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척추마취시 Midazolam 과 Diazepam 의 진정작용에 대한 비교
김미운,김성태,김혜경 대한마취과학회 1991 Korean Journal of Anesthesiology Vol.24 No.3
Midazolam, a water soluble benzodiazepine, was compared with diazepam as a sedation for spinal anesthesia. Forthy healthy patients were allocated at random to receive midazolam 0.1mg/kg or diazepam 0.2mg/kg at 15 min after tetracaine inction for spinal anesthesia and increments of half of the initial dose every 2 min to induce sleep. Mean dose of midazolam 8.5 mg and diazepam 17.1 mg were injected for sedation throughout surgery. There was no difference concerning sedation level during surgery and speed of recovery. With the same degree of sedation, midazolam produced a higher frequency of anterograde amnesia(70% vs. 30%). Uenous tolerance was better for midazolam. Neither drug caused obstruction of airway nor significant cardiovascular change. Higher degree of amnesia and venous tolerance with midazolam may be advantages of sedation for spinal anesthesia.
Kim, Min-Soo,Jung, Ui-Won,Kim, Sungtae,Lee, Jung-Seok,Lee, In-Seop,Choi, Seong-Ho Korean Academy of Periodontology 2013 Journal of Periodontal & Implant Science Vol.43 No.1
Purpose: The purpose of this study was to evaluate the osseointegration of calcium phosphate (CaP)-coated implants by ion beam assisted deposition with a lack of primary stability. Methods: A total of 20 CaP-coated implants were bilaterally placed in the mandible of five dogs. In the rotational implant group, the implants were inserted in oversized drilled sockets without mechanical engagement, while the conventional surgical protocol was followed in the control group. Each group was allowed to heal for 4 and 8 weeks. The bone-to-implant contact (BIC, %) was measured by a histometric analysis. Results: All of the implants were well-maintained and healing was uneventful. In the histologic observation, all of the implants tested were successfully osseointegrated with a high level of BIC at both observation intervals. There was no significant difference in BIC among any of the groups. Conclusions: Within the limitation of this study, successful osseointegration of CaP-coated implants could be achieved in unfavorable conditions without primary stability.
Kim, Dae-Hyun,Kim, Hyun Ju,Kim, Sungtae,Koo, Ki-Tae,Kim, Tae-Il,Seol, Yang-Jo,Lee, Yong-Moo,Ku, Young,Rhyu, In-Chul Korean Academy of Periodontology 2018 Journal of Periodontal & Implant Science Vol.48 No.2
Purpose: The purpose of this retrospective study with 4-12 years of follow-up was to compare the marginal bone loss (MBL) between external-connection (EC) and internal-connection (IC) dental implants in posterior areas without periodontal or peri-implant disease on the adjacent teeth or implants. Additional factors influencing MBL were also evaluated. Methods: This retrospective study was performed using dental records and radiographic data obtained from patients who had undergone dental implant treatment in the posterior area from March 2006 to March 2007. All the implants that were included had follow-up periods of more than 4 years after loading and satisfied the implant success criteria, without any peri-implant or periodontal disease on the adjacent implants or teeth. They were divided into 2 groups: EC and IC. Subgroup comparisons were conducted according to splinting and the use of cement in the restorations. A statistical analysis was performed using the Mann-Whitney U test for comparisons between 2 groups and the Kruskal-Wallis test for comparisons among more than 2 groups. Results: A total of 355 implants in 170 patients (206 EC and 149 IC) fulfilled the inclusion criteria and were analyzed in this study. The mean MBL was 0.47 mm and 0.15 mm in the EC and IC implants, respectively, which was a statistically significant difference (P<0.001). Comparisons according to splinting (MBL of single implants: 0.34 mm, MBL of splinted implants: 0.31 mm, P=0.676) and cement use (MBL of cemented implants: 0.27 mm, MBL of non-cemented implants: 0.35 mm, P=0.178) showed no statistically significant differences in MBL, regardless of the implant connection type. Conclusions: IC implants showed a more favorable bone response regarding MBL in posterior areas without peri-implantitis or periodontal disease.
Evaluation Model of Defense Information Systems Use
Sungtae Kim,Hanjun Lee,Hyukjin Kwon,Sangho Lee 한국정보기술융합학회 2015 JoC Vol.6 No.1
The Republic of Korea’s Ministry of National Defense (ROK-MND) has developed various defense information systems, and most of the projects for the development of such information systems are now in their completion or maintenance stage. Because information system (IS) use is a precondition to get the benefit and it can show what IS should be improved, measuring IS use is important. In this study, we benchmarked ISO/IEC 25010 and a guideline of Korean government for operational performance of information systems. We proposed the framework that can measure the degree of IS use with three perspectives such as task support, relevant information provision, and user convenience from the viewpoint of users, and conducted an evaluation of defense information systems with it. Moreover, we classified the defense information systems into four groups by two dimensions such as the status of use and the frequency of maintenance demand, and then made suggestions for better management of IS in each classification.
