Age-Associated Molecular Changes in the Kidney in Aged Mice

Lim, Ji Hee,Kim, Eun Nim,Kim, Min Young,Chung, Sungjin,Shin, Seok Joon,Kim, Hyung Wook,Yang, Chul Woo,Kim, Yong-Soo,Chang, Yoon Sik,Park, Cheol Whee,Choi, Bum Soon Hindawi Publishing Corporation 2012 Oxidative medicine and cellular longevity Vol.2012 No.-

<P><I>Background</I>. Aging is a multifactorial process characterized by a progressive decline in physiological function. Decreased kidney function is associated with cardiovascular disease and mortality. Therefore, increasing our insight into kidney aging by understanding the anatomic, physiologic, and pathologic changes of aging in the kidney is important to prevent disastrous outcomes in elderly people. <I>Methods</I>. Male two-, 12-, and 24-month-old C57/BL6 mice were used in this study. We measured histological change, oxidative stress, and aging-related protein expression in the kidneys. <I>Results</I>. Twenty-four-month-old mice displayed increased albuminuria. Creatinine clearance decreased with aging, although this was not statistically significant. There were increases in mesangial volume and tubulointerstitial fibrosis in 24-month-old mice. There were also increases in F4/80 expression and in apoptosis detected by TUNEL assay. Urine isoprostane excretion increased with aging and SOD1 and SOD2 were decreased in 24-month-old mice. Oxidative stress may be mediated by a decrease in Sirt1, PGC-1<I><I>α</I></I>, ERR-1<I><I>α</I></I>, and PPAR<I><I>α</I></I> expression. Klotho expression also decreased. <I>Conclusions</I>. Our results demonstrate that Sirt1 was decreased with aging and may relate to changed target molecules including PGC-1<I><I>α</I></I>/ERR-1<I><I>α</I></I> signaling and PPAR<I><I>α</I></I>. Klotho can also induce oxidative stress. Pharmacologically targeting these signaling molecules may reduce the pathologic changes of aging in the kidney.</P>

왜 다문화교육이 한국의 신학생들에게 필요한가?

Sungjin Chang 한국선교신학회 2017 선교신학 Vol.48 No.-

한국의 이주민의 증가와 현저한 다문화 현상이 나타나는 것을 통하여 현 교육 시스템에 다문화교육을 통합해 보려는 것은 한국사회에서도 도전적 인 부분이다. 이러한 상황에서 저자는 한국의 신학교육이 빠르게 변화하는 목회현장과 선교 상황에서 다문화주의에 대한 학습을 시작할 필요가 있다고 생각한다. 이를 위해 ‘양적 연구’를 시행하였으며 3일 동안 진행되었던 프로그램인 ‘다문화목회’와 한 시간 동안 시행되었던 강의인, ‘다문화 선교’ 전과 후에 설문조사를 통하여 신학생들(38명의 장로회 신학대학원생과 50명의 한신대학교 학부생 및 대학원생)의 이해를 조사하였고 여기서 모아진 자료를 가지고 SPSS (사회과학을 위한 통계적 패키지) 프로그램을 사용하여 분류하고 조사하여 몇 가지 효과적인 결과를 도출하였다. 이는 다문화 교육이 가능한 한 빨리 신학생들에게 필요하다는 사실을 말해준다. Shown by an increasing number of immigrants and the remarkable phenomena of multiculturalism in Korea, integrating multicultural education into the current education system is challenging for the Korean society. In this situation, it seems to the author that theological education in Korea needs to begin to incorporate the study of multiculturalism in a rapidly changing pastoral field and a transforming mission situation. For this, Quantitative Research was conducted to figure out the current understanding of theological students (38 of Presbyterian Seminary and 50 of Hanshin University) by questionnaires, before and after a three-day program on “Multicultural Ministry” and a one-hour lecture, “Multicultural Mission”, and there are some effective results from sorting and analyzing the data of SPSS. This leads to the conclusion that multicultural education is a must for theological students in Korea, and that education programs should be implemented as soon as possible.

