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Postoperative Radiation for Soft Tissue Sarcoma
Kang,Yong-Koo,Kim,Hyoung-Min,Bahk,Won-Jong,Lee,Seong-Koo,Kim,Yun-Sil,Kim,Jung-Mang,Moon,Myung-Sang,Woo,Young-yun,Chang,Jee-Young,Yoon,Se-Chul,Song,Seok-Whan 가톨릭중앙의료원 가톨릭암센터 1994 암심포지움 Vol.- No.2
To evaluate the role of radiation and chemotherapy after limb-saving operation in the management of soft tissue sarcoma, the authors analysed retrospectively 33 patients treated in Department of Orthopaedic Surgery and Radiation Therapy, Catholic University Medical College, in terms of survival rate, local recurrence and prognostic factors. The sex distribution was 16 males and 17 females. The age distribution ranged from 16 to 81 year old with mean age of 48. The follow-up period ranged from 1 year to 10 years with average of 5.5 years. The histologic diagnoses were 9 liposarcoma(27.2%), 8 MFH(24.2%), 7 unclassifiable(21.2%), 3 rhabdomyosarcoma(9.1%), and 3 fibrosarcoma(9.1%) in orders. While marginal and intralesional margins were gained in 24 patients(72.2%), wide and radical margins were obtained only in 9 patients(27.3%). On postoperative 3 weeks, local irradiation of 5000-7000 cGy was delivered to all patients by shrinking field technique for 5-8 weeks. Of 33 patients, 16(45.5%) patients were recieved adjuvant chemotherapy in combination of adriamycin, cyclophosphamide & vicristine, or VP16 & ifosfamide based on histologic type and obtained surgical margin. The survival rates at 2 years and 5 years were 58% and 37% respectively. Local recurrences occured in 15 patients(45.5%) at average 16 months after operation. In addition, the authors considered surgical margin, presence of local recurrence and tumor size as a significant prognostic factors.
Kang, Min Soo,Kang, Sung Ho,Kim, Sang Gyun,Choi, In Taek,Ryu, Jung Ho,Ju, Myung Jong,Cho, Daeheum,Lee, Jin Yong,Kim, Hwan Kyu The Royal Society of Chemistry 2012 Chemical communications Vol.48 No.75
<P>A high solar-to-electricity conversion efficiency of 7.22% was achieved with a short circuit current (<I>J</I><SUB>sc</SUB>) of 15.30 mA cm<SUP>−2</SUP>, an open circuit voltage (<I>V</I><SUB>oc</SUB>) of 669 mV and a fill factor (FF) of 0.71 for the 2Flu–ZnP–CN–COOH dye with a multi-functional co-adsorbent, under 100 mW cm<SUP>−2</SUP> AM 1.5 G simulated light.</P> <P>Graphic Abstract</P><P>A high photovoltaic efficiency of 7.22% was achieved with a <I>J</I><SUB>sc</SUB> of 15.30 mA cm<SUP>-2</SUP>, a <I>V</I><SUB>oc</SUB> of 669 mV and a FF of 0.71 for 2Flu-ZnP-CN-COOH with a multi-functional co-adsorbent, under 100 mW cm<SUP>-2</SUP> AM 1.5 G simulated light. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cc31384g'> </P>
Kang, Kyoung-Ah,Chae, Sung-Wook,Lee, Kyoung-Hwa,Zhang, Rui,Jung, Myung-Sun,You, Ho-Jin,Kim, Jin-Sook,Hyun, Jin-Won The Korean Society for Biotechnology and Bioengine 2005 Biotechnology and Bioprocess Engineering Vol.10 No.6
Homogentisic acid was found to scavenge intracellular reactive oxygen species (ROS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and thus prevented lipid peroxidation in human fibroblast (Wl 38) cells. The radical scavenging activity of homogentisic acid was found to protect Wl 38 cells against hydrogen peroxide $(H_2O_2)$ induced oxidative stress, via the activation of extracellular signal regulated kinase (ERK) protein. Homogentisic acid increased the activity of catalase. Hence, from the present study, it is suggested that homogentisic acid protects Wl 38 cells against $H_2O_2$ damage by enhancing the intracellular antioxidative activity.
( Sang Duk Han ),( Hyun Jung Sung ),( Ga Hyeon Lee ),( Joon Ho Jun ),( Miwon Son ),( Myung Joo Kang ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.5
Chitosan-based film-forming gel is regarded as a promising vehicle for topical delivery of antimicrobial agents to skin wounds, since it protects from microbial infection and the cationic polymer itself possesses antibacterial activity. In this study, possible synergistic interaction against common skin pathogens between the cationic polymer and tyrothricin (TRC), a cyclic polypeptide antibiotic, was investigated, by determining the concentration to inhibit 90% of bacterial isolates (MIC). The addition of the polysaccharide to TRC dramatically reduced the MIC values of TRC by 1/33 and 1/4 against both methicillin-resistant and methicillinsusceptible Staphylococcus aureus, respectively. The synergism of TRC and chitosan combination against both strains was demonstrated by the checkerboard method, with a fractional inhibitory concentration index below 0.5. Moreover, co-treatment of TRC and chitosan exhibited antibacterial activity against Pseudomonas aeruginosa, due to the antibacterial activity of chitosan, whereas TRC itself did not inhibit the gram-negative bacterial growth. These findings suggested that the use of chitosan-based film for topical delivery of TRC could be an alternative to improve TRC antimicrobial activity against strains that are abundant in skin wounds.
