보문 : 큰느타리버섯 갓우수 품종 육종

임착한 ( Chak Han Im ),김민근 ( Min Keun Kim ),제희정 ( Hee Jung Je ),김경희 ( Kyung Hee Kim ),김선영 ( Sun Young Kim ),김계자 ( Kye Ja Kim ),박성자 ( Sung Ja Park ),하영아 ( Young A Ha ),김미진 ( Mi Jin Kim ),김설화 ( Sul Ha Kim 한국균학회 2012 韓國菌學會誌 Vol.40 No.3

갓모양이 우수한 계통과 대길이가 길고 속성형질을 가진 계통을 모본으로부터 교배육종으로 두 가지 형질을 모두 가진 우수품종을 육성하고자 하였다. 낮은 갓명도 형질의 동형접합체를 만들기 위하여 KNR2312 유래 단핵균사들로 자가교배를 실시하여 갓명도가 45.2, 품질이 6.5인 중간모본 KNR2312-2636-10 × 18을 선발하였고, 이를 A8B10(나) 유래 단핵균사와 이종교배 하였다. 이후 낮은 품질을 개선하기 위하여 KNR2312 유래 단핵균사와 여교배를 실시하여 갓명도가 49.5, 품질이 7.3 수확량이 95.1 g인 가5나5KNR2312-47KNR2312-12 × 38 계통을 선발하였다. 선발된 계통은 갓모양이 우수하고 특히 갓끝이 24mm로 다듬기나 유통중 파손이 적을 것으로 사료된다. Two strains Pleurotus eryngii KNR2312 and A8B10 (Na) which have good traits in cap quality and speedy growing were selected to breed a new strain carrying the two traits. KNR2312-2636-10 × 18 (Ga) with 45.2 cap lightness and 6.5 quality was breeded by a consecutive inbreeding between KNR2312-derived monokaryons. Ga5 × Na5 came from outcrossing between Ga and Na was backcrossed with KNR2312-derived monokaryons twice to improve quality in cap color and shape. Therethrough Ga5NaKNR2312-47KNR2312-12 × 38 carrying lightness of 49.5, quality of 7.3 and weight of 95.1 g was selected. The selected strain possesses good quality and dark color of cap. Especially its edge is 24 mm thick, therefore it is not likely damaged during processing and distribution.

[P085] A case of multiple papular skin lesions in a pediatric patient

( Sun Bum Kwon ),( Sul Hee Lee ),( A Young Park ),( Sang Hoon Lee ),( Jung Eun Kim ),( Moon Kyun Cho ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

A 4-year-old male patient presented with a month history of multiple pinkish papules on both buttocks and posterior thighs, which had begun abruptly. Each lesion had been enlarged slightly from its beginning, but they were generally stable in terms of morphology of lesions. A punch biopsy was taken from a papule located on left buttock. Histologic examination revealed his disease as generalized granuloma annulare(GGA). He was given tacrolimus 0.1% ointments for treatment. During 3-months follow up, his papular lesions were flattened, and their color became dusky, which indicated the alleviation of the disease. GGA is, by definition, the presence of 10 or more skin lesions or by widespread papules or annular plaques. It affects at least the trunk and either upper or lower, or both extremities, and the face, scalp, palms, and soles may also be affected. There has been no consensus on the most effective therapy for treating GA. Herein we chose the topical tacrolimus for the management of GGA, which successfully improved patient`s symptoms. This case also focuses that GGA should be included in the differential diagnoses of the multiple papular skin lesions in a pediatric patient and skin biopsy can be considered for confirming what the skin conditions stand for, although the onset of GGA in childhood is relatively uncommon in general.

