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A New Infrared Probe Targeting Mitochondria via Regulation of Molecular Hydrophobicity
Sung, June,Rho, Jun Gi,Jeon, Gyeong G.,Chu, Yeonjeong,Min, Jun Sik,Lee, Sanghee,Kim, Jong H.,Kim, Wook,Kim, Eunha American Chemical Society 2019 Bioconjugate chemistry Vol.30 No.1
<P>Herein, we developed a near-infrared (NIR) fluorescent probe for mitochondrial staining based on the NIR fluorochrome, silicon-rhodamine. The hydrophobicity of the fluorescent core was systematically modified by conjugation with 10 different commercial amines. The resulting fluorescent compounds exhibited similar photophysical properties but diverse hydrophobicity. We identified the optimal level of hydrophobicity associated with high mitochondrial targeting efficiency. In particular, the SiR-Mito 8 probe provided excellent mitochondrial staining and successfully differentiated the live Hep3B cancer cells from normal L02 cells <I>in vitro</I>.</P> [FIG OMISSION]</BR>
Development of Theragnostic Tool Using NIR Fluorescence Probe Targeting Mitochondria in Glioma Cells
Chu, Yeonjeong,Shin, Min Chul,Sung, June,Park, Jongmin,Kim, Eunha,Lee, Sanghee American Chemical Society 2019 Bioconjugate chemistry Vol.30 No.6
<P>Because mitochondria are essential organelles for regulating energy homeostasis and intrinsic apoptosis, the perturbation of mitochondrial functions has been considered as an anticancer treatment. In this study, a new near-infrared (NIR) fluorescent probe, SiR-Mito11 was developed as a theragnostic agent for brain tumor by targeting mitochondria. SiR-Mito11 exhibited potential anticancer activity against glioma cells but tolerance in normal neuronal cells. We further confirmed that the selective accumulation of SiR-Mito11 in glioma cells disrupted mitochondria membrane potential, followed by apoptotic cell death.</P> [FIG OMISSION]</BR>
바나듐 레독스 흐름전지용 Poly(arylene ether sulfone) 막의 특성
오성준 ( Sung June Oh ),정재현 ( Jae Hyeon Jeong ),신용철 ( Yong Cheol Shin ),이무석 ( Moo Seok Lee ),이동훈 ( Dong Hoon Lee ),추천호 ( Cheun Ho Chu ),김영숙 ( Young Sook Kim ),박권필 ( Kwon Pil Park ) 한국화학공학회 2013 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.51 No.6
최근에 대용량 에너지 저장 시스템으로 레독스 흐름전지(Redox Flow Battery, RFB)가 활발히 연구·개발되고 있다. 불소계막을 대신할 저가의 탄화수소막이 RFB막으로 주목받고 있다. 본 연구에서는 Poly(arylene ether sulfone) (PAES)막을 사용해 고가의 불소계막과 그 특성을 바나듐 레독스 흐름전지(VRB, Vanadium Redox Flow Battery)조건에서 비교하였다. 바나듐 이온투과도, 이온 교환 용량, OCV 변화, 팽윤, 충·방전 곡선, 에너지 효율 등을 측정했다. PAES 막은 Nafion 117막에 비해 바나듐 이온투과도가 낮고, 이온교환용량은 커서 Nafion 117을 사용한 RFB보다 에너지 효율이 높았다. Recently, there are many efforts focused on development of Redox Flow Battery (RFB) for large energy storage system. Economical hydrocarbon membranes alternative to fluorinated membranes for RFB membrane are receiving attention. In this study, characteristics of poly(arylene ether sulfone) (PAES) were compared with expensive fluorinated membrane at VRB (Vanadium Redox Flow Battery) operation condition. Permeability of vanadium ion through membrane, ion exchange capacity (IEC), change of OCV, swelling, charge-discharge curves and energy efficiency were measured. PAES membrane showed lower permeability of vanadium ion, higher IEC and then higher energy efficiency compared with Nafion 117 membranes.
The Material and Device Characterization of InP JFET's for OEIC's
Jeong, Chang Oh,Park, Chu Roo,Choe, Byung Doo,Kim, Sung June 대한전자공학회 1991 ICVC : International Conference on VLSI and CAD Vol.2 No.1
We present results of making shallow p-type layers in InP by ion implantation. The layers are characterized for their electrical and optical properties. Be is used as p-type dopant and P or Ar is co-implanted with Be for comparison. Changes in activation efficiency and photoluminescence signal are observed as we vary the dose of P or Ar and these results can be explained by the stoichiometry effect and the damage effect. Activation efficiency over 74% is achieved with co-implantation. Using P and Ar as co-implant species, we quantatively analyze the conribution from the damage and stoichiometry effects. Fully implanted pn junction is used far making an InP JFET. The active region is mesa-isolated and the gate is defined self-aligned to the gate metal using wet etching. Results of electrical characterization of the fabricated FFT's with 2.5㎛ gate length are presented. Large series resistance and gain compression are seen to limit the maximum trans conductance. Our preliminary results on the backgating effect in InP JFET show the effect is negligible in the InP JFET as compared to that in the GaAs MESFET.
