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Linh Nhat Nguyen,Neha Kaushik,Pradeep Bhartiya,Sintayehu Kebede Gurmessa,김화정,Liem Quang Nguyen,Nagendra Kumar Kaushik,최은하 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.100 No.-
The development of an efficient tumor-specific therapeutic approach, which functions against theprimary tumor and also repairs the host immune system to eradicate distant tumors, remains a clinicalissue. Herein, this study focuses on the use of polydopamine-coated gold nanoparticles (Au@PDA NPs)that showed excellent selectivity towards cancer cells. The Au@PDA NPs were prepared by a plasmasynthesis method with a short reaction time and minimize the use of chemicals. Prominently, Au@PDANPs not only exhibited high cellular internalization but also stimulated immunogenic cell death (ICD) inaggressive breast carcinoma cells. Moreover, it was observed that damage-associated molecular patterns(DAMPs) were released by damaged cells together with the autophagy process after Au@PDA NPsexposure, which acted as endogenous danger signals to regulate the consequent immune response. Thisstudy highlights the novel mechanism of Au@PDA NPs-triggered anti-tumor immunity againstimmunosuppressive cancers, demonstrated the potential of the Au@PDA NPs for cancer immunotherapy.