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( Tae Hoon Yim ),( Jee Seon Kim ),( Byung Chul Kim ),( Hak Ro Kim ),( Sungjin Choi ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Mefenamic acid is a widely used nonsteroidal anti-in. ammatory drug and its hypersensitivity reaction such as bronchial obstruction, wheals and angioedema is well known, but few cases of fixed drug eruption due to mefenamic acid have been reported. Here we report a case of fixed drug eruption simultaneously with angioedema after exposure to mefenamic acid. Case: A 34-year-old female came to our hospital with complaints of itching and erythematous skin lesions on her right axillar and left foot with diffuse swelling of upper lip. She took medicines 3 days ago for fiu-like symptoms and experienced fixed drug eruption and angioedema simultaneously the next day. Past medical history revealed that she had allergic rhinitis and similar experiencies twice over three year. Laboratory test including serum total IgE and allergen-specific IgE using the Immuno CAP was unremarkable. We reviewed the drugs she was prescribed and performed oral provocation test using aspirin and mefenamic acid. Mefenamic acid was the causative drug of fixed drug eruption and angioedema without cross-reactivity with aspirin. she was informed about the use of mefenamic acid. Conclusion: The fact that the patient do not show cross reactivity with aspirin suggests that immunological mechanism mediated by IgE may be involved in the development of angioedema not by COX inhibition mechanism. We report a rare case of fixed drug eruption due to mefenamic acid simultaneously with angioedema which might be mediated with immunological mechanism
Acute Myocardial Infarction with Simultaneous Thrombosis of Multiple Coronary Arteries
Tae Hoon Yim,Jee Seon Kim,Byung Chul Kim,Hak Ro Kim,Tae Jin Kim,Young Bok Kim 순천향대학교 순천향의학연구소 2015 Journal of Soonchunhyang Medical Science Vol.21 No.1
Simultaneous thrombosis of multiple coronary arteries in acute myocardial infarction is very rare in clinical settings. Its mechanism is not yet clear, but patients displaying multivessel simultaneous thrombosis tend to have poor clinical outcomes. Hence, it is important to recognize this condition and provide timely and proper management. We report a case of simultaneous thrombosis involving multiple coronary arteries in a patient with ST-segment elevation myocardial infarction.
( Sun Young Yim ),( Tae Hyung Kim ),( Suh Sang Jun ),( Eun Sun Kim ),( Bora Keum ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Yoon Tae Jeen ),( Hoon Jai Chun ),( Hong Sik Lee ),( Soon Ho Um ),( Chang Duck 대한간학회 2017 Gut and Liver Vol.11 No.3
Background/Aims: We aimed to clarify the association of hepatitis B surface antigen (HBsAg)/hepatitis B core antigen (HBcAg) with the disease status and treatment response in patients with chronic hepatitis B (CHB). Methods: We investigated 171 biopsy-proven entecavir-treated CHB patients (109 hepatitis B e antigen [HBeAg]-positive, 62 HBeAg-negative). HBcAg expression was positive when ≥10% of hepatocytes stained, and classified into nuclear, mixed, and cytoplasmic patterns. HBsAg expressions were intracytoplasmic (diffuse, globular, and submembranous) and membranous. The histologic activity index (HAI) and fibrosis stage followed Ishak system. Results: In HBeAg-positive patients, older age, increased HAI score, advanced fibrosis, and reduced viral load were observed when HBcAg expression shifted from nucleus to cytoplasm in HBcAg-positive patients, and HBsAg expression from non-submembranous to submembranous in HBcAg-negative patients (all, p<0.05). In HBeAg-negative patients, only intracytoplasmic HBsAg expression patterns had clinical relevance with decreased ALT levels and viremia. In HBeAg-positive patients without favorable predictors of virologic response, negative HBcAg and membranous HBsAg expression predicted greater virologic response (both, p<0.05). The probability of HBeAg seroclearance was higher in patients with increased HAI or lacking HBcAg expression (both, p<0.05). Higher serum HBsAg levels and hepatocyte HBcAg positivity were associated with reduced serum HBsAg during first and post-first year treatment, respectively (both, p<0.05). Conclusions: Hepatocyte HBcAg/HBsAg expression is a good marker for disease status and predicting treatment response. (Gut Liver 2017;11:417-425)
Yim, Yeong Shin,Choi, Jin-sil,Kim, Gun Tae,Kim, Chul Hoon,Shin, Tae-Hyun,Kim, Dong Goo,Cheon, Jinwoo The Royal Society of Chemistry 2012 Chemical communications Vol.48 No.1
