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Atlantoaxial Stabilization Using C1 and C2 Laminar Screw Fixation
Takashi Tsuji,Kazuhiro Chiba,Yosuke Horiuchi,Tadahisa Urabe,Shota Fujita,Morio Matsumoto 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.2
We describe the use of a C1 laminar screw in combination with a C2 laminar screw as a salvage technique to treat two patients, one with persistent first intersegmental artery and the other with vertebral artery occlusion after cervical spine fracture. The combined use of C1 and C2 laminar screws allows for good fixation of the atlantoaxial joint with a lower risk of vertebral artery injury; therefore, it can be an alternative surgical procedure for patients with congenital or traumatic anomalous vertebral artery.
Visible-light-driven photocatalytic water oxidation catalysed by iron-based metal–organic frameworks
Horiuchi, Yu,Toyao, Takashi,Miyahara, Kenta,Zakary, Lionet,Van, Dang Do,Kamata, Yusuke,Kim, Tae-Ho,Lee, Soo Wohn,Matsuoka, Masaya The Royal Society of Chemistry 2016 Chemical communications Vol.52 No.29
<P>An iron-based metal-organic framework, MIL-101(Fe), promotes photocatalytic water oxidation to produce oxygen from aqueous silver nitrate solution under visible-light irradiation. The finely dispersed iron-oxo clusters embedded as nodes of the porous framework would contribute importantly to the efficient promotion of the reaction as compared to bulk hematite (alpha-Fe2O3).</P>
Toyao, Takashi,Miyahara, Kenta,Fujiwaki, Mika,Kim, Tae-Ho,Dohshi, Satoru,Horiuchi, Yu,Matsuoka, Masaya American Chemical Society 2015 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.119 No.15
<P>A catalytically competent Cu species has been immobilized within the framework of a Zr-based metal–organic framework with bipyridine units, Zr-MOF-bpy, by a simple postsynthetic modification method from CuBr<SUB>2</SUB> (Zr-MOF-bpy-CuBr<SUB>2</SUB>) and used for the selective oxidation of cyclooctene to cyclooctene oxide. Zr-MOF-bpy was synthesized by a simple solvothermal method and was shown to have a UiO-type structure. Diffuse reflectance UV–vis and XAFS measurements have revealed that the immobilized Cu species has a square-planar geometry of two N atoms and two Br atoms. Zr-MOF-bpy-CuBr<SUB>2</SUB> catalyzed the selective oxidation of cyclooctene to cyclooctene oxide with high activity and selectivity in the presence of <I>tert</I>-butyl hydroperoxide as an oxidant. In addition, the catalytic ability of Zr-MOF-bpy-CuBr<SUB>2</SUB> was demonstrated to be superior to that of the corresponding homogeneous catalyst ((bpy)CuBr<SUB>2</SUB>). It was also confirmed that Zr-MOF-bpy-CuBr<SUB>2</SUB> can be reused as a heterogeneous catalyst without significant loss of its activity and selectivity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2015/jpccck.2015.119.issue-15/jp512749y/production/images/medium/jp-2014-12749y_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp512749y'>ACS Electronic Supporting Info</A></P>
Toyao, Takashi,Ueno, Nana,Miyahara, Kenta,Matsui, Yasunori,Kim, Tae-Ho,Horiuchi, Yu,Ikeda, Hiroshi,Matsuoka, Masaya The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.89
<P>A Zr-based metal-organic framework with tetrakis(carboxyphenyl)porphyrin groups (Zr-MOF-TCPP: MOF-525) has been utilized as a photoredox catalyst to promote oxidative hydroxylation of arylboronic acids under green LED light irradiation. Zr-MOF-TCPP displays a superior catalytic activity for this process over the corresponding homogeneous catalyst (H4TCPP).</P>
Tumor necrosis factor-α converting enzyme is a key mediator of abdominal aortic aneurysm development
Kaneko, Hidehiro,Anzai, Toshihisa,Horiuchi, Keisuke,Kohno, Takashi,Nagai, Toshiyuki,Anzai, Atsushi,Takahashi, Toshiyuki,Sasaki, Aya,Shimoda, Masayuki,Maekawa, Yuichiro,Shimizu, Hideyuki,Yoshikawa, Tsu Elsevier 2011 Atherosclerosis Vol.218 No.2
