http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Sisi Tao (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Sisi Tao,Weidong Wang,Pengfei Liu,Hua Wang,Weirong Chen 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6
Retinoblastoma (Rb) is one of the most common eye malignancies occur in childhood. The crucial roles of non-coding RNAs, particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been widely reported in Rb progression. In the present study, we found the expression of lncRNA T-cell leukemia/lymphoma 6 (TCL6) was significantly downregulated in Rb tissues and cell lines. Knockdown of lncRNA TCL6 promoted cell proliferation while reduced cell apoptosis in Rb cells. Moreover, lncRNA TCL6 serves as a sponge for miR-21, a previously-reported oncogenic miRNA in Rb, by direct targeting to negatively regulated miR-21 expression, therefore modulating Rb proliferation through miR-21. TCL6 overexpression inhibited Rb cell proliferation while miR-21 overexpression exerted an opposing effect; the effect of TCL6 overexpression was partially attenuated by miR-21 overexpression. PTEN/PI3K/AKT signaling pathway was involved in lncRNA TCL6/miR-21 axis modulating Rb cell proliferation. Taken together, lncRNA TCL6 serves as a tumor suppressor by acting as a sponge for miR-21 to counteract miR-21-mediated PTEN repression.
-
Tao, Sisi,Wang, Weidong,Liu, Pengfei,Wang, Hua,Chen, Weirong The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6
Retinoblastoma (Rb) is one of the most common eye malignancies occur in childhood. The crucial roles of non-coding RNAs, particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been widely reported in Rb progression. In the present study, we found the expression of lncRNA T-cell leukemia/lymphoma 6 (TCL6) was significantly downregulated in Rb tissues and cell lines. Knockdown of lncRNA TCL6 promoted cell proliferation while reduced cell apoptosis in Rb cells. Moreover, lncRNA TCL6 serves as a sponge for miR-21, a previously-reported oncogenic miRNA in Rb, by direct targeting to negatively regulated miR-21 expression, therefore modulating Rb proliferation through miR-21. TCL6 overexpression inhibited Rb cell proliferation while miR-21 overexpression exerted an opposing effect; the effect of TCL6 overexpression was partially attenuated by miR-21 overexpression. PTEN/PI3K/AKT signaling pathway was involved in lncRNA TCL6/miR-21 axis modulating Rb cell proliferation. Taken together, lncRNA TCL6 serves as a tumor suppressor by acting as a sponge for miR-21 to counteract miR-21-mediated PTEN repression.
-
Application of self-centering wall panel with replaceable energy dissipation devices in steel frames
Sisi Chao,Hanheng Wu,Tianhua Zhou,Tao Guo,Chenglong Wang 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.32 No.2
The self-centering capacity and energy dissipation performance have been recognized critically for increasing the seismic performance of structures. This paper presents an innovative steel moment frame with self-centering steel reinforced concrete (SRC) wall panel incorporating replaceable energy dissipation devices (SF-SCWD). The self-centering mechanism and energy dissipation mechanism of the structure were validated by cyclic tests. The earthquake resilience of wall panel has the ability to limit structural damage and residual drift, while the energy dissipation devices located at wall toes are used to dissipate energy and reduce the seismic response. The oriented post-tensioned strands provide additional overturning force resistance and help to reduce residual drift. The main parameters were studied by numerical analysis to understand the complex structural behavior of this new system, such as initial stress of post-tensioning strands, yield strength of damper plates and height-width ratio of the wall panel. The static push-over analysis was conducted to investigate the failure process of the SF-SCWD. Moreover, nonlinear time history analysis of the 6-story frame was carried out, which confirmed the availability of the proposed structures in permanent drift mitigation.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
