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Choi, Young Deuk,Ham, Won Sik,Kim, Won Tae,Cho, Kang Su,Lee, Joo Hyoung,Cho, Soung Yong,Seo, Ju Wan,Jin, Ok Hyun Mary Ann Liebert 2009 Journal of endourology Vol.23 No.6
<P>PURPOSE: To evaluate the efficacy and safety of single-session OK-432 sclerotherapy for the treatment of renal cysts. MATERIALS AND METHODS: From October 2005 to November 2006, 48 patients (61 simple renal cysts) were included in the study. Indications were determined as flank discomfort (n = 37) or patient reassurance due to increasing size (n = 11). The simple renal cysts were aspirated under ultrasonography (US), at which point OK-432 was injected into the cyst. Follow-up was performed with US or computed tomography scan every 3 months until 1 year. Complete regression of the renal cyst or more than 70% reduction in size with no symptoms indicated a successful treatment. RESULTS: Among 61 renal cysts of 48 patients, the overall success rate was 98.4%. Complete regression occurred in 46 cysts (75.4%), and more than 90% reduction in size occurred in 6 cysts (9.8%). A size reduction of 80% to 90% and 70% to 80% occurred in five (8.2%) and three cysts (4.9%), respectively. A size reduction less than 70% occurred in only one cyst (1.6%). The success of cyst regression was correlated with cyst volume. Clinical symptoms resolved in 100% of patients with symptomatic cysts, and there was no enlargement of the aspirated cysts at the 1-year follow-up. After the procedure, there were only some minor complications, such as mild fever, flank pain, and leukocytosis, which subsided with the conservative treatment. CONCLUSIONS: Percutaneous OK-432 sclerotherapy is simple, safe, and effective, and it can be an alternative first-line therapy for simple renal cysts.</P>
Su-Hae Lee,Eun-Yong Jung,Kyong-Ok No,JI Soon Sin,Chang-Nam Ahn 한국독성학회 2002 Toxicological Research Vol.18 No.2
Hantaan (HTNV) and Puumala (PUUV) viruses cause hemorrhagic fever with renal syndrome in human. In the present study, the repeated dose toxicity of the HTNV-PUUV combination vaccine was evaluated in Sprague-Dawley rats. Animals were injected subcutaneously for 28 days with dosages of 0, 0.017, 0.17 and 1.7 dose/kg body weight per day, respectively. No any significant changes of body weight, food and water consumptions were shown. There were no death and clinical findings during the experimental period. In both male and female rats, there were not significant changes in hematological and serum biochemical analysis, urinalysis, and ophthalmoscopic and histopathological examinations. These results indicate that the HTNV-PUUV combination vaccine may have no toxic effects and no observed adverse effect level (NOAEL) may be over 1.7 dose/kg/day at subcutaneous route in rats.
Alterations in the Properties of Agar by ionizing Radiation
Lee, Su-Rae,Park, Sang-Ki,Cho, Han-Ok Korean Nuclear Society 1976 Nuclear Engineering and Technology Vol.8 No.3
Alkali-treated red algae, Gracilaria sp. was irradiated with various doses of cobalt-60 gamma-rays and the yeild and properties of agar extracted from the seaweed were examined and compared with the quality of commercial agar powder after irradiation. Extraction yield of agar from irradiated seaweed was proportionally increased as the radiation dose was raised up to 2 Mrad whereas it tended to decrease slightly thereafter. Gelation ability, gelation point, gel hardness and specific viscosity of the agar were increased up to 1 Mrad and decreased at higher dose levels while its melting point, total nitrogen, crude ash and total sulfur decreased up to 1 Mrad level and remained unchanged thereafter. Irradiation of commercial agar powder caused remarkable decreases in the gelation ability, specific viscosity and gel hardness and slight decreases in the gelation point and melting point. The pattern of alterations in the properties of agar samples differed whether the polysaccharide was irradiated in free state or bound state in seaweed.