<p>This study provides an easy and simple method to obtain inorganic nanoparticles that can penetrate the blood–brain barrier, the heavily guarded system in the brain, <I>via</I> cross-linked serum albumin surface coatings. Their intact BBB permeability was confirmed in both <I>in vitro</I> and <I>in vivo</I> tests.</p> <P>Graphic Abstract</P><P>Through a simple surface coating with serum albumin, inorganic nanoparticles can enter into brain across blood-brain barrier. Such penetration ability is confirmed with in vitro and in vivo studies. <img src='http://pubs.rsc.org/ej/CC/2011/c1cc15113d/c1cc15113d-ga.gif'> </P>
Yim, Sun Young,Um, Soon Ho,Jung, Jin Young,Seo, Yeon Seok,Yim, Hyung Joon,Ryu, Ho Sang,Chun, Hoon Jai,Jeen, Yoon Tae,Kim, Chang Duck,Keum, Bora,Lee, Hong Sik RAVEN PRESS PUBLISHERS 2014 JOURNAL OF CLINICAL GASTROENTEROLOGY Vol.48 No.2
BACKGROUND:: Inactive and active phases of hepatitis B e antigen-negative chronic hepatitis B virus (HBV) infection are diagnosed by serum HBV DNA levels, with cutoff at 2000 IU/mL. However, it is difficult to distinguish inactive carriers at a single time point because HBV DNA levels can transiently decrease to <2000 IU/mL even in noninactive carriers. GOALS:: We aimed to establish the role of serum hepatitis B surface antigen (HBsAg) in identifying “true inactive carriers” among treatment-naive genotype C HBV-infected patients with low viremia. STUDY:: A total of 133 hepatitis B e antigen-negative carriers with serum HBV DNA levels of <2000 IU/mL and normal alanine aminotransferase levels were enrolled and followed up for >12 months. RESULTS:: Forty patients (30.1%) were classified as noninactive carriers (HBV DNA ≥2000 IU/mL and/or alanine aminotransferase >40 IU/L) during 12 months from enrollment. No baseline serum HBV DNA levels could identify true inactive carriers with 100% specificity, whereas baseline serum HBsAg levels (50 IU/mL) identified true inactive carriers with 100% specificity and 29% detection rate. Detection rate increased when different cutoff levels were applied to different age groups according to median age (46 y). It was comparable in both younger and older groups (37.2% vs. 38%) even when HBsAg cutoff level was increased in the former (400 vs. 50 IU/mL). Furthermore, none reversed to noninactive phase during long-term follow-up when these cutoff levels were applied. CONCLUSIONS:: Baseline serum HBsAg levels at a single time point can identify persistently true inactive carriers, with different cutoff levels according to age.
Comparison of Prognostic Efficacy of Acute Kidney Injury Criteria in Patients with Liver Cirrhosis
( Tae Hyung Kim ),( Yeon Seok Seo ),( Seung Woon Park ),( Han Ah Lee ),( Sang Jung Park ),( Sang Jun Suh ),( Young Kul Jung ),( Ji Hoon Kim ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ),( S 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Development of acute kidney injury (AKI) is closely associated with mortality in patients with liver cirrhosis. Recently, several new definitions of AKI were published. This study was performed to compare the efficacy of several definitions of AKI for predicting prognosis in cirrhotic patients. Methods: Cirrhotic patients who hospitalized to our hospital were enrolled. Patients with hepatocellular carcinoma and parenchymal kidney disease were excluded. AKI was defined by conventional, RIFLE, and KDIGO criteria. Results: A total of 696 cirrhotic patients were enrolled. Age was 54.1±10.7 years and 526 patients (75.6%) were men. Child-Pugh and MELD scores were 8.7±2.4 and 15.5±6.9, respectively. During follow-up, 155 patients died. Six and 12 months mortality rates were 10.7% and 14.2%, respectively. Among all patients, 22 (3.2%), 29 (4.2%), and 52 (7.5%) patients fulfilled the criteria of AKI of conventional, RIFLE, and KDIGO definitions, respectively. Survival time differed significantly between patients without and with AKI according to the conventional (92.3±2.1 vs 18.7±6.2 months, P<0.001), RIFLE (92.3±2.2 vs 42.8±11.2 months, P<0.001), and KDIGO (94.0±2.2 vs 44.0±8.3 months, P<0.001) criteria. Both conventional and KDIGO criteria were fulfilled in 22 patients (3.2%), while 30 patients (4.3%) fulfilled only KDIGO criteria. There was a trend of worse prognosis in patients who fulfilled both conventional and KDIGO criteria than those who only fulfilled KDIGO criteria (18.7±6.2 vs 53.3±11.1 months, P=0.051). Both RIFLE and KDIGO criteria were fulfilled in 29 patients (4.2%), while 23 patients (3.3%) fulfilled only KDIGO criteria. Survival did not differ between patients who fulfilled both RIFLE and KDIGO criteria and those who fulfilled only KDIGO criteria (42.8±11.2 vs 30.1±7.7 months, P=0.106). Conclusions: KDIGO criteria for AKI predicted survival in cirrhotic patients more accurately compared to conventional and RIFLE criteria. Our results suggest that even subtle changes in the serum creatinine level requires close attention in these patients.
