considerably large compared with the previous single hole nozzle under high-ambient pressure of Pa=1.6 MPa and ambient temperature of Ta=300 K; almost same conditions at just before top dead center of actual Diesel engine.

Wideband Optical Isolator for 1.5 μm Band Using ( TbBi )3 Fe5O12 Grown By solid-Phase reaction Method

T. Tamaki,N. Ishii,M. Imaeda,T. Yoshino,Y. Kozuka,K. Takizawa 한국통신학회 1997 OPTOELECTRONICS & COMMUNICATIONS CONFERENCE Vol.2 No.1