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RETRACTED: Marine actinobacterial metabolites: Current status and future perspectives
Manivasagan, P.,Venkatesan, J.,Sivakumar, K.,Kim, S.K. G. Fischer 2013 Microbiological research Vol.168 No.6
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor. Authors and Editor agreed to retract this article because substantial parts of the text were copied from the following sources without proper attribution: Lam, K.S. (2006), Discovery of novel metabolites from marine actinomycetes. Current Opinion in Microbiology 9(3), pp. 245-251; Subramani, R., Aalbersberg, W. (2012), Marine actinomycetes: An ongoing source of novel bioactive metabolites. Microbiological Research 167(10), pp. 571-580; Dharmaraj, S. (2010), Marine Streptomyces as a novel source of bioactive substances. World Journal of Microbiology and Biotechnology 26(12), pp. 2123-2139. The authors apologize for this oversight and any inconvenience caused.
T Sivakumar,R Rajavel,D Karthikeyan,R Duraisamy,K Srinivasan,S Suresh kumar,Subhas S Karki 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.3
The chloroform extract of Croton roxburghii (Family: Euphorbiaceae) was evaluated for its antipyretic effects in Brewer’s yeast induced hyperthermia in rats. The anti-inflammatory effect of the Croton roxburghii was also evaluated by using carrageenan, dextran, histamine, serotonin induced rat paw oedema and cotton pellet induced granuloma (chronic) models in rats. The chloroform extract of Croton roxburghii (CECR) exhibited significant anti-pyretic and antiinflammatory effect at the dose 50, 100 and 200 mg/kg. Maximum inhibition (55.32%) was noted at the dose of 200 mg/kg after 3 h of drug treatment in carrageenan induced paw oedema, whereas the Indomethacin (standard drug) produced 61.33% of inhibition. The extract exhibited significant anti-inflammatory activity in dextran induced paw edema in a dose dependent manner. In the chronic model (cotton pellet induced granuloma) the CECR (200 mg/kg) and Indomethacin (10 mg/kg) showed decreased formation of granuloma tissue by 52.32% and 56.32% respectively. The extract also exhibited a significant antipyretic response in Brewer’s yeast induced pyrexia in rats. Thus, the present study revealed that the CECR exhibited significant antipyretic and anti-inflammatory activity in the tested animal models. The chloroform extract of Croton roxburghii (Family: Euphorbiaceae) was evaluated for its antipyretic effects in Brewer’s yeast induced hyperthermia in rats. The anti-inflammatory effect of the Croton roxburghii was also evaluated by using carrageenan, dextran, histamine, serotonin induced rat paw oedema and cotton pellet induced granuloma (chronic) models in rats. The chloroform extract of Croton roxburghii (CECR) exhibited significant anti-pyretic and antiinflammatory effect at the dose 50, 100 and 200 mg/kg. Maximum inhibition (55.32%) was noted at the dose of 200 mg/kg after 3 h of drug treatment in carrageenan induced paw oedema, whereas the Indomethacin (standard drug) produced 61.33% of inhibition. The extract exhibited significant anti-inflammatory activity in dextran induced paw edema in a dose dependent manner. In the chronic model (cotton pellet induced granuloma) the CECR (200 mg/kg) and Indomethacin (10 mg/kg) showed decreased formation of granuloma tissue by 52.32% and 56.32% respectively. The extract also exhibited a significant antipyretic response in Brewer’s yeast induced pyrexia in rats. Thus, the present study revealed that the CECR exhibited significant antipyretic and anti-inflammatory activity in the tested animal models.
Sivakumar Subramanian,A. S. Sekhar,B. V. S. S. S. Prasad 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.6
Leakage characteristics, influenced by centrifugal and thermal radial growth are determined computationally for a generic rotating labyrinthseal used in the gas turbine secondary air system. Three seal locations, namely, R25, R50 and R75 are represented by means ofvarying the rotor radius mimicking different radial positions of the seal from the shaft axis. The combined influence of seal location andits radial (Centrifugal and thermal) growth on the leakage performance is investigated for a wide-ranging speeds from 1000 to 3000 rad/s,temperatures ranging from 200 to 450 oC and pressure ratios varying from 1.1 to 2.5, for a chosen initial clearance of 500 micron. Acomparison of the effect of rotation and temperature gradient among different rotors shows that the radial growth and leakage flow ratessignificantly vary with the increasing radius.
