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      • KCI등재

        The prediction of the tooth size in the mixed dentition for Korean

        Moon, Sung-Hwan,Kim, Seong-Oh,Yu, Hyung-Seong,Choi, Byung-Jai,Choi, Hyung-Jun,Lee, Jae-Ho 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.2

        이번 연구의 목적은 혼합치열기 아동에서 미맹출된 견치와 소구치의 크기를 예측하는데 있어서 한국인에 맞는 방정식을 만들기 위함이다. 미맹출 치아의 크기를 예측하는 것은 혼합치열기 교정 진단과 치료계획 수립에 있어서 매우 중요하다. 미맹출된 견치와 소구치 크기를 예측하는 방법은 몇가지가 있지만 그중에서도 가장 흔하게 쓰이는 것이 모이어의 예측표와 다나카와 존스턴의 방정식이 있다. 하지만 그것들은 백인을 위해서 제작된 것이고 치아 크기는 인종에 따라서 다르다고 알려져 있다. 이번 연구에서는 치아크기를 측정하여 하악 영구 절치의 크기 합과 견치 및 소구치의 크기 합 사이의 상관관계를 구하고 회귀방정식을 이용해서 한국인에 맞는 예측표를 만들었다. 연세대학교 치과대학에 재학중인 178명의 한국 학생(남 108명, 여 70명, 평균연령 21.63)을 대상으로 실험하였다. 영구치의 근원심 폭경을 석고모형상에서 calipers를 이용해서 측정하였다. 성별간의 치아 크기는 차이가 있었다(p<0.05). Correlation coefficient는 0.57에서 0.64의 범위였고, standard errors of the estimates 는 여성에서 0.6으로써 남성보다 우수하였다. r^(2)값은 0.27에서 0.41의 범위를 나타내었다. Estimating the size of unerupted teeth is an essential aspect of orthodontic diagnosis and treatment planning in the mixed dentition. Several methods were introduced and used for the prediction. The most common methods among these would be Moyers probability chart and Tanaka and Johnston equations. These are currently used widely, but they were developed for Caucasians. Because there are clear racial differences in teeth size, the objectives of this study were to produce correlation coefficients between the combined mesiodistal widths of the permanent mandibular incisors and those of the canines and premolars for each quadrant, and prediction tables with regression equations, specifically for Korean. 178 young adults (70 women, 108 men, mean age 21.63 years) were selected from the College of Dentistry, Yonsei University, Seoul, Korea. The mesiodistal crown diameters of the permanent teeth were measured with calipers. Significant sexual dimorphism was found in tooth sizes. The correlation coefficients between the total mesiodistal width of the mandibular permanent incisors and those of the maxillary and mandibular canines and premolars were found to be between 0.52 and 0.64. The standard error of the estimatation was better (0.60) for women and the r^(2) values ranged from 0.27 to 0.41 for both sexes, Prediction tables were prepared for Korean. This study showed larger canine and premolar diameters than Tanaka and Johnston's and Moyers' studies which might be due to the racial differences. Further investigations with a larger sample size will be needed for more representative data on the Korean population.

      • KCI등재

        Effects of Hepatocyte Growth Factor on Collagen Synthesis and Matrix Metalloproteinase Production in Keloids

        Lee, Won Jai,Park, Sang Eun,Rah, Dong Kyun The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.8

        <P>Keloids are pathologic proliferations of the dermal layer of the skin resulting from excessive collagen production and deposition. Hepatocyte growth factor (HGF) increases the expression of matrix metalloproteinase (MMP)-1 and suppresses collagen synthesis to modulate extracellular matrix turnover. To investigate the anti-fibrotic effects of HGF, we examine the mRNA expression of collagen types I and III and matrix metalloproteinase (MMP-1, MMP-3) on human dermal fibroblast (HDF) cell lines and keloid fibroblasts (KFs, n = 5) after adding various amount of HGF protein. We also evaluated the enzymatic activity of MMP-2, MMP-9 by zymograghy. In HDFs treated with TGF-β1 and HGF protein simultaneously, both type I and III collagen mRNA expression significantly decreased (<I>P</I> < 0.05). Expression of MMP-1, MMP-3 mRNA also decreased. However, the mRNA expression of MMP-1, MMP-3 significantly increased in KFs with increasing amount of HGF in dose dependent manner (<I>P</I> < 0.05). The enzymatic activities of MMP-2 increased with increasing HGF protein in a dose-dependent manner. However, the enzymatic activity of MMP-9 did not change. These results suggest that the anti-fibrotic effects of HGF may have therapeutic effects on keloids by reversing pathologic fibrosis.</P>

