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KIM, SUNG-BAE,KIM, JI-EUN,KANG, OK-HWA,MUN, SU-HYUN,SEO, YUN-SOO,KANG, DA-HYE,YANG, DA-WUN,RYU, SHI-YONG,LEE, YOUNG-MI,KWON, DONG-YEUL UNKNOWN 2015 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.35 No.5
<P>Human skin is the first line of defense for the protection of the internal organs of the body from different stimuli. Ultraviolet B (UVB), one of the harmful radiations for skin, is widely known to induce abnormally increased cytokine release from keratinocytes leading to inflammatory skin disorders. IL-6 and IL-8 induce an acute-phase response and stimulate leukocyte infiltration in the skin. Previous studies have shown that chronic exposure to UVB radiation increases cyclooxygenase-2 (COX?2) expression through various cell signaling pathways, resulting in skin cancer. Recent studies have shown that the activation of extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38 MAPK is strongly correlated with acute inflammation and development of skin cancer caused by an increased expression of COX-2. Ixerisoside A (IXA) is an active constituent of Ixeris dentata of the Compositae (Asteraceae) family. The effect of IXA on skin inflammation has yet to be elucidated. To determine the anti-inflammatory effects of IXA, we examined its effect on UVB-induced pro-inflammatory cytokine production in human keratinocytes (HaCaT cells) by observing these cells in the presence or absence of IXA. In this study, pro-inflammatory cytokine production was determined by enzyme-linked immunosorbent assay (ELISA), reverse transcription-polymerase chain reaction (rt-pcr), and western blot analysis to evaluate the activation of mitogen-activated protein kinases (MAPKs). IXA inhibited UVB-induced production of the pro-inflammatory cytokines IL-6 and IL-8 in a dose-dependent manner. Moreover, IXA inhibited the expression of COX-2, ERK, JNK, and p38 MAPKs, indicating that the secretion of the pro-inflammatory cytokines IL-6 and IL-8, and COX-2 expression was inhibited by blocking MAPK phosphorylation. These results indicated that IXA potentially protects against UVB-induced skin inflammation.</P>
Kim, Byung Soo,Seo, Jae Hong,Choi, Chul Won,Shin, Sang Won,Kim, Yeul Hong,Kim, Jun Suk 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.1
배경: laminar air flow(LAF) 무균실을 설치하는데 드는 막대한 비용은 조혈모세포이식환자들의 의료비용을 상승시키는 한 요인으로 작용하고 있다. 방법: 저자 등은 LAF 무균실 대신에 무균실의 요건인 BioLogical Clean Room Class 100만을 만족시키는 LAF 텐트를 일반 1인실에 장착하였다. 본고에서는 LAF 텐트의 보호격리 효과를 보고자한다. 결과: 46명이 LAF 텐트에서 조혈모세포이식을 시행받았다. 전체 생착율은 97.8%(45/46)이었다. 발열을 경험한 25명 (54.3%, 평균 기간은 4.5일)중 1명을 제외하고는 모두 적절한 항균치료로 회복되었다. 동종 조혈모세포이식을 시행받은 환자들 중 CMV 감염은 38.9%(7/18)에서 발생하였고 pre-emptive gancyclovir 투여로 치유되었으며, 급성 이식편대숙주반응은 22.2%(4/18)에서 관찰되었고 적절한 면역억제제치료로 조절이 가능하였다. 텐트에서 퇴원후, 22명 (47.8%)이 양호한 느낌을, 9명(19.6%)이 보통 느낌을 보고하였다. 나쁜 느낌을 호소한 15명(32.6%) 중 14명이 발열을, 3명이 급성 이식편대숙주반응을 경험한 바 있었다. 텐트에 입원 중, 76.1%(35/46)이 밀폐감을, 47.8%(22/46)이 시끄러움을 호소하였지만 모두 조절이 가능하였다. 결론: 본 연구결과는 일반 1인실에 장착한 Class 100 청정도의 LAF 텐트는 LAF 무균실에 버금가는 기능을 지니고 있음을 암시할 수 있다고 사료된다. Background: High cost for setting up laminar air flow(LAF) unit room is a cause that hematopoietic stem cell transplantation (HSCT) patients should bear the excessive expense. Methods: We installed an inexpensive LAF plastic tent, which met standard requirement of BioLogical Clean Room Class 100, in a simple single room as a substitute of LAF unit room. The protective isolation effect of LAF plastic tent is reported, here. Results: Forty-six HSCT patients were enrolled in this study. Overall engaftment rate was 97.8%(45/46). Fever was developed in 25 patients (54.3%) and mean duration was 4.5days. All of them except one were recovered with appropriate antimicrobial therapies . Among allogeneic HSCT patients, 38.9%(7/18) showed CMV-infection curable by preemptive ganciclovir therapy and 22.2%(4/18) underwent acute GVHD controllable with immunosuppressive therapy. 22 (47.8%) patients represented excellent of good feeling and 9 (19.6%) patients expressed common feeling. In 15 (32.6%) patients with bad of grave feeling, fourteen were suffered from fever and three underwent acute GVHD. Oppressive (35/46, 76.1%) and noisy (22/46, 47.8%) sensation could be alleviated by encouragement and medication. Conclusoin: These data may suggest that the LAF plastic tent placed in a simple single room have a function next to LAF unit isolation room.
