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Jaewon Lee,Nam-Joon Yi,Jae-Yoon Kim,Hyun Hwa Choi,Jiyoung Kim,Sola Lee,Su young Hong,Ung Sik Jin,Seong-Mi Yang,Jeong-Moo Lee,Suk Kyun Hong,YoungRok Choi,Kwang-Woong Lee,Kyung-Suk Suh 한국간담췌외과학회 2023 Annals of hepato-biliary-pancreatic surgery Vol.27 No.3
Attenuated portal vein (PV) flow is challenging in pediatric liver transplantation (LT) because it is unsuitable for classic end-to-end jump graft reconstruction from a small superior mesenteric vein (SMV). We thus introduce a novel technique of an end-to-side jump graft from SMV during pediatric LT using an adult partial liver graft. We successfully performed two cases of end-to-side retropancreatic jump graft using an iliac vein graft for PV reconstruction. One patient was a 2-year-old boy with hepatoblastoma and a Yerdel grade 3 PV thrombosis who underwent split LT. Another patient was an 8-month-old girl who had biliary atresia and PV hypoplasia with stenosis on the confluence level of the SMV; she underwent retransplantation because of graft failure related to PV thrombosis. After native PV was resected at the SMV confluence level, an end-to-side reconstruction was done from the proximal SMV to an interposition iliac vein. The interposition vein graft through posterior to the pancreas was obliquely anastomosed to the graft PV. There was no PV related complication during the follow-up period. Using a jump vascular graft in an end-to-side manner to connect the small native SMV and the large graft PV is a feasible treatment option in pediatric recipients with inadequate portal flow due to thrombosis or hypoplasia of the PV.
모델링 툴과 게임엔진을 이용한 캐릭터 구현 및 스토리텔링
이솔아(Sola Lee),전수인(Suin Jun),박미혜(Mihye Park),박수이(Sui Park),최종인(Jongin Choi) 한국정보통신학회 2021 한국정보통신학회 종합학술대회 논문집 Vol.25 No.1
게임 산업이 부상하며 게임의 세계관과 스토리텔링의 중요도 또한 커지고 있다. 게임의 특정 세계관을 전달하는 것은 게임의 몰입도에 막대한 영향을 미침으로 스토리를 전달하는 방식은 계속 연구될 필요가 있다. 본 연구에서는 모델링 툴을 이용하여 캐릭터를 구현하고 게임엔진을 사용하여 게임의 초반 스토리를 대화창을 통해 전달하였다. 연구를 통해 스토리를 전달하기 위한 워크플로우를 세우고, 그 과정을 심도 있게 이해할 수 있었으며, 이는 차후에 보다 더 정교한 게임 캐릭터 개발과 원활한 스토리텔링을 위한 기반이 될 것이라고 기대한다. With the rise of the game industry, the importance of the game's storytelling is also increasing. Delivering a specific world view of a game has a tremendous effect on the immersion of the game, so the method of delivering a story needs to be studied continuously. In this study, the character was implemented using 3D modelling tool, and the initial story of the game was delivered through a dialogue window using a game engine. Through the research, we were able to establish a workflow for telling stories using a character and understand each process in depth, which we expect to be the basis for more sophisticated game character development and smooth storytelling in the future.
Jiyoung Kim,Suk Kyun Hong,Jae-Yoon Kim,Jaewon Lee,Hyun Hwa Choi,Sola Lee,Su young Hong,Jeong-Moo Lee,YoungRok Choi,Nam-Joon Yi,Kwang-Woong Lee,Kyung-Suk Suh 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.105 No.1
Purpose: Total necrosis of hepatocellular carcinoma (HCC) achieved via locoregional treatment (LRT) is considered to indicate a lack of tumor viability. Nonetheless, there is insufficient evidence of recurrence after liver transplantation (LT) in patients with such a status. The aim of this study was to investigate the prognosis of patients diagnosed with totally necrotic nodules upon explant hepatectomy after LT. Methods: We conducted a retrospective study of patients diagnosed with totally necrotic nodules after LT for HCC. A total of 165 patients with HCC who underwent living- or deceased-donor LT from 2000 to 2020 in our hospital were included. Results: A total of 5 patients (3.0%) exhibited HCC recurrence during a median follow-up of 84 months (range, 4–243 months) after LT. The 5-year overall and recurrence-free survival rates of these patients were 92.8% and 92.2%, respectively. Four patients in the HCC-recurrence group (80.0%) died even after further treatment, including transarterial chemoembolization, surgery, and systemic treatment. Both univariate and multivariate analyses of clinicopathological factors identified a maximum diameter of the totally necrotic nodules of >5 cm as the only factor associated with tumor recurrence following LT (P = 0.005 and P = 0.009, respectively). Conclusion: Total necrosis of HCC via LRT yielded excellent survival outcomes for patients undergoing LT. Nevertheless, patients with large tumors should be considered at high risk of recurrence after LT, suggesting the need for their active surveillance during the follow-up period.
Kim Jae-Yoon,이남준,Kim Yoon Jun,Chie Eui Kyu,Kim Jiyoung,Choi Hyun Hwa,Lee Jaewon,Lee Sola,Hong Su Young,Lee Jeong-Moo,Hong Suk Kyun,Choi YoungRok,Lee Kwang-Woong,Suh Kyung-Suk 대한이식학회 2023 Korean Journal of Transplantation Vol.37 No.1
Adrenal and spinal metastases of hepatocellular carcinoma (HCC) are rare entities with significant morbidity and mortality, particularly after liver transplantation (LT). We report a case of a 49-year-old man who underwent LT for hepatitis B-related end-stage liver disease and HCC (single 4.5 cm lesion [T1N0], without vascular invasion) in 2016. Eighteen months later, adrenal metastasis and hepatitis B seropositive conversion were developed with normal serum tumor. Adrenal metastasis was treated with radiation therapy (RT) and hepatitis B showed spontaneous seronegative conversion. However, 35 months later, spinal metastasis occurred with elevation of the protein induced by vitamin K absence or antagonist-II (PIVKA-II) level (197 mAU/mL), along with hepatitis B seropositive conversion. After sorafenib, sequential regorafenib with RT led to partial response of the spinal lesions, along with hepatitis B seronegative conversion and normal PIVKA-II levels. After 9 months of regorafenib combined with RT, two recurrent lesions were found, as well as hepatitis B seropositive conversion and lesions were treated with transarterial chemoembolization. The patient survived for more than 71 months after LT and 53 months after recurrence under various combinations of therapy. Combined systemic and locoregional therapies can be a treatment option for HCC recurrence, even in LT patients.