Seo-Yeon Ahn,Sang Kyun Son,Gyu Hyung Lee,Inho Kim,June-Won Cheong,Won Sik Lee,Byung Soo Kim,Deog-Yeon Jo,Chul Won Jung,Chu Myoung Seong,Jae Hoon Lee,Young Jin Yuh,Min Kyoung Kim,Hun-Mo Ryoo,Moo-Rim Pa 대한혈액학회 2022 Blood Research Vol.57 No.2
Background Nilotinib is a tyrosine kinase inhibitor approved by the Ministry of Food and Drug Safety for frontline and 2nd line treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). This study aimed to confirm the safety and efficacy of nilotinib in routine clinical practice within South Korea. Methods An open-label, multicenter, single-arm, 12-week observational post-marketing surveillance (PMS) study was conducted on 669 Korean adult patients with Ph+ CML from December 24, 2010, to December 23, 2016. The patients received nilotinib treatment in routine clinical practice settings. Safety was evaluated by all types of adverse events (AEs) during the study period, and efficacy was evaluated by the complete hematological response (CHR) and cytogenetic response. Results During the study period, AEs occurred in 61.3% (410 patients, 973 events), adverse drug reactions (ADRs) in 40.5% (271/669 patients, 559 events), serious AEs in 4.5% (30 patients, 37 events), and serious ADRs in 0.7% (5 patients, 8 events). Furthermore, unexpected AEs occurred at a rate of 6.9% (46 patients, 55 events) and unexpected ADRs at 1.2% (8 patients, 8 events). As for the efficacy results, CHR was achieved in 89.5% (442/494 patients), and minor cytogenetic response or major cytogenetic response was achieved in 85.8% (139/162 patients). Conclusion This PMS study shows consistent results in terms of safety and efficacy compared with previous studies. Nilotinib was well tolerated and efficacious in adult Korean patients with Ph+ CML in routine clinical practice settings.
간세포암의 자연경과와 여러 치료방법에 따른 생존률에 관한 연구 - 과거 20 년간의 경험을 토대로 -
김정룡(Chung Yong Kim),이준성(June Sung Lee),이한주(Han Chu Lee),이효석(Hyo Suk Lee),윤용범(Yong Bum Yoon),송인성(In Sung Song),박재형(Jae Hyung Park),김수태(Soo Tae Kim) 대한내과학회 1993 대한내과학회지 Vol.45 No.2
N/A Background: Hepatocellular carcinoma (HCC) is the most common form of primary hepatic carcinoma and is a pressing sociomedical problem in Korea. Of the various solid cancers, HCC is perhaps the most diffcult to treat because of the frequently associated cirrhosis and advanced stage of tumor. In recent years, diagnostic procedures, surgical techniques and various therapeutic modalities other than surgery have been developed and improved. So, the prognosis of these patients may have changed from what it was in the past and it is necessary to establish the criteria for selection of therapeutic modality in indivisual patient with HCC. The purpose of this study was to elucidate the natural history of HCC and the survival rate of patients with HCC in relation to various therapeutic modalities in different stage of chronic liver disease. Method: A total of 1149 patients with HCC seen during the last 20 years were analyzed retropectively. The effects of treatment on survival were analyzed with regard to Child's grading and UICC stage of HCC. Results: In the 265 patients who received no specific treatment, the cumulative survival rates of 6 month and 1 year were 37.5%, 16.6% and the median survival time was 4 months. Survival rates of the surgically treated patients were better than that of other patients groups in comparable Child's grade and UICC stage, Especially, among patients with Child's A or B the actuarial survival rate for surgery was significantly better than that for transarterial chemoembolization. Transarterial chemoembolization gave a significantly better survival rate compared with systemic chemotherapy and no specific treatment in all child's grade and UICC stage. Systemic chemotherapy improved survival as compared with no specific treatment in Child's A or B patients and with UICC stage IV and Child's C with stage IV, patients. The major causes of death were hepatic failure and gastrointestinal bleeding irrespective of treatment modality. Conclusion: Adequate therapeutic modalities according to the severity of liver cirrhosis and tumor stage could improve the prognosis of HCC patients.
NaBH4 가수분해 반응기 소재로서 알루미늄 합금의 특성 연구
정현승 ( Hyeon Seong Jung ),오성준 ( Sung June Oh ),정재진 ( Jae Jin Jeong ),나일채 ( Il Chai Na ),추천호 ( Cheun Ho Chu ),박권필 ( Kwon Pil Park ) 한국화학공학회 2015 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.53 No.6
NaBH4 가수 분해용 경량반응기의 재질로서 알루미늄 합금을 검토하였다. 알루미늄은 알칼리에 용해되는데, NaBH4반응 용액중에 안정화제로 NaOH가 포함되어 있다. 알루미늄의 부식 속도를 낮추기 위해서 NaOH 농도를 낮추면 저장중에 NaBH4가 손실된다. 그래서 최적의 NaOH 농도를 결정할 때 알루미늄 부식과 NaBH4 안정화를 모두 고려해야한다. NaBH4 안정화와 알루미늄 부식속도는 수소발생속도에 의해 측정하였다. NaBH4 안정화는 20~50 oC에서 알루미늄 부식속도는 60~90 oC 온도에서 실험하였다. 알루미늄 부식과 NaBH4 안정화를 모두 고려한 최적의 NaOH농도는 0.30 wt% 였다. 알루미늄 합금 6061를 사용해 반응기 온도 80~90 oC에서 NaOH 0.3 wt%로 200분간 반응을 진행하였다. Aluminum alloy was examined as a material of low weight reactor for hydrolysis of NaBH4. Aluminum is dissolved with alkali, but there is NaOH as a stabilizer in NaBH4 solution. To decrease corrosion rate of aluminum, decrease NaOH concentration and this result in loss of NaBH4 during storage of NaBH4 solution. Therefore stability of NaBH4 and corrosion of aluminum should be considered in determining the optimum NaOH concentration. NaBH4 stability and corrosion rate of aluminum were measured by hydrogen evolution rate. NaBH4 stability was tested at 20~50 oC and aluminum corrosion was measured at 60~90 oC. The optimum concentration of NaOH was 0.3 wt%, considering both NaBH4 stability and aluminun corrosion. NaBH4 hydrolysis reaction continued 200min in aluminum No 6061 alloy reactor with 0.3 wt% NaOH at 80~90 oC.