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Ok Taedong,Yoon Pyeong Ho,Kim Gyu Sik,Seo Kwon-Duk 대한의학회 2022 Journal of Korean medical science Vol.37 No.50
Background: Mechanical thrombectomy (MT) of ischemic stroke was recommended as a clinical guideline in 2015, and the indication for time was expanded in 2018 based on two clinical studies. We aimed to compare and analyze the prognosis of patients treated under the extended time indication before and after the introduction of advanced software. Methods: We obtained data from medical records between 2016 to 2020. From 2016 to 2017, patients who did not receive MT who visited the hospital within 24 hours from the last normal time (LNT) were classified as standard medical treatment (SMT) group. Among patients who underwent MT between 2019 and 2020, patients who visited the hospital between 6-24 hours from the LNT were classified into the extended MT (EMT) group. Good outcome was defined as 3-months modified rankin scale (mRS) ≤ 2, and a poor outcome as mRS ≥ 4. Results: From 2016 to 2017, 1,058 patients were hospitalized for ischemic stroke, of which 60 (5.7%) received MT, and 27 patients were classified into the SMT group. Among 1,019 patients between 2019 and 2020, 85 (8.3%) received MT, and 24 patients were in the EMT group. Among the SMT group, only 3 had a good prognosis, and 24 (88.9%) had a poor prognosis. However, in the EMT group, 10 (41.7%) had a good prognosis, and 9 (37.5%) had a poor prognosis. The SMT group had a 49.1 times higher risk of poor prognosis compared to the EMT group (P = 0.008). Conclusion: The number of patients with ischemic stroke who receive MT has increased by using advanced imaging software. It was confirmed that patients treated based on the extended time indication also had a good prognosis.
Ok Taedong,Seo Kwon-Duk,Lee Il Hyung 대한신경중재치료의학회 2024 Neurointervention Vol.19 No.1
A rupture of a femoral pseudoaneurysm is an extremely rare complication of endovascular procedures, but its outcome can be life-threatening. In this report, we present a case of a femoral pseudoaneursym rupture in a patient in their early 90s following intra-arterial mechanical thrombectomy for acute ischemic stroke. Despite receiving medical and surgical interventions, the patient subsequently developed multiple organ failure, ultimately resulting in death. This case emphasizes the critical role of appropriate selection of vascular closure technique and careful post-procedural monitoring, particularly in high-risk patients.
Delayed Migration of Tapered Open-Cell Design Carotid Stent: A Case Report
Lee Il Hyung,Ok Taedong,Jung Yo Han,Lee Kyung-Yul,Suh Sang Hyun 대한신경중재치료의학회 2023 Neurointervention Vol.18 No.3
We present a case of delayed migration of an open-cell design carotid stent, which is a rare complication following carotid artery stenting (CAS). A 65-year-old patient with carotid artery stenosis underwent CAS with an open-cell stent, initially achieving successful deployment. However, 4 months later, the stent migrated and resulted in restenosis. The patient underwent balloon angioplasty and received an additional stent, leading to improved blood flow. The rarity of stent migration, particularly in the absence of risk factors, highlights the need for clinicians to be vigilant and consider early imaging follow-up for patients at risk of this complication after CAS.
Kim, Kyung Hwan,Ok, Taedong,Lee, Kwangyeol,Lee, Hee-Seung,Chang, Kyu Tae,Ihee, Hyotcherl,Sohn, Jeong-Hun American Chemical Society 2010 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.132 No.34
<P>Herein we present the long-sought quantitative catalyst−substrate association relationships based on experimentally measured quantitative association preferences of diverse metathesis Mo and Ru catalysts (<B>Mo-1</B>, Schrock Mo; <B>Mo-2</B>, Schrock−Hoveyda Mo; <B>Ru-1</B>, Grubbs first generation Ru; <B>Ru-2</B>, Grubbs second generation Ru; <B>Ru-3</B>:, Grubbs−Hoveyda first generation Ru; and <B>Ru-4</B>, Grubbs−Hoveyda second generation Ru) to their substrates (alkenes, alkynes and allenes), determined directly by a general method based on FRET principle. The determined substrate preferences are proved to be dependent on the molecular identity of the catalyst, exhibiting the preference order of alkyne > alkene > allene for <B>Mo-1</B> and <B>Mo-2</B>, allene > alkene > alkyne for <B>Ru-1</B> and <B>Ru-3</B>, and alkyne > allene > alkene for <B>Ru-2</B> and <B>Ru-4</B>. The results enable us to probe metathesis mechanisms by answering issues in metathesis reactions including the controversial reaction initiation in enyne or allenyne metathesis.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2010/jacsat.2010.132.issue-34/ja104193s/production/images/medium/ja-2010-04193s_0001.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja104193s'>ACS Electronic Supporting Info</A></P>
Byeong Joo Choi,Taedong Ok,Yunjung Choi,이경열 대한신경초음파학회 2022 대한신경초음파학회지 (JNN) Vol.14 No.1
Cytotoxic edema at the site of a lesion following cerebral infarction is shown as a high signal on diffusion-weighted imaging, with a corresponding decreased apparent diffusion coefficient value on magnetic resonance imaging. These imaging findings have been used clinically as imaging markers of the infarction core, implying irreversible ischemic damage. However, reversal of diffusion lesions has been reported in patients with small lesions, relatively higher values of the apparent diffusion coefficient, or rapid endovascular reperfusion. Herein, we report a case of reversal of a large ischemic lesion on diffusion-weighted imaging with corresponding low apparent diffusion coefficient values in an acute middle cerebral artery infarction after immediate spontaneous recanalization. This case suggests that large ischemic lesions revealed by diffusion-weighted imaging may be reversed upon timely reperfusion, and could be considered as therapeutic targets.