Delta Neutrophil Index is a Predictor of Disease Severity in Patients with Acute Pyelonephritis

( Geun Woo Ryu ),( Hyung Woo Kim ),( Seohyun Park ),( Sul A Lee ),( Jonghyun Jhee ),( Su-young Jung ),( Hyung Jung Oh ),( Jung Tak Park ),( Seung Hyeok Han ),( Shin-wook Kang ),( Tae-hyun Yoo ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Background: Delta neutrophil index (DNI) is the fraction of immature granulocytes provided by a complete blood count analyzer. Previous studies demonstrated that DNI is a novel marker to predict outcomes in sepsis patients. Therefore, this study aimed to evaluate DNI as a predictor of disease severity in patients with acute pyelonephritis (APN). Methods: Patients diagnosed with APN at Severance Hospital from December 2009 to July 2012 were retrospectively investigated. DNI levels were measured at the time of admission. The patients were classified into two groups according to the median value of DNI at baseline. Severe APN was diagnosed with one or more of these conditions including bacteremia, acute kidney injury, hypotension requiring use of vasopressors and admission of intensive care unit. Independent risk factors for severe APN were determined by multiple logistic regression analysis. Receiver operating characteristic (ROC) curves were plotted for DNI, white blood cell (WBC) count and C-reactive protein (CRP). Results: A total of 258 patients were included in this study. The median age was 61.0 (19.0-87.0), 237 patients (91.9%) were female, and the median DNI level was 2.5%. Severe APN was significantly more prevalent in high DNI group. Multivariate analysis showed that DNI, WBC count and CRP level independently predicted severe APN. DNIwas a better predictive marker of severe APN than WBC count, as reflectd by area under the ROC curve analysis (0.697 [95% CI, 0.637-0.753] vs. 0.562 [95% CI, 0.499-0.624], p=0.0013). DNI was not inferior to CRP levels to predict severe APN (0.697 [95% CI, 0.637-0.753] vs. 0.633 [95% CI, 0.571-0.692], p=0.1185). Conclusions: DNI level at admission is a valuable predictor of disease severity in patients with APN.

중국 온라인시장 현황 연구

전외술(Jeon, Oi Sul),정성아(Jung, Seong A) 한국창업학회 2017 한국창업학회지 Vol.12 No.1

The fast development of the Internet drives new vigor and opportunities to the world’s economy, especially, with the development of the new commercial technology and network technology, the Internet technology application has achieved the unprecedented progress. The network is not only a latent big market, but also a new commercial carrier with huge potential. In the network economy age, the commodity retail has a new way network marketing. Shopping on-line also becomes one fashion which the consumers now pursuing. The investigation demonstrates that the consumers shopping on line every year are growing steadily; the growing interests of users to the network shopping mean that in the future several years, China will be cultivating a huge expense market of electronic commerce. This paper about benefit segmentation of network market was discussed as follows: firstly the development of the research in the field was explained in and abroad, including several important methods and the traits and defaults of the method application in research reports; Secondly, we outlined the benefit segmentation for network marketing.

[P141] Eosinophilic pustular folliculitis occurring after orthognathic surgery

( A Young Park ),( Sul Hee Lee ),( Sun Bum Kwon ),( Sang Hoon Lee ),( Moon Kyun Cho ),( Jung Eun Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Eosinophilic pustular folliculitis (EPF) or Ofuji`s disease was first described by Ofuji et al. in 1970. It is a cutaneous inflammatory follicular disorder of unknown etiology. The etiology of EPF is still obscure and most theories have implied immunologic mechanisms in the initiation of lesions. We report a case of EPF, which occurring after orthognathic surgery. A 21-year old Korean female visited our clinic presenting pruritic erythematous scaly plaques studded with papules or pustules on both cheeks for the past 2 months. It appeared 8 months after double jaw surgery. Laboratory studies showed a white blood count of 6650/mm3, with an eosinophil count of 670/mm3 (10.1% eosinophils). The plaque was surgically incised under local anesthesia. Histopathologically, the incised specimen showed infiltration of eosinophils, neutrophils and lymphoid cells in follicular epithelium, sebaceous glands and perifollicular area with focal follicular mucinosis. Based on clinical and histological examination, we diagnosed eosinophilic pustular folliculitis. EPF is rare disorder characterized by recurrent crops or clusters of pruritic sterile papulopustules in an annular or polycyclic pattern on the face and other seborrheic areas. Some authors found immunologic mechanism of EPF. We speculate orthognathic surgery could cause immunologic reactions leading to this condition.

