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Molecular Cloning and Characterization of ARS Elements from the Mud Loach (Misgurnus mizolepis)
Hak-Seob Lim,Moo-Sang Kim,Jin-Young Park,Kang-Eun Choi,Jee-Youn Hwang,DongSoo Kim 한국분자세포생물학회 2002 Molecules and cells Vol.13 No.2
Autonomously replicating sequences (ARSs) are thought to occur within, or adjacent to, the matrix attachment regions (MARs). To identify fish ARSs, MARs of the mud loach fish were obtained from nuclear matrices using a modified LIS method. These DNA fragments were screened for their ability to act as ARSs by being cloned into the ARS cloning vector, pURY19, and transformed into Saccharomyces cerevisiae. Sixteen ARSs were isolated, most of which were more efficient in transformation than the positive control vector, pURY19-2 μm, which contained the 2 μm circle origin of yeast. In particular, one clone, pURY19- ARS223, was 18 times more efficient in back-transforming E. coli than the positive control vector. Therefore, ARS223, which has strong ARS activity in yeast, could be a good candidate for inclusion in expression vehicles that are used to transfect fish cell lines or embryos. A DNA sequence analysis showed that the essential ARS elements contain potential ARS consensus sequences, and are predicted to have hairpin loop structures, or curved or kinked DNA. In addition, the MAR-Finder program suggested that ARSs also contain MAR motifs. These include AT tracts, ORI patterns, kinked DNA, ATC tracts, and Topoisomerase II consensus sequences. The in vitro matrix binding assay confirmed that all of the cloned ARSs could associate with the nuclear matrix. This indicates that ARSs elements may be located in or near the MARs. This is the first study that has identified and characterized ARSs in fish.
Changes in metabolic syndrome in American and Korean youth, 1997-2008.
Lim, Soo,Jang, Hak Chul,Park, Kyong Soo,Cho, Sung Il,Lee, Man-Gyoon,Joung, Hyojee,Mozumdar, Arupendra,Liguori, Gary American Academy of Pediatrics [etc.] 2013 Pediatrics Vol.131 No.1
<P>Metabolic syndrome (MetSyn) in children and adolescence is increasing worldwide; however, its pattern may be different between Asians and Americans. We compare the prevalence and patterns of MetSyn between American and Korean children and adolescents between roughly 1998 and 2007.</P>
Lim, Soo,Kwon, Sung-Youn,Yoon, Ji Won,Kim, So Yeon,Choi, Sung Hee,Park, Young Joo,Yoon, Ho Il,Chang, Yoon Seok,Lee, Jae Ho,Lee, Choon-Taek,Kim, Ki Woong,Park, Kyong Soo,Jang, Hak Chul NAASO, the Obesity Society 2011 Obesity Vol.19 No.3
<P>The age-related increase in body fat and decrease in muscle mass are associated with increased morbidity in elderly populations. Pulmonary function also decreases with age, but no study has investigated whether regional body composition is associated with pulmonary function in an older population. The Korean Longitudinal Study on Health and Aging is a community-based cohort study of people aged > 65 years selected by random stratified sampling. Anthropometrics, biochemical factors, and lung function by spirometry were evaluated in 439 men (mean age of 75.9 ± 8.6 years) and 561 women (mean age of 76.0 ± 8.8 years). Dual-energy X-ray absorptiometry (DXA) was performed to assess the whole and regional body composition. Computed tomography (CT) was also used to measure fat or muscle distribution at the abdominal and mid-thigh levels. Although pulmonary function and muscle mass were inversely related to age, fat mass was not. After adjusting for age, height, BMI, smoking and exercise status, and high sensitivity C-reactive protein (hsCRP), fat mass in trunk or central area was inversely associated with lung function in both sexes (P < 0.01). Men with more muscle in trunk and mid-thigh level had better lung function (P < 0.01). The results of this community-based study show that regional body composition is significantly associated with lung function. Augmentation of muscle in the trunk and low extremity in men, and reduction of fat in the trunk and upper body in men and women may be helpful in maintaining lung function in the elderly population.</P>
Lim, Soo,Kang, Seon Mee,Shin, Hayley,Lee, Hak Jong,Won Yoon, Ji,Yu, Sung Hoon,Kim, So-Youn,Yoo, Soo Young,Jung, Hye Seung,Park, Kyong Soo,Ryu, Jun Oh,Jang, Hak C. American Diabetes Association 2011 Diabetes care Vol.34 No.2
<P><B>OBJECTIVE</B></P><P>To improve quality and efficiency of care for elderly patients with type 2 diabetes, we introduced elderly-friendly strategies to the clinical decision support system (CDSS)-based ubiquitous healthcare (u-healthcare<B>)</B> service, which is an individualized health management system using advanced medical information technology.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>We conducted a 6-month randomized, controlled clinical trial involving 144 patients aged >60 years. Participants were randomly assigned to receive routine care (control, <I>n</I> = 48), to the self-monitored blood glucose (SMBG, <I>n</I> = 47) group, or to the u-healthcare group (<I>n</I> = 49). The primary end point was the proportion of patients achieving A1C <7% without hypoglycemia at 6 months. U-healthcare system refers to an individualized medical service in which medical instructions are given through the patient’s mobile phone. Patients receive a glucometer with a public switched telephone network-connected cradle that automatically transfers test results to a hospital-based server. Once the data are transferred to the server, an automated system, the CDSS rule engine, generates and sends patient-specific messages by mobile phone.</P><P><B>RESULTS</B></P><P>After 6 months of follow-up, the mean A1C level was significantly decreased from 7.8 ± 1.3% to 7.4 ± 1.0% (<I>P</I> < 0.001) in the u-healthcare group and from 7.9 ± 1.0% to 7.7 ± 1.0% (<I>P</I> = 0.020) in the SMBG group, compared with 7.9 ± 0.8% to 7.8 ± 1.0% (<I>P</I> = 0.274) in the control group. The proportion of patients with A1C <7% without hypoglycemia was 30.6% in the u-healthcare group, 23.4% in the SMBG group (23.4%), and 14.0% in the control group (<I>P <</I> 0.05).</P><P><B>CONCLUSIONS</B></P><P>The CDSS-based u-healthcare service achieved better glycemic control with less hypoglycemia than SMBG and routine care and may provide effective and safe diabetes management in the elderly diabetic patients.</P>