A Microelectrode Study of Interfacial Reactions at the Platinum-Alkaline Polymer Interface
Yim, Sung-Dae,Chung, Hoon T.,Chlistunoff, Jerzy,Kim, Dae-Sik,Fujimoto, Cy,Yang, Tae-Hyun,Kim, Yu Seung The Electrochemical Society 2015 Journal of the Electrochemical Society Vol.162 No.6
<P>Hydrogen oxidation (HOR) and oxygen reduction (ORR) reactions at the platinum/alkaline ionomer interface were investigated using two different alkaline polymer electrolytes, i.e., benzyl-trimethyl ammonium tethered poly(phenylene) (ATM-PP) and phenyl-pentamethyl guanidinium tethered perfluorinated polymer (M-Nafion-FA-TMG). Substantial inhibition of HOR was taking place at the platinum-ATM-PP interface due to the possible cationic group adsorption of ATM-PP, whereas the reaction was virtually unaffected at the platinum-M-Nafion-FA-TMG interface after high anodic potential preconditioning. Moreover, the apparent ORR activity of platinum coated with M-Nafion-FA-TMG was found higher than that in 0.1 M tetra methyl guanidinium solution. In addition, the oxygen permeability of M-Nafion-FA-TMG was found to be ∼2.5 times higher than that of ATM-PP. The above properties of the perfluorinated polymer make it a very promising ionomeric binder for the use in both anode and cathode of alkaline membrane fuel cells.</P>
( Tae Hyung Kim ),( Yeon Seok Seo ),( Han Ah Lee ),( Jung Mi Chang ),( Hyun Gil Goh ),( Dae Hoe Gu ),( Sang Jun Suh ),( Young Kul Jung ),( Ji Hoon Kim ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Considering the frequency and prognostic impact of acute kidney injury (AKI) in cirrhotic patients, early detection and appropriate management are very important. AKI could be divided into prerenal azotemia (PRA) and acute tubular necrosis (ATN). Although appropriate management is quite different between two conditions, appropriate tests for differentiation have not been presented. Urinary-N-acetyl- β-D-glucosaminidase (NAG) have been proposed as a good tubular injury marker in many studies, but its efficacy is not clear in cirrhotic patients. This study was performed to evaluate the usefulness of urinary NAG in cirrhotic patients. Methods: Hospitalized patients with liver cirrhosis who performed urinary NAG test from September 2016 to February 2017 were included. The patients with malignancy or chronic kidney disease were excluded. AKI was defined by IAC-AKI criteria. Results: A total of 59 cirrhotic patients were included. Age was 58.8±12.0 years and 41 patients (69.5%) were men. Serum creatinine and urinary NAG scores were 1.0±0.3 mg/dL and 30.0±29.6 U/g urinary Cr, respectively. AKI was not combined in 41 patients (69.5%), while PRA and ATN were combined in 15 (25.4%) and 3 (5.1%) patients, respectively. Serum creatinine level was significantly higher in patients with PRA (1.6±0.2 mg/dL, P<0.001) and those with ATN (1.5±0.4 mg/dL, P=0.002) than those without AKI (0.8±0.2 mg/dL), while it did not differ between patients with PRA and those with ATN (P=0.422). Urinary NAG level was comparable between patients without AKI and those with PRF (22.6±15.6 vs. 38.2±40.6 U/g urinary Cr, P=0.241), while it was significantly higher in patients with ATN (88.5±46.9 U/g urinary Cr) than those without AKI (P=0.001) and those with PRA (P=0.025). Conclusions: The urinary NAG level was significantly increased in patients with ATN in patients with liver cirrhosis. It could be useful for discrimination of cirrhotic patients with ATN among those with AKI.
Determination of the Cause of Pleural Effusion in ICU Patients with Thoracentesis
Tae Yun Park,이진우,Young Sik Park,Chang-Hoon Lee,Jae-Joon Yim,Chul-Gyu Yoo,Young Whan Kim,Sung Koo Han,Seok-Chul Yang,이상민 대한중환자의학회 2012 Acute and Critical Care Vol.27 No.4
Background: Pleural effusion is a common and important problem in the intensive care unit (ICU). However, only few studies have focused on the etiology of pleural effusion in the ICU. The aim of this study is to elucidate the etiology of pleural effusion in ICU patients in a tertiary care hospital. Methods: Patients with pleural effusion in the medical ICU (MICU) and in the emergency ICU (EICU) were studied retrospectively from January 1, 2006 to December 31, 2009. The etiology and profile of pleural effusion were analyzed. Results: Of 1,592 patients admitted to the MICU and EICU during the study period, 78 patients (4.8%) underwent thoracentesis. The mean age was 66.8 ± 13.3 years, and 52 (66.7%) were men. Parapneumonic effusion (32/78, 41%) was the leading cause of all effusions; malignancy- and heart failure-related effusions accounted for 15 (19.2%) and 14 (17.7%) cases, respectively. Fifteen patients (19.2%) had tube insertion after thoracentesis; in these patients, parapneumonic effusion or empyema was the most common reason for drainage (9/15, 60%). Pneumothorax developed after thoracentesis in 2 patients. Conclusions: Diagnostic thoracentesis was performed in 4.8% of patients admitted to the ICU; one-fifth of these cases required therapeutic drainage. Parapneumonic effusion was the most common cause of pleural effusion in the ICU in this study.