Kim, Hee-Young,Jeon, Hyongjun,Kim, Hyungwoo,Koo, Sungtae,Kim, Seungtae Frontiers Media S.A. 2018 FRONTIERS IN AGING NEUROSCIENCE Vol.10 No.-
<P><I>Sophora flavescens</I> Aiton (SF) has been used to treat various diseases including fever and inflammation in China, South Korea and Japan. Several recent reports have shown that SF has anti-inflammatory and anti-apoptotic effects, indicating that it is a promising candidate for treatment of Parkinson’s disease (PD). We evaluated the protective effect of SF against neurotoxin 1-methyl-4-phenylpyridinium ion (MPP<SUP>+</SUP>)-induced mitochondrial dysfunction in SH-SY5Y human neuroblastoma cells, an <I>in vitro</I> PD model. SH-SY5Y cells were incubated with SF for 24 h, after which they were treated with MPP<SUP>+</SUP>. MPP<SUP>+</SUP>-induced cytotoxicity and apoptosis were confirmed by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling assay. MitoSOX red mitochondrial superoxide indicator, tetramethylrhodamine methyl ester perchlorate and Parkin, PTEN-induced putative kinase 1 (PINK1), and DJ-1 immunofluorescent staining were conducted to confirm the mitochondrial function. In addition, western blot was performed to evaluate apoptosis factors (Bcl-2, Bax, caspase-3 and cytochrome c) and mitochondrial function-related factors (Parkin, PINK1 and DJ-1). SF suppressed MPP<SUP>+</SUP>-induced cytotoxicity, apoptosis and collapse of mitochondrial membrane potential by inhibiting the increase of reactive oxidative species (ROS) and DNA fragmentation, and controlling Bcl-2, Bax, caspase-3 and cytochrome <I>c</I> expression. Moreover, it attenuated Parkin, PINK1 and DJ-1 expression from MPP<SUP>+</SUP>-induced decrease. SF effectively suppressed MPP<SUP>+</SUP>-induced cytotoxicity, apoptosis and mitochondrial dysfunction by regulating generation of ROS, disruption of mitochondrial membrane potential, mitochondria-dependent apoptosis and loss or mutation of mitochondria-related PD markers including Parkin, PINK1 and DJ-1.</P>
Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups
Kim, Dongsoo,Bae, Chang-Hwan,Jun, Ye Lee,Jeon, Hyongjun,Koo, Sungtae,Kim, Seungtae Springer-Verlag 2017 CHINESE JOURNAL OF INTEGRATIVE MEDICINE Vol.23 No.12
<P>Acupuncture stimulation at HT 7 can alleviate the behavioral impairment and changes of the cytokines by MS, indicating that acupuncture can help to relieve MS-induced depression.</P>
Kim, Sulhee,Chang, Hyeyoon,Hwang, Jin wook,Kim, Sungtae,Koo, Ki-Tae,Kim, Tae-Il,Seol, Yang-Jo,Lee, Yong-Moo,Ku, Young,Lee, Jong-Ho,Rhyu, In-Chul Korean Academy of Periodontology 2017 Journal of Periodontal & Implant Science Vol.47 No.6
Purpose: The purpose of this study was to investigate the feasibility of regenerative therapy with a collagenated bone graft and resorbable membrane in intrabony defects, and to evaluate the effects of the novel extracellular matrix (ECM)-based membrane clinically and radiologically. Methods: Periodontal tissue regeneration procedure was performed using an ECM-based resorbable membrane in combination with a collagenated bovine bone graft in intrabony defects around the teeth and implants. A novel extracellular matrix membrane (NEM) and a widely-used membrane (WEM) were randomly applied to the test group and the control group, respectively. Cone-beam computed tomography images were obtained on the day of surgery and 6 months after the procedure. Alginate impressions were taken and plaster models were made 1 week and 6 months postoperatively. Results: The quantity of bone tissue, the dimensional changes of the surgically treated intrabony defects, and the changes in width and height below the grafted bone substitutes showed no significant difference between the test and control groups at the 6-month examination. Conclusions: The use of NEM for periodontal regeneration with a collagenated bovine bone graft showed similar clinical and radiologic results to those obtained using WEM.