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RISS 인기검색어
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- 저자 : Sijing Wang (검색결과 4 건)
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Guinian Wang,Longzi Wang,Sijing Sun,Juan Wu,Qinglu Wang 대한진단검사의학회 2015 Annals of Laboratory Medicine Vol.35 No.2
Background: Breast cancer is the most common type of cancer in females. Aberrant expression of microRNA-21 (miR-21) has previously been reported in breast cancer tissue. The aim of this study was to investigate expression levels of serum miR-21 in breast cancer patients and evaluate its prognostic value in Chinese females. Methods: Real-time quantitative (RQ)-PCR was used to analyze miR-21 expression in archived serum, tumor tissue, and adjacent normal tissue from 549 participants (326 with breast cancer, 223 without breast cancer). We also analyzed associations between serum miR-21 expression and breast cancer subtypes and patient prognosis. Recurrence and survival were analyzed by using the multivariate Cox proportional hazards model. Results: Expression of miR-21 was significantly higher in breast cancer tissues compared with normal adjacent breast tissues (P<0.001). The 2-ΔΔCt values for serum miR-21 in breast cancer patients versus healthy controls were 9.12±3.43 and 2.96±0.73, respectively. Multivariate Cox proportional hazards model suggested that serum miR-21 expression was an independent poor prognostic factor for both recurrence (hazard ratio [HR]= 2.942; 95% confidence interval [CI]=1.420-8.325; P=0.008) and disease-free survival (HR=2.732; 95% CI=1.038-7.273, P=0.003) in breast cancer. Conclusions: Increased serum miR-21 expression level was correlated with poor prognosis of breast cancer patients, indicating that serum miR-21 may be a novel prognostic marker for recurrence and survival of breast cancer patients before resection.
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Chi Liu,Xiaoli Liu,Chunlu Wu,Enzhi Wang,Sijing Wang,Haoyang Peng 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.3
The mechanical properties and failure mechanisms of geomaterials are greatly affected by their heterogeneity. As a special complex rock medium, the mechanical response of red bed soft rock is of considerable importance in stability analyses and the protection of slopes. In this study, X-ray micro-computerized tomography (micro-CT) was used to obtain the spatial distribution of minerals in red bed soft rock. An image processing procedure was proposed to incorporate the extracted mesoscopic mineral and crack distribution into the model of the grain-based finite-discrete element method (GB-FDEM). Subsequently, a uniaxial compression test and Brazilian disc splitting test were performed to obtain the mechanical response and failure modes of mudstone. The microscopic fracture morphology and traces of intragranular and intergranular cracks under tensile and shear stress were analyzed in detail. The numerical results show that the GB-FDEM model successfully characterized the mechanical response, which was similar to that of the laboratory tests and the traditional homogeneous models. The presence of minerals and pre-existing cracks disturbed the stress distribution in the heterogeneous model, which resulted in a difference in local stress that reasonably explained the phenomenon of local fragmentation. The simulated macroscopic failure mode of the heterogeneous models was most consistent with the results of the laboratory tests. The systematic framework proposed in this study provides a powerful tool for further understanding the multiscale (micro, meso, and macro) failure mechanism of red bed soft rock and predicting a realistic fracture process while reducing the tedious and redundant laboratory tests.
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Geng Shiyang,Xie Hua,Chen Liping,Chen Dong,Lu Sijing,Zhao Nan,Yang Ruiming,Wang Zhao,He Shaoheng,Zhang Huiyun 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.6
Purpose: To explore expression of SP and NK1R in basophils of allergic asthma (AA), allergic rhinitis (AR) and AR combined with AA (ARA), and influence of allergens and immunoglobulin E (IgE) mediated mechanisms on SP and NK1R expression. Methods: Expression of SP and NK1R was detected by flow cytometry, NK1R mRNA expression was detected by real time quantitative polymerase chain reaction (qPCR), and mouse AR and AA models were employed for in vivo study. Results: SP+ and NK1R+ cells increased in CCR3+ and CD123+HLA-DR− granulocytes of AA. PPE elevated proportions of SP+ cells in CCR3+ and CD123+HLA-DR− granulocytes, whereas ASWE and HDME augmented SP+ cells in CD123+HLA-DR− granulocytes of AR and ARA patients. ASWE, HDME and PPE increased proportions of NK1R+ cells in CCR3+ PBMC and CD123+HLA-DR− granulocytes of AR patients. OVA, Der p1, IL-33, IL-37, IgE and SP enhanced NK1R expression on KU812 cells. NK1R expressing basophils were increased in blood of OVA sensitized and challenged AR and AA mice. FcεRI-KO AA mice seemed to have less NK1R+ basophils than WT AA mice in their blood. Conclusion: CCR3+ and CD123+HLA-DR− cells are likely involved in AA and AR via SP and NK1R. IgE-related mechanism may participate in upregulation of NK1R expression.
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