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Age-Related Decline in Oligodendrogenesis Retards White Matter Repair in Mice
Miyamoto, Nobukazu,Pham, Loc-Duyen D.,Hayakawa, Kazuhide,Matsuzaki, Toshinori,Seo, Ji Hae,Magnain, Caroline,Ayata, Cenk,Kim, Kyu-Won,Boas, David,Lo, Eng H.,Arai, Ken American Heart Association, Inc. 2013 Stroke Vol.44 No.9
<P><B>Background and Purpose—</B></P><P>Aging is one of the major risk factors for white matter injury in cerebrovascular disease. However, the effects of age on the mechanisms of injury/repair in white matter remain to be fully elucidated. Here, we ask whether, compared with young brains, white matter regions in older brains may be more vulnerable in part because of decreased rates of compensatory oligodendrogenesis after injury.</P><P><B>Methods—</B></P><P>A mouse model of prolonged cerebral hypoperfusion was prepared by bilateral common carotid artery stenosis in 2-month and 8-month-old mice. Matching in vitro studies were performed by subjecting oligodendrocyte precursor cells to sublethal 7-day CoCl<SUB>2</SUB> treatment to induce chemical hypoxic stress.</P><P><B>Results—</B></P><P>Baseline myelin density in the corpus callosum was similar in 2-month and 8-month-old mice. But after induction of prolonged cerebral hypoperfusion, older mice showed more severe white matter injury together with worse deficits in working memory. The numbers of newborn oligodendrocytes and their precursors were increased by cerebral hypoperfusion in young mice, whereas these endogenous responses were significantly dampened in older mice. Defects in cyclic AMP response element-binding protein signaling may be involved because activating cyclic AMP response element-binding protein with the type-III phosphodiesterase inhibitor cilostazol in older mice restored the differentiation of oligodendrocyte precursor cells, alleviated myelin loss, and improved cognitive dysfunction during cerebral hypoperfusion. Cell culture systems confirmed that cilostazol promoted the differentiation of oligodendrocyte precursor cells.</P><P><B>Conclusions—</B></P><P>An age-related decline in cyclic AMP response element-binding protein–mediated oligodendrogenesis may compromise endogenous white matter repair mechanisms, and therefore, drugs that activate cyclic AMP response element-binding protein signaling provide a potential therapeutic approach for treating white matter injury in aging brains.</P>
Construction for Ontology of Domain Terms and Tasks (ODT<sup>2</sup>)
Miyamoto, Junya,Kawabata, Ryo,Itoh, Kiyoshi The Korean Institute of Electrical Engineers 2013 The Journal of International Council on Electrical Vol.3 No.1
This papers proposes Diagram for Ontology of Domain Terms and Tasks (referred to as $DODT^2$) in order to visualize Ontology. $DODT^2$ is divided into two diagrams. The first diagram is Diagram for Ontology of Domain Tasks (referred to as DODTasks). DODTasks visualize Ontology of Domain Tasks represented in Case Grammar. A component of this diagram describes a term which corresponds to each case of Case Grammar. In addition, to respond to any of various situations, three notations for DODTasks are proposed: Conditional Branch, Parallel Execution, and Random Order. The second diagram is Diagram for Ontology of Domain Terms (referred to as DODTerms). DODTerms represents the super-/sub-relation of Domain Terms. Moreover, to assist Construction of Ontology, the author implemented $DODT^2$ Editor. It can edit $DODT^2$. $DODT^2$ Editor involves functions to help construction of Ontology.
Sensitivity analysis of mechanical behaviors for bridge damage assessment
Miyamoto, Ayaho,Isoda, Satoshi Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.41 No.4
The diagnosis of bridge serviceability is carried out by a combination of in-situ visual inspection, static and dynamic loading tests and analyses. Structural health monitoring (SHM) using information technology and sensors is increasingly being used for providing a better estimate of structural performance characteristics rather than above traditional methods. Because the mechanical behavior of bridges with various kinds of damage can not be made clear, it is very difficult to estimate both the damage mode and degree of damage of existing bridges. In this paper, the sensitivity of both static and dynamic behaviors of bridges are studied as a measure of damage assessment through experiments on model bridges induced with some specified artificial damages. And, a method of damage assessment of bridges based on those behaviors is discussed in detail. Finally, based on the results, a possible application for structural health monitoring systems for existing bridges is also discussed.
Miyamoto, Tomofumi,Yamamoto, Atsushi,Sakai, Maki,Tanaka, Hiroyuki,Shoyama, Yukihiro,Higuchi, Ryuichi The Korean Society for Marine Biotechnology 2006 한국해양바이오학회지 Vol.1 No.4
In this study, we establish a thin-layer chromatography (TLC) immunostaining method for detecting starfish gangliosides. A new monoclonal antibody (MAb) against AG-2, the major gangliosides molecular species of Acanthaster planci, was produced by fusing hybridoma with splenocytes immunized to liposomal AG-2. BALB/c male mice were injected with liposomal AG-2 antigen, and immunized. Their splenocytos were isolated and fused with hypoxanthine-aminopterine-thimidine (HAT)-sensitive mouse myeloma cells. Hybridomas producing MAb reactive to AG-2 were cloned using the limited dilution method. Established hybridomas were cultured in eRDF medium. Crude MAb produced from clone 8D4 was purified with a magnesium pyrophosphate column. Enzyme immunoassay and TLC immunostaining of AG-2 were performed using the purified MAb. Structurally related gangliosides did not cross-react with anti-AG-2 antibodies. The detection limit of TLC immunostaining was 50 ng of AG-2. The newly established immunostaining method was further developed for detecting AG-2 distribution and qualitative analysis in tissues and/or organs. Our results show that the majority of AG-2 is present in the stomach of male A. planci, while AG-2 is distributed not only in the stomach but also in the the pyloric caeca of female A. planci.