      • SCIESCOPUSKCI등재

        Application of Sensor Technology for the Efficient Positioningand Assembling of Ship Blocks

        Lee, Sang-Don,Eun, Seong-Bae,Jung, Jai-Jin,Song, Ha-Cheol The Society of Naval Architects of Korea 2010 International Journal of Naval Architecture and Oc Vol.2 No.3

        This paper proposes the application of sensor technology to assemble ship blocks efficiently. A sensor-based monitoring system is designed and implemented to improve shipbuilding productivity by reducing the labor cost for the adjustment of adequate positioning between ship blocks during pre-erection or erection stage. For the real-time remote monitoring of relative distances between two ship blocks, sensor nodes are applied to measure the distances between corresponding target points on the blocks. Highly precise positioning data can be transferred to a monitoring server via wireless network, and analyzed to support the decision making which needs to determine the next construction process; further adjustment or seam welding between the ship blocks. The developed system is expected to put to practical use, and increase the productivity during ship blocks assembly.

      • KCI등재후보

        An MRI-Based Quantification for Correlation of Imaging Biomarker and Clinical Performance in Chronic Phase of Carbon Monoxide Poisoning

        Lee, Aleum,Hwang, Ji-sun,Bae, Won-kyung,Park, Jai-soung,Goo, Dong Erk,Park, Sung-Tae Korean Society of Magnetic Resonance in Medicine 2019 Investigative Magnetic Resonance Imaging Vol.23 No.3

        Purpose: The purpose of this study was to determine the relation between quantitative magnetic resonance imaging biomarkers, and clinical performances in chronic phase of carbon monoxide intoxication. Materials and Methods: Eighteen magnetic resonance scans and cognitive evaluations were performed, on patients with carbon monoxide intoxication in chronic phase. Apparent diffusion coefficient (ADC) ratios of affected versus unaffected centrum semiovale, and corpus callosum were obtained. Signal intensity (SI) ratios between affected centrum semiovale, and normal pons in T2-FLAIR (fluid-attenuated inversion recovery) images were obtained. The Mini-Mental State Exam, and clinical outcome scores were assessed. Correlation coefficients were calculated, between MRI and clinical markers. Patients were further classified into poor-outcome and good-outcome groups based on clinical performance, and imaging parameters were compared. T2-SI ratio of centrum semiovale was compared, with that of 18 sex-matched and age-matched controls. Results: T2-SI ratio of centrum semiovale was significantly higher in the poor-outcome group, than that in the good-outcome group and was strongly inversely correlated, with results from the Mini-Mental State Exam. ADC ratios of centrum semiovale were significantly lower in the poor outcome group than in the good outcome group, and were moderately correlated with the Mini-Mental State Exam score. Conclusion: A higher T2-SI and a lower ratio of ADC values in the centrum semiovale, may indicate presence of more severe white matter injury and clinical impairment. T2-SI ratio and ADC values in the centrum semiovale, are useful quantitative imaging biomarkers for correlation with clinical performance in individuals with carbon monoxide intoxication.

      • KCI등재

        Factors to Assess for Re-breeding after Parturition in Milking Cows

        Sung Jai Park,Kwang-Soo Baek,김현섭,Byeong-Soon Jeon,Tai-Young Her,Hyun-Joo Lim,Seok-Jin Kang,Hyun-June Lee,Woon-Mo Jo,김상범,Young-Hun Jung,Byeong-Seog Ahn 사단법인 한국동물생명공학회 2009 Reproductive & developmental biology Vol.33 No.3

