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Shuang Mi,Jian Song,Yuanyuan Che,Huajun Zheng,Jianqiang Lin,Jianqun Lin 한국미생물학회 2011 The journal of microbiology Vol.49 No.6
Leptospirillum ferriphilum has been identified as the dominant, moderately thermophilic, bioleaching microorganism in bioleaching processes. It is an acidic and chemolithoautrophic bacterium that gains electrons from ferrous iron oxidation for energy production and cell growth. Genetic information about this microorganism has been limited until now, which has hindered its further exploration. In this study, the complete genome of L. ferripilum ML-04 is sequenced and annotated. The bacterium has a single circular chromosome of 2,406,157 bp containing 2,471 coding sequences (CDS), 2 rRNA operons, 48 tRNA genes, a large number of mobile genetic elements and 2 genomic islands. In silico analysis shows L. ferriphilum ML-04 fixes carbon through a reductive citric acid (rTCA) cycle, and obtains nitrogen through ammonium assimilation. The genes related to “cell envelope biogenesis, outer membrane” (6.9%) and “DNA replication, recombination and repair” (5.6%) are abundant, and a large number of genes related to heavy metal detoxification, oxidative and acidic stress defense, and signal transduction pathways were detected. The genomic plasticity, plentiful cell envelope components, inorganic element metabolic abilities and stress response mechanisms found the base for this organism’s survival in the bioleaching niche.
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Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2
Ting-Wei Mi,Xiao-Wen Sun,Zhi-Meng Wang,Ying-Ying Wang,Xuan-Cheng He,Cong Liu,Shuang-Feng Zhang,Hong-Zhen Du,Chang-Mei Liu,Zhao-Qian Teng 한국뇌신경과학회 2020 Experimental Neurobiology Vol.29 No.2
Neuropsychiatric disorders are the leading cause of mental and intellectual disabilities worldwide. Current therapies against neuropsychiatric disorders are very limited, and very little is known about the onset and development of these diseases, and their most effective treatments. MIR137 has been previously identified as a risk gene for the etiology of schizophrenia, bipolar disorder, and autism spectrum disorder. Here we generated a forebrain-specific MIR137 knockout mouse model, and provided evidence that loss of miR-137 resulted in impaired homeostasis of potassium in mouse hippocampal neurons. KCC2, a potassium-chloride co-transporter, was a direct downstream target of miR-137. The KCC2 specific antagonist VU0240551 could balance the current of potassium in miR-137 knockout neurons, and knockdown of KCC2 could ameliorate anxiety-like behavior in MIR137 cKO mice. These data suggest that KCC2 antagonists or knockdown might be beneficial to neuropsychiatric disorders due to the deficiency of miR-137.
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중국 SNS 인플루언서의 인상관리가 유저의 몰입도와 구매의도에 미치는 복합적 관계에 관한 연구
조상(Zhao, Shuang),김미현(Kim, Mi Hyun) 한국전시산업융합연구원 2020 한국과학예술융합학회 Vol.38 No.2
본 연구는 인터넷 기반의 SNS 플랫폼 환경에서 유명인으로 영향력이 커지고 있는 중국 SNS 인플루언서의 인상관리가 유저의 몰입도와 구매의도에 영향을 미치는지에 연구문제 제기에서 시작되었다. 본 연구의 목적은, 첫째, 중국 1인 미디어 인플루언서, 인상관리, SNS 몰입도, 구매의도에 대한 이론적 이해와 용어 정립을 통해 변수 선정의 이론적 근거를 마련 한다. 둘째, SNS 플랫폼 기반에서 중국 SNS 인플루어서와 유저와의 상호작용에서 인상관리의 영향을 알아보기 위하여 몰입도와 구매의도 변수에 대한 실증연구 기반을 마련한다. 셋째, 중국 SNS 인플루언서의 인상관리가 유저의 몰입도와 구매의도에 미치는 영향 관계를 도출하는 것이다. 따라서 본 논문은 중국 SNS 인플루언서의 인상관리가 유저의 몰입도와 구매의도에 영향을 미치는지 살펴보기 위해 가설을 설정하고 설문 조사를 통해 검증을 시도하였다. 이에 따른 연구 결과 및 내용은 다음과 같다. 첫째, 중국 SNS 인플루언서의 인상관리에서 자기중심적, 타인중심적, 비언어적 인상관리는 유저의 인플루언서에 대한 몰입도에 유의미한 영향을 미치는 것으로 나타났다. 둘째, 인터넷 SNS 플랫폼을 활용하는 유저의 몰입도는 구매의도에 유의미한 영향을 주는 것으로 나타났다. 셋째, 중국 SNS 인플루언서의 인상관리에서 자기중심적, 타인중심적, 비언어적 인상관리는 유저의 구매의도에 유의미한 영향을 미쳤다. 이와 같은 연구 결과를 바탕으로 몰입도와 구매의도 변수의 중요성을 반영한 유저와의 커뮤니케이션 전략을 수립한다면 효과적인 마케팅 방안이 되리라 기대한다. The study is about the effect of impression management of Chinese SNS influencers whose influence is growing as the celebrities in the SNS platform environment based on internet, on the users" flow and purchase intension. The purposes of this study, firstly, is to find the theoretical basis of variable selection through theoretical understanding and terms establishment of Chinese personal media influencers, impression management, SNS flow and purchase intension; Secondly, is to provide empirical research of the variables-flow and purchase intention, in order to inquiry the effect of impression management during the interaction between Chinese SNS influencers and users based on SNS platform; Thirdly, is to deduce the effect relationship of Chinese SNS influencers" impression management on users" flow and purchase intension. The conclusion of this study are as follows: firstly, the self-focused, other-focused and non-verbal impression management of Chinese SNS influencers have a meaningful effect on users‘ flow in influencers; secondly, the flow of Internet SNS platform users has a meaningful influence on purchase intension; thirdly, the self-focused, other-focused and non-verbal impression management of Chinese SNS influencers have a meaningful effect on users" purchase intension. Based on other research results like this, it would be an effective marketing measure if we establish the communication strategy with users which reflects the importance of the variables-flow and purchase intension.
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Zu-Guo Zhao,Shuang-Shuang Yan,Yun-Mei Yu,Na Mi,La-Xi Zhang,Jun Liu,Xiao-Ling Li,Fang Liu,Jun-Fa Xu,Wei-Qing Yang,Guo-Ming Li 한국미생물학회 2013 The journal of microbiology Vol.51 No.2
Yunnan Baiyao is a famous Chinese medicine that has long been directly applied to wounds to reduce bleeding, pain, and swelling without causing infection. However, little is known about its ability to prevent infection. The present study aimed to assess in vitro the anti-virulence activity of an aqueous extract of Yunnan Baiyao (YBX) using Pseudomonas aeruginosa as a pathogenic model. We found that a sub-MIC (2.5 mg/ml) of YBX can efficiently interfere with the quorum-sensing (QS) signaling circuit. Real-time polymerase chain reaction analysis showed that a sub-MIC of YBX downregulated the transcriptions of lasR, lasI, rhlR, and rhlI,which resulted in global attenuation of QS-regulated virulence activities, such as biofilm formation, and secretion of LasA protease, LasB elastase and pyocyanin. Further, YBX reduced the motility of P. aeruginosa related to QS, and impaired the formation of biofilms. These results suggest that YBX may possess global inhibitory activity against the virulence of P. aeruginosa and that YBX may also exhibit antimicrobial activity in vivo. The present study suggests that Yunnan Baiyao represents a potential source for isolating novel, safe, and efficacious antimicrobial agents.
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