Kang, Myung Joo,Park, Sang Han,Kang, Mean Hyung,Park, Min Jung,Choi, Young Wook Dove Medical Press 2013 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.8 No.-
<P><B>Background</B></P><P>A novel dual ligand–modified liposome, folic acid-tethered Pep-1 peptide-conjugated liposomal nanocarrier (FP-Lipo), was designed to overcome the nonselectivity of conventional penetrating peptide-tagged nanoparticulates and to provide the advantage of selective targeting of the folic acid receptor, which is frequently overexpressed on epithelial cancer cells.</P><P><B>Methods</B></P><P>FP-Lipo was prepared by a sequential process of formation of a maleimide-derivatized small unilamellar vesicle, postinsertion of distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000–folate to the vesicle, and Pep-1 peptide conjugation via thiol-maleimide linkage. Conformational and physical characteristics of the FP-Lipo nanocarriers were investigated for the extent of Pep-1 peptide and folic acid on the surface, vesicle size, and zeta potential. In vitro cellular uptake behaviors of the novel carrier containing a fluorescein dextran isothiocyanate probe were examined by spectrophotometry or by confocal laser scanning microscopy.</P><P><B>Results</B></P><P>A novel nanocarrier bearing approximately 750 folate ligands and 100 penetrating peptides per vesicle was successfully prepared. The physical properties were as follows: 140 nm in size; 5 mV in zeta potential; less than 0.3 in polydispersity index. An in vitro cellular uptake study revealed that the FP-Lipo nanocarrier system exhibited more than twofold enhanced translocation into the folic acid receptor–positive HeLa cells compared with the single Pep-1 peptide–modified liposome. Meanwhile, its cellular association and internalization into the folic acid receptor–negative normal HaCaT cells was comparable with that of Pep-1 peptide–modified liposome.</P><P><B>Conclusion</B></P><P>An advanced dual ligand-modified liposome is potentially useful for the treatment of folic acid receptor–positive tumors with high translocation capability of the penetrating peptide–modified liposome.</P>
Kang, Byeong-Teck,Son, Young-Don,Lee, Sang-Rae,Jung, Dong-In,Kim, Dong-Eog,Chang, Kyu-Tae,Cho, Zang-Hee,Park, Hee-Myung The Society ; Maruzen Co. [distributor] 2012 The Journal of veterinary medical science Vol.74 No.10
<P>The purpose of this study was to assess the normal distribution of (18)F-fluoro-2-deoxy-D-glucose (FDG) uptake of canine brain structures using a high-resolution research tomography-positron emission tomography (HRRT-PET) and 7 T-magnetic resonance imaging (MRI) fusion system. FDG-PET and T2-weighted MRI of the brain were performed on 4 healthy laboratory beagle dogs. On MRI, regions of interests (ROIs) were manually drawn over 51 intracranial structures, including nine gross structures and 42 detailed structures. Relative standard uptake value ratio (rSUV=SUV of ROI/SUV of whole brain) was calculated for each ROI. The HRRT-PET and 7 T-MRI fusion imaging system demonstrated significant differences in glucose metabolism among various intracranial structures. Among gross structures, the midbrain and the pons and medulla oblongata had the highest uptake (rSUV: 1.12 0.03) and lowest uptake (rSUV: 0.90 0.06) of FDG, respectively. When rSUVs were calculated on detailed regions, the caudal colliculus and the longitudinal fibers of pons had the highest (rSUV: 1.62 0.05) and the lowest (rSUV: 0.63 0.03) glucose metabolism, respectively. Because the high resolution of PET-MRI fusion images provided clearly identifiable metabolic activities of canine brain, the HRRT-PET and 7 T-MRI fusion imaging might be a good tool for evaluation of intracranial diseases in canines.</P>
Sung-Kug Park,Meehye Kim,You Sub Sho,So Young Chung,Soojung Hu,Jong Ok Lee,Moo Ki Hong,Myung Chul Kim,Ju Seop Kang,Ok Hwa Jhee 한국식품과학회 2007 Food Science and Biotechnology Vol.16 No.6
The microbiological and chemical identification of antibiotic residues was attempted for livestock and seafood products including pork (n=34), beef (n=34), chicken (n=32), flatfish (n=37), armorclad rockfish (n=36), and sea bream (n=27). The meat (n=100) and seafood (n=100) samples were collected from 9 markets in 5 major Korean cities. Antibiotic substances were identified from the classes of tetracyclines, macrolides, penicillins, aminoglycosides, polyethers, peptides, sulfonamides, quinolones, chlorampenicols, and novobiocins using a microbiological assay, the Charm II test and high performance liquid chromatography (HPLC) with ultra violet (UV) and fluorescence detectors. The results showed that 2 tetracyclines (oxytetracycline and tetracycline) and 3 quinolones (ciprofloxacin, norfloxacin, and enrofloxacin) were detected in 4 samples of flatfish among all 100 seafood samples tested. No antibiotic residues were detected in the 100 livestock product samples tested. The amounts (min-max, mg/kg) of the residual antibiotics were as follows; tetracycline 0.78-0.85, oxytetracycline 0.49-0.74, ciprofloxacin 0.09-0.83, norfloxacin 0.01-0.21, enrofloxacin 0.12-2.98. These data indicate that the total detection rate of antibiotics in livestock and seafood products was approximately 2%.