Sivakumar, T,Kumar, R Sambath,Perumal, P,Vamsi, MLM,Sivakumar, P,Kanagasabai, R,Baskaran, MV,Karki, Subhas S,Mazumder, UK,Gupta, M Kyung Hee Oriental Medicine Research Center 2005 Oriental pharmacy and experimental medicine Vol.5 No.4
The plant Bryonia laciniosa (Family: Cucurbitaceae) has been indicated for the treatment of various diseases one among which is cancer. The purpose of this study was investigating experimentally the possible anti-tumor effect and antioxidant role of Bryonia laciniosa leaves in animal model. The methanol extract of Bryonia laciniosa (MEBL) administered at the doses of 62.5, 125 and 250 mg/kg in mice for 14 days after 24 h of tumor inoculation. The effect of MEBL on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters (lipid peroxidation, antioxidant enzymes) were estimated. Treatment with MEBL decreased the tumor volume and viable cell count thereby increasing the life span of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of MEBL also decreases the levels of lipid peroxidation and increased the levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). The present work indicates that the methanol extract of Bryonia laciniosa exhibited significant antitumor and antioxidant activity in vivo.
Effect and design of Mn2+ doped ZnO nanostructures for photodegradation and energy storage devices
Sivakumar S.,Robinson Yengkokpam 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.82 No.12
This paper studies the synthesis of Zn1-xMnxO (x=0.00, 0.03, 0.06) nanoparticles using the co-precipitation method. The structural, morphological and optical properties were characterized by XRD, FTIR, SEM, HR-TEM and UV–Visible DRS analysis. The structural analysis indicated a hexagonal shape with good crystallinity of the samples. The FTIR absorption peaks confrmed the formation of Zn–O bonding. The surface morphology and particle size were observed by SEM and HRTEM analysis. The EDS spectra determined the presence of elements Zn, Mn, and O in the samples. The optical band-gap of Mn-doped nanoparticles decreased with increasing concentration from 3.27 eV to 3.09 eV. The photocatalytic activity has been observed with methylene blue (MB) dye under solar irradiation. The Zn0.94Mn0.06O (Mn=0.06) nanoparticles photocatalyst has the highest degradation efciency at 94.08% within 180 min. This result shows that the Mn-doped ZnO enhanced the performance of the photocatalytic activity. In electrochemical performance analysis, undoped and Mn-doped electrodes have been studied 10 mV/s to 100 mV/s scan rate. Mn-doped electrodes decrease the specifc capacitance due to low surface area. However, all the undoped and Mn-doped electrodes possess reduction and oxidation peaks, which is considerable for suitable electrode materials for energy storage devices.
Marine Plastic Pollution in Indo-Pacific: ‘Together’ for Better ‘Future’
S. Sivakumar,Prakash Sharma 한국법제연구원 2021 KLRI journal of law and legislation Vol.11 No.2
According to a 2020 study titled “Changing Sails: Accelerating Regional Actions for Sustainable Oceans in Asia and the Pacific,” the Indo-Pacific region produces nearly half, together with consuming “more than one-third of the total world’s plastic.” It further reveals that owing to the inbuilt constraints in terms of methodology, coupled with inconvenient statistical systems, there remains serious concern for proper data procurement. Further, due to unchecked and uncontrolled human activities, the salubrity of oceans and seas is now “being pushed to a tipping point” and without proper data, the world appears to “swim in the dark.” The picture appears more horrific with COVID-19, particularly with additional reliance placed on the use of plastic. With plenty of challenges there are calls for review of goods production cycles through efficient strategies. In this perspective, we argue, first, no matter where we live, the ocean influences all of us. Therefore, the future we want demand easing of the complex relation between human and oceans, especially in the light of limited Earth’s ability to back rampant human desires. Secondly, the inherently wasteful linear plastic economy has resulted in overconsumption, destructive practices, acidification and subsidies that have caused irreplaceable damage to the state of oceans. As a result, the article maintains that (a) there is a weak legal and institutional framework, and (b) interaction between ocean and human activities, calls for better data demands. Further, the Sustainable Development Goal No. 14 strives towards promoting the health and sustainability of oceans. This holds a great importance, especially for the viable development of the Asia and the Pacific region which inhibits richest pool of the living natural resources in the world. The article suggests that both India and South Korea can take the lead and build up a mechanism of strengthening and promoting scientific know-how, develop research skills and share marine technology.