FERMENTATION PRODUCTS AND PROTEIN CONCENTRATIONS IN DIGESTIVE TRACKS IN MICROTUS MONTEBELLI FED WITH DIFFERENT RATIONS

Sugawara, M.,Arai, T.,Oki, Y. Asian Australasian Association of Animal Productio 1989 Animal Bioscience Vol.2 No.3

The world data center on microorganisms

Sugawara, Hideaki The Microbiological Society of Korea 1989 微生物과 産業 Vol.15 No.1

It is our common understanding that biological materials like microorganisms, tissue and cell cultures, seeds, plants and animals are inevitable resources for the development of science and technology. Culture collections which are reservior of biological materials now occupy a central position in life sciences and biotechnology. The World Data Center of Microorganisms (WDC) is a infrastructure of culture collections in the world realizing quick and smooth exchanges of information and microorganisms to support research and development in those fields. The WDC was relocated from University of Queensland in Australia to out institute RIKEN in 1986. This article introduces a function for WDC in RIKEN (RIKAGAKU-KENKYUUSHO, the Institute of Physical and Chemical Research)

THE FUTURE OF EARLY CHILDHOOD EDUCATION : DEVELOPMENTALLY APPROPRIATE PRACTICES?

Sugawara, Alan I. 淑明女子大學校 兒童硏究所 兒童福祉學科 1991 兒童硏究 Vol.6 No.1

Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist

Sugawara, Reiko,Lee, Eun-Jung,Jang, Min Seong,Jeun, Eun-Ji,Hong, Chun-Pyo,Kim, Jung-Hwan,Park, Areum,Yun, Chang Ho,Hong, Sung-Wook,Kim, You-Me,Seoh, Ju-Young,Jung, YunJae,Surh, Charles D.,Miyasaka, Ma The Rockefeller University Press 2016 The Journal of experimental medicine Vol.213 No.4

<▼1><P>Jang et al. show that eosinophils in the small intestine can suppress Th17 cell differentiation through the secretion of the IL-1 receptor antagonist.</P></▼1><▼2><P>Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the ΔdblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4<SUP>+</SUP> T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1β. Moreover, small intestinal eosinophils isolated from IL-1Ra−deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra.</P></▼2>

Hepatitis C and Liver Transplantation

( Yasuhiko Sugawara ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.5(S)

OBJECTIVES: Hepatitis C virus (HCV) is the most common indication for living donor liver transplantation in Japan. A recent paper in the Western world reported that HCV infection was associated with a 23% increase in mortality and a 30% increase in the rate of liver graft failure. The poor results might be due to recurrence of HCV disease in the graft. If HCV recurs earlier and more severely after transplantation, a specific strategy for preventing the detrimental effects of HCV on the grafts must be developed. METHODS: One strategy might be aggressive treatment for HCV. Treatment of recurrent HCV disease with interferon and ribavirin after liver transplantation is used. One standard regimen includes interferon-alpha2b (3 MU x 3 per week) or PEG interferon (1.5 microg/kg) and ribavirin (600-800 mg/day) for 48 weeks. RESULTS: We have adopted the preemptive therapy in the 92 living donor liver transplant recipients until the end of 2006 and obtained a sustained viral response rate 35%. The 5-year survival rate was 82% which was not significantly different from that of the non hepatitis patients. CONCLUSIONS: Living donor liver transplantation is an effective life saving option with excellent outcome for patients suffering from end-stage liver disease including those due to HCV in regions where deceased donor liver transplantation remains an unrealistic option.

Interactive Flocking Simulator based on Deterministic Kinetic Model

Ken Sugawara,Kanako Hata 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

We propose a new drawing tool based on the dynamics of collective behaviors reported in our previous work. Dynamics of collective motion is described by fundamental kinetics of particles and the dynamics of the heading which each element has as a degree of freedom. We firstly explain the model in detail and show various types of behavior such as marching, oscillatory, wandering and swarming emerges by computer simulation. Next, we show the drawing tool based on the dynamics. Users can draw any object by electric pen, and the drawn objects are characterized by their shape, and show collective motions based on the characteristics. Performance of the tool is evaluated by two-dimensional mood scale.

Causal Mechanisms in Neurosciences: Toward the Integration of Optogenetics and Brain Imaging Studies

Yuki Sugawara 한국과학철학회 2014 과학철학 Vol.17 No.3

Although a central aim of neuroscience is to describe the causal relationshipbetween brain structure and function, it is unclear whether the methodscurrently used in neuroscience describe such a relationship. My aim was toarticulate some of the methods by which neuroscience can describe this causalrelationship and provide explanations. Thus, I used optogenetics and functionalmagnetic resonance imaging (fMRI) studies to analyze this relationship. I thenargued that although optogenetics, but not fMRI studies, can describe thecausal relationship, one can solve the problem by integrating optogenetics withfMRI studies on basis of the conception of mechanisms.