Lee, Hyung-Chahn,Park, In-Chul,Park, Myung-Jin,An, Sungkwan,Woo, Sang-Hyeok,Jin, Hyeon-Ok,Chung, Hee Yong,Lee, Su-Jae,Gwak, Ho-Shin,Hong, Young-Jun,Yoo, Doo-Hyun,Rhee, Chang-Hun,Hong, Seok-Il Wiley Subscription Services, Inc., A Wiley Company 2005 Journal of cellular biochemistry Vol.94 No.3
<P>Non-steroidal anti-inflammatory drug (NSAID), sulindac has chemopreventive and anti-tumorigenic properties, however, the molecular mechanism of this inhibitory action has not been clearly defined. The Akt/protein kinase B, serine/threonine kinase is well known as an important mediator of many cell survival signaling pathways. In the present study, we demonstrate that down-regulation of Akt is a major effect of anti-invasiveness property of sulindac and its metabolites in glioblastoma cells. Myristoylated Akt (MyrAkt) transfected U87MG glioblastoma cells showed increase invasiveness, whereas DN-Akt transfected cells showed decrease invasiveness indicating that Akt potently promoted glioblastoma cell invasion. MMP-2 promoter and enzyme activity were up-regulated in Akt kinase activity dependent manner. Sulindac and its metabolites down-regulated Akt phosphorylation, inhibited MMP-2 production, and significantly inhibited invasiveness of human glioblastoma cells. In addition, sulindac and LY294002, a selective inhibitor of phosphoinositide 3-kinase (PI3K), synergistically inhibited the invasion of glioblastoma cells. Furthermore, only celecoxib showed Akt phosphorylation reduction and an anti-invasivness in glioblastoma cells, whereas aspirin, ketoprofen, ketorolac, and naproxen did not. In conclusion, our results provide evidence that down-regulation of Akt pathway and MMP-2 may be one of the mechanisms by which sulindac and its metabolites inhibit glioblastoma cell invasion. © 2004 Wiley-Liss, Inc.</P>
Leuconostoc miyukkimchii sp. nov., isolated from brown algae (Undaria pinnatifida) kimchi
Lee, Seung Hyeon,Park, Moon Su,Jung, Ji Young,Jeon, Che Ok Microbiology Society 2012 International journal of systematic and evolutiona Vol.62 No.5
<P>A Gram-staining-positive, non-motile and non-spore-forming lactic acid bacterium, designated strain M2<SUP>T</SUP>, was isolated from fermented brown algae (<I>Undaria pinnatifida</I>) kimchi in South Korea. Cells of the isolate were facultatively anaerobic ovoids and showed catalase- and oxidase-negative reactions. Growth of strain M2<SUP>T</SUP> was observed at 4-35 °C and at pH 5.0-9.0. The G+C content of the genomic DNA was 42.5 mol%. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain M2<SUP>T</SUP> belonged to the genus <I>Leuconostoc</I> and was most closely related to <I>Leuconostoc inhae</I> IH003<SUP>T</SUP>, <I>Leuconostoc kimchii</I> IH25<SUP>T</SUP>, <I>Leuconostoc gasicomitatum</I> LMG 18811<SUP>T</SUP>, <I>Leuconostoc gelidum</I> DSM 5578<SUP>T</SUP>, <I>Leuconostoc palmae</I> TMW2.694<SUP>T</SUP> and <I>Leuconostoc holzapfelii</I> BFE 7000<SUP>T</SUP> with 98.9 %, 98.8 %, 98.8 %, 98.7 %, 98.5 % and 98.2 % sequence similarity, respectively. DNA-DNA hybridization values between strain M2<SUP>T</SUP> and <I>Leuconostoc inhae</I> KACC 12281<SUP>T</SUP>, <I>Leuconostoc kimchii</I> IH25<SUP>T</SUP>, <I>Leuconostoc gelidum</I> KACC 12256<SUP>T</SUP>, <I>Leuconostoc gasicomitatum</I> KACC 13854<SUP>T</SUP>, <I>Leuconostoc palmae</I> DSM 21144<SUP>T</SUP> and <I>Leuconostoc holzapfelii</I> DSM 21478<SUP>T</SUP> were 13.8±3.2 %, 14.3±3.4 %, 9.9±1.0 %, 13.2±0.8 %, 22.4±4.9 % and 16.2±4.6 %, respectively, which allowed differentiation of strain M2<SUP>T</SUP> from the closely related species of the genus <I>Leuconostoc</I>. On the basis of phenotypic and molecular properties, strain M2<SUP>T</SUP> represents a novel species in the genus <I>Leuconostoc</I>, for which the name <I>Leuconostoc miyukkimchii</I> sp. nov. is proposed. The type strain is M2<SUP>T</SUP> ( = KACC 15353<SUP>T</SUP> = JCM 17445<SUP>T</SUP>).</P>
Lee, Kyung-Ok,Jeong, Su-Jin,Park, Min-Young,Seong, Hye-Soon,Shin, Eun-Sim,Choi, Kyeong-Hwan,Kim, Gee-Young,Lee, Sun-Hwa The Korean Society for Microbiology 2009 Journal of Bacteriology and Virology Vol.39 No.4
The infections by human papillomaviruses (HPVs) are clearly associated with the subsequent development of cervical cancer. In this study, HPV genotype distribution and prevalence were detected in Korean women from January to December 2008 using PCR-DNA sequencing. A total of 2,562 cervical samples from Korean women having routine Pap smear cytology screening were used. HPV DNA was extracted from cervical swab samples and amplified by PCR in L1 region of HPV. HPV DNA was detected in 23.2% and 65.5% from the groups of normal and abnormal Pap cytology, respectively. The prevalence of high-risk types of HPV had the highest frequency in the <30 year-olds' group (50.6%). The prevalence of HPV in normal, ASCUS, LSIL and HSIL groups was 23.2%, 58.1%, 96.3% and 97.0%, respectively. Moreover, the frequencies of the high-risk types of HPV were 16.2% in the normal Pap cytology, 44.7% in the ASCUS, 76.1% in the LSIL and 94.1% in the HSIL groups. The prevalence of the high-risk types of HPV increased in proportion to the severity of the cytological classification. In the HSIL group, HPV type 16 was the most frequently found at 32.4%, followed by types 58, 53 and 33 at 17.6%, 14.7% and 11.8%, respectively. HPV type 82 was found in 5.6% of the HSIL group and was not detected in the normal Pap cytology group. The frequency of high-risk type of HPV 82 is firstly reported in Korean women. This finding could be an informative basis for the development of future HPV vaccination strategies in Korean women.