The Differential Immunomodulating Effects of Levan and DFA-IV on Macrophage Function

Park, Sul-Kyoung,Jang, Ki-Hyo,Kim, Mi-Hyun,Lim, Jung-Dae,Han, Eun-Tek,Jang, Seon-A,Kim, Kyung-Ho,Pyo, Suhk-Neung,Sohn, Eun-Hwa The Korean Society of Food Science and Nutrition 2008 Preventive Nutrition and Food Science Vol.13 No.1

Di-D-fructose-2,6':6,2'-dianhydride (DFA-IV) is a disaccharide consisting of two fructose residues that are prepared from levan by levan fructotransferase. Levan is a homopolysaccharide composed of D-fructofuranosyl residues joined by $\beta$-(2,6) and $\beta$-(2,1) linkages. We compared the immunomodulatory effects of levan with DFA-IV. Tumoricidal activity, phagocytosis and nitric oxide (NO) production were examined in levan- and DFA-IV-treated RAW264.7 cells. The NO production, tumoricidal and phagocytic activities were significantly increased in both treated cells. The results indicate that levan has significantly greater effects on tumoricidal activity than DFA-IV at low concentrations (1 ${\mu}g/mL$) and its effect on NO production shows a similar pattern. These results suggest that tumoricidal activity induced by both samples is mediated by NO production.

The Comparative Immunomodulatory Effects of β-Glucans from Yeast, Bacteria, and Mushroom on the Function of Macrophages

Jang, Seon-A,Park, Sul-Kyoung,Lim, Jung-Dae,Kang, Se-Chan,Yang, Kwang-Hee,Pyo, Suh-Kneung,Sohn, Eun-Hwa The Korean Society of Food Science and Nutrition 2009 Preventive Nutrition and Food Science Vol.14 No.2

The comparative immunomodulatory effects of ${\beta}$-glucans isolated from mushroom fungi (Coriolus versicol), yeast (Saccharomyces cerevisiae) and bacteria (Agrobacterium) on the major functions of macrophages were evaluated. As parameters of macrophage functions, we examined tumoricidal activity, phagocytosis, nitric oxide (NO) production, and the induction of inducible NO synthetase (iNOS) in RAW264.7 cells, following treatments with ${\beta}$-glucans from the three different sources. The results indicated that all ${\beta}$-glucan treatments significantly induced tumoricidal activity in the RAW264.7 cells, with a remarkable effect shown by the beta-glucan from Agrobacterium at a concentration of $10{\mu}g/mL$. There was also a significant increase in iNOS-NO system activity in macrophages treated with ${\beta}$-glucans extracted from yeast; however, iNOS-NO system activity was not markedly changed by the treatment of ${\beta}$-glucans from C. versicolor mushroom fungi or Agrobacterium. Furthermore, the ${\beta}$-glucans from C. versicolor had a significant phagocytotic effect at concentrations of 1, 10, and $100{\mu}g/mL$. Taken together, the present data suggest that these ${\beta}$-glucans, isolated from three different sources, have different effects on macrophage function, and therefore, may have different clinical uses in different for various types of diseases.

한국창업시장의 중국진출에 있어 필요한 중국문화 이해

전외술(Jeon Oi Sul),정성아(Jung Seong A) 한국창업학회 2015 한국창업학회지 Vol.10 No.2

From 1980’s to 1990’s, with the further development of the reform and opening-up of China, the enterprise culture was introduced into Chinese enterprises as a mode of management in enter of foreign countries. China has already emerged as not the “world factory” of the “world market”, and it shows that there is fierce competition between the growth of Chinese enterprises , does mean that countries inside and outside the enterprise. In the Chinese market it is needed in order to understand the socio-cultural . This article Korea companies would like to search for a Chinese culture that must be understood as advancing in China. This paper relating to the relationship between culture and management, mainly describes the characteristics of Chinese culture as well as relationship between culture and management.