        The purpose of this study was to assess for re-breeding concentrate period in postpartum in milking cows. The 48 cows aged 3.5~5.5 years and of 400~600 kg body weight were examined every 3rd day from 15 to 36 day postpartum. Blood samples for progesterone and estradiol 17 β hormone analyses were withdrawn from the coccygeal vein every third day until the end of the experiment. The ovarian follicular numbers were verified and measured using a multi frequency probe. The least squares means are presented for each day by GLM of SAS. The results showed that ovary lengths (right ovary; 1.64±0.62 cm, left ovary; 1.44±0.46 cm) were similar in right and left ovary activity level during estrous cycle of postpartum cows. We were judged completed uterus on day at 2.31±0.17 cm level of cervix diameter. And we were monitoring started at 6.44±2.03 cm from day 15 after postpartum. The results showed that mean plasma concentration of progesterone (3.28 ng/ml) in large follicle gradually increased days 30 in postpartum. And, monitoring of estradiol 17β (22.18 pg/ml) hormone during postpartum period would be useful to predict the ovarian and uterus activity for re-breeding in postpartum milking cows. From these results, we conclude that cervix diameter (mean: 2.31 cm) was very important for reproductive organ recovery standard level of postpartum milking cows, hormone secretion level (P4: 3.28 ng/ml, E2: 22.18 pg/ml) and body condition score (2.5~2.75) level about 30 days in postpartum period.

      • KCI등재

        Mirror Syndrome Resulting from Metastatic Congenital Neuroblastoma to Placenta

        ( Sung Hyeon Park ),( Jung-man Namgoong ),( Kyeong Nam Ko ),( Chong Jai Kim ),( Pil-ryang Lee ),( Euiseok Jung ),( Byong Sop Lee ),( Ki-soo Kim ),( Ellen Ai-rhan Kim ) 대한주산의학회 2018 Perinatology Vol.29 No.4

        Congenital neuroblastoma is a rare disease. Placental metastasis is extremely rare and poor prognosis has been reported in neonates. Mirror syndrome could occur in mother with placental metastasis with possibilities of hypertension and edema. We report a case of detection of left suprarenal mass in fetus at 31<sup>+5</sup> weeks’ gestation. Mother presented with palpitation, edema, headache, and hypertension. Maternal 24 hours urine vanillylmandelic acid (VMA) and normetanephrine (NME) level at 34 weeks’ gestation were elevated. Consequently, emergent cesarean section was done. Based on abdominal ultrasonography and whole body magnetic resonance imaging, left adrenal tumor with liver metastasis was suspected. Neuroblastoma was confirmed by liver and placenta biopsy. Chemotherapy was started with Pediatric Oncology Group 9243 at day 7 and changed into Children's Oncology Group 3961 due to cholestasis and poor response during 2nd cycle. Plasma exchange was done for aggravated direct hyperbilirubinemia. The baby expired at 73 days due to multi-organ failure. Maternal symptoms were completely resolved in 2 weeks after delivery along with normalization of the elevated level of VMA and NME. We report a first case of mirror syndrome in Korean mother and fetus resulting from metastatic congenital neuroblastoma to placenta.

      • SCISCIESCOPUSKCI등재

        The Performances of Proto - Type Ni/MH Secondary Batteries Using Zr-Based Hydrogen Storage Alloys and Filamentary Type Ni

        Lee, Sang Min,Kim, Jin Ho,Lee, Ho,LEE, Jai Young,Lee, Paul S . 대한금속재료학회(대한금속학회) 2001 METALS AND MATERIALS International Vol.7 No.2