Bionanosphere Lithography via Hierarchical Peptide Self-Assembly of Aromatic Triphenylalanine
Han, Tae Hee,Ok, Taedong,Kim, Jangbae,Shin, Dong Ok,Ihee, Hyotcherl,Lee, Hee-Seung,Kim, Sang Ouk WILEY-VCH Verlag 2010 Small Vol.6 No.8
<P>A nanolithographic approach based on hierarchical peptide self-assembly is presented. An aromatic peptide of N-(t-Boc)-terminated triphenylalanine is designed from a structural motif for the β-amyloid associated with Alzheimer's disease. This peptide adopts a turnlike conformation with three phenyl rings oriented outward, which mediate intermolecular π–π stacking interactions and eventually facilitate highly crystalline bionanosphere assembly with both thermal and chemical stability. The self-assembled bionanospheres spontaneously pack into a hexagonal monolayer at the evaporating solvent edge, constituting evaporation-induced hierarchical self-assembly. Metal nanoparticle arrays or embossed Si nanoposts could be successfully created from the hexagonal bionanosphere array masks in conjunction with a conventional metal-evaporation or etching process. Our approach represents a bionanofabrication concept that biomolecular self-assembly is hierarchically directed to establish a straightforward nanolithography compatible with conventional device-fabrication processes.</P> <B>Graphic Abstract</B> <P>A bionanosphere lithography method based on hierarchical peptide self-assembly is presented. The N-(t-Boc)-terminated triphenylalanine is designed for spherical nanoassembly. This peptide hierarchically assembles into a hexagonal monolayer of bionanospheres upon solvent evaporation. Highly crystalline, thermally stable triphenylalanine assembly is successfully employed as lithographic mask for metal or silicon nanopatterning. <img src='wiley_img_2010/16136810-2010-6-8-SMLL200902050-content.gif' alt='wiley_img_2010/16136810-2010-6-8-SMLL200902050-content'> </P>
Seo, Yeo-Jin,Lim, Jisoo,Lee, Eun-Hae,Ok, Taedong,Yoon, Juyoung,Lee, Joon-Hwa,Lee, Hee-Seung Oxford University Press 2011 Nucleic acids research Vol.39 No.16
<P>Peptide nucleic acids (PNA) are one of the most widely used synthetic DNA mimics where the four bases are attached to a <I>N</I>-(2-aminoethyl)glycine (<I>aeg</I>) backbone instead of the negative-charged phosphate backbone in DNA. We have developed a chimeric PNA (<I>chi</I>PNA), in which a chiral GNA-like γ<SUP>3</SUP>T monomer is incorporated into <I>aeg</I>PNA backbone. The base pair opening kinetics of the <I>aeg</I>PNA:DNA and <I>chi</I>PNA:DNA hybrid duplexes were studied by NMR hydrogen exchange experiments. This study revealed that the <I>aeg</I>PNA:DNA hybrid is much more stable duplex and is less dynamic compared to DNA duplex, meaning that base pairs are opened and reclosed much more slowly. The site-specific incorporation of γ<SUP>3</SUP>T monomer in the <I>aeg</I>PNA:DNA hybrid can destabilize a specific base pair and its neighbors, maintaining the thermal stabilities and dynamic properties of other base pairs. Our hydrogen exchange study firstly revealed the unique kinetic features of base pairs in the <I>aeg</I>PNA:DNA and <I>chi</I>PNA:DNA hybrids, which will provide an insight into the development of methodology for specific DNA recognition using PNA fragments.</P>