Vitamin D Deficiency is Significantly Associated with Depression in Chronic Kidney Disease Patients

( Jong Hyun Jhee ),( Su-young Jung ),( Hyung Woo Kim ),( Geun Woo Ryu ),( Sul A Lee ),( Seohyun Park ),( Hyung Jung Oh ),( Jung Tak Park ),( Seung Hyeok Han ),( Shin-wook Kang ),( Tae-hyun Yoo ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Background: Recent studies have reported significant associations between vitamin D deficiency and depression in the generalpopulation. Even though both vitamin D deficiency and depression are common in patients with chronic kidney disease (CKD), the association between these two prevalent factors remains poorly elucidated. Therefore, we investigated the association between vitamin D deficiency and depression in CKD patients. Methods: The data from Korean National Health and Nutritional Examination Survey between 2010 and 2012 were used. Patients with estimated glomerular filtration rate ≤60 mL/min/1.73 m2 were enrolled. VitaminD deficiency was defined as 25-hydroxyvitamin D3 [25(OH)D3] levels ≤10 ng/mL. The patients were divided into groups with or without vitamin D deficiency. Depression was determined by the EuroQOL-5D (EQ5D) questionnaire.Associations between vitamin D deficiency and depression were evaluated by multiple logistic regression analysis. Results: The mean age was 71.2±9.3 years, and 257 patients (51.9%) were female. The mean 25(OH)D3 levels were 17.9 ng/mL in total, 8.7 ng/mL in vitamin D deficient group, and 18.9 ng/mL in non-vitamin D deficient group. The prevalence of depression in CKD patients was higher compared to the general population (14.3% versus 11.1%, p=0.031). Moreover, the prevalence of depression was significantly higher in patients with vitamin D deficiency than those without vitamin D deficiency (27% versus 13.3%, p=0.022). Multiple logistic regression analysis showed that vitamin D deficiency was a significantly independent predictor of depression after adjusting for age, sex, alcohol, body mass index, hypertension, diabetes mellitus, anemia, suicidal idea, EQ5D index and serum parathyroid hormone levels (odds ratio=6.27, 95% confidence interval=1.57 to 25.05, p=0.009). Conclusions: Depression was highly prevalent in CKD patients. The prevalence ofdepression was higher in CKD patients with vitamin D deficiency. In addition, vitamin D deficiency was a significantly independent predictor of depression in CKD patients. Therefore, determining vitamin D levels might be helpful in predicting depression in these patients.

2008년 지역사회건강조사 질관리정도 평가

김종희 ( Jong Hee Kim ),박해용 ( Hye Yong Park ),김윤아 ( Yun A Ki ),강양화 ( Yang Hwa Gang ),김정숙 ( Jung Suk Kim ),임도상 ( Do Sang Im ),탁양주 ( Yang Ju Tak ),임현술 ( Hyun Sul Im ),김호 ( Ho Kim ) 한국보건정보통계학회(구 한국보건통계학회) 2010 한국보건정보통계학회지 Vol.35 No.2

Objective: 2008 Community health survey is an survey to produce health statistics of 253 communities. This study aims to develope quality management`s system and assess the quality of [2008 Community Health Survey]. Method: We reviewed literatures related to health interview survey in and out countries and visited the survey site to get information. We set up 3-step system for managing quality of [2008 Community health survey], which consists of community health center, college and KCDC. We also developed a survey manuals, a quality management system and a quality index. Using quality-evaluation index, we assessed quality of [2008 Community Health Survey]. Result: Out of 231,355 participants which were 101,307 male, 118,941 female, 220,248(95.2%) completed the questionnaire. Spot-replacement, Household-replacement was 0.6%, 7.2%, respectively. Kappa index of answer-concordance was 0.68 which means a good concordance. According to results of survey site evaluation, quality poor items were Questioning order(Insufficiency 45.6%), Question completion(Insufficiency 36.8%), Explanation of survey goal(Insufficiency 31.6%), Probing(Insufficiency 28.1%) orderly. Conclusion: The quality of [2008 Community Health Survey] was fine, but more efforts to improve health-survey quality need in the future.