        For the purpose of developing a Zr-based Laves phase alloy with higher capacity and better performance for electrochemical application, extensive work has been carried out. After careful alloy design of ZrMn2based hydrogen storage alloys through varying their stoichiometry by means of substituting or adding alloying elements, the Zr_(0.9)Ti_(0.1)(Mn_(0.7)V_(0.5)Ni_(1.4))_(0.92) with high capacity (392 mAh/g at the 0.25C) and improved performance (comparable to that of commercialized AB_5 type alloy) was developed. Another endeavor was made to improve the poor activation property and the low rate capability of the developed Zr-based Laves phase alloy for commercialization. The combination method of hot-immersion and slow-charging was introduced. It was found that electrode activation was greatly improved after hot immersion at 80℃ for 12 h followed by charging at 0.05C. The effects of this method are discussed in comparison with other activation methods. The combination method was successfully applied to the formation process of 80 Ah Ni/MH cells. A series of systematic investigations has been rendered to analyze the inner cell pressure characteristics of a sealed type Ni-MH battery. It was found that the increase of inner cell pressure in the sealed type Ni/MH battery of the above-mentioned Zr-Ti-Mn-V-Ni alloy was mainly due to the accumulation of oxygen gas during chargeldischarge cycling. The fact identified that the surface catalytic activity was affected more dominantly by the oxygen recombination reaction than the reaction surface area was also identified. In order to improve the surface catalytic activity of a Zr-Ti-Mn-V-Ni alloy, which is closely related to the inner pressure behavior in a sealed cell, the electrode was fabricated by mixing the alloy with Cu powder and a filamentary type of Ni and replacing 75% of the carbon black with them; thus, the inner cell pressure rarely increases with cycles due to the active gas recombination reaction. Measurements of the surface area of the electrode and the surface catalytic activity showed that the surface catalytic activity for the oxygen recombination reaction was greatly improved by the addition of Cu powder and the filamentary type of Ni. Finally, we have collaborated with Hyundai Motors Company on fabrication of the 80Ah cells for Electric Vehicles and evaluated the cell performance.

      • SCIESCOPUSKCI등재

        The Inhibitory Mechanism of Aloe Glycoprotein (NY945) on the Mediator Release in the Guinea Pig Lung Mast Cell Activated with Antigen-Antibody Complexes

        Jai Youl Ro,Byung Chul Lee,Myung Hee Chung,Seung Ki Lee,Chung Ki Sung,Kyung Hwan Kim,Young In Park 대한생리학회-대한약리학회 1998 The Korean Journal of Physiology & Pharmacology Vol.2 No.1

        It has been reported that the g1ycoprotein extracted from A10e has strong anti-inflammatory response,However, there has been no research report yet about the effect of A10e on allergic hypersensitivity reactivity, By using guinea pig 1ung mast cells, this study aimed to examine the effects of A10e g1ycoprotein (NY945) on the mediator re1eases caused by mast cell activation, and a1so aimed to assess the effects of NY945 on the mechanism of mediator re1eases in the mast cell activation. We partially purified mast cell from guinea pig 1ung tissues by using the enzyme digestion, the rough and the discontinuous density percoll gradient method. Mast cells were sensitized with IgG1 (anti-OA) and challenged with ova1bumin. Histamine was assayed by fluorometric ana1yzer, 1eukotrienes by radioimmunoassay. The phospholipase D activity was assessed by the production of 1abe1ed phosphatidy1alcoho1. The amount of mass 1,2-diacy1g1ycero1 (DAG) was measured by the eH]DAG produced when pre1abe1ed with eH]myristic acid. The phosph01ipid methy1ation was assessed by measuring the incorporation of the eH]methy1 moiety into phosph01ipids of cellu1ar membranes. Pretreatment of NY945 (10 μg) significant1y decreased histamine and 1eukotrienes re1eases during mast cell activation. The decrease of histamine re1ease was stronger than that of 1eukotriene during mast cell activation. The phospholipase D activity increased by the mast cell activation was decreased by the dose-dependent manner in the pretreatment of NY945. The amount of DAG produced by PLC activity was decreased by NY945 pretreatment. The amount of mass 1, 2-diacy1g1ycero1 produced by activation of mast cells was decreased in the pretreatment of NY945. NY945 pretreatment strong1y inhibited the incorporation of the eH]methy1 moiety into phosph01ipids. The data suggest that NY945 purified from A10e inhibi엄 in part an increase of 1, 2-diacy1g1ycero1 which is produced by activating mast cells with antigen-antibody reactions, which is mediated via phosphatidylcholinephospholipase D and phosphatidylinosit01-phospholipase C systems, and then followed by the inhibition of histamine re1ease. Furthermore, NY945 reduces the production of phosphatidylch01ine by inhibiting the methy1transferase 1 and II, which decreases the conversion of phosphatidylcho1ine into arachidonic acid and inhibits the production of 1eukotrienes.

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