Kim, Seung T,Choi, Yoon J,Park, Kyong H,Oh, Sang C,Seo, Jae H,Shin, Sang W,Kim, Jun S,Kim, Yeul H Blackwell Pub. Asia 2011 Asia-Pacific journal of clinical oncology Vol.7 No.1
<P>Aim:??There has been limited data on capecitabine monotherapy in metastatic colorectal cancer (CRC) patients who were previously treated with both oxaliplatin/5-fluorouracil(FU)/leucovorin (FOLFOX) and irinotecan/5-FU/leucovorin (FOLFIRI). Methods:??We analyzed 20 patients between August 2002 and March 2008 with metastatic CRC who had been treated with capecitabine monotherapy after the failure of FOLFOX and FOLFIRI. Results:??Overall, one partial response was observed (overall response rate, 5%) and stable disease was observed in 11 patients (55.0%). The disease control rate was 60.0%. The median progression-free survival (PFS) was 2.3?onths (95% CI 1.9-2.7) and the median overall survival (OS) was 5.3?onths (95% CI 4.6-6.0). Patients without ascites had longer PFS than those with ascites (P????.02). Patients with more than three metastatic sites had poorer OS than those with less than two (P????.01). Grade 3 or 4 non-hematological toxicities included hand-foot syndrome in one patient. There were no grade 3 or 4 hematological toxicities or treatment-related deaths. Conclusion:??The capecitabine monotherapy had a moderate disease control rate and a tolerable toxicity profile as third-line or fourth-line treatment for metastatic CRC patients who were refractory to standard chemotherapy with no further treatment options.</P>
Effect of Pore Size on the High Temperature Oxidation of Ni-Fe-Cr-Al Porous Metal
Sung-Hwan Choi,Song-Yi Kim,Jung-Yeul Yun,Byoung-Kee Kim,이기안,공영민 대한금속·재료학회 2011 METALS AND MATERIALS International Vol.17 No.2
This study investigated the effect of the pore size of Ni-22.4%Fe-22%Cr-6%Al porous metal on its hightemperature oxidation. Two types of open porous metals with pore sizes of 800 μm and 580 μm were used. A 24-hour isothermal oxidation test was conducted at three different temperatures of 900 °C, 1000 °C, and 1100 °C under a 79% N_2 + 21% O2 atmosphere. The results of the BET analysis revealed that the specific surface area increased as the pore size decreased from 800 μm to 580 μm. The high- temperature oxidation results showed that porous metals exhibited far lower levels of oxidation resistance compared with bulk metals,and that the oxidation resistance of porous metals decreased with a decreasing pore size. According to the microstructural observations of the oxide layers, the 900 °C and 1000 °C oxidation layer contained Ni, Cr,and Al oxides mainly on the strut. The 800 μm porous metal strut exhibited similar oxidation behavior at 1100 °C to that found at lower temperatures. In contrast, the 580 μm porous metal strut was found to consist of Ni and Fe oxides in the upper layer and Ni, Cr, and Al oxides in the lower layer, representing a low oxidation resistance. For powders affixed to the strut inside the porous metal, a different oxide-forming behavior from that of the strut was observed. In addition, the Ni-Fe-Cr-Al porous metal high- temperature oxidation microscopic mechanism is also discussed.
No Association between PIK3CA Polymorphism and Lung Cancer Risk in the Korean Population
Sung, Jae-Sook,Park, Kyong-Hwa,Kim, Seung-Tae,Seo, Jae-Hong,Shin, Sang-Won,Kim, Jun-Suk,Kim, Yeul-Hong Korea Genome Organization 2010 Genomics & informatics Vol.8 No.4
The PIK3CA gene, oncogenic gene located on human chromosome 3q26.3, is an important regulator of cell proliferation, death, motility and invasion. To evaluate the role of PIK3CA gene in the risk of Korean lung cancer, genotypes of the PIK3CA polymorphisms (rs11709323, rs2699895, rs3729679, rs17849074 and rs1356413) were determined in 423 lung cancer patients and 443 normal controls. Statistical analyses revealed that the genotypes and haplotypes in the PIK3CA gene were not significantly associated with the risk of lung cancer in the Korean population, suggesting that these PIK3CA polymorphisms do not contribute to the genetic susceptibility to lung cancer in the Korean population.
Kim, Hye Sook,Lee, Soon Wook,Choi, Yoon Ji,Shin, Sang Won,Kim, Yeul Hong,Cho, Min Sun,Lee, Soon Nam,Park, Kyong Hwa Korean Cancer Association 2015 Cancer Research and Treatment Vol.47 No.3
<P>We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a <I>BRCA1</I> gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the <I>BRCA1</I> gene: 277_279delinsCC (Phe93fs). It is a novel <I>BRCA1</I> mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer.</P>