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Sung, Pil Soo,Choi, Hee Baeg,Kim, Su-Yeon,Hong, Sung Woo,Park, Chung-Hwa,Song, Myeong Jun,Lee, Sung Won,Yoo, Chan Ran,Choi, Sang Wook,Han, Nam Ik,Kim, Tai-Gyu,Yoon, Seung Kew The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.11
<P>Natural killer (NK) cells play an important role in innate immunity, especially in the response to viral infections, such as hepatitis C virus (HCV). Killer cell immunoglobulin-like receptors (KIRs) are the primary receptors of NK cells that mediate innate immunity. KIRs are also involved in acquired immunity, because some KIRs are expressed on the surface of certain subsets of T cells. In this study, the frequency of KIR genes, <I>HLA-C</I> allotypes, and combinations of KIR genes with their <I>HLA-C</I> ligands were evaluated in two different groups of the Korean population: controls and patients with chronic HCV infection. The study population consisted of 147 Korean patients with chronic HCV infection. The frequency of KIR2DS2 in patients with chronic HCV infection was 9.5% which was significantly lower than 19.5% of the control (<I>P</I> < 0.01). However, there were no significant differences in the frequency of other KIR genes, <I>HLA-C</I> allotypes or different combinations of KIR genes with their <I>HLA-C</I> ligands. This study can contribute to the further prospective study with a larger scale, suggesting the assumption that <I>KIR2DS2</I> might aid in HCV clearance by enhancing both the innate and acquired immune responses of people in Korea.</P>
RPL36 as a prognostic marker in hepatocellular carcinoma
Song, Myeong Jun,Jung, Chan Kwon,Park, Chung‐,Hwa,Hur, Wonhee,Choi, Jung Eun,Bae, Si Hyun,Choi, Jong Young,Choi, Sang Wook,Han, Nam Ik,Yoon, Seung Kew Blackwell Publishing Asia 2011 Pathology international Vol.61 No.11
<P>Ribosomal proteins (RP) play key roles in the regulation of apoptosis, multidrug resistance and carcinogenesis. The aim of this study was to investigate the expression of ribosomal protein L36 (RPL36) in hepatocellular carcinoma (HCC) and to correlate it with clinicopathological parameters and clinical outcome. Liver specimens were obtained from 60 HCC patients who had undergone a partial hepatectomy. Expression of RPL36 in tumor tissue and surrounding non‐tumorous tissues was evaluated on a tissue microarray by immunohistochemistry. RPL36 was expressed in 45 of 60 (75%) HCC by immunohistochemistry, but was not detected in corresponding non‐tumors. RPL36 expression correlated significantly with serum levels of albumin (<I>P</I>= 0.044) and prothrombin time (<I>P</I>= 0.026), which reflect liver synthetic function. Moreover, expression of RPL36 was found to be higher in patients with early tumor stages (I/II) (<I>P</I>= 0.038) or without portal vein thrombosis (<I>P</I>= 0.005). In univariate analysis, patients with RPL36 expression revealed better overall survival (<I>P</I>= 0.037). By multivariate survival analysis, RPL36 expression was found to be an independent prognostic factor for overall survival (<I>P</I>= 0.026). Our data suggest that RPL36 may be involved in the early stage of hepatocarcinogenesis, and it can be used as an independent and potential prognostic marker for resected HCC.</P>
( Sang Gyun Lee ),( Song-ee Kim ),( Soo-chan Kim ),( Sang Eun Lee ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.-
Background: Intractable pruritus is common and the most disabling symptom among patients with recessive dystrophic epidermolysis bullosa (RDEB), however the underlying mechanism is largely unknown. Objectives: To investigate the mechanisms of RDEB-associated pruritus, focusing on the major itch mediators, including IL-31. Methods: Serum IL-31 and TSLP levels were measured in 13 RDEB patients and healthy subjects. Expression of various itch mediators on skin sections from 11 RDEB patients and healthy controls was evaluated by immunofluorescence. Results: Serum levels of IL-31 and TSLP in RDEB patients were elevated compared with healthy controls, but were not correlated with visual analog scale (VAS) pruritus score. In RDEB skin, the number of dermal infiltrating IL-31(+) cells were increased compared with healthy skin and was correlated with itch severity. Il-31(+) cells were mostly c-kit (+) mast cells and some were CD206(+) macrophages. The number of IL-4Rα(+) or IL-13(+) cells, dermal expression of periostin, and epidermal expression of TSLP were increased in RDEB skin compared with healthy skin, but did not correlate with the degree of itch. TRPV1 and TRPA1 immunorecativity was increased in the epidermis and dermal cells of RDEB skin than in healthy skin. Substance P(+) cells were increased and most were mast cells in RDEB skin. Conclusion: IL-31 from mast cells and macrophages may play a role in itch in RDEB.