일본인 여성 야스다 야스코(安田靖子)의 대조선 인식

스가와라유리 ( Sugawara Yuri ) 한국여성사학회 2010 여성과 역사 Vol.- No.12

본 논문은 대한제국 시절에 조선에 건너와서 3년 6개월 거주했던 일본인 여성 저널리스트 야스다 야스코(安田靖子)의 사례를 분석의 대상으로 삼아 당시 재조선 일본인 여성이 가졌던 대조선 인식의 일단을 규명해 보고자 했다. 야스다는 조선에서 진남포와 경성에 거주하였으며 각 거주지에서 현지 상황을 전하는 기고문을 연재하였다. 진남포 시절에는「진남포에서(鎭南浦より)」 등을 『부녀신문(婦女新聞)』에 연재하여 현지 생활과 조선인의 풍습을 통해 일본 독자들에게 조선의 실정을 바르고 정확하게 소개하는 데 역점을 두었다. 경성 시절에는 진남포 시절과 달리 현지의 상황을 전하는 내용보다는 수필이 많았다. 이들 가운데 「한국절참배(韓寺詣)」와 「한국초혼제(韓國招魂祭)」에는 조선인과 교류하려고 노력했던 흔적이 엿보인다. 이는 야스다가 조선생활에 익숙해져 현지 조선의 풍습과 조선인과의 교류에도 이전 시기보다 적극적으로 대응하려는 자세를 보인 것이다. 또 일본 여성으로서의 자세와 기개를 바르게 갖는 것을 강조하는데 역점을 두기도 하였다. 야스다의 조선 체류 동안의 기고문은 당시 일본에 있던 일본여성 독자들에게 현지 생활에 대한 현장감 있는 정보를 전달하는데 큰 몫을 하였다. 야스다의 재조선 인식은 당시 일본 정부의 대외정책 방향과 일치하고 있다. 동시에 그녀가 선택한 언론매체인 『부녀신문』의 간행목적이나 편집방향 등의 성격과도 일치하고 있다. 야스다는 당시의 시대적 상황과 배경 아래 자신이 갖고 있던 문필가로서의 능력과 조선에 거주하고 있다는 상황을 조합하여, 『부녀신문』을 통해 자신의 인식을 세상에 발표하였다. 그 글들은 결과적으로 일본정부의 방침에 충실하게 부합된 것이었다. 야스다의 20세기 초반 조선 거주 체험과 그와 관련된 기고문 그리고 이를 통해서 드러난 그녀의 대조선 인식은 그 시대의 일본인들이 쉽게 빠져들었던 삶의 한 전형을 보여주었다. 이는 당시 일본 정부가 추구했던 제국주의적 팽창전략에 대한 무비판적인 동조와 자발적인 기여 및 그에 대한 과도한 자부심이었다. This study purposed to explain a part of how Japanese women living in Korea perceived Korea by analyzing the case of Japanese woman Yasuda Yasuko (安田靖子) who came to Korea during the period of of the Daehan Empire and lived in the country for 3 years and 6 months. While residing in Jinnampo and Gyeongseong in Chosun, Yasuda contributed a series of articles reporting local situations of the place where she was staying. During the days in Jinnampo, she wrote about local life and Korean people`s customs and published them in Women`s News under the title “In Jinnampo,” and in the writings she focused on informing Japanese readers of Korean situations correctly and accurately. Different from the period in Jinnampo, while staying in Gyeongseong, she wrote more essays than reports on local situations. Among the essays, “Korean people`s temple worship” and “Memorial services in Korea” suggest traces of her efforts to exchange with Koreans. As she was accustomed to Korean life, Yasuda showed an active attitude toward Korean local customs and association with Koreans compared to other Japanese before her. She also emphasized that Japanese women should have a right attitude and spirit as the citizens of Japan. Her contributions written on her experiences during her stay in Chosun played a significant role for Japanese female readers in Japan to get realistic contents and information on local life. It was found that Yasuda`s perception of Chosun was consistent with the Japanese government`s direction of foreign policies. At the same time, it agreed with the purpose and editorial direction of Women`s News, the medium that she chose. Her writings out of the historical situation and background of the days, her abilities in writing, and her experiences in Chosun were published in Women`s News, and they were faithful to the Japanese government`s policies. Yasuda Yasuko`s stay in Korea during the early 20th century, her contributions written on her experiences, and her perception of Chosun revealed in the writings show a typical life that Japanese in those days fell in easily. It was uncritical conformity with, voluntary contribution to, and excessive pride in the Japanese government`s cruel strategy for imperial expansion

Relationship between Clozapine-Induced Electroencephalogram Abnormalities and Serum Concentration of Clozapine in Japanese Patients with Treatment-Resistant Schizophrenia

Yuka Sugawara Kikuchi,Takashi Kanbayashi,Tetsuo Shimizu 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.4

ObjectiveaaThe objective of this study was to investigate the relationship between the serum concentration of clozapine (C-CLZ), Ndesmethylclozapine (N-CLZ) and the daily dose of CLZ (D-CLZ), and the relationships among CLZ and electroencephalogram (EEG) abnormalities. MethodsaaTwenty-eight patients were recruited to this study, but 8 patients were excluded because clozapine was discontinued before the post-treatment measurement of EEG or C-CLZ. Ultimately, 20 patients (6 men, 14 women) with an average age of 36 years were enrolled. The subjects were divided into EEG normal and abnormal groups. C-CLZ and N-CLZ were measured at 4, 12, 26, and 52 weeks after initiating CLZ administration. ResultsaaAll patients had normal baseline EEG signals, and 8 patients showed EEG abnormalities later. There were significant correlations between C-CLZ and D-CLZ, and between N-CLZ and D-CLZ. The C-CLZ/D-CLZ, N-CLZ/D-CLZ, and C-CLZ/N-CLZ ratio were not significantly different between the EEG normal and EEG abnormal groups. The EEG abnormal group had significant higher proportion of patients with high intra-individual variability in their C-CLZ/D-CLZ ratio. ConclusionaaThere is no relationship between C-CLZ and EEG abnormalities. However, patients with high intra-individual variability in their C-CLZ/D-CLZ ratio had greater possibility of exhibiting EEG abnormalities.

Cooperative Foraging Behavior of Multi Robot System with Simple Interaction

Ken Sugawara,Masaki Sano,Ikuo Yoshihara,Kenichi Abe,Toshinori Watanabe 제어로봇시스템학회 2001 제어로봇시스템학회 국제학술대회 논문집 Vol.2001 No.10