Sung, Hye Young,Kim, Sang Woo,Kang, Won Kyung,Kim, Su Young,Jung, Chan-Kwon,Cho, Yu Kyung,Park, Jae Myung,Lee, In Seok,Choi, Myung-Gyu,Chung, In-Sik Lippincott Williams Wilkins, Inc. 2012 European journal of gastroenterology & hepatology Vol.24 No.8
BACKGROUND AND AIM: The endoscopic techniques for treating a small rectal neuroendocrine tumor (NET) are performed in most large centers; however, the endoscopic management of this condition is not well established. This study was designed to determine the long-term prognosis of endoscopically resected NET. METHODS: We prospectively studied patients with endoscopically treated rectal NET in Seoul St Mary’s hospital, between January 2000 and June 2010. The long-term outcomes were analyzed in association with the pathological complete resection and resection procedures. RESULTS: Seventy-seven patients (48 men and 29 women; mean age, 52.3 years; range, 23–77 years) were included. The average NET size was 7.0±2.8 mm (range, 3–16 mm). There was no procedure-related complication. En-bloc removal was achieved for all lesions, and the rate of histological complete resection was 75.3% (58/77). Histological complete resection rates were 71.4% (10/14) by conventional endoscopic mucosal resection (EMR), 74.1% (43/58) by a two-channel EMR, and 100.0% (5/5) by endoscopic submucosal dissection (ESD). Among six patients with incomplete histological resection, two underwent additional EMR, two underwent transanal endoscopic microsurgery, and two underwent low anterior section with lymph node dissection. The remaining 13 patients with ‘possible’ remnant NET underwent regular endoscopic surveillance without additional resection. In the latter group, only one patient had local recurrence, detected on regular colonoscopic surveillance, after 56 months and was treated with additional EMR. All of the patients are alive and 98.7% (76/77) of the patients are free from disease during the follow-up periods. CONCLUSION: Endoscopic resection is a safe and effective modality and may potentially be used for the treatment of NETs smaller than 15 mm in diameter, those confined to the submucosal layer, and those without metastasis. Local treatment was believed to be curative in cases with complete histological resection. In addition, this treatment may have an excellent prognosis in patients with ‘possible’ remnant NET.
Effect of Dieckol, a Component of <i>Ecklonia cava</i> , on the Promotion of Hair Growth
Kang, Jung-Il,Kim, Sang-Cheol,Kim, Min-Kyoung,Boo, Hye-Jin,Jeon, You-Jin,Koh, Young-Sang,Yoo, Eun-Sook,Kang, Sung-Myung,Kang, Hee-Kyoung Molecular Diversity Preservation International (MD 2012 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.13 No.5
<P>This study was conducted to evaluate the effect of <I>Ecklonia cava</I>, a marine alga native to Jeju Island in Korea, on the promotion of hair growth. When vibrissa follicles were cultured in the presence of <I>E. cava</I> enzymatic extract (which contains more than 35% of dieckol) for 21 days, <I>E. cava</I> enzymatic extract increased hair-fiber length. In addition, after topical application of the 0.5% <I>E. cava</I> enzymatic extract onto the back of C57BL/6 mice, anagen progression of the hair-shaft was induced. The treatment with <I>E. cava</I> enzymatic extract resulted in the proliferation of immortalized vibrissa dermal papilla cells (DPC). Especially, dieckol, among the isolated compounds from the <I>E. cava</I> enzymatic extract, showed activity that increased the proliferation of DPC. When NIH3T3 fibroblasts were treated with the <I>E. cava</I> enzymatic extract and the isolated compounds from the <I>E. cava</I> enzymatic extract, the <I>E. cava</I> enzymatic extract increased the proliferation of NIH3T3 fibroblasts, but the isolated compounds such as eckol, dieckol, phloroglucinol and triphlorethol-A did not affect the proliferation of NIH3T3 fibroblasts. On the other hand, the <I>E. cava</I> enzymatic extract and dieckol significantly inhibited 5α-reductase activity. These results suggest that dieckol from <I>E. cava</I> can stimulate hair growth by the proliferation of DPC and/or the inhibition of 5α-reductase activity.</P>