<P><B>Abstract</B></P><P><B>Objective</B></P><P>Tumor necrosis factor (TNF)-α is known to be elevated in plasma and the aorta in abdominal aortic aneurysm (AAA) patients. We sought to clarify the role of TNF-α converting enzyme (Tace), which cleaves the transmembrane precursor of TNF-α, in AAA development.</P><P><B>Methods</B></P><P>We obtained aortic sample of AAA during surgical operation to assess the histological features and protein expression of human AAA. AAA was induced in mice with temporal systemic deletion of Tace by the inducible Mx-1 Cre transgene (TaceMx1) and in wild-type littermates (CON) by periaortic application of CaCl<SUB>2</SUB> (AAA/TaceMx1, AAA/CON).</P><P><B>Results</B></P><P>Tace expression was increased in human AAA samples as compared with normal aorta. Six weeks postoperatively, aortic diameter in AAA/TaceMx1 was decreased than in AAA/CON in association with attenuated TNF-α expression and extracellular matrix disruption. Increased activities of matrix metalloproteinase (MMP)-9 and MMP-2, numbers of Mac-2-positive macrophages, CD3-positive T lymphocytes and CD31-positive vessels in periaortic tissues, mRNA expression of CD68, monocyte chemotactic protein-1, TNF-α, vascular endothelial growth factor-A, p47 and glutathione peroxidases, and protein expression of phospho-c-Jun N-terminal kinase in AAA were all attenuated by Tace deletion. Protein expression of transforming growth factor (TGF)-β1 was upregulated by Tace deletion in sham-operated mice. TGF-β1 expression was further increased in AAA/TaceMx1.</P><P><B>Conclusions</B></P><P>Tace was overexpressed in the aortic wall in human and experimental AAA. Temporal systemic deletion of Tace prevented AAA development in association with attenuating inflammation, oxidative stress, neoangiogenesis and extracellular matrix disruption, suggesting a crucial role of Tace in AAA development.</P>
Naoki Kakuta,Ryuichi Nakano,Akiyo Nakano,Yuki Suzuki,Ayako Tanouchi,Takashi Masui,Saori Horiuchi,Shiro Endo,Risako Kakuta,Yasuo Ono,Hisakazu Yano 대한진단검사의학회 2020 Annals of Laboratory Medicine Vol.40 No.1
Background: Mutations in the quinolone resistance-determining regions (QRDRs) of Acinetobacter baumannii DNA gyrase (gyrA) and topoisomerase IV (parC) are linked to fluoroquinolone (FQ) resistance. We developed a mismatched PCR-restriction fragment length polymorphism (RFLP) assay to detect mutations in the gyrA and parC QRDRs associated with FQ resistance in A. baumannii. Methods: Based on the conserved sequences of A. baumannii gyrA and parC, two primer sets were designed for mismatched PCR-RFLP to detect mutations in gyrA (codons 83 and 87) and parC (codons 80 and 84) by introducing an artificial restriction enzyme cleavage site into the PCR products. This assay was evaluated using 58 A. baumannii strains and 37 other Acinetobacter strains that have been identified by RNA polymerase β-subunit gene sequence analysis. Results: PCR amplification of gyrA and parC was successful for all A. baumannii strains. In 11 FQ -susceptible strains, the gyrA and parC PCR products were digested by the selected restriction enzymes at the site containing gyrA (codons 83 and 87) and parC (codons 80 and 84). PCR products from 47 FQ-resistant strains containing mutations in gyrA and parC were not digested by the restriction enzymes at the site containing the mutation. As for the non-baumannii Acinetobacter strains, although amplification products for gyrA were obtained for 28 strains, no parC amplification product was obtained for any strain. Conclusions: This assay specifically amplified gyrA and parC from A. baumannii and detected A. baumannii gyrA and parC mutations with FQ resistance.