Sung-chan Yang,Byung-Eon Noh,Eun Jung Lee,Bong Gu song,Hyunwoo Kim,Tea-Kyu Kim,Seong Yoon Kim,Won Il Park,Hyung-Woo Lim,Hak Seon Lee,Gi-Hun Kim,Chang won Jang,Jin Hwan Jeon,Se Jin Jeong,Hyunah Kim,Kyu 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.04
We performed a survey for flavivirus infection and distribution of Aedes albopictus that known as Zika and Dengue virus vector using black–light trap and BG-sentinel trap around urban area in Korea. Mosquitoes were collected in 27 cities during March to November (twice a month) year 2016. Total numbers of mosquitoes collected 102,102 including 19 species 8 genera during collecting period. Total 21,467 Ae. albopictus was collected that 20,961(24.3%) by BG-sentinel trap and 506 (3.2%) by Black-light trap in urban area. Trap index(trap/night) of Ae. albopictus was showed highest in Hamyang (TI:992.3) and lowest in Taebaek (TI:0.3) there was only collected by Black-light trap. A total of 894 pools from all collecting Ae. albopictus were performed a Flavivirus detection. Flavivirus was not detected during study period. This study may provide basic information for surveillance of imported diseases (include Zika virus) and vectors in Korea.
Song Ji-Hoon,Kang Ji-Hoon,Kang Hee-Kyung,Kim Kwang-Sik,Lee Sung-Ho,Choi Don-Chan,Cheon Min-Seok,Park Deok-Bae,Lee Young-Ki 한국발생생물학회 2011 발생과 생식 Vol.15 No.3
Ethanol treatment during the brain growth spurt period has been known to induce the death of Purkinje cells. The underlying molecular mechanisms and the role of reactive oxygen species (ROS) in triggering ethanol-induced Purkinje cell death are, however, largely unresolved. We undertook TUNEL staining, western blotting assay and immunohistochemistry for the cleaved forms of caspase-3 and -9, with calbindin D28K double immunostaining to identify apoptotic Purkinje cells. The possibility of ROS-induced Purkinje cell death was immunohistochemically determined by using anti-8-hydroxy-2'deoxyguanosine (8-OHdG), a specific cellular marker for oxidative damage. The results show that Purkinje cell death of PD 5 rat cerebellum following ethanol administration is mediated by the activation of caspase-3 and -9. However, unexpectedly, TUNEL staining did not reveal any positive Purkinje cells while there were some TUNEL-positive cells in the internal and external granular layer. 8-OHdG was detected in the Purkinje cell layers at 8 h, peaked at 12-24 h, but not at 30 h post-ethanol treatment. No 8-0HdG immunoreactive cells were detected in the internal and external granular layer. The lobule specific 8-OHdG staining patterns following ethanol exposure are consistent with that of ethanol-induced Purkinje cell loss. Thus, we suggest that ethanol-induced Purkinje cell death may not occur by the classical apoptotic pathway and oxidative damage is involved in ethanol-induced Purkinje cell death in the developing cerebellum.