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Bae, Sul-Hee,Han, Dong-Kyun,Baek, Hee-Jo,Park, Sun-Ju,Chang, Nam-Kyu,Kook, Hoon,Hwang, Tai-Ju The Korean Pediatric Society 2011 Clinical and Experimental Pediatrics (CEP) Vol.54 No.4
Purpose: Acute internal hemorrhage is an occasionally life-threatening complication in pediatric cancer patients. Many therapeutic approaches have been used to control bleeding with various degrees of success. In this study, we evaluated the efficacy of selective internal iliac artery embolization for controlling acute intractable bleeding in children with malignancies. Methods: We retrospectively evaluated the cases of 6 children with various malignancies (acute lymphoblastic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, T-cell prolymphocytic leukemia, Langerhans cell histiocytosis, and rhabdomyosarcoma), who had undergone selective arterial embolization (SAE) of the internal iliac artery at the Chonnam National University Hwasun Hospital between January 2004 and December 2009. SAE was performed by an interventional radiologist using Gelfoam$^{(R)}$ and/or Tornado$^{(R)}$ coils. Results: The patients were 5 boys and 1 girl with median age of 6.9 years (range, 0.7-14.8 years) at the time of SAE. SAE was performed once in 4 patients and twice in 2, and the procedure was unilateral in 2 and bilateral in 4. The causes of hemorrhage were as follows: hemorrhagic cystitis (HC) in 3 patients, procedure-related internal iliac artery injuries in 2 patients, and tumor rupture in 1 patient. Initial attempt at conservative management was unsuccessful. Of the 6 patients, 5 (83.3%) showed improvement after SAE without complications. Conclusion: SAE may be a safe and effective procedure for controlling acute intractable hemorrhage in pediatric malignancy patients. This procedure may obviate the need for surgery, which carries an attendant risk of morbidity and mortality in cancer patients with critical conditions.
Thermosensitive and mucoadhesive delivery systems of mucosal vaccines
Han, In-Kwon,Kim, Young Bong,Kang, Hung-Sik,Sul, Donggeun,Jung, Woon-Won,Cho, Hee Jeong,Oh, Yu-Kyoung Elsevier 2006 Methods Vol.38 No.2
<P><B>Abstract</B></P><P>Mucosal vaccination is emerging as a potential administration route for eliciting antigen-specific mucosal and systemic immunogenicity. Most mucosal vaccines have been administered in a phosphate-buffered saline vehicle that may limit the exposure of antigens to the mucosal surfaces and result in poor immunogenicity. To improve the potency of the mucosal vaccines, we have developed mucosal vaccine delivery systems that might prevent leakage and increase retention of vaccines on mucosal surfaces. Thermosensitive polymers have been used to reduce the leakage problems of nasal or vaginal vaccines, while mucoadhesive polymers have been employed to increase the mucosal contact of the vaccines. Here, we describe the formulation and delivery methods of mucosal vaccines using thermosensitive and mucoadhesive polymers.</P>
Han, Seungnam,Nam, Jungyong,Li, Yan,Kim, Seho,Cho, Suk-Hee,Cho, Yi Sul,Choi, So-Yeon,Choi, Jeonghoon,Han, Kihoon,Kim, Youngrim,Na, Moonseok,Kim, Hyun,Bae, Yong Chul,Choi, Se-Young,Kim, Eunjoon The Society 2010 The Journal of neuroscience Vol.30 No.45
<P>PSD-95 (postsynaptic density-95) is thought to play important roles in the regulation of dendritic spines and excitatory synapses, but the underlying mechanisms have not been fully elucidated. TANC1 is a PSD-95-interacting synaptic protein that contains multiple domains for protein-protein interactions but whose function is not well understood. In the present study, we provide evidence that TANC1 and its close relative TANC2 regulate dendritic spines and excitatory synapses. Overexpression of TANC1 and TANC2 in cultured neurons increases the density of dendritic spines and excitatory synapses in a manner that requires the PDZ (PSD-95/Dlg/ZO-1)-binding C termini of TANC proteins. TANC1-deficient mice exhibit reduced spine density in the CA3 region of the hippocampus, but not in the CA1 or dentate gyrus regions, and show impaired spatial memory. TANC2 deficiency, however, causes embryonic lethality. These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory, and implicate TANC2 in embryonic development.</P>
Isoflavone Content and Estrogen Activity in Arrowroot Puerariae Radix
Hee-Yun Kim,Jin-Hwan Hong,Dong-Sul Kim,Kil-Jin Kang,Sang-Bae Han,Eun-Ju Lee,Hyung-Wook Chung,Kyung-Hee Song,Kyung-A Sho,Seung-Jun Kwack,Soon-Sun Kim,Kui-Lea Park,Si-Kyung Lee,Myung-Chul Kim,Chang-Min 한국식품과학회 2003 Food Science and Biotechnology Vol.12 No.1
Ventilation impairment of residents around a cement plant
Sul Ha Kim,Chul Gab Lee,Han Soo Song,Hyun Seung Lee,Min Soo Jung,Jae Yoon Kim,Choong Hee Park,Seung Chul Ahn,Seung Do Yu 대한직업환경의학회 2015 대한직업환경의학회지 Vol.27 No.-
Objectives: To identify adverse health effects due to air pollution derived from a cement plant in Korea. The ventilation impairment in residents around a cement plant was compared to another group through a pulmonary function test (PFT). Methods: From June to August of 2013, both a pre and post-bronchodilator PFT was conducted on a “more exposed group (MEG)” which consisted of 318 people who lived within a 1 km radius of a cement plant and a “less exposed group (LEG)” which consisted of 129 people who lived more than 5 km away from the same plant. The largest forced expiratory volume in a one second (FEV1) reading and a functional residual capacity (FVC) reading were recorded after examining the data from all of the usable curves that were agreed upon as valid by PFT experts of committee of National Institute of Environmental Research. The global initiative for chronic obstructive lung disease (GOLD) criteria for COPD, defined the FEV1/FVC ratio < 0.7 as the obstructive type, and the FEV1/FVC ratio ? 0.7 and FVC% predicted < 80% were as the restrictive type. The FVC% predicted value was estimated using Korean equation. We compared the proportion of lung function impairments between the MEG and the LEG by using a chi-square, and estimated the OR of obstructive and restrictive ventilation impairments by logistic regression. Results: The obstructive type impairment proportion was 9.7% in the MEG, whereas it was 8.5% in the LEG. The restrictive type was 21.6% in the MEG which was more than the 12.4% of the LEG. The odds ratio (OR) of total ventilation impairment in the MEG was 2.63 (95% CI 1.50 ~ 4.61) compared to the LEG. The OR of obstructive type in the MEG was 1.60 (95% CI 0.70 ~ 3.65), the smoking history was 3.10 (CI 1.10 ~ 8.66) whereas OR of restrictive type in the MEG was 2.55 (95% CI 1.37 ~ 4.76), the smoking history was 0.75 (95% CI 0.35 ~ 1.60) after adjusting for sex and age. Level of exposure to particulate played a role in both types. However, it appeared to be a significant variable in restrictive type, while smoking history was also an important variable in obstructive type. Conclusion: Although this study is a limited cross-section study with a small number of subjects, ventilation impairment rate is higher in the MEG. There might be a possibility that it is due to long-term exposure to particulate dust generated by the cement plant.