Nafcillin-Induced Bullous Skin Eruption with Granulocytopenia in a Patient with End-Stage Renal Disease

Chang, Mine-Ok,Sil Koh, Eun,Ju Kim, Min,Joon Shin, Seok,Whee Park, Cheol,Sik Chang, Yoon,Chung, Sungjin The Japanese Society of Internal Medicine 2012 Internal medicine Vol.51 No.3

<P>Nafcillin is an antibiotic used for infections due to penicillin-resistant <I>Staphylococcus aureus</I>. In general, the adverse reactions to nafcillin have not been frequent and serious. We report here a new type of adverse reaction to nafcillin in a patient with end-stage renal disease in whom nafcillin caused the unexpected complication of bullous drug eruption and subseqent neutropenia. Three weeks after the start of intravenous nafcillin for the treatment of peritoneal dialysis peritonitis, the patient developed blisters on his right ankle. These became progressive and widespread, with bullae affecting most of the body surface. In addition, neutropenia developed three days after the appearance of bullous skin lesions. Spontaneous recovery of skin lesions and neutropenia was observed after the withdrawal of naficillin. When treating patients with chronic renal failure, physicians should be aware of these rare but potentially severe adverse reactions.</P>

Toward Discovering the Hidden Women`s History Concerning the Role of Women in Mission

Chang, Christine Sungjin 한국기독교학회 2007 한국기독교신학논총 Vol.51 No.-

리차드 십즈의 설교에 나타난 가시적 교회 -개혁주의생명신학적 적용

장성진 ( Sungjin Chang ) 개혁주의생명신학회 2015 생명과 말씀 Vol.11 No.-

이 글에서는 영국 청교도 신학자 리차드 십즈(Richard Sibbes, 1577- 1635)의 설교문들에 나타난 가시적 교회 이해를 다룬다. 십즈가 가시적교회 내의 신자들과 목회자들이 가시적 교회 안에서 발견되는 세상적요소 때문에 절망에 빠질 때가 많다는 사실을 전제한다. 하지만 십즈는 가시적 교회를 긍정적 관점에서 보고자 한다. 이 글의 목적은 그의 긍정적 관점의 근거가 교회의 완성을 보증하시는 그리스도의 재림에 대한 종말론적 소망에 있음을 보여주는데 있다. 십즈가 가시적 교회를 사랑하고, 그의 설교를 통해 신자들을 양육할 수 있었던 이유가 바로 여기에 있다. 십즈는 가시적 교회가 불완전함을 당연하게 여기지만, 가시적 교회 내에서 그리스도인의 긍정적 측면을 격려하는 편을 선호한다. 그러나 가시적 교회를 향한 십즈의 낙관주의가 가시적 교회 내의 신자들의 성화 과정에서서 인간의 책임이 있다는 점을 시하는 것은 아니다. 십즈가 가시적 교회를 전투하는 교회로 이해하고, 가시적 교회가악과 유혹에 맞서 맹렬히 싸워야 할 필요가 있다고 강조하는 이유가 바로 여기에 있다. 동시에 십즈는 그리스도를 소망하는 신자들의 삶에서 예견되고 그리스도의 재림에서 성취되는 영적 전투의 승리를 확고히 하고자 한다. 물론 가시적 교회는 때로 영적 전투에서 일시적으로 패배하기도 한다. 이 글은 십즈가 그러한 패배에 대해 내놓는 해결책들을 일부 보여준다. 십즈는 우리에게 가시적 교회의 연약함을 더 이상 감추지 말라고 조언한다. 가시적 교회의 연약함은 드러나고 고백될 때, 가시적 교회가 하나님께 도움을 구하며 나아가는 출발점이 된다. This writing deals to the concept of visible church in the sermons of Richard Sibbes (1577-1635), an English puritan theologian. Sibbes assumes that saints and ministers in visible churches often fall into despair because of worldly elements found in visible churches. However, he tries to see visible churches not from negative, but from positive perspective. The purpose of this article is to show that his attempt is done from the eschatological hope for church which ensures his positive perspective. An victory ensured by Christ will be realized in the end. That is why Sibbes was able to love visible churches and upbring believers through his sermons. Sibbes takes it for granted to find imperfections in visible churches but he prefers to encourage positive aspects of Christian life in visible churches. However, it should be emphasized that Sibbes’ optimism towards visible churches does not mean ignoring human responsibility in the process of sanctification of the believers in visible churches. That is whySibbes understands visible churches as combating churches and emphasizes the need to fight fiercely against evils and temptations in them. At the same time, Sibbes wants to ensure the victory of the spiritual battle anticipated in the life of believers with hope for Christ and achieved in the second coming of Christ, even though visible churches sometimes suffer from temporary defeats of spiritual battle. This article shows some resolutions to the defeats suggested by Sibbes. Sibbe advises us to stop hiding weaknesses of visible churches. When revealed and confessed the weaknesses of visible churches are staring points for visible churches to turn to God for their help.

Limited Feedback Precoding for Wireless MIMO Broadcast Channels

Sungjin Kim,Hojin Kim,Chang Soon Park,Kwang Bok Lee 한국통신학회 2005 한국통신학회 학술대회 및 강연회 Vol.2005 No.4

GOLGA2/GM130, cis-Golgi Matrix Protein, is a Novel Target of Anticancer Gene Therapy

Chang, Seung-Hee,Hong, Seong-Ho,Jiang, Hu-Lin,Minai-Tehrani, Arash,Yu, Kyeong-Nam,Lee, Jae-Ho,Kim, Ji-Eun,Shin, Ji-Young,Kang, Bitna,Park, Sungjin,Han, Kiwon,Chae, Chanhee,Cho, Myung-Haing Elsevier Science B.V., Amsterdam 2012 MOLECULAR THERAPY Vol.20 No.11

Binary mask designs with single- and double-layer absorber stacks for extreme ultraviolet lithography and actinic inspection

Park, Sungjin,Lim, Jai Dong,Peranantham, Pazhanisami,Kang, Hee Young,Hwangbo, Chang Kwon,Lee, SuYoung,Kim, Seong-Su The Optical Society 2014 Applied Optics Vol.53 No.4

<P>In this study, we propose binary mask (BIM) designs with single- and double-layer absorber stacks with high optical contrast at a wavelength of 13.5?nm for use in extreme ultraviolet lithography (EUVL) and actinic defect inspection. The optimum thickness of the absorber stack was estimated using a method based on the transfer matrix. In the double-layer designs, [Ag/SnTe] has a minimum thickness of 32??nm with almost 100% optical contrast compared to the TaN layer. In addition, a SnTe absorber layer was deposited using radio frequency magnetron sputtering. The optical constant of the SnTe layer at 13.5?nm wavelength was determined using the density of the layer, which was obtained from x-ray reflectivity measurements. The reflectance of the SnTe single-layer absorber stack was measured in the EUV region and compared with the simulated reflectance by using the calculated optical constants. The results show that the new BIM designs for EUVL and actinic inspection can be helpful in reducing the geometric shadow effect compared to the TaN absorber layer with a thickness of 70??nm.</P>

개방식 장치를 이용한 난연성-가연성 이성분계 혼합물(CCl₄+o-Xylene and CCl₄+p-Xylene)의 인화점 측정

김창섭(Chang-Seob Kim),이성진(Sungjin Lee),하동명(Dong-Myeong Ha) 한국에너지학회 2015 에너지공학 Vol.24 No.4

Exposure to pesticides and the prevalence of diabetes in a rural population in Korea

Park, Sungjin,Kim, Sung-Kyung,Kim, Jae-Yeop,Lee, Kyungsuk,Choi, Jung Ran,Chang, Sei-Jin,Chung, Choon Hee,Park, Kyu-Sang,Oh, Sung-Soo,Koh, Sang-Baek Elsevier 2019 Neurotoxicology Vol.70 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Among the adverse health effects of exposure to pesticides, an association with diabetes has been reported. However, there is a lack of epidemiologic studies on the health effects of exposure to pesticides, particularly investigating the association between occupational pesticide exposure and diabetes prevalence.</P> <P><B>Purpose</B></P> <P>The present study examined the association between pesticide exposure and prevalence of diabetes in a rural population in Korea.</P> <P><B>Methods</B></P> <P>This cross-sectional study used data from the Korea Farmers Cohort study, and included 2559 participants in the baseline survey between November 2005 and January 2008. We performed a clinical examination including blood sampling and assessed data on diabetes diagnosis, demographics, and pesticide exposure. Logistic regression was performed to evaluate the association between pesticide exposure and diabetes prevalence, adjusting for age, sex, monthly income, and marital status. In addition, a stratified analysis by body mass index (BMI) was conducted, with two categories: normal weight (<25 kg/m<SUP>2</SUP>) and overweight or obese (≥25 kg/m<SUP>2</SUP>).</P> <P><B>Results</B></P> <P>At baseline, the prevalence of diabetes was 9.30%. Pesticide exposure was associated with the risk of diabetes after adjustment for covariates. In the analysis stratified by BMI, all the variables related to pesticide exposure were associated with prevalence of diabetes in the overweight or obese group, whereas no significant association was found in the normal weight group.</P> <P><B>Conclusion</B></P> <P>Exposure to pesticides was associated with diabetes, and this association was stronger in overweight or obese individuals than in normal weight individuals. Further longitudinal studies that consider information on BMI are necessary.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We report an association between pesticide exposure and diabetes in Korean adults. </LI> <LI> The association was stronger in overweight/obese than in normal weight people. </LI> <LI> Pesticide use may contribute to high rates of diabetes. </LI> </UL> </P>