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대식세포에서 국산약용식물의 항암 및 항Virus 에 대한 효과
표석능(Suhkneung Pyo),지옥표(Ok Pyo Zee),엄성희(Sung Hee Um),김대근(Dae Keun Kim),곽종환(Jong Whan Kwak),이강노(Kang Ro Lee),이동권(Dong Kwon Rhee) 한국생약학회 1995 생약학회지 Vol.26 No.3
In the present work, 70 extracts from 23 plants have been determined to induce cytotoxic and antiviral activities of macrophages using both MTT assay and neutral red dye uptake assay. We show that 13 extracts have induced cytotoxic activities and 5 extracts induced antiviral activity in mouse peritoneal macrophages. Among 13 extracts, macrophages treated with extracts from Salvia plebeia have demonstrated significant cytotoxicity but not antiviral activity. The present findings indicate that extracts from plants can stimulate macrophages to become resistant to virus and to kill tumor cells.
Enhanced macrophage function of red ginseng acidic polysaccharide (RGAP) in combination with IFN-γ
Hye-Sook Choi,Yi-Seong Kwak,Jong-Dae Park,Suhkneung Pyo(표석능) 고려인삼학회 2006 고려인삼학회 학술대회 Vol.- No.-
In this study we examined the potential for the synergistic augmentation of the activity of inflammatory mouse peritoneal macrophages by stimulation with RGAP combined with IFN-γ. The moderate augmentative effect induced by preincubation with RGAP was observed in the production of IL-1, IL-6 and NO but not TNF-α. In addition, IFN-γ had a low activating effect. Following preincubation with both RGAP A and IFN-γ, a marked enhancement of secretory activity and tumoricidal activity was noted in mouse peritoneal macrophages. Treatment of peritoneal macrophage with combination increased the generation of IL-1, IL-6, TNF-α and NO, whereas the production of reactive oxygen species were not altered. These results demonstrate the synergistic effects on macrophage function of RGAP in combination with IFN-γ and suggest that the ability of IFN-γ to prime macrophages to produce secretory molecules in response to RGAP may have implications for immunotherapy with this combination.
표석능 성균관대학교 약학연구소 1993 成均藥硏論文集 Vol.5 No.1
The synthetic, double-stranded RNAs including polyriboinosinic: polyribocytidylic acid (poly I : C)exert a wide diversity of biologic effects which has been shown at both the cellular and organism levels. Poly I : C is effective in vitro in inducing resistance to virus infection in a variety of cell types and in activating the cytotoxic potential of macrophages. In addition, poly I : C is a potent macrophage or NK cell activator and interferon inducer, which is effective in the prophylactic and therapeutic treatment of viral infections and in the therapy of tumor. Thus synthetic ds RNA can be utilized as a therapeutic agent, either alone or in combination with interferon.
The Mechanisms of Interferon-α and Interferon-γ Induced Antiviral Activity in Peritoneal Macrophages
Pyo, Suhkneung,Lee, Jae-Hag,Rhee, Dong-Kwon 성균관대학교 약학연구소 1997 成均藥硏論文集 Vol.9 No.1
대식세포는 세포 내에서 바이러스복제를 억제함으로서 바이러스 감염에 대한 숙주반응에서 중요한 역할을 한다. 인터페론은 바이러스 감염시 세포가 분비하는 항바이러스 효과를 갖고 있는 단백질로서 인터페론 생성을 유도하는 poly I : C와 같이 대식세포에서 다른 인터페론을 유도하여 항바이러스작용을 나타낼 가능성이 있기 때문에 인터페론에 의해 활성화된 대식세포가 HSV-1의 감염에 대한 저항작용기전을 연구하였다. 대식세포를 인터페론-α 또는 인터페론-γ 및 인터페론 항체를 함께 처리하여 HSV-1감염에 대하여 저항하는 대식세포의 능력을 평가하였다. 인터페론 항체는 HSV-1에 감염된 대식세포에서 인터페론의 보호효과를 중화시키지 못하였다. 또한 인터페론을 처리한 대식세포의 상층액에서 인터페론을 탐지할 수 없었다. 이는 poly I : C가 인터페론-β 생성을 유도하여 항바이러스효과를 나타내는 작용기전 (Pyo et al. J. Leukocyte Biol. 50:479)과는 달리 인터페론-α와 인터페론-γ는 인터페론-β 생성과정을 경유하지 않고 직접적으로 대식세포에 작용하여 항바이러스 효과를 나타내는 듯하다.
Pyo, Suhkneung,Rhee, Dong-Kwon 성균관대학교 약학연구소 1995 成均藥硏論文集 Vol.7 No.1
Abstract - Poly I:C에 의해 유도된 대식세포의 항바이러스 작용에 RNA 또는 단백질 합성이 필요한지를 결정하였다. Actinomycin D 또는 cycloheximide로 대식세포를 전처리 하였을 때 poly I:C의 항바이러스 효과가 감소되었으나 actinomycin D 또는 cycloheximide를 후처리하였을 때는 억제되지않아 poly I:C의 항바이러스 작용에 RNA와 단백질 합성이 요구되는 듯 하며 poly I:C 처리의 초기단계에서 interferon이 생성되는 듯하다.
유전자치료를 위한 벡터 개발의 연구 동향 : A Current Research Insight
손은화,손은수,표석능 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5
The basic concept underlying gene therapy is that human diseases may be treated by the transfer of genetics material into specific cells of a patient in order to correct or supplement defective genes responsible for disease development. There are several systems that can be used to transfer foreign genetic material into the human body. Both viral and non-viral vectors are developed and evaluated for delivering therapeutic genes. Viral vectors are biological systems derived from naturally evolved viruses capable of transferring their genetics materials into host cells. However, the limitations associated with viral vectors, in terms of their safety, particularly immunogenecity, and their limited capacity of transgenic materials, have encouraged researchers to increasingly focus on non-viral vectors as an alternative to viral vectors. Although non-viral vectors are less efficient than viral ones, they have the advantages of safety, simplicity of preparation and high gene encapsulation capability. This article reviews the most recent studies highlighting the advantages and the limitation of gene delivery systems focused on non-viral systems compared to viral systems.
문은이,이동권,표석능 성균관대학교 약학연구소 1996 成均藥硏論文集 Vol.8 No.1
Aflatoxin B1 (AFB1) has been reported to directly suppress the immune responses. In the present study, the effect of AFB1 on immune functions was investigated. Splenic lymphocytes were treated with various doses of the mitogens (lipopolysaccharide, concanavalin A) in the presence of AFB1. AFB1 pretretment decreased the number of plaque forming cells (PFC) in a dose-dependent manner. Antibody production of IgM and IgG class was significantly decreased in AFB1-treated splenic cells. In addition, when animals were exposed to AFB1, the susceptibility of bacterial infection as well as the growth of tumor cells was increased. These data suggest that AFB1 affected the immune function and humoral immunity impaired by AFB1